Simultaneous improvement of specificity and affinity of aptamers against Streptococcus mutans by in silico maturation for biosensor development

Biotechnology and Bioengineering

Volumn 111, Issue 3, 2014, Pages 454-461

  Savory, Nasa ^a   Takahashi, Yayoi ^b   Tsukakoshi, Kaori ^a   Hasegawa, Hijiri ^a   Takase, Madoka ^a   Abe, Koichi ^a   Yoshida, Wataru ^a   Ferri, Stefano ^a   Kumazawa, Shizuko ^b   Sode, Koji ^a   Ikebukuro, Kazunori ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b TDK CORPORATION   (Japan)

Author keywords

Aptamers; Cell SELEX; Flow through test; In silico maturation; Streptococcus mutans

Indexed keywords

APTAMERS; CELL-SELEX; FLOW-THROUGH TESTS; IN-SILICO; STREPTOCOCCUS MUTANS;

BIOTECHNOLOGY; CHEMICAL REACTIONS;

BINDING ENERGY;

APTAMER; COLLOIDAL GOLD; GUANINE QUADRUPLEX;

ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; BIOSENSOR; COMPUTER MODEL; CONTROLLED STUDY; GENETIC ALGORITHM; IN SILICO MATURATION; LACTOBACILLUS ACIDOPHILUS; NONHUMAN; NUCLEOTIDE BINDING SITE; NUCLEOTIDE SEQUENCE; STREPTOCOCCUS MUTANS; WHOLE CELL;

LACTOBACILLUS ACIDOPHILUS; STREPTOCOCCUS MUTANS;

APTAMERS; CELL-SELEX; FLOW-THROUGH TEST; IN SILICO MATURATION; STREPTOCOCCUS MUTANS;

APTAMERS, NUCLEOTIDE; BIOSENSING TECHNIQUES; COMPUTER SIMULATION; SENSITIVITY AND SPECIFICITY; STREPTOCOCCUS MUTANS;

EID: 84892821922     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.25111     Document Type: Article

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