Predicting the uncertain future of aptamer-based diagnostics and therapeutics

Molecules

Volumn 20, Issue 4, 2015, Pages 6866-6887

  Bruno, John G ^a  

^a Operational Technologies Corporation   (United States)

Author keywords

Antibody; Aptamer; Diagnostic; Humanized; Modified base; Multivalent; Therapeutic

Indexed keywords

APTAMER; TOXIN;

ANTAGONISTS AND INHIBITORS; DIAGNOSTIC PROCEDURE; DRUG EFFECTS; HUMAN; MEDICAL RESEARCH; METABOLISM; STEM CELL; TRENDS;

APTAMERS, NUCLEOTIDE; BIOMEDICAL RESEARCH; DIAGNOSTIC TECHNIQUES AND PROCEDURES; HUMANS; STEM CELLS; TOXINS, BIOLOGICAL;

EID: 84928780864     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules20046866     Document Type: Review

References (132)

1. Penner, G. Commercialization of an aptamer-based diagnostic test. IVD Technol. 2012, 18, 31-37.
2. Webber, J.; Stone, T.C.; Katilius, E.; Smith, B.C.; Gordon, B.; Mason, M.D.; Tabi, Z.; Brewis, I.A.; Clayton, A. Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform. Mol. Cell. Proteomics 2014, 13, 1050-1064.
3. Lollo, B.; Steele, F.; Gold, L. Beyond antibodies: New affinity reagents to unlock the proteome. Proteomics 2014, 14, 638-644.
4. Vance, S.A.; Sandros, M.G. Zeptomole detection of C-reactive protein in serum by a nanoparticle amplified surface plasmon resonance imaging aptasensor. Sci. Rep. 2014, 4, 5129.
5. Bruno, J.G.; Richarte, A.M.; Phillips, T. Preliminary development of a DNA aptamer-magnetic bead capture electrochemiluminescence sandwich assay for Brain Natriuretic Peptide. Microchem. J. 2014, 115, 32-38.
6. Bruno, J.G. A review of therapeutic aptamer conjugates with emphasis on new approaches. Pharmaceuticals 2013, 6, 340-357.
7. Jayasena, S.D. Aptamers: An emerging class of molecules that rival antibodies in diagnostics. Clin. Chem. 1999, 45, 1628-1650.
8. Lee, J.F.; Cox, J.C.; Collett, J.R.; Ellington, A.D. Exploring sequence space through automated aptamer selection. J. Lab. Autom. 2005, 10, 213-218.
9. Wochner, A.; Cech, B.; Menger, M.; Erdmann, V.A.; Glökler, J. Semi-automated selection of DNA aptamers using magnetic particle handling. BioTechniques 2007, 43, 344-353.
10. Lai, H.; Wang, C.; Weng, C.; Liou, T.; Lee, G. An integrated SELEX microfluidic system for rapid screening of influenza virus specific aptamers. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Okinawa, Japan, 28 October-1 November 2012; pp. 1402-1404.
11. Cheng, C.; Dong, J.; Yao, L.; Chen, A.; Jia, R.; Huan, L.; Guo, J.; Shu, Y.; Zhang, Z. Potent inhibition of human influenza H5N1 virus by oligonucleotides derived by SELEX. Biochem. Biophys. Res. Commun. 2008, 366, 670-674.
12. Binning, J.M.; Wang, T.; Luthra, P.; Shabman, R.S.; Borek, D.M.; Liu, G.; Xu, W.; Leung, D.W.; Basler, C.F.; Amarasinghe, G.K. Development of RNA aptamers targeting Ebola virus VP35. Biochemistry 2013, 52, 8406-8419.
13. Dobler, R.K.; Maki, W.C. Mars health care delivery systems: Aptamers provide critical technology. In Proceedings of the 12th NASA Symposium of VLSA Design, Coeur d'Alene, ID, USA, 4-5 October 2005.
14. Schmidt, M.A.; Goodwin, T.J. Personalized medicine in human space flight: Using omics based analyses to develop individualized countermeasures that enhance astronaut safety and performance. Metabolomics 2013, 9, 1134-1156.
15. Sommer, G.J.; Hecht, A.H.; Durland, R.H.; Yang, X.; Singh, A.K.; Hatch, A.V. A fully automated aptamer-based affinity assay platform for monitoring astronaut health in space. In Proceedings of the 14th International Conference on Miniaturized Systems in the Life Sciences, Groningen, The Netherlands, 3-7 October, 2010; pp. 1463-1465.
16. Murray, E.; Norton, M.L.; Towler, W.I. Method for a continuous rapid thermal cycle system. U.S. Patent 8,163,489, 24 April 2012.
17. Dutton, G. DNA vaccines inch toward human use. Gen. Eng. Biotechnol. News 2009, 29, 1-4.
18. Quaak, S.G.; Haanen, J.B.; Beijnen, J.H.; Nuijen, B. Naked plasmid DNA formulation: Effect of different disaccharides on stability after lyophilisation. AAPS PharmSciTech 2010, 11, 344-350.
19. Park, J.H.; Byun, J.Y.; Mun, H.; Shim, W.B.; Shin, Y.B.; Li, T.; Kim, M.G. A regeneratable, label-free, localized surface plasmon resonance (LSPR) aptasensor for the detection of ochratoxin A. Biosens. Bioelectron. 2014, 59, 321-327.
20. Shen, T.; Yue, Q.; Jiang, X.; Wang, L.; Xu, S.; Li, H.; Gu, X.; Zhang, S.; Liu, J. A reusable and sensitive biosensor for total mercury in canned fish based on fluorescence polarization. Talanta 2013, 117, 81-86.
21. Xu, S.; Zhang, X.; Liu, W.; Sun, Y.; Zhang, H. Reusable light-emitting-diode induced chemiluminescence aptasensor for highly sensitive and selective detection of riboflavin. Biosens. Bioelectron. 2013, 43, 160-164.
22. Cload, S.T.; McCauley, T.G.; Keefe, A.D.; Healy, J.M.; Wilson, C. Chapter 17: Properties of therapeutic aptamers. In The Aptamer Handbook; Klussmann, S., Ed.; Wiley-VCH, Verlag GmBH & Co.: Weinheim, Germany, 2006; pp. 363-416.
23. Avci-Adali, M.; Steinle, H.; Michel, T.; Schlensak, C.; Wendel, H.P. Potential capacity of aptamers to trigger immune activation in human blood. PLoS ONE 2013, 8, e68810.
24. Harding, F.A.; Stickler, M.M.; Razo, J.; DuBridge, R.B. The immunogenicity of humanized and fully human antibodies: Residual immunogenicity resides in the CDR regions. MAbs 2010, 2, 256-265.
25. Barhona, F.; Bardliving, C.; Phifer, A.; Bruno, J.G.; Batt, C. New aptasensor based on polymer-gold nanoparticles composite microspheres for the detection of malathion using surface-enhanced Raman spectroscopy. Ind. Biotechnol. 2013, 9, 42-49.
26. Najafabadi, M.E.; Khayamian, T.; Hashemian, Z. Aptamer-conjugated magnetic nanoparticles for extraction of adenosine from urine followed by electrospray ion mobility spectrometry. J. Pharm. Biomed. Anal. 2015, 107, 244-250.
27. Weiss, R.L. The long and winding regulatory road for laboratory-developed tests. Am. J. Clin. Pathol. 2012, 138, 20-26.
28. Anonymous. FDA announces plans to regulate LDTs. Cancer Discov. 2014, 4, 1250.
29. Mertz, A. Duplicative and unnecessary regulation of LDTs will hamper diagnostic innovation. Med. Lab. Opt. 2014, 46, 44.
30. Shi, H.; Lis, J.T. Multivalent RNA Aptamers and Their Expression in Multicellular Organisms. U.S. Patent 6,458,559, 1 October 2002.
31. Ahmad, K.M.; Xiao, Y.; Soh, H.T. Selection is more intelligent than design: Improving the affinity of a bivalent ligand through directed evolution. Nucleic Acids Res. 2012, 40, 11777-11783.
32. Zhao, X.; Lis, J.T.; Shi, H. A systematic study of the features critical for designing a high avidity multivalent aptamer. Nucleic Acid Ther. 2013, 23, 238-242.
33. Mallikaratchy, P.R.; Ruggiero, A.; Gardner, J.R.; Kuryavyi, V.; Maguire, W.F.; Heaney, M.L.; McDevitt, M.R.; Patel, D.J.; Scheinberg, D.A. A multivalent DNA aptamer specific for the B-cell receptor on human lymphoma and leukemia. Nucleic Acids Res. 2011, 39, 2458-2469.
34. Stovall, G.M.; Bedenbaugh, R.S.; Singh, S.; Meyer, A.J.; Hatala, P.J.; Ellington, A.D.; Hall, B. In vitro selection using modified or unnatural nucleotides. Curr. Protoc. Nucleic Acid Chem. 2014, 56, doi:10.1002/0471142700.nc0906s56.
35. Sefah, K.; Yang, Z.; Bradley, K.M.; Hoshika, S.; Jiménez, E.; Zhang, L.; Zhu, G.; Shanker, S.; Yu, F.; Turek, D.; et al. In vitro selection with artificial expanded genetic information systems. Proc. Natl. Acad. Sci. USA 2014, 111, 1449-1454.
36. Vallone, P.M.; Devaney, J.M.; Marino, M.A.; Butler, J.M. A strategy for examining complex mixtures of deoxyoligonucleotides using ion-pair-reverse-phase high-performance liquid chromatography, matrix-assisted laser desorption ionization time-of-flight mass spectrometry, and informatics. Anal. Biochem. 2002, 304, 257-265.
37. He, W.; Elizondo-Riojas, M.A.; Li, X.; Lokesh, G.L.; Somasunderam, A.; Thiviyanathan, V.; Volk, D.E.; Durland, R.H.; Englehardt, J.; Cavasotto, C.N.; et al. X-aptamers: A bead-based selection method for random incorporation of druglike moieties onto next-generation aptamers for enhanced binding. Biochemistry 2012, 51, 8321-8323.
38. Fujita, S.; Arinaga, K.; Fujihara, T.; Aki, M.; Kichise, T. Novel protein detection system using DNA as a constituent material. Fujitsu Sci. Tech. J. 2012, 48, 237-243.
39. Shigdar, S.; MacDonald, J.; O'Connor, M.; Wang, T.; Xiang, D.; Al Shamaileh, H.; Qiao, L.; Wei, M.; Zhou, S.; Zhu, Y.; et al. Aptamers as theranostic agents: Modifications, serum stability and functionalisation. Sensors 2013, 13, 13624-13637.
40. Pinheiro, V.B.; Taylor, A.I.; Cozens, C.; Abramov, M.; Renders, M.; Zhang, S.; Chaput, J.C.; Wengel, J.; Peak-Chew, S.Y.; McLaughlin, S.H.; et al. Synthetic genetic polymers capable of heredity and evolution. Science 2012, 336, 341-344.
41. Taylor, A.I.; Arangundy-Franklin, S.; Holliger, P. Towards applications of synthetic genetic polymers in diagnosis and therapy. Curr. Opin. Chem. Biol. 2014, 22, 79-84.
42. Pinheiro, V.B.; Holliger, P. Towards XNA nanotechnology: New materials from synthetic genetic polymers. Trends Biotechnol. 2014, 32, 321-328.
43. Darmostuk, M.; Rimpelová, S.; Gbelcová, H.; Ruml, T. Current approaches in SELEX: An update to aptamer selection technology. Biotechnol. Adv. 2015, in press.
44. Kong, H.Y.; Byun, J. Nucleic acid aptamers: New methods for selection, stabilization, and application in biomedical science. Biomol. Ther. (Seoul) 2013, 21, 423-434.
45. Fan, M.; Roper-McBurnett, S.; Andrews, C.J.; Allman, A.M.; Bruno, J.G.; Kiel, J.L. Aptamer selection express (ASExp): A novel method for rapid single step selection and sensing of aptamers. J. Biomol. Tech. 2008, 19, 311-321.
46. Nitsche, A.; Kurth, A.; Dunkhorst, A.; Pänke, O.; Sielaff, H.; Junge, W.; Muth, D.; Scheller, F.; Stöcklein, W.; Dahmen, C.; et al. One-step selection of Vaccinia virus-binding DNA aptamers by MonoLEX. BMC Biotechnol. 2007, 7, 48.
47. Bruno, J.G.; Carrillo, M.P.; Phillips, T.; Hanson, D.; Bohmann, J.A. DNA aptamer beacon assay for C-telopeptide and handheld fluorometer to monitor bone resorption. J. Fluoresc. 2011, 21, 2021-2033.
48. Chushak, Y.; Stone, M.O. In silico selection of RNA aptamers. Nucleic Acids Res. 2009, 37, e87.
49. Ashrafuzzaman, M.; Tseng, C.Y.; Kapty, J.; Mercer, J.R.; Tuszynski, J.A. A computationally designed DNA aptamer template with specific binding to phosphatidylserine. Nucleic Acid Ther. 2013, 23, 418-426.
50. Sánchez-Luque, F.J.; Stich, M.; Manrubia, S.; Briones, C.; Berzal-Herranz, A. Efficient HIV-1 inhibition by a 16 nt-long RNA aptamer designed by combining in vitro selection and in silico optimisation strategies. Sci. Rep. 2014, 4, 6242-6251.
51. Savory, N.; Takahashi, Y.; Tsukakoshi, K.; Hasegawa, H.; Takase, M.; Abe, K.; Yoshida, W.; Ferri, S.; Kumazawa, S.; Sode, K.; et al. Simultaneous improvement of specificity and affinity of aptamers against Streptococcus mutans by in silico maturation for biosensor development. Biotechnol. Bioeng. 2014, 111, 454-461.
52. Savory, N.; Lednor, D.; Tsukakoshi, K.; Abe, K.; Yoshida, W.; Ferri, S.; Jones, B.V.; Ikebukuro, K. In silico maturation of binding-specificity of DNA aptamers against Proteus mirabilis. Biotechnol. Bioeng. 2013, 110, 2573-2580.
53. Bruno, J.G.; Carrillo, M.P.; Phillips, T.; Vail, N.K.; Hanson, D. Competitive FRET-aptamer-based detection of methylphosphonic acid: A common nerve agent metabolite. J. Fluoresc. 2008, 18, 867-876.
54. Bruno, J.G.; Carrillo, M.P.; Cadieux, C.L.; Lenz, D.L.; Cerasoli, D.M.; Phillips, T. DNA aptamers developed against a soman derivative cross-react with methylphosphonic acid but not with the flanking hydrophobic groups. J. Mol. Recognit. 2009, 22, 197-204.
55. Bruno, J.G.; Carrillo, M.P. Development of aptamer beacons for rapid presumptive detection of Bacillus spores. J. Fluoresc. 2012, 22, 915-924.
56. Bruno, J.G.; Richarte, A.M.; Carrillo, M.P.; Edge, A. An aptamer beacon responsive to botulinum toxins. Biosens. Bioelectron. 2012, 31, 240-243.
57. Lamont, E.A.; He, L.; Warriner, K.; Labuza, T.P.; Sreevatsan, S. A single DNA aptamer functions as a biosensor for ricin. Analyst 2011, 136, 3884-3895.
58. Liu, X.; Zhang, X. Aptamer-based technology for food analysis. Appl. Biochem. Biotechnol. 2015, 175, 603-624.
59. Bruno, J.G.; Phillips, T.; Carrillo, M.P.; Crowell, R. Plastic-adherent DNA aptamer-magnetic bead and quantum dot sandwich assay for Campylobacter detection. J. Fluoresc. 2009, 19, 427-435.
60. Dwivedi, H.P.; Smiley, R.D.; Jaykus, L.A. Selection and characterization of DNA aptamers with binding selectivity to Campylobacter jejuni using whole-cell SELEX. Appl. Microbiol. Biotechnol. 2010, 87, 2323-2334.
61. Bruno, J.G.; Carrillo, M.P.; Phillips, T.; Andrews, C.J. A novel screening method for competitive FRET-aptamers applied to E. coli assay development. J. Fluoresc. 2010, 20, 1211-1223.
62. Queirós, R.B.; Gouveia, C.; Fernandes, J.R.; Jorge, P.A. Evanescent wave DNA-aptamer biosensor based on long period gratings for the specific recognition of E. coli outer membrane proteins. Biosens. Bioelectron. 2014, 62, 227-233.
63. Queirós, R.B.; de-los-Santos-Álvarez, N.; Noronhae, J.P.; Sales, M.G.F. A label-free DNA aptamer-based impedance biosensor for the detection of E. coli outer membrane proteins. Sens. Actuators B Chem. 2013, 181, 766-772.
64. Bruno, J.G.; Phillips, T.; Montez, T.; Garcia, A.; Sivils, J.C.; Mayo, M.W.; Greis, A. Metrix360 Laboratories. Development of a fluorescent enzyme-linked DNA aptamer-magnetic bead sandwich assay and portable fluorometer for ultrasensitive and rapid Listeria detection. J. Fluoresc. 2015, 25, 173-183.
65. Lee, S.H.; Ahn, J.Y.; Lee, K.A.; Um, H.J.; Sekhon, S.S.; Sun Park, T.; Min, J.; Kim, Y.H. Analytical bioconjugates, aptamers, enable specific quantitative detection of Listeria monocytogenes. Biosens. Bioelectron. 2015, 68, 272-280.
66. Bruno, J.G. Application of DNA aptamers and quantum dots to lateral flow test strips for detection of foodborne pathogens with improved sensitivity versus colloidal gold. Pathogens 2014, 3, 341-355.
67. Park, H.C.; Baig, I.A.; Lee, S.C.; Moon, J.Y.; Yoon, M.Y. Development of ssDNA aptamers for the sensitive detection of Salmonella typhimurium and Salmonella enteritidis. Appl. Biochem. Biotechnol. 2014, 174, 793-802.
68. Moon, J.; Kim, G.; Lee, S.; Park, S. Identification of Salmonella Typhimurium-specific DNA aptamers developed using whole-cell SELEX and FACS analysis. J. Microbiol. Methods 2013, 95, 162-166.
69. Dwivedi, H.P.; Smiley, R.D.; Jaykus, L.A. Selection of DNA aptamers for capture and detection of Salmonella Typhimurium using a whole-cell SELEX approach in conjunction with cell sorting. Appl. Microbiol. Biotechnol. 2013, 97, 3677-3686.
70. Duan, N.; Wu, S.; Chen, X.; Huang, Y.; Xia, Y.; Ma, X.; Wang, Z. Selection and characterization of aptamers against Salmonella typhimurium using whole-bacterium Systemic Evolution of Ligands by Exponential Enrichment (SELEX). J. Agric. Food Chem. 2013, 61, 3229-3234.
71. Joshi, R.; Janagama, H.; Dwivedi, H.P.; Senthil Kumar, T.M.; Jaykus, L.A.; Schefers, J.; Sreevatsan, S. Selection, characterization, and application of DNA aptamers for the capture and detection of Salmonella enterica serovars. Mol. Cell. Probes 2009, 23, 20-28.
72. Escudero-Abarca, B.I.; Suh, S.H.; Moore, M.D.; Dwivedi, H.P.; Jaykus, L.A. Selection, characterization and application of nucleic acid aptamers for the capture and detection of human norovirus strains. PLoS ONE 2014, 9, e106805.
73. Beier, R.; Pahlke, C.; Quenzel, P.; Henseleit, A.; Boschke, E.; Cuniberti, G.; Labudde, D. Selection of a DNA aptamer against norovirus capsid protein VP1. FEMS Microbiol. Lett. 2014, 351, 162-169.
74. Giamberardino, A.; Labib, M.; Hassan, E.M.; Tetro, J.A.; Springthorpe, S.; Sattar, S.A.; Berezovski, M.V.; DeRosa, M.C. Ultrasensitive norovirus detection using DNA aptasensor technology. PLoS ONE 2013, 8, e79087.
75. DeGrasse, J.A. A single-stranded DNA aptamer that selectively binds to Staphylococcus aureus enterotoxin B. PLoS ONE 2012, 7, e33410.
76. Nikolaus, N.; Strehlitz, B. DNA-aptamers binding aminoglycoside antibiotics. Sensors 2014, 14, 3737-3755.
77. Wang, S.; Liu, J.; Yong, W.; Chen, Q.; Zhang, L.; Dong, Y.; Su, H.; Tan, T. A direct competitive assay-based aptasensor for sensitive determination of tetracycline residue in honey. Talanta 2015, 131, 562-569.
78. Pang, S.; Labuza, T.P.; He, L. Development of a single aptamer-based surface enhanced Raman scattering method for rapid detection of multiple pesticides. Analyst 2014, 139, 1895-1901.
79. Wang, L.; Liu, X.; Zhang, Q.; Zhang, C.; Liu, Y.; Tu, K.; Tu, J. Selection of DNA aptamers that bind to four organophosphorus pesticides. Biotechnol. Lett. 2012, 34, 869-874.
80. Jyoti, A.; Vajpayee, P.; Singh, G.; Patel, C.B.; Gupta, K.C.; Shanker, R. Identification of environmental reservoirs of nontyphoidal salmonellosis: Aptamer-assisted bioconcentration and subsequent detection of Salmonella typhimurium by quantitative polymerase chain reaction. Environ. Sci. Technol. 2011, 45, 8996-9002.
81. Singh, G.; Vajpayee, P.; Rani, N.; Jyoti, A.; Gupta, K.C.; Shanker, R. Bio-capture of S. Typhimurium from surface water by aptamer for culture-free quantification. Ecotoxicol. Environ. Saf. 2012, 78, 320-326.
82. Suh, S.H.; Jaykus, L.A. Nucleic acid aptamers for capture and detection of Listeria spp. J. Biotechnol. 2013, 167, 454-461.
83. Biagi, C.; Conti, V.; Montanaro, N.; Melis, M.; Buccellato, E.; Donati, M.; Covezzoli, A.; Amato, R.; Pazzi, L.; Venegoni, M.; et al. Comparative safety profiles of intravitreal bevacizumab, ranibizumab and pegaptanib: The analysis of the WHO database of adverse drug reactions. Eur. J. Clin. Pharmacol. 2014, 70, 1505-1512.
84. Ni, X.; Castanares, M.; Mukherjee, A.; Lupold, S.E. Nucleic acid aptamers: Clinical applications and promising new horizons. Curr. Med. Chem. 2011, 18, 4206-4214.
85. Sundaram, P.; Kurniawan, H.; Byrne, M.E.; Wower, J. Therapeutic RNA aptamers in clinical trials. Eur. J. Pharm. Sci. 2013, 48, 259-271.
86. Zhou, J.; Rossi, J.J. Cell-type-specific, aptamer-functionalized agents for targeted disease therapy. Mol. Ther. Nucleic Acids 2014, 3, e169.
87. Manoharan, M.; Inamati, G.B.; Lesnik, E.A.; Sioufi, N.B.; Freier, S.M. Improving antisense oligonucleotide binding to human serum albumin: Dramatic effect of ibuprofen conjugation. ChemBioChem 2002, 3, 1257-1260.
88. Dougan, H.; Lyster, D.M.; Vo, C.V.; Stafford, A.; Weitz, J.I.; Hobbs, J.B. Extending the lifetime of anticoagulant oligodeoxynucleotide aptamers in blood. Nucl. Med. Biol. 2000, 27, 289-297.
89. Keefe, A.D.; Pai, S.; Ellington, A. Aptamers as therapeutics. Nat. Rev. Drug Discov. 2010, 9, 537-550.
90. Healy, J.M.; Lewis, S.D.; Kurz, M.; Boomer, R.M.; Thompson, K.M.; Wilson, C.; McCauley, T.G. Pharmacokinetics and biodistribution of novel aptamer compositions. Pharm. Res. 2004, 21, 2234-2246.
91. Duclair, S.; Gautam, A.; Ellington, A.; Prasad, V.R. High-affinity RNA aptamers against the HIV-1 protease inhibit both in vitro protease activity and late events of viral replication. Mol. Ther. Nucleic Acids 2015, 4, e228.
92. Wandtke, T.; Woźniak, J.; Kopiński, P. Aptamers in diagnostics and treatment of viral infections. Viruses 2015, 7, 751-780.
93. Shum, K.T.; Zhou, J.; Rossi, J.J. Aptamer-based therapeutics: New approaches to combat human viral diseases. Pharmaceuticals 2013, 6, 1507-1542.
94. Kwon, H.M.; Lee, K.H.; Han, B.W.; Han, M.R.; Kim, D.H.; Kim, D.E. An RNA aptamer that specifically binds to the glycosylated hemagglutinin of avian influenza virus and suppresses viral infection in cells. PLoS ONE 2014, 9, e97574.
95. Suenaga, E.; Kumar, P.K. An aptamer that binds efficiently to the hemagglutinins of highly pathogenic avian influenza viruses (H5N1 and H7N7) and inhibits hemagglutinin-glycan interactions. Acta Biomater. 2014, 10, 1314-1323.
96. Shiratori, I.; Akitomi, J.; Boltz, D.A.; Horii, K.; Furuichi, M.; Waga, I. Selection of DNA aptamers that bind to influenza A viruses with high affinity and broad subtype specificity. Biochem. Biophys. Res. Commun. 2014, 443, 37-41.
97. Musafia, B.; Oren-Banaroya, R.; Noiman, S. Designing anti-influenza aptamers: Novel quantitative structure activity relationship approach gives insights into aptamer-virus interaction. PLoS ONE 2014, 9, e97696.
98. Gopinath, S.C.; Kumar, P.K. Aptamers that bind to the hemagglutinin of the recent pandemic influenza virus H1N1 and efficiently inhibit agglutination. Acta Biomater. 2013, 9, 8932-8941.
99. Bruno, J.G.; Carrillo, M.P.; Richarte, A.M.; Phillips, T.; Andrews, C.; Lee, J.S. Development, screening, and analysis of a small DNA aptamer library potentially useful for diagnosis and passive immunity of arboviruses. BMC Res. Notes 2012, 5, 633.
100. DiGiandomenico, A.; Keller, A.E.; Gao, C.; Rainey, G.J.; Warrener, P.; Camara, M.M.; Bonnell, J.; Fleming, R.; Bezabeh, B.; Dimasi, N.; et al. A multifunctional bispecific antibody protects against Pseudomonas aeruginosa. Sci. Transl. Med. 2014, 6, doi:10.1126/scitranslmed.3009655.
101. Oleksiewicz, M.B.; Nagy, G.; Nagy, E. Anti-bacterial monoclonal antibodies: Back to the future? Arch. Biochem. Biophys. 2012, 526, 124-131.
102. Saylor, C.; Dadachova, E.; Casadevall, A. Monoclonal antibody-based therapies for microbial diseases. Vaccine 2009, 27 (Suppl. 6), G38-G46.
103. Kolovskaya, O.S.; Savitskaya, A.G.; Zamay, T.N.; Reshetneva, I.T.; Zamay, G.S.; Erkaev, E.N.; Wang, X.; Wehbe, M.; Salmina, A.B.; Perianova, O.V.; et al. Development of bacteriostatic DNA aptamers for salmonella. J. Med. Chem. 2013, 56, 1564-1572.
104. Schlesinger, S.R.; Lahousse, M.J.; Foster, T.O.; Kim, S. Metallo-β-lactamase and aptamer-based inhibition. Pharmaceuticals 2011, 4, 419-428.
105. Bruno, J.G.; Carrillo, M.P.; Phillips, T. In vitro antibacterial effects of anti-lipopolysaccharide DNA aptamer-C1qrs complexes. Folia Microbiol. 2008, 53, 295-302.
106. Bruno, J.G. Aptamer-biotin-streptavidin-C1q complexes can trigger the classical complement pathway to kill cancer cells. In Vitro Cell. Dev. Biol. 2010, 46, 107-113.
107. Stecker, J.R.; Savage, A.; Bruno, J.G.; Garcia, D.M.; Koke, J.R. Dynamics and visualization of MCF7 adenocarcinoma cell death by aptamer-C1q-mediated membrane attack. Nucleic Acid Ther. 2012, 22, 275-282.
108. Mallik, P.K.; Nishikawa, K.; Millis, A.J.; Shi, H. Commandeering a biological pathway using aptamer-derived molecular adaptors. Nucleic Acids Res. 2010, 38, e93.
109. Bruno, J.G.; Carrillo, M.P.; Crowell, R. Preliminary development of DNA aptamer-Fc conjugate opsonins. J. Biomed. Mater. Res. A 2009, 90, 1152-1161.
110. Wang, K.; Gan, L.; Jiang, L.; Zhang, X.; Yang, X.; Chen, M.; Lan, X. Neutralization of Staphylococcal enterotoxin B by aptamer antagonist. Antimicrob. Agents Chemother. 2015, in press.
111. Vivekananda, J.; Salgado, C.; Millenbaugh, N.J. DNA aptamers as a novel approach to neutralize Staphylococcus aureus α-toxin. Biochem. Biophys. Res. Commun. 2014, 444, 433-438.
112. Ye, F.; Zheng, Y.; Wang, X.; Tan, X.; Zhang, T.; Xin, W.; Wang, J.; Huang, Y.; Fan, Q.; Wang, J. Recognition of Bungarus multicinctus venom by a DNA aptamer against β-bungarotoxin. PLoS ONE 2014, 9, e105404.
113. Lauridsen, L.H.; Shamaileh, H.A.; Edwards, S.L.; Taran, E.; Veedu, R.N. Rapid one-step selection method for generating nucleic acid aptamers: Development of a DNA aptamer against α-bungarotoxin. PLoS ONE 2012, 7, e41702.
114. Sapag, A.; Salinas-Luypaert, C.; Constenla-Muñoz, C. First report of in vitro selection of RNA aptamers targeted to recombinant Loxosceles laeta spider toxins. Biol. Res. 2014, 47, 2.
115. Bruno, J.G. In vitro selection of DNA to chloroaromatics using magnetic microbead-based affinity separation and fluorescence detection. Biochem. Biophys. Res. Commun. 1997, 234, 117-120.
116. Bruno, J.G.; Kiel, J.L. Use of magnetic beads in selection and detection of biotoxin aptamers by ECL and enzymatic methods. BioTechniques 2002, 32, 178-183.
117. Bruno, J.G.; Kiel, J.L. In vitro selection of DNA aptamers to anthrax spores with electrochemiluminescence detection. Biosens. Bioelectron. 1999, 14, 457-464.
118. Lin, H.; Zhang, W.; Jia, S.; Guan, Z.; Yang, C.J.; Zhu, Z. Microfluidic approaches to rapid and efficient aptamer selection. Biomicrofluidics 2014, 8, 041501.
119. Lai, H.C.; Wang, C.H.; Liou, T.M.; Lee, G.B. Influenza A virus-specific aptamers screened by using an integrated microfluidic system. Lab Chip 2014, 14, 2002-2013.
120. Oh, S.S.; Ahmad, K.M.; Cho, M.; Kim, S.; Xiao, Y.; Soh, H.T. Improving aptamer selection efficiency through volume dilution, magnetic concentration, and continuous washing in microfluidic channels. Anal. Chem. 2011, 83, 6883-6889.
121. Ahmad, K.M.; Oh, S.S.; Kim, S.; McClellen, F.M.; Xiao, Y.; Soh, H.T. Probing the limits of aptamer affinity with a microfluidic SELEX platform. PLoS ONE 2011, 6, e27051.
122. Haller, C.; Sobolewska, B.; Schibilsky, D.; Avci-Adali, M.; Schlensak, C.; Wendel, H.P.; Walker, T. One-staged aptamer-based isolation and application of endothelial progenitor cells in a porcine myocardial infarction model. Nucleic Acid Ther. 2015, 25, 20-26.
123. Qi, P.; Yan, W.; Yang, Y.; Li, Y.; Fan, Y.; Chen, J.; Yang, Z.; Tu, Q.; Huang, N. Immobilization of DNA aptamers via plasma polymerized allylamine film to construct an endothelial progenitor cell-capture surface. Colloids Surf. B Biointerfaces 2015, 126, 70-79.
124. Hoffmann, J.; Paul, A.; Harwardt, M.; Groll, J.; Reeswinkel, T.; Klee, D.; Moeller, M.; Fischer, H.; Walker, T.; Greiner, T.; et al. Immobilized DNA aptamers used as potent attractors for porcine endothelial precursor cells. J. Biomed. Mater. Res. A 2008, 84, 614-621.
125. Guo, K.T.; Schafer, R.; Paul, A.; Gerber, A.; Ziemer, G.; Wendel, H.P. A new technique for the isolation and surface immobilization of mesenchymal stem cells from whole bone marrow using high-specific DNA aptamers. Stem Cells 2006, 24, 2220-2231.
126. Wang, Y.; Khaing, Z.Z.; Li, N.; Hall, B.; Schmidt, C.E.; Ellington, A.D. Aptamer antagonists of myelin-derived inhibitors promote axon growth. PLoS ONE 2010, 5, e9726.
127. Dalziel, M.; Crispin, M.; Dwek, R.A. Directing stem cell differentiation with antibodies. Proc. Natl. Acad. Sci. USA 2013, 110, 17608-17609.
128. Xie, J.; Zhang, H.; Yea, K.; Lerner, R.A. Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells. Proc. Natl. Acad. Sci. USA 2013, 110, 8099-8104.
129. Yea, K.; Zhang, H.; Xie, J.; Jones, T.M.; Yang, G.; Song, B.D.; Lerner, R.A. Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections. Proc. Natl. Acad. Sci. USA 2013, 110, 14966-14971.
130. Shetty, S.; Ghosh, K. Novel therapeutic approaches to haemophilia. Haemophlilia 2015, 21, 152-161.
131. Altman, M.O.; Chang, Y.M.; Xiong, X.; Tan, W. Modifying cellular properties using artificial aptamer-lipid receptors. Sci. Rep. 2013, 3, 3343.
132. Baird, G.S. Where are all the aptamers? Am. J. Clin. Pathol. 2010, 134, 529-531.