메뉴 건너뛰기




Volumn 17, Issue 14, 2003, Pages 1755-1767

Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53

Author keywords

Checkpoint; Claspin; DNA damage; Mediator; Rad53; Replication fork

Indexed keywords

CHECKPOINT KINASE 2; DNA; MEC1 KINASE; MEDIATOR PROTEIN; NUCLEIC ACID BINDING PROTEIN; PHOSPHOTRANSFERASE; PROTEIN MRC1; UNCLASSIFIED DRUG;

EID: 0038506000     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1098303     Document Type: Article
Times cited : (318)

References (45)
  • 2
    • 0027953230 scopus 로고
    • The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast
    • Allen, J.B., Zhou, Z., Siede, W., Friedberg, E.C., and Elledge, S.J. 1994. The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes & Dev. 8: 2401-2415.
    • (1994) Genes & Dev. , vol.8 , pp. 2401-2415
    • Allen, J.B.1    Zhou, Z.2    Siede, W.3    Friedberg, E.C.4    Elledge, S.J.5
  • 3
    • 0030886099 scopus 로고    scopus 로고
    • Components and dynamics of DNA replication complexes in S. cerevisiae: Redistribution of MCM proteins and Cdc45p during S phase
    • Aparicio, O.M., Weinstein, D.M., and Bell, S.P. 1997. Components and dynamics of DNA replication complexes in S. cerevisiae: Redistribution of MCM proteins and Cdc45p during S phase. Cell 91: 59-69.
    • (1997) Cell , vol.91 , pp. 59-69
    • Aparicio, O.M.1    Weinstein, D.M.2    Bell, S.P.3
  • 4
    • 0029592020 scopus 로고
    • Dpb11, which interacts with DNA polymerase II(ε) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint
    • Araki, H., Leem, S.H., Phongdara, A., and Sugino, A. 1995. Dpb11, which interacts with DNA polymerase II(ε) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint. Proc. Natl. Acad. Sci. 92: 11791-11795.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 11791-11795
    • Araki, H.1    Leem, S.H.2    Phongdara, A.3    Sugino, A.4
  • 5
    • 0032079366 scopus 로고    scopus 로고
    • RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation
    • de la Torre-Ruiz, M.A., Green, C.M., and Lowndes, N.F. 1998. RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation. EMBO J. 17: 2687-2698.
    • (1998) EMBO J. , vol.17 , pp. 2687-2698
    • De la Torre-Ruiz, M.A.1    Green, C.M.2    Lowndes, N.F.3
  • 6
    • 0032530824 scopus 로고    scopus 로고
    • Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway
    • Desany, B.A., Alcasabas, A.A., Bachant, J.B., and Elledge, S.J. 1998. Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway. Genes & Dev. 12: 2956-2970.
    • (1998) Genes & Dev. , vol.12 , pp. 2956-2970
    • Desany, B.A.1    Alcasabas, A.A.2    Bachant, J.B.3    Elledge, S.J.4
  • 7
    • 0035162698 scopus 로고    scopus 로고
    • Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p
    • Gasch, A.P., Huang, M., Metzner, S., Botstein, D., Elledge, S.J., and Brown, P.O. 2001. Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. Mol. Biol. Cell 12: 2987-3003.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 2987-3003
    • Gasch, A.P.1    Huang, M.2    Metzner, S.3    Botstein, D.4    Elledge, S.J.5    Brown, P.O.6
  • 8
    • 0034881760 scopus 로고    scopus 로고
    • Budding yeast Rad9 is an ATP-dependent Rad53 activating machine
    • Gilbert, C.S., Green, C.M., and Lowndes, N.F. 2001. Budding yeast Rad9 is an ATP-dependent Rad53 activating machine. Mol. Cell 8: 129-136.
    • (2001) Mol. Cell , vol.8 , pp. 129-136
    • Gilbert, C.S.1    Green, C.M.2    Lowndes, N.F.3
  • 9
    • 0032483576 scopus 로고    scopus 로고
    • The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor
    • Huang, M., Zhou, Z., and Elledge, S.J. 1998. The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Cell 94: 595-605.
    • (1998) Cell , vol.94 , pp. 595-605
    • Huang, M.1    Zhou, Z.2    Elledge, S.J.3
  • 11
    • 0031658237 scopus 로고    scopus 로고
    • Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication
    • Kamimura, Y., Masumoto, H., Sugino, A., and Araki, H. 1998. Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol. Cell. Biol. 18: 6102-6109.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 6102-6109
    • Kamimura, Y.1    Masumoto, H.2    Sugino, A.3    Araki, H.4
  • 12
    • 0033621392 scopus 로고    scopus 로고
    • Substrate specificities and identification of putative substrates of ATM kinase family members
    • Kim, S.T., Lim, D.S., Canman, C.E., and Kastan, M.B. 1999. Substrate specificities and identification of putative substrates of ATM kinase family members. J. Biol. Chem. 274: 37538-37543.
    • (1999) J. Biol. Chem. , vol.274 , pp. 37538-37543
    • Kim, S.T.1    Lim, D.S.2    Canman, C.E.3    Kastan, M.B.4
  • 13
    • 0035955398 scopus 로고    scopus 로고
    • Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms
    • Kondo, T., Wakayama, T., Naiki, T., Matsumoto, K., and Sugimoto, K. 2001. Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms. Science 294: 867-870.
    • (2001) Science , vol.294 , pp. 867-870
    • Kondo, T.1    Wakayama, T.2    Naiki, T.3    Matsumoto, K.4    Sugimoto, K.5
  • 14
    • 0033634679 scopus 로고    scopus 로고
    • Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
    • Kumagai, A. and Dunphy, W.G. 2000. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol. Cell 6: 839-849.
    • (2000) Mol. Cell , vol.6 , pp. 839-849
    • Kumagai, A.1    Dunphy, W.G.2
  • 15
    • 0037291130 scopus 로고    scopus 로고
    • Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17
    • Lee, J., Kumagai, A., and Dunphy, W.G. 2003. Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. Mol. Cell 11: 329-340.
    • (2003) Mol. Cell , vol.11 , pp. 329-340
    • Lee, J.1    Kumagai, A.2    Dunphy, W.G.3
  • 16
    • 0030804309 scopus 로고    scopus 로고
    • The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast
    • Longhese, M.P., Paciotti, V., Fraschini, R., Zaccarini, R., Plevani, P., and Lucchini, G. 1997. The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast. EMBO J. 16: 5216-5226.
    • (1997) EMBO J. , vol.16 , pp. 5216-5226
    • Longhese, M.P.1    Paciotti, V.2    Fraschini, R.3    Zaccarini, R.4    Plevani, P.5    Lucchini, G.6
  • 17
    • 0031820288 scopus 로고    scopus 로고
    • Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
    • Longtine, M.S., McKenzie III, A., Demarini, D.J., Shah, N.G., Wach, A., Brachat, A., Philippsen, P., and Pringle, J.R. 1998. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14: 953-961.
    • (1998) Yeast , vol.14 , pp. 953-961
    • Longtine, M.S.1    McKenzie A. III2    Demarini, D.J.3    Shah, N.G.4    Wach, A.5    Brachat, A.6    Philippsen, P.7    Pringle, J.R.8
  • 19
    • 0035498938 scopus 로고    scopus 로고
    • Two checkpoint complexes are independently recruited to sites of DNA damage in vivo
    • Melo, J.A., Cohen, J., and Toczyski, D.P. 2001. Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes & Dev. 15: 2809-2821.
    • (2001) Genes & Dev. , vol.15 , pp. 2809-2821
    • Melo, J.A.1    Cohen, J.2    Toczyski, D.P.3
  • 20
    • 0034903652 scopus 로고    scopus 로고
    • Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway
    • Naiki, T., Kondo, T., Nakada, D., Matsumoto, K., and Sugimoto, K. 2001. Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway. Mol. Cell. Biol. 21: 5838-5845.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 5838-5845
    • Naiki, T.1    Kondo, T.2    Nakada, D.3    Matsumoto, K.4    Sugimoto, K.5
  • 21
    • 0028979332 scopus 로고
    • DNA polymerase ε links the DNA replication machinery to the S phase checkpoint
    • Navas, T.A., Zhou, Z., and Elledge, S.J. 1995. DNA polymerase ε links the DNA replication machinery to the S phase checkpoint. Cell 80: 29-39.
    • (1995) Cell , vol.80 , pp. 29-39
    • Navas, T.A.1    Zhou, Z.2    Elledge, S.J.3
  • 22
    • 0029859168 scopus 로고    scopus 로고
    • RAD9 and DNA polymerase ε form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae
    • Navas, T.A., Sanchez, Y., and Elledge, S.J. 1996. RAD9 and DNA polymerase ε form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae. Genes & Dev. 10: 2632-2643.
    • (1996) Genes & Dev. , vol.10 , pp. 2632-2643
    • Navas, T.A.1    Sanchez, Y.2    Elledge, S.J.3
  • 23
    • 0034663809 scopus 로고    scopus 로고
    • The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast
    • Paciotti, V., Clerici, M., Lucchini, G., and Longhese, M.P. 2000. The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast. Genes & Dev. 14: 2046-2059.
    • (2000) Genes & Dev. , vol.14 , pp. 2046-2059
    • Paciotti, V.1    Clerici, M.2    Lucchini, G.3    Longhese, M.P.4
  • 24
    • 0034329474 scopus 로고    scopus 로고
    • LCD1: An essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae
    • Rouse, J. and Jackson, S.P. 2000. LCD1: An essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae. EMBO J. 19: 5801-5812.
    • (2000) EMBO J. , vol.19 , pp. 5801-5812
    • Rouse, J.1    Jackson, S.P.2
  • 25
    • 0030593033 scopus 로고    scopus 로고
    • Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways
    • Sanchez, Y., Desany, B.A., Jones, W.J., Liu, Q., Wang, B., and Elledge, S.J. 1996. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271: 357-360.
    • (1996) Science , vol.271 , pp. 357-360
    • Sanchez, Y.1    Desany, B.A.2    Jones, W.J.3    Liu, Q.4    Wang, B.5    Elledge, S.J.6
  • 26
    • 0036281710 scopus 로고    scopus 로고
    • Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint
    • Schwartz, M.F., Duong, J.F., Sun, Z., Morrow, J.S., Pradhan, D., and Stern, D.F. 2002. Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint. Mol. Cell 9: 1055-1065.
    • (2002) Mol. Cell , vol.9 , pp. 1055-1065
    • Schwartz, M.F.1    Duong, J.F.2    Sun, Z.3    Morrow, J.S.4    Pradhan, D.5    Stern, D.F.6
  • 27
    • 0037115462 scopus 로고    scopus 로고
    • ORC and the intra-S-phase checkpoint: A threshold regulates Rad53p activation in S phase
    • Shimada, K., Pasero, P., and Gasser, S.M. 2002. ORC and the intra-S-phase checkpoint: A threshold regulates Rad53p activation in S phase. Genes & Dev. 16: 3236-3252.
    • (2002) Genes & Dev. , vol.16 , pp. 3236-3252
    • Shimada, K.1    Pasero, P.2    Gasser, S.M.3
  • 28
    • 0031027431 scopus 로고    scopus 로고
    • SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast
    • Strahl-Bolsinger, S., Hecht, A., Luo, K., and Grunstein, M. 1997. SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast. Genes & Dev. 11: 83-93.
    • (1997) Genes & Dev. , vol.11 , pp. 83-93
    • Strahl-Bolsinger, S.1    Hecht, A.2    Luo, K.3    Grunstein, M.4
  • 29
    • 0030793718 scopus 로고    scopus 로고
    • Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway
    • Sugimoto, K., Ando, S., Shimomura, T., and Matsumoto, K. 1997. Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway. Mol. Cell. Biol. 17: 5905-5914.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5905-5914
    • Sugimoto, K.1    Ando, S.2    Shimomura, T.3    Matsumoto, K.4
  • 30
    • 0029928222 scopus 로고    scopus 로고
    • Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways
    • Sun, Z., Fay, D.S., Marini, F., Foiani, M., and Stern, D.F. 1996. Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes & Dev. 10: 395-406.
    • (1996) Genes & Dev. , vol.10 , pp. 395-406
    • Sun, Z.1    Fay, D.S.2    Marini, F.3    Foiani, M.4    Stern, D.F.5
  • 31
    • 0032504069 scopus 로고    scopus 로고
    • Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint
    • Sun, Z., Hsiao, J., Fay, D.S., and Stern, D.F. 1998. Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint. Science 281: 272-274.
    • (1998) Science , vol.281 , pp. 272-274
    • Sun, Z.1    Hsiao, J.2    Fay, D.S.3    Stern, D.F.4
  • 32
    • 0035736486 scopus 로고    scopus 로고
    • Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1
    • Tanaka, K. and Russell, P. 2001. Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1. Nat. Cell Biol. 3: 966-972.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 966-972
    • Tanaka, K.1    Russell, P.2
  • 33
    • 0035797444 scopus 로고    scopus 로고
    • Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint
    • Tercero, J.A. and Diffley, J.F. 2001. Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature 412: 553-557.
    • (2001) Nature , vol.412 , pp. 553-557
    • Tercero, J.A.1    Diffley, J.F.2
  • 34
    • 0029157031 scopus 로고
    • Segregation of unreplicated chromosomes in Saccharomyces cerevisiae reveals a novel G1/M-phase checkpoint
    • Toyn, J.H., Johnson, A.L., and Johnston, L.H. 1995. Segregation of unreplicated chromosomes in Saccharomyces cerevisiae reveals a novel G1/M-phase checkpoint. Mol. Cell. Biol. 15: 5312-5321.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 5312-5321
    • Toyn, J.H.1    Johnson, A.L.2    Johnston, L.H.3
  • 35
    • 0032189952 scopus 로고    scopus 로고
    • The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage
    • Vialard, J.E., Gilbert, C.S., Green, C.M., and Lowndes, N.F. 1998. The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage. EMBO J. 17: 5679-5688.
    • (1998) EMBO J. , vol.17 , pp. 5679-5688
    • Vialard, J.E.1    Gilbert, C.S.2    Green, C.M.3    Lowndes, N.F.4
  • 36
    • 0035138557 scopus 로고    scopus 로고
    • Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae
    • Wakayama, T., Kondo, T., Ando, S., Matsumoto, K., and Sugimoto, K. 2001. Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae. Mol. Cell. Biol. 21: 755-764.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 755-764
    • Wakayama, T.1    Kondo, T.2    Ando, S.3    Matsumoto, K.4    Sugimoto, K.5
  • 37
    • 0033616679 scopus 로고    scopus 로고
    • DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae
    • Wang, H. and Elledge, S.J. 1999. DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. 96: 3824-3829.
    • (1999) Proc. Natl. Acad. Sci. , vol.96 , pp. 3824-3829
    • Wang, H.1    Elledge, S.J.2
  • 38
    • 0036237806 scopus 로고    scopus 로고
    • Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway
    • 2002. Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 160: 1295-1304.
    • (2002) Genetics , vol.160 , pp. 1295-1304
  • 39
    • 0023712476 scopus 로고
    • The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae
    • Weinert, T.A. and Hartwell, L.H. 1988. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science 241: 317-322.
    • (1988) Science , vol.241 , pp. 317-322
    • Weinert, T.A.1    Hartwell, L.H.2
  • 40
    • 0027212282 scopus 로고
    • Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint
    • 1993. Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint. Genetics 134: 63-80.
    • (1993) Genetics , vol.134 , pp. 63-80
  • 41
    • 0028353634 scopus 로고
    • Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair
    • Weinert, T.A., Kiser, G.L., and Hartwell, L.H. 1994. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes & Dev. 8: 652-665.
    • (1994) Genes & Dev. , vol.8 , pp. 652-665
    • Weinert, T.A.1    Kiser, G.L.2    Hartwell, L.H.3
  • 42
    • 0033215306 scopus 로고    scopus 로고
    • Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway
    • Weinreich, M. and Stillman, B. 1999. Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway. EMBO J. 18: 5334-5346.
    • (1999) EMBO J. , vol.18 , pp. 5334-5346
    • Weinreich, M.1    Stillman, B.2
  • 43
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou, B.B. and Elledge, S.J. 2000. The DNA damage response: Putting checkpoints in perspective. Nature 408: 433-439.
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 44
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou, L. and Elledge, S.J. 2003. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300: 1542-1548.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 45
    • 0032562610 scopus 로고    scopus 로고
    • Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin
    • Zou, L. and Stillman, B. 1998. Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin. Science 280: 593-596.
    • (1998) Science , vol.280 , pp. 593-596
    • Zou, L.1    Stillman, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.