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Volumn 31, Issue 4, 2012, Pages 895-907

Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype

Author keywords

deoxyribonucleoside triphosphates; DNA damage; DNA replication; mutagenesis; ribonucleotide reductase

Indexed keywords

DEOXYRIBONUCLEOTIDE; DNA; RAD54 PROTEIN;

EID: 84857047373     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2011.485     Document Type: Article
Times cited : (90)

References (96)
  • 1
    • 37748999305 scopus 로고    scopus 로고
    • Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination
    • Alvaro D, Lisby M, Rothstein R (2007) Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. PLoS Genet 3: e228
    • (2007) PLoS Genet , vol.3
    • Alvaro, D.1    Lisby, M.2    Rothstein, R.3
  • 3
    • 39549114009 scopus 로고    scopus 로고
    • Differential regulation of the cellular response to DNA double-strand breaks in G1
    • DOI 10.1016/j.molcel.2008.01.016, PII S1097276508001548
    • Barlow JH, Lisby M, Rothstein R (2008) Differential regulation of the cellular response to DNA double-strand breaks in G1. Mol Cell 30: 73-85 (Pubitemid 351470149)
    • (2008) Molecular Cell , vol.30 , Issue.1 , pp. 73-85
    • Barlow, J.H.1    Lisby, M.2    Rothstein, R.3
  • 6
    • 0041966011 scopus 로고    scopus 로고
    • Elg1 forms an alternative RFC complex important for DNA replication and genome integrity
    • DOI 10.1093/emboj/cdg406
    • Bellaoui M, Chang M, Ou J, Xu H, Boone C, Brown GW (2003) Elg1 forms an alternative RFC complex important for DNA replication and genome integrity. EMBO J 22: 4304-4313 (Pubitemid 37021757)
    • (2003) EMBO Journal , vol.22 , Issue.16 , pp. 4304-4313
    • Bellaoui, M.1    Chang, M.2    Ou, J.3    Xu, H.4    Boone, C.5    Brown, G.W.6
  • 10
    • 45549085055 scopus 로고    scopus 로고
    • Genetic instability is not a requirement for tumor development
    • discussion 3560-3551
    • Bodmer W, Bielas JH, Beckman RA (2008) Genetic instability is not a requirement for tumor development. Cancer Res 68: 3558-3560; discussion 3560-3551
    • (2008) Cancer Res , vol.68 , pp. 3558-3560
    • Bodmer, W.1    Bielas, J.H.2    Beckman, R.A.3
  • 11
    • 0032579440 scopus 로고    scopus 로고
    • Designer deletion strains derived from Saccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR-mediated gene disruption and other applications
    • DOI 10.1002/(SICI)1097-0061(19980130)14:2<115::AID-YEA204>3.0.CO;2- 2
    • Brachmann CB, Davies A, Cost GJ, Caputo E, Li J, Hieter P, Boeke JD (1998) Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 14: 115-132 (Pubitemid 28062863)
    • (1998) Yeast , vol.14 , Issue.2 , pp. 115-132
    • Brachmann, C.B.1    Davies, A.2    Cost, G.J.3    Caputo, E.4    Li, J.5    Hieter, P.6    Boeke, J.D.7
  • 14
    • 0037423223 scopus 로고    scopus 로고
    • Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase
    • DOI 10.1016/S0092-8674(03)00075-8
    • Chabes A, Georgieva B, Domkin V, Zhao X, Rothstein R, Thelander L (2003) Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase. Cell 112: 391-401 (Pubitemid 36183658)
    • (2003) Cell , vol.112 , Issue.3 , pp. 391-401
    • Chabes, A.1    Georgieva, B.2    Domkin, V.3    Zhao, X.4    Rothstein, R.5    Thelander, L.6
  • 15
    • 33846576261 scopus 로고    scopus 로고
    • Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae
    • DOI 10.1073/pnas.0610585104
    • Chabes A, Stillman B (2007) Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae. Proc Natl Acad Sci USA 104: 1183-1188 (Pubitemid 46183979)
    • (2007) Proceedings of the National Academy of Sciences of the United States of America , vol.104 , Issue.4 , pp. 1183-1188
    • Chabes, A.1    Stillman, B.2
  • 16
    • 46649089698 scopus 로고    scopus 로고
    • The N-and C-termini of Elg1 contribute to the maintenance of genome stability
    • Davidson MB, Brown GW (2008) The N-and C-termini of Elg1 contribute to the maintenance of genome stability. DNA Repair (Amst) 7: 1221-1232
    • (2008) DNA Repair (Amst) , vol.7 , pp. 1221-1232
    • Davidson, M.B.1    Brown, G.W.2
  • 19
    • 67849119511 scopus 로고    scopus 로고
    • Comparative genome hybridization on tiling microarrays to detect aneuploidies in yeast
    • Dion B, Brown GW (2009) Comparative genome hybridization on tiling microarrays to detect aneuploidies in yeast. Methods Mol Biol 548: 1-18
    • (2009) Methods Mol Biol , vol.548 , pp. 1-18
    • Dion, B.1    Brown, G.W.2
  • 20
    • 0034700511 scopus 로고    scopus 로고
    • A role for Saccharomyces cerevisiae histone H2A in DNA repair
    • DOI 10.1038/35050000
    • Downs JA, Lowndes NF, Jackson SP (2000) A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature 408: 1001-1004 (Pubitemid 32101649)
    • (2000) Nature , vol.408 , Issue.6815 , pp. 1001-1004
    • Downs, J.A.1    Lowndes, N.F.2    Jackson, S.P.3
  • 21
    • 0023395932 scopus 로고
    • Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability
    • Elledge SJ, Davis RW (1987) Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability. Mol Cell Biol 7: 2783-2793
    • (1987) Mol Cell Biol , vol.7 , pp. 2783-2793
    • Elledge, S.J.1    Davis, R.W.2
  • 22
    • 0024376690 scopus 로고
    • DNA damage induction of ribonucleotide reductase
    • Elledge SJ, Davis RW (1989) DNA damage induction of ribonucleotide reductase. Mol Cell Biol 9: 4932-4940 (Pubitemid 19275963)
    • (1989) Molecular and Cellular Biology , vol.9 , Issue.11 , pp. 4932-4940
    • Elledge, S.J.1    Davis, R.W.2
  • 23
    • 0025350420 scopus 로고
    • Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase
    • Elledge SJ, Davis RW (1990) Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase. Genes Dev 4: 740-751
    • (1990) Genes Dev , vol.4 , pp. 740-751
    • Elledge, S.J.1    Davis, R.W.2
  • 24
    • 0027605113 scopus 로고
    • DNA damage and cell cycle regulation of ribonucleotide reductase
    • Elledge SJ, Zhou Z, Allen JB, Navas TA (1993) DNA damage and cell cycle regulation of ribonucleotide reductase. Bioessays 15: 333-339
    • (1993) Bioessays , vol.15 , pp. 333-339
    • Elledge, S.J.1    Zhou, Z.2    Allen, J.B.3    Navas, T.A.4
  • 28
    • 33646359442 scopus 로고    scopus 로고
    • Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells
    • DOI 10.1074/jbc.M512894200
    • Hakansson P, Hofer A, Thelander L (2006) Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells. J Biol Chem 281: 7834-7841 (Pubitemid 43847398)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.12 , pp. 7834-7841
    • Hakansson, P.1    Hofer, A.2    Thelander, L.3
  • 29
    • 40449120350 scopus 로고    scopus 로고
    • An oncogene-induced DNA damage model for cancer development
    • DOI 10.1126/science.1140735
    • Halazonetis TD, Gorgoulis VG, Bartek J (2008) An oncogeneinduced DNA damage model for cancer development. Science 319: 1352-1355 (Pubitemid 351354863)
    • (2008) Science , vol.319 , Issue.5868 , pp. 1352-1355
    • Halazonetis, T.D.1    Gorgoulis, V.G.2    Bartek, J.3
  • 30
    • 0035051062 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae CTF18 and CTF4 are required for sister chromatid cohesion
    • DOI 10.1128/MCB.21.9.3144-3158.2001
    • Hanna JS, Kroll ES, Lundblad V, Spencer FA (2001) Saccharomyces cerevisiae CTF18 and CTF4 are required for sister chromatid cohesion. Mol Cell Biol 21: 3144-3158 (Pubitemid 32298381)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.9 , pp. 3144-3158
    • Hanna, J.S.1    Kroll, E.S.2    Lundblad, V.3    Spencer, F.A.4
  • 31
    • 0031036674 scopus 로고    scopus 로고
    • Role of the casein kinase i isoform, Hrr25, and the cell cycle-regulatory transcription factor, SBF, in the transcriptional response to DNA damage in Saccharomyces cerevisiae
    • Ho Y, Mason S, Kobayashi R, Hoekstra M, Andrews B (1997) Role of the casein kinase I isoform, Hrr25, and the cell cycle-regulatory transcription factor, SBF, in the transcriptional response to DNA damage in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 94: 581-586
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 581-586
    • Ho, Y.1    Mason, S.2    Kobayashi, R.3    Hoekstra, M.4    Andrews, B.5
  • 32
    • 0030813561 scopus 로고    scopus 로고
    • Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae
    • Huang M, Elledge SJ (1997) Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae. Mol Cell Biol 17: 6105-6113 (Pubitemid 27411119)
    • (1997) Molecular and Cellular Biology , vol.17 , Issue.10 , pp. 6105-6113
    • Huang, M.1    Elledge, S.J.2
  • 33
    • 0032483576 scopus 로고    scopus 로고
    • The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor
    • DOI 10.1016/S0092-8674(00)81601-3
    • Huang M, Zhou Z, Elledge SJ (1998) The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Cell 94: 595-605 (Pubitemid 28427578)
    • (1998) Cell , vol.94 , Issue.5 , pp. 595-605
    • Huang, M.1    Zhou, Z.2    Elledge, S.J.3
  • 34
    • 0036242094 scopus 로고    scopus 로고
    • Pol32, a subunit of Saccharomyces cerevisiae DNA polymerase δ, suppresses genomic deletions and is involved in the mutagenic bypass pathway
    • Huang ME, Rio AG, Galibert MD, Galibert F (2002) Pol32, a subunit of Saccharomyces cerevisiae DNA polymerase delta, suppresses genomic deletions and is involved in the mutagenic bypass pathway. Genetics 160: 1409-1422 (Pubitemid 34454365)
    • (2002) Genetics , vol.160 , Issue.4 , pp. 1409-1422
    • Huang, M.-E.1    Rio, A.-G.2    Galibert, M.-D.3    Galibert, F.4
  • 36
    • 0023426281 scopus 로고
    • Identification of the gene for the yeast ribonucleotide reductase small subunit and its inducibility by methyl methanesulfonate
    • Hurd HK, Roberts CW, Roberts JW (1987) Identification of the gene for the yeast ribonucleotide reductase small subunit and its inducibility by methyl methanesulfonate. Mol Cell Biol 7: 3673-3677
    • (1987) Mol Cell Biol , vol.7 , pp. 3673-3677
    • Hurd, H.K.1    Roberts, C.W.2    Roberts, J.W.3
  • 37
    • 0037179175 scopus 로고    scopus 로고
    • A stable and sensitive genotoxic testing system based on DNA damage induced gene expression in Saccharomyces cerevisiae
    • DOI 10.1016/S1383-5718(02)00129-8, PII S1383571802001298
    • Jia X, Zhu Y, Xiao W (2002) A stable and sensitive genotoxic testing system based on DNA damage induced gene expression in Saccharomyces cerevisiae. Mutat Res 519: 83-92 (Pubitemid 34874989)
    • (2002) Mutation Research - Genetic Toxicology and Environmental Mutagenesis , vol.519 , Issue.1-2 , pp. 83-92
    • Jia, X.1    Zhu, Y.2    Xiao, W.3
  • 38
    • 0141504148 scopus 로고    scopus 로고
    • Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability
    • DOI 10.1016/S0960-9822(03)00578-5
    • Kanellis P, Agyei R, Durocher D (2003) Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability. Curr Biol 13: 1583-1595 (Pubitemid 37215882)
    • (2003) Current Biology , vol.13 , Issue.18 , pp. 1583-1595
    • Kanellis, P.1    Agyei, R.2    Durocher, D.3
  • 39
    • 33745199392 scopus 로고    scopus 로고
    • Genomic approach for the understanding of dynamic aspect of chromosome behavior
    • Katou Y, Kaneshiro K, Aburatani H, Shirahige K (2006) Genomic approach for the understanding of dynamic aspect of chromosome behavior. Methods Enzymol 409: 389-410
    • (2006) Methods Enzymol , vol.409 , pp. 389-410
    • Katou, Y.1    Kaneshiro, K.2    Aburatani, H.3    Shirahige, K.4
  • 40
    • 0042865938 scopus 로고    scopus 로고
    • S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex
    • DOI 10.1038/nature01900
    • Katou Y, Kanoh Y, Bando M, Noguchi H, Tanaka H, Ashikari T, Sugimoto K, Shirahige K (2003) S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature 424: 1078-1083 (Pubitemid 37064311)
    • (2003) Nature , vol.424 , Issue.6952 , pp. 1078-1083
    • Katou, Y.1    Kanoh, Y.2    Bando, M.3    Noguchi, H.4    Tanaka, H.5    Ashikari, T.6    Sugimoto, K.7    Shirahige, K.8
  • 41
    • 0345791546 scopus 로고    scopus 로고
    • Hydroxyurea Arrests DNA Replication by a Mechanism that Preserves Basal dNTP Pools
    • DOI 10.1074/jbc.M303952200
    • Koc A, Wheeler LJ, Mathews CK, Merrill GF (2004) Hydroxyurea arrests DNA replication by a mechanism that preserves basal dNTP pools. J Biol Chem 279: 223-230 (Pubitemid 38044818)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.1 , pp. 223-230
    • Koc, A.1    Wheeler, L.J.2    Mathews, C.K.3    Merrill, G.F.4
  • 42
    • 0028292454 scopus 로고
    • Cell cycle regulated transcription in yeast
    • DOI 10.1016/0955-0674(94)90039-6
    • Koch C, Nasmyth K (1994) Cell cycle regulated transcription in yeast. Curr Opin Cell Biol 6: 451-459 (Pubitemid 24170018)
    • (1994) Current Opinion in Cell Biology , vol.6 , Issue.3 , pp. 451-459
    • Koch, C.1    Nasmyth, K.2
  • 43
    • 0037178722 scopus 로고    scopus 로고
    • Maintenance of genome stability in Saccharomyces cerevisiae
    • DOI 10.1126/science.1075277
    • Kolodner RD, Putnam CD, Myung K (2002) Maintenance of genome stability in Saccharomyces cerevisiae. Science 297: 552-557 (Pubitemid 34815331)
    • (2002) Science , vol.297 , Issue.5581 , pp. 552-557
    • Kolodner, R.D.1    Putnam, C.D.2    Myung, K.3
  • 44
    • 0014321572 scopus 로고
    • Inhibition of ribonucleoside diphosphate reductase by hydroxyurea
    • Krakoff IH, Brown NC, Reichard P (1968) Inhibition of ribonucleoside diphosphate reductase by hydroxyurea. Cancer Res 28: 1559-1565
    • (1968) Cancer Res , vol.28 , pp. 1559-1565
    • Krakoff, I.H.1    Brown, N.C.2    Reichard, P.3
  • 46
    • 77955079173 scopus 로고    scopus 로고
    • Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint
    • Kumar D, Viberg J, Nilsson AK, Chabes A (2010) Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint. Nucleic Acids Res 38: 3975-3983
    • (2010) Nucleic Acids Res , vol.38 , pp. 3975-3983
    • Kumar, D.1    Viberg, J.2    Nilsson, A.K.3    Chabes, A.4
  • 47
    • 0026352951 scopus 로고
    • Modulation of mutagenesis by deoxyribonucleotide levels
    • Kunz BA, Kohalmi SE (1991) Modulation of mutagenesis by deoxyribonucleotide levels. Annu Rev Genet 25: 339-359 (Pubitemid 21903725)
    • (1991) Annual Review of Genetics , vol.25 , Issue.1 , pp. 339-359
    • Kunz, B.A.1    Kohalmi, S.E.2
  • 48
    • 0001313535 scopus 로고
    • The distribution of the numbers of mutants in bacterial populations
    • Lea D, Coulson C (1949) The distribution of the numbers of mutants in bacterial populations. J Genet 49: 264-285
    • (1949) J Genet , vol.49 , pp. 264-285
    • Lea, D.1    Coulson, C.2
  • 49
    • 77951210668 scopus 로고    scopus 로고
    • Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1
    • Lee KY, Yang K, Cohn MA, Sikdar N, D'Andrea AD, Myung K (2010) Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1. J Biol Chem 285: 10362-10369
    • (2010) J Biol Chem , vol.285 , pp. 10362-10369
    • Lee, K.Y.1    Yang, K.2    Cohn, M.A.3    Sikdar, N.4    D'Andrea, A.D.5    Myung, K.6
  • 51
    • 32044442056 scopus 로고    scopus 로고
    • Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1
    • DOI 10.1101/gad.1380506
    • Lee YD, Elledge SJ (2006) Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1. Genes Dev 20: 334-344 (Pubitemid 43200287)
    • (2006) Genes and Development , vol.20 , Issue.3 , pp. 334-344
    • Lee, Y.D.1    Elledge, S.J.2
  • 52
    • 53349151829 scopus 로고    scopus 로고
    • Dif1 is a DNA-damageregulated facilitator of nuclear import for ribonucleotide reductase
    • Lee YD, Wang J, Stubbe J, Elledge SJ (2008) Dif1 is a DNA-damageregulated facilitator of nuclear import for ribonucleotide reductase. Mol Cell 32: 70-80
    • (2008) Mol Cell , vol.32 , pp. 70-80
    • Lee, Y.D.1    Wang, J.2    Stubbe, J.3    Elledge, S.J.4
  • 53
    • 37249008557 scopus 로고    scopus 로고
    • Ninety-six haploid yeast strains with individual disruptions of open reading frames between YOR097C and YOR192C, constructed for the Saccharomyces genome deletion project, have an additional mutation in the mismatch repair gene MSH3
    • DOI 10.1534/genetics.107.079368
    • Lehner KR, Stone MM, Farber RA, Petes TD (2007) Ninety-six haploid yeast strains with individual disruptions of open reading frames between YOR097C and YOR192C, constructed for the Saccharomyces genome deletion project, have an additional mutation in the mismatch repair gene MSH3. Genetics 177: 1951-1953 (Pubitemid 350277084)
    • (2007) Genetics , vol.177 , Issue.3 , pp. 1951-1953
    • Lehner, K.R.1    Stone, M.M.2    Farber, R.A.3    Petes, T.D.4
  • 54
    • 33748424969 scopus 로고    scopus 로고
    • Establishment of sister chromatid cohesion at the S. cerevisiae replication fork
    • DOI 10.1016/j.molcel.2006.08.018, PII S1097276506005995
    • Lengronne A, McIntyre J, Katou Y, Kanoh Y, Hopfner KP, Shirahige K, Uhlmann F (2006) Establishment of sister chromatid cohesion at the S. cerevisiae replication fork. Mol Cell 23: 787-799 (Pubitemid 44344523)
    • (2006) Molecular Cell , vol.23 , Issue.6 , pp. 787-799
    • Lengronne, A.1    McIntyre, J.2    Katou, Y.3    Kanoh, Y.4    Hopfner, K.-P.5    Shirahige, K.6    Uhlmann, F.7
  • 55
    • 3042595897 scopus 로고    scopus 로고
    • Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors
    • DOI 10.1074/jbc.M402056200
    • Lin ZP, Belcourt MF, Cory JG, Sartorelli AC (2004) Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors. J Biol Chem 279: 27030-27038 (Pubitemid 38812539)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.26 , pp. 27030-27038
    • Lin, Z.P.1    Belcourt, M.F.2    Cory, J.G.3    Sartorelli, A.C.4
  • 56
    • 0025773554 scopus 로고
    • Mutator phenotype may be required for multistage carcinogenesis
    • Loeb LA (1991) Mutator phenotype may be required for multistage carcinogenesis. Cancer Res 51: 3075-3079
    • (1991) Cancer Res , vol.51 , pp. 3075-3079
    • Loeb, L.A.1
  • 57
    • 45549102966 scopus 로고    scopus 로고
    • Cancers exhibit a mutator phenotype: Clinical implications
    • discussion 3557
    • Loeb LA, Bielas JH, Beckman RA (2008) Cancers exhibit a mutator phenotype: clinical implications. Cancer Res 68: 3551-3557; discussion 3557
    • (2008) Cancer Res , vol.68 , pp. 3551-3557
    • Loeb, L.A.1    Bielas, J.H.2    Beckman, R.A.3
  • 60
    • 34249066085 scopus 로고    scopus 로고
    • PCNA, the maestro of the replication fork
    • DOI 10.1016/j.cell.2007.05.003, PII S0092867407005946
    • Moldovan GL, Pfander B, Jentsch S (2007) PCNA, the maestro of the replication fork. Cell 129: 665-679 (Pubitemid 46802385)
    • (2007) Cell , vol.129 , Issue.4 , pp. 665-679
    • Moldovan, G.-L.1    Pfander, B.2    Jentsch, S.3
  • 61
    • 28544441180 scopus 로고    scopus 로고
    • DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex
    • DOI 10.1093/nar/gki938
    • Mulder KW, Winkler GS, Timmers HT (2005) DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex. Nucleic Acids Res 33: 6384-6392 (Pubitemid 41742575)
    • (2005) Nucleic Acids Research , vol.33 , Issue.19 , pp. 6384-6392
    • Mulder, K.W.1    Winkler, G.S.2    Timmers, H.Th.M.3
  • 65
    • 0033570894 scopus 로고    scopus 로고
    • Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase
    • DOI 10.1093/emboj/18.22.6561
    • Pellicioli A, Lucca C, Liberi G, Marini F, Lopes M, Plevani P, Romano A, Di Fiore PP, Foiani M (1999) Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase. EMBO J 18: 6561-6572 (Pubitemid 29533260)
    • (1999) EMBO Journal , vol.18 , Issue.22 , pp. 6561-6572
    • Pellicioli, A.1    Lucca, C.2    Liberi, G.3    Marini, F.4    Lopes, M.5    Plevani, P.6    Romano, A.7    Di Fiore, P.P.8    Foiani, M.9
  • 66
    • 84857060479 scopus 로고    scopus 로고
    • DNTP pools determine fork progression and origin usage under replication stress
    • (advance online publication, 10 January 2012; doi:10.1038/emboj.2011.470)
    • Poli J, Tsaponina O, Crabbe L, Keszthelyi A, Pantesco V, Chabes A, Lengronne A, Pasero P (2012) dNTP pools determine fork progression and origin usage under replication stress. EMBO J (advance online publication, 10 January 2012; doi:10.1038/emboj.2011.470)
    • (2012) EMBO J
    • Poli, J.1    Tsaponina, O.2    Crabbe, L.3    Keszthelyi, A.4    Pantesco, V.5    Chabes, A.6    Lengronne, A.7    Pasero, P.8
  • 67
    • 0023925454 scopus 로고
    • Interactions between deoxyribonucleotide and DNA synthesis
    • Reichard P (1988) Interactions between deoxyribonucleotide and DNA synthesis. Annu Rev Biochem 57: 349-374
    • (1988) Annu Rev Biochem , vol.57 , pp. 349-374
    • Reichard, P.1
  • 68
    • 79953312638 scopus 로고    scopus 로고
    • A common telomeric gene silencing assay is affected by nucleotide metabolism
    • Rossmann MP, Luo W, Tsaponina O, Chabes A, Stillman B (2011) A common telomeric gene silencing assay is affected by nucleotide metabolism. Mol Cell 42: 127-136
    • (2011) Mol Cell , vol.42 , pp. 127-136
    • Rossmann, M.P.1    Luo, W.2    Tsaponina, O.3    Chabes, A.4    Stillman, B.5
  • 69
    • 55249101776 scopus 로고    scopus 로고
    • Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage
    • Sabouri N, Viberg J, Goyal DK, Johansson E, Chabes A (2008) Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage. Nucleic Acids Res 36: 5660-5667
    • (2008) Nucleic Acids Res , vol.36 , pp. 5660-5667
    • Sabouri, N.1    Viberg, J.2    Goyal, D.K.3    Johansson, E.4    Chabes, A.5
  • 70
    • 0030593033 scopus 로고    scopus 로고
    • Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways
    • Sanchez Y, Desany BA, Jones WJ, Liu Q, Wang B, Elledge SJ (1996) Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271: 357-360
    • (1996) Science , vol.271 , pp. 357-360
    • Sanchez, Y.1    Desany, B.A.2    Jones, W.J.3    Liu, Q.4    Wang, B.5    Elledge, S.J.6
  • 71
    • 0025978949 scopus 로고
    • Getting started with yeast
    • Sherman F (1991) Getting started with yeast. Methods Enzymol 194: 3-21
    • (1991) Methods Enzymol , vol.194 , pp. 3-21
    • Sherman, F.1
  • 75
    • 0034594978 scopus 로고    scopus 로고
    • A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
    • DOI 10.1038/35003506
    • Tanaka H, Arakawa H, Yamaguchi T, Shiraishi K, Fukuda S, Matsui K, Takei Y, Nakamura Y (2000) A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature 404: 42-49 (Pubitemid 30143125)
    • (2000) Nature , vol.404 , Issue.6773 , pp. 42-49
    • Tanaka, H.1    Arakawa, H.2    Yamaguchi, T.3    Shiraishi, K.4    Fukuda, S.5    Matsui, K.6    Takei, Y.7    Nakamura, Y.8
  • 77
    • 79959820842 scopus 로고    scopus 로고
    • Multiple regulatory mechanisms to inhibit untimely initiation of DNA replication are important for stable genome maintenance
    • Tanaka S, Araki H (2011) Multiple regulatory mechanisms to inhibit untimely initiation of DNA replication are important for stable genome maintenance. PLoS Genet 7: e1002136
    • (2011) PLoS Genet , vol.7
    • Tanaka, S.1    Araki, H.2
  • 78
    • 73449116050 scopus 로고    scopus 로고
    • Loss of yeast peroxiredoxin Tsa1p induces genome instability through activation of the DNA damage checkpoint and elevation of dNTP levels
    • Tang HM, Siu KL, Wong CM, Jin DY (2009) Loss of yeast peroxiredoxin Tsa1p induces genome instability through activation of the DNA damage checkpoint and elevation of dNTP levels. PLoS Genet 5: e1000697
    • (2009) PLoS Genet , vol.5
    • Tang, H.M.1    Siu, K.L.2    Wong, C.M.3    Jin, D.Y.4
  • 79
    • 34249823347 scopus 로고    scopus 로고
    • Ribonucleotide reductase and mitochondrial DNA synthesis
    • DOI 10.1038/ng0607-703, PII NG0607703
    • Thelander L (2007) Ribonucleotide reductase and mitochondrial DNA synthesis. Nat Genet 39: 703-704 (Pubitemid 46848577)
    • (2007) Nature Genetics , vol.39 , Issue.6 , pp. 703-704
    • Thelander, L.1
  • 81
    • 79958001799 scopus 로고    scopus 로고
    • Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools
    • Tsaponina O, Barsoum E, Astrom SU, Chabes A (2011) Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools. PLoS Genet 7: e1002061
    • (2011) PLoS Genet , vol.7
    • Tsaponina, O.1    Barsoum, E.2    Astrom, S.U.3    Chabes, A.4
  • 82
    • 32644463172 scopus 로고    scopus 로고
    • Generation of mutator mutants during carcinogenesis
    • DOI 10.1016/j.dnarep.2005.10.012, PII S1568786405002892
    • Venkatesan RN, Bielas JH, Loeb LA (2006) Generation of mutator mutants during carcinogenesis. DNA Repair (Amst) 5: 294-302 (Pubitemid 43247596)
    • (2006) DNA Repair , vol.5 , Issue.3 , pp. 294-302
    • Venkatesan, R.N.1    Bielas, J.H.2    Loeb, L.A.3
  • 83
    • 27844495735 scopus 로고    scopus 로고
    • Stimulation of mutagenesis by proportional deoxyribonucleoside triphosphate accumulation in Escherichia coli
    • DOI 10.1016/j.dnarep.2005.09.003, PII S1568786405002545
    • Wheeler LJ, Rajagopal I, Mathews CK (2005) Stimulation of mutagenesis by proportional deoxyribonucleoside triphosphate accumulation in Escherichia coli. DNA Repair (Amst) 4: 1450-1456 (Pubitemid 41653306)
    • (2005) DNA Repair , vol.4 , Issue.12 , pp. 1450-1456
    • Wheeler, L.J.1    Rajagopal, I.2    Mathews, C.K.3
  • 85
    • 33846160492 scopus 로고    scopus 로고
    • Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length
    • DOI 10.1242/jcs.03221
    • Woolstencroft RN, Beilharz TH, Cook MA, Preiss T, Durocher D, Tyers M (2006) Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length. J Cell Sci 119 (Pt 24): 5178-5192 (Pubitemid 46085196)
    • (2006) Journal of Cell Science , vol.119 , Issue.24 , pp. 5178-5192
    • Woolstencroft, R.N.1    Bellharz, T.H.2    Cook, M.A.3    Preiss, T.4    Durocher, D.5    Tyers, M.6
  • 86
    • 57349130603 scopus 로고    scopus 로고
    • Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunit
    • Wu X, Huang M (2008) Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunit. Mol Cell Biol 28: 7156-7167
    • (2008) Mol Cell Biol , vol.28 , pp. 7156-7167
    • Wu, X.1    Huang, M.2
  • 88
    • 0024990267 scopus 로고
    • The DNA damage-inducible gene DIN1 of Saccharomyces cerevisiae encodes a regulatory subunit of ribonucleotide reductase and is identical to RNR3
    • Yagle K, McEntee K (1990) The DNA damage-inducible gene DIN1 of Saccharomyces cerevisiae encodes a regulatory subunit of ribonucleotide reductase and is identical to RNR3. Mol Cell Biol 10: 5553-5557 (Pubitemid 20293902)
    • (1990) Molecular and Cellular Biology , vol.10 , Issue.10 , pp. 5553-5557
    • Yagle, K.1    McEntee, K.2
  • 90
    • 12844268576 scopus 로고    scopus 로고
    • Identification of new genes regulated by the Crt1 transcription factor, an effector of the DNA damage checkpoint pathway in Saccharomyces cerevisiae
    • DOI 10.1074/jbc.M404669200
    • Zaim J, Speina E, Kierzek AM (2005) Identification of new genes regulated by the Crt1 transcription factor, an effector of the DNA damage checkpoint pathway in Saccharomyces cerevisiae. J Biol Chem 280: 28-37 (Pubitemid 40164961)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.1 , pp. 28-37
    • Zaim, J.1    Speina, E.2    Kierzek, A.M.3
  • 91
    • 67650531172 scopus 로고    scopus 로고
    • Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response
    • Zhang YW, Jones TL, Martin SE, Caplen NJ, Pommier Y (2009) Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response. J Biol Chem 284: 18085-18095
    • (2009) J Biol Chem , vol.284 , pp. 18085-18095
    • Zhang, Y.W.1    Jones, T.L.2    Martin, S.E.3    Caplen, N.J.4    Pommier, Y.5
  • 92
    • 0034626734 scopus 로고    scopus 로고
    • PCNA connects DNA replication to epigenetic inheritance in yeast
    • Zhang Z, Shibahara K, Stillman B (2000) PCNA connects DNA replication to epigenetic inheritance in yeast. Nature 408: 221-225
    • (2000) Nature , vol.408 , pp. 221-225
    • Zhang, Z.1    Shibahara, K.2    Stillman, B.3
  • 93
    • 0032161269 scopus 로고    scopus 로고
    • A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools
    • Zhao X, Muller EG, Rothstein R (1998) A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol Cell 2: 329-340 (Pubitemid 128379273)
    • (1998) Molecular Cell , vol.2 , Issue.3 , pp. 329-340
    • Zhao, X.1    Muller, E.G.D.2    Rothstein, R.3
  • 95
    • 0026651652 scopus 로고
    • Isolation of crt mutants constitutive for transcription of the DNA damage inducible gene RNR3 in Saccharomyces cerevisiae
    • Zhou Z, Elledge SJ (1992) Isolation of crt mutants constitutive for transcription of the DNA damage inducible gene RNR3 in Saccharomyces cerevisiae. Genetics 131: 851-866
    • (1992) Genetics , vol.131 , pp. 851-866
    • Zhou, Z.1    Elledge, S.J.2
  • 96
    • 0027145127 scopus 로고
    • DUN1 encodes a protein kinase that controls the DNA damage response in yeast
    • DOI 10.1016/0092-8674(93)90321-G
    • Zhou Z, Elledge SJ (1993) DUN1 encodes a protein kinase that controls the DNA damage response in yeast. Cell 75: 1119-1127 (Pubitemid 24006108)
    • (1993) Cell , vol.75 , Issue.6 , pp. 1119-1127
    • Zhou, Z.1    Elledge, S.J.2


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