Metallo-β-Lactamases and aptamer-based inhibition

Pharmaceuticals

Volumn 4, Issue 2, 2011, Pages 419-428

  Schlesinger, Sara R ^a   Lahousse, Mieke J ^a   Foster, Taylor O ^a   Kim, Sung Kun ^a  

^a BAYLOR UNIVERSITY   (United States)

Author keywords

Aptamer; Bacillus cereus; Inhibitor; Metallo lactamase; SELEX

Indexed keywords

APTAMER; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; METALLO BETA LACTAMASE; SINGLE STRANDED RNA; THROMBIN; VASCULOTROPIN ANTIBODY;

ANTIBIOTIC RESISTANCE; BACILLUS CEREUS; BACTERIAL GROWTH; COMBINATORIAL CHEMISTRY; DRUG SCREENING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SPECIFICITY; GROWTH INHIBITION; HYDROLYSIS; IC 50; NONHUMAN; REVIEW;

EID: 79952162855     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph4020419     Document Type: Review

References (31)

1. Yong, D.; Toleman, M.A.; Giske, C.G.; Cho, H.S.; Sundman, K.; Lee, K.; Walsh, T.R. Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob. Agents Chemother. 2009, 53, 5046-5054.
2. Walsh, T.R. Emerging carbapenemases: a global perspective. Int. J. Antimicrob. Agents 2010, 36 (Suppl. 3), S8-S14.
3. Perez, F.; Endimiani, A.; Hujer, K.M.; Bonomo, R.A. The continuing challenge of ESBLs. Curr. Opin. Pharmacol. 2007, 7, 459-469.
4. Walsh, C.; Wright, G. Introduction: Antibiotic resistance. Chem. Rev. 2005, 105, 391-394.
5. Crowder, M.W.; Spencer, J.; Vila, A.J. Metallo-beta-lactamases: novel weaponry for antibiotic resistance in bacteria. Acc. Chem. Res. 2006, 39, 721-728.
6. Walsh, T.R.; Toleman, M.A.; Poirel, L.; Nordmann, P. Metallo-beta-lactamases: the quiet before the storm? Clin. Microbiol. Rev. 2005, 18, 306-325.
7. Buynak, J.D.; Chen, H.; Vogeti, L.; Gadhachanda, V.R.; Buchanan, C.A.; Palzkill, T.; Shaw, R.W.; Spencer, J.; Walsh, T.R. Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases. Bioorg. Med. Chem. Lett. 2004, 14, 1299-1304.
8. Tuerk, C.; Gold, L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 1990, 249, 505-510.
9. Ellington, A.D.; Szostak, J.W. In vitro selection of RNA molecules that bind specific ligands. Nature 1990, 346, 818-822.
10. Joyce, G.F. Amplification, mutation and selection of catalytic RNA. Gene 1989, 82, 83-87.
11. Gold, L.; Polisky, B.; Uhlenbeck, O.; Yarus, M. Diversity of oligonucleotide functions. Annu. Rev. Biochem. 1995, 64, 763-797.
12. Jayasena, S.D. Aptamers: an emerging class of molecules that rival antibodies in diagnostics. Clin. Chem. 1999, 45, 1628-1650.
13. Maberley, D. Pegaptanib for neovascular age-related macular degeneration. Issues Emerg. Health Technol. 2005, 76, 1-4.
14. Chapman, J.A.; Beckey, C. Pegaptanib: A novel approach to ocular neovascularization. Ann. Pharmacother. 2006, 40, 1322-1326.
15. Lee, J.H.; Canny, M.D.; Erkendez, A.D.; Krilleke, D.; Ng, Y.S.; Shima, D.T.; Pardi, A.; Jucker, F. A therapeutic aptamer inhibits angiogenesis by specifically targeting the heparin binding domain of VEGF165. Proc. Natl. Acad. Sci. USA 2005, 102, 18902-18907.
16. Wu, Y.; Zhong, Z.; Huber, J.; Bassi, R.; Finnerty, B.; Corcoran, E.; Li, H.; Navarro, E.; Balderes, P.; Jimenez, X.; Koo, H.; Mangalampalli, V.R.; Ludwig, D.L.; Tonra, J.R.; Hicklin, D.J. Antivascular endothelial growth factor receptor-1 antagonist antibody as a therapeutic agent for cancer. Clin. Cancer Res. 2006, 12, 6573-6584.
17. Tucker, C.E.; Chen, L.S.; Judkins, M.B.; Farmer, J.A.; Gill, S.C.; Drolet, D.W. Detection and plasma pharmacokinetics of an anti-vascular endothelial growth factor oligonucleotide-aptamer (NX1838) in rhesus monkeys. J. Chromatogr. B Biomed. Sci. Appl. 1999, 732, 203-212.
18. Ng, E.W.; Shima, D.T.; Calias, P.; Cunningham, E.T., Jr.; Guyer, D.R.; Adamis, A.P. Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease. Nat. Rev. Drug Discov. 2006, 5, 123-132.
19. Kim, S.K.; Sims, C.L.; Wozniak, S.E.; Drude, S.H.; Whitson, D.; Shaw, R.W. Antibiotic resistance in bacteria: novel metalloenzyme inhibitors. Chem. Biol. Drug Des. 2009, 74, 343-348.
20. Bock, L.C.; Griffin, L.C.; Latham, J.A.; Vermaas, E.H.; Toole, J.J. Selection of single-stranded DNA molecules that bind and inhibit human thrombin. Nature 1992, 355, 564-566.
21. Griffin, L.C.; Tidmarsh, G.F.; Bock, L.C.; Toole, J.J.; Leung, L.L. In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits. Blood 1993, 81, 3271-3276.
22. Fukuda, K.; Vishinuvardhan, D.; Sekiya, S.; Kakiuchi, N.; Shimotohno, K.; Kumar, P.K.; Nishikawa, S. Specific RNA aptamers to NS3 protease domain of hepatitis C virus. Nucleic Acids Symp. Ser. 1997, 37, 237-238.
23. Pietras, K.; Ostman, A.; Sjoquist, M.; Buchdunger, E.; Reed, R.K.; Heldin, C.H.; Rubin, K. Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors. Cancer Res. 2001, 61, 2929-2934.
24. Kim, S.K. Inhibition of Metallo-Beta-Lactamase by Rational and Combinatorial Approaches; Ph.D. Dissertation. Texas Tech University: Lubbock, TX, USA; 2002.
25. Zuker, M. On finding all suboptimal foldings of an RNA molecule. Science 1989, 244, 48-52.
26. Turner, D.H.; Sugimoto, N.; Freier, S.M. RNA structure prediction. Annu. Rev. Biophys. Biophys. Chem. 1988, 17, 167-192.
27. Allawi, H.T.; SantaLucia, J., Jr. Thermodynamics and NMR of internal G.T mismatches in DNA. Biochemistry 1997, 36, 10581-10594.
28. Bicknell, R.; Schaffer, A.; Waley, S.G.; Auld, D.S. Changes in the coordination geometry of the active-site metal during catalysis of benzylpenicillin hydrolysis by Bacillus cereus beta-lactamase II. Biochemistry 1986, 25, 7208-7215.
29. Bicknell, R.; Waley, S.G. Cryoenzymology of Bacillus cereus beta-lactamase II. Biochemistry 1985, 24, 6876-6887.
30. Fishburn, C.S. The pharmacology of PEGylation: balancing PD with PK to generate novel therapeutics. J. Pharm. Sci. 2008, 97, 4167-4183.
31. Zeuzem, S.; Welsch, C.; Herrmann, E. Pharmacokinetics of peginterferons. Semin. Liver. Dis. 2003, 23, 23-28.