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Volumn 3, Issue , 2014, Pages

Cell-type-specific, aptamer-functionalized agents for targeted disease therapy

Author keywords

aptamer; cell type specific delivery; RNAi; SELEX; targeted therapy

Indexed keywords

ANTIINFECTIVE AGENT; APTAMER; DENDRIMER; GOLD NANOPARTICLE; LIPOSOME; MEMBRANE PROTEIN; NANOMATERIAL; OLIGONUCLEOTIDE; RNA; SHORT HAIRPIN RNA; SINGLE WALLED NANOTUBE; SMALL INTERFERING RNA; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; ANTINEOPLASTIC AGENT; DNA; MICRORNA; NANOCARRIER; POLYMER; QUANTUM DOT;

EID: 84902825431     PISSN: None     EISSN: 21622531     Source Type: Journal    
DOI: 10.1038/mtna.2014.21     Document Type: Review
Times cited : (214)

References (128)
  • 1
    • 40749142413 scopus 로고    scopus 로고
    • Systemic chemotherapy for cancer: from weapon to treatment
    • DOI 10.1016/S1470-2045(08)70075-5, PII S1470204508700755
    • Joensuu, H (2008). Systemic chemotherapy for cancer: from weapon to treatment. Lancet Oncol 9: 304. (Pubitemid 351722950)
    • (2008) The Lancet Oncology , vol.9 , Issue.3 , pp. 304
    • Joensuu, H.1
  • 2
    • 0036918282 scopus 로고    scopus 로고
    • Impact of tumor hypoxia and anemia on radiation therapy outcomes
    • DOI 10.1634/theoncologist.7-6-492
    • Harrison, LB, Chadha, M, Hill, RJ, Hu, K and Shasha, D (2002). Impact of tumor hypoxia and anemia on radiation therapy outcomes. Oncologist 7: 492-508. (Pubitemid 36008998)
    • (2002) Oncologist , vol.7 , Issue.6 , pp. 492-508
    • Harrison, L.B.1    Chadha, M.2    Hill, R.J.3    Hu, K.4    Shasha, D.5
  • 3
    • 77950673784 scopus 로고    scopus 로고
    • Targeted immunotherapy for colorectal cancer: Monoclonal antibodies and immunotoxins
    • Shapira, S, Lisiansky, V, Arber, N and Kraus, S (2010). Targeted immunotherapy for colorectal cancer: monoclonal antibodies and immunotoxins. Expert Opin Investig Drugs 19 (suppl. 1): S67-S77.
    • (2010) Expert Opin Investig Drugs , vol.19 , Issue.SUPPL. 1
    • Shapira, S.1    Lisiansky, V.2    Arber, N.3    Kraus, S.4
  • 5
    • 0032580354 scopus 로고    scopus 로고
    • Drug delivery and targeting
    • Langer, R (1998). Drug delivery and targeting. Nature 392 (suppl. 6679): 5-10. (Pubitemid 28215187)
    • (1998) Nature , vol.392 , Issue.6679 SUPPL. , pp. 5-10
    • Langer, R.1
  • 7
    • 79951818184 scopus 로고    scopus 로고
    • Cell-specific aptamer-mediated targeted drug delivery
    • Zhou, J and Rossi, JJ (2011). Cell-specific aptamer-mediated targeted drug delivery. Oligonucleotides 21: 1-10.
    • (2011) Oligonucleotides , vol.21 , pp. 1-10
    • Zhou, J.1    Rossi, J.J.2
  • 8
    • 0035980983 scopus 로고    scopus 로고
    • Selective activation of anticancer prodrugs by monoclonal antibody-enzyme conjugates
    • DOI 10.1016/S0169-409X(01)00206-X, PII S0169409X0100206X
    • Senter, PD, and Springer, CJ (2001). Selective activation of anticancer prodrugs by monoclonal antibody-enzyme conjugates. Adv Drug Deliv Rev 53: 247-264. (Pubitemid 34024909)
    • (2001) Advanced Drug Delivery Reviews , vol.53 , Issue.3 , pp. 247-264
    • Senter, P.D.1    Springer, C.J.2
  • 9
  • 10
    • 0036781811 scopus 로고    scopus 로고
    • Ligand-targeted therapeutics in anticancer therapy
    • DOI 10.1038/nrc903
    • Allen, TM (2002). Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer 2: 750-763. (Pubitemid 37328910)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.10 , pp. 750-763
    • Allen, T.M.1
  • 11
    • 0025332385 scopus 로고
    • Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA
    • Robertson, DL and Joyce, GF (1990). Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA. Nature 344: 467-468.
    • (1990) Nature , vol.344 , pp. 467-468
    • Robertson, D.L.1    Joyce, G.F.2
  • 12
    • 0025194307 scopus 로고
    • Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
    • Tuerk, C and Gold, L (1990). Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249: 505-510.
    • (1990) Science , vol.249 , pp. 505-510
    • Tuerk, C.1    Gold, L.2
  • 13
    • 0025074907 scopus 로고
    • In vitro selection of RNA molecules that bind specific ligands
    • Ellington, AD and Szostak, JW (1990). In vitro selection of RNA molecules that bind specific ligands. Nature 346: 818-822.
    • (1990) Nature , vol.346 , pp. 818-822
    • Ellington, A.D.1    Szostak, J.W.2
  • 15
    • 70349786346 scopus 로고    scopus 로고
    • The chemical biology of aptamers
    • Mayer, G (2009). The chemical biology of aptamers. Angew Chem Int Ed Engl 48: 2672-2689.
    • (2009) Angew Chem Int Ed Engl , vol.48 , pp. 2672-2689
    • Mayer, G.1
  • 16
    • 22544477581 scopus 로고    scopus 로고
    • Aptamers as tools for target validation
    • DOI 10.1016/j.cbpa.2005.06.011, PII S1367593105000906, Next-Generation Therapeutics
    • Blank, M and Blind, M (2005). Aptamers as tools for target validation. Curr Opin Chem Biol 9: 336-342. (Pubitemid 41019677)
    • (2005) Current Opinion in Chemical Biology , vol.9 , Issue.4 , pp. 336-342
    • Blank, M.1    Blind, M.2
  • 18
    • 84899760519 scopus 로고    scopus 로고
    • Aptamer-modified nanoparticles and their use in cancer diagnostics and treatment
    • Reinemann, C and Strehlitz, B (2014). Aptamer-modified nanoparticles and their use in cancer diagnostics and treatment. Swiss Med Wkly 144: w13908.
    • (2014) Swiss Med Wkly , vol.144
    • Reinemann, C.1    Strehlitz, B.2
  • 20
    • 77950537612 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors in kidney transplant recipients receiving tacrolimus: Statins not associated with improved patient or graft survival
    • Younas, N, Wu, CM, Shapiro, R, McCauley, J, Johnston, J, Tan, H et al. (2010). HMG-CoA reductase inhibitors in kidney transplant recipients receiving tacrolimus: statins not associated with improved patient or graft survival. BMC Nephrol 11: 5.
    • (2010) BMC Nephrol , vol.11 , pp. 5
    • Younas, N.1    Wu, C.M.2    Shapiro, R.3    McCauley, J.4    Johnston, J.5    Tan, H.6
  • 21
    • 38349089990 scopus 로고    scopus 로고
    • Methods for selection of aptamers to protein targets
    • Kulbachinskiy, AV (2007). Methods for selection of aptamers to protein targets. Biochemistry (Mosc) 72: 1505-1518.
    • (2007) Biochemistry (Mosc) , vol.72 , pp. 1505-1518
    • Kulbachinskiy, A.V.1
  • 23
    • 70450183948 scopus 로고    scopus 로고
    • Mutations in the Salmonella enterica serovar Choleraesuis cAMP-receptor protein gene lead to functional defects in the SPI-1 Type III secretion system
    • Chen ZW, Hsuan SL, Liao JW, Chen TH, Wu CM, Lee WC et al. (2010). Mutations in the Salmonella enterica serovar Choleraesuis cAMP-receptor protein gene lead to functional defects in the SPI-1 Type III secretion system. Vet Res 41: 5.
    • (2010) Vet Res , vol.41 , pp. 5
    • Chen, Z.W.1    Hsuan, S.L.2    Liao, J.W.3    Chen, T.H.4    Wu, C.M.5    Lee, W.C.6
  • 28
    • 0037099536 scopus 로고    scopus 로고
    • Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen
    • Lupold, SE, Hicke, BJ, Lin, Y and Coffey, DS (2002). Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostatespecific membrane antigen. Cancer Res 62: 4029-4033. (Pubitemid 34791070)
    • (2002) Cancer Research , vol.62 , Issue.14 , pp. 4029-4033
    • Lupold, S.E.1    Hicke, B.J.2    Lin, Y.3    Coffey, D.S.4
  • 29
    • 0032081316 scopus 로고    scopus 로고
    • + T lymphocyte function
    • Kraus, E, James, W and Barclay, AN (1998). Cutting edge: novel RNA ligands able to bind CD4 antigen and inhibit CD4+ T lymphocyte function. J Immunol 160: 5209-5212. (Pubitemid 28267804)
    • (1998) Journal of Immunology , vol.160 , Issue.11 , pp. 5209-5212
    • Kraus, E.1    James, W.2    Barclay, A.N.3
  • 30
    • 66249129385 scopus 로고    scopus 로고
    • Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells
    • Zhou, J, Swiderski, P, Li, H, Zhang, J, Neff, CP, Akkina, R et al. (2009). Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells. Nucleic Acids Res 37: 3094-3109.
    • (2009) Nucleic Acids Res , vol.37 , pp. 3094-3109
    • Zhou, J.1    Swiderski, P.2    Li, H.3    Zhang, J.4    Neff, C.P.5    Akkina, R.6
  • 31
    • 84876526812 scopus 로고    scopus 로고
    • Dual functional BAFF receptor aptamers inhibit ligand-induced proliferation and deliver siRNAs to NHL cells
    • Zhou, J, Tiemann, K, Chomchan, P, Alluin, J, Swiderski, P, Burnett, J et al. (2013). Dual functional BAFF receptor aptamers inhibit ligand-induced proliferation and deliver siRNAs to NHL cells. Nucleic Acids Res 41: 4266-4283.
    • (2013) Nucleic Acids Res , vol.41 , pp. 4266-4283
    • Zhou, J.1    Tiemann, K.2    Chomchan, P.3    Alluin, J.4    Swiderski, P.5    Burnett, J.6
  • 33
    • 77956876990 scopus 로고    scopus 로고
    • Targeting cancer cells with nucleic acid aptamers
    • Cerchia, L and de Franciscis, V (2010). Targeting cancer cells with nucleic acid aptamers. Trends Biotechnol 28: 517-525.
    • (2010) Trends Biotechnol , vol.28 , pp. 517-525
    • Cerchia, L.1    De Franciscis, V.2
  • 34
  • 36
    • 75449119505 scopus 로고    scopus 로고
    • Aptamers generated from cell-SELEX for molecular medicine: A chemical biology approach
    • Fang, X and Tan, W (2010). Aptamers generated from cell-SELEX for molecular medicine: a chemical biology approach. Acc Chem Res. 43: 48-57.
    • (2010) Acc Chem Res. , vol.43 , pp. 48-57
    • Fang, X.1    Tan, W.2
  • 38
    • 34249870129 scopus 로고    scopus 로고
    • Aptamers evolved from cultured cancer cells reveal molecular differences of cancer cells in patient samples
    • DOI 10.1373/clinchem.2006.083246
    • Shangguan, D, Cao, ZC, Li, Y and Tan, W (2007). Aptamers evolved from cultured cancer cells reveal molecular differences of cancer cells in patient samples. Clin Chem 53: 1153-1155. (Pubitemid 46867534)
    • (2007) Clinical Chemistry , vol.53 , Issue.6 , pp. 1153-1155
    • Shangguan, D.1    Cao, Z.C.2    Li, Y.3    Tan, W.4
  • 40
    • 84983203127 scopus 로고    scopus 로고
    • Cell-SELEX technology
    • Ohuchi, S (2012). Cell-SELEX Technology. Biores Open Access 1: 265-272.
    • (2012) Biores Open Access , vol.1 , pp. 265-272
    • Ohuchi, S.1
  • 43
    • 50449105530 scopus 로고    scopus 로고
    • SELEX with modified nucleotides
    • Keefe, AD and Cload, ST (2008). SELEX with modified nucleotides. Curr Opin Chem Biol 12: 448-456.
    • (2008) Curr Opin Chem Biol , vol.12 , pp. 448-456
    • Keefe, A.D.1    Cload, S.T.2
  • 45
    • 84865298982 scopus 로고    scopus 로고
    • DNA aptamer functionalized nanomaterials for intracellular analysis, cancer cell imaging and drug delivery
    • Xing, H, Wong, NY, Xiang, Y and Lu, Y (2012). DNA aptamer functionalized nanomaterials for intracellular analysis, cancer cell imaging and drug delivery. Curr Opin Chem Biol 16: 429-435.
    • (2012) Curr Opin Chem Biol , vol.16 , pp. 429-435
    • Xing, H.1    Wong, N.Y.2    Xiang, Y.3    Lu, Y.4
  • 47
    • 84896725070 scopus 로고    scopus 로고
    • Stable RNA nanoparticles as potential new generation drugs for cancer therapy
    • Shu, Y, Pi, F, Sharma, A, Rajabi, M, Haque, F, Shu, D et al. (2014). Stable RNA nanoparticles as potential new generation drugs for cancer therapy. Adv Drug Deliv Rev 66C: 74-89.
    • (2014) Adv Drug Deliv Rev , vol.66 C , pp. 74-89
    • Shu, Y.1    Pi, F.2    Sharma, A.3    Rajabi, M.4    Haque, F.5    Shu, D.6
  • 48
    • 74049099526 scopus 로고    scopus 로고
    • The therapeutic potential of cell-internalizing aptamers
    • Zhou, J and Rossi, JJ (2009). The therapeutic potential of cell-internalizing aptamers. Curr Top Med Chem 9: 1144-1157.
    • (2009) Curr Top Med Chem , vol.9 , pp. 1144-1157
    • Zhou, J.1    Rossi, J.J.2
  • 49
    • 33745915834 scopus 로고    scopus 로고
    • Preclinical safety and pharmacokinetic profile of ferumoxtran-10, an ultrasmall superparamagnetic iron oxide magnetic resonance contrast agent
    • DOI 10.1097/01.rli.0000197669.80475.dd, PII 0000442420060300000015
    • Bourrinet, P, Bengele, HH, Bonnemain, B, Dencausse, A, Idee, JM, Jacobs, PM et al. (2006). Preclinical safety and pharmacokinetic profile of ferumoxtran-10, an ultrasmall superparamagnetic iron oxide magnetic resonance contrast agent. Invest Radiol 41: 313-324. (Pubitemid 44406193)
    • (2006) Investigative Radiology , vol.41 , Issue.3 , pp. 313-324
    • Bourrinet, P.1    Bengele, H.H.2    Bonnemain, B.3    Dencausse, A.4    Idee, J.-M.5    Jacobs, P.M.6    Lewis, J.M.7
  • 50
    • 84892145144 scopus 로고    scopus 로고
    • T Cell immunoglobulin mucin domain (TIM)-3 promoter activity in a human mast cell line
    • Kim, JS, Shin, DC, Woo, MY, Kwon, MH, Kim, K and Park, S (2012). T Cell immunoglobulin mucin domain (TIM)-3 promoter activity in a human mast cell line. Immune Netw 12: 207-212.
    • (2012) Immune Netw , vol.12 , pp. 207-212
    • Kim, J.S.1    Shin, D.C.2    Woo, M.Y.3    Kwon, M.H.4    Kim, K.5    Park, S.6
  • 51
    • 84876181392 scopus 로고    scopus 로고
    • Density dependence across multiple life stages in a temperate old-growth forest of northeast China
    • Piao, T, Comita, LS, Jin, G and Kim, JH (2013). Density dependence across multiple life stages in a temperate old-growth forest of northeast China. Oecologia 172: 207-217.
    • (2013) Oecologia , vol.172 , pp. 207-217
    • Piao, T.1    Comita, L.S.2    Jin, G.3    Kim, J.H.4
  • 52
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans
    • DOI 10.1038/35888
    • Fire, A, Xu, S, Montgomery, MK, Kostas, SA, Driver, SE and Mello, CC (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806-811. (Pubitemid 28099681)
    • (1998) Nature , vol.391 , Issue.6669 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 53
    • 79954580272 scopus 로고    scopus 로고
    • Current prospects for RNA interference-based therapies
    • Davidson, BL and McCray, PB Jr (2011). Current prospects for RNA interference-based therapies. Nat Rev Genet 12: 329-340.
    • (2011) Nat Rev Genet , vol.12 , pp. 329-340
    • Davidson, B.L.1    McCray Jr., P.B.2
  • 54
    • 77957820261 scopus 로고    scopus 로고
    • RNAi and small interfering RNAs in human disease therapeutic applications
    • Lares, MR, Rossi, JJ and Ouellet, DL (2010). RNAi and small interfering RNAs in human disease therapeutic applications. Trends Biotechnol 28: 570-579.
    • (2010) Trends Biotechnol , vol.28 , pp. 570-579
    • Lares, M.R.1    Rossi, J.J.2    Ouellet, D.L.3
  • 56
    • 58749104364 scopus 로고    scopus 로고
    • The promises and pitfalls of RNA-interference-based therapeutics
    • Castanotto, D and Rossi, JJ (2009). The promises and pitfalls of RNA-interference-based therapeutics. Nature 457: 426-433.
    • (2009) Nature , vol.457 , pp. 426-433
    • Castanotto, D.1    Rossi, J.J.2
  • 58
    • 70249110439 scopus 로고    scopus 로고
    • Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
    • Dassie, JP, Liu, XY, Thomas, GS, Whitaker, RM, Thiel, KW, Stockdale, KR et al. (2009). Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. Nat Biotechnol 27: 839-849.
    • (2009) Nat Biotechnol , vol.27 , pp. 839-849
    • Dassie, J.P.1    Liu, X.Y.2    Thomas, G.S.3    Whitaker, R.M.4    Thiel, K.W.5    Stockdale, K.R.6
  • 59
    • 77952380547 scopus 로고    scopus 로고
    • Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay
    • Pastor, F, Kolonias, D, Giangrande, PH and Gilboa, E (2010). Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay. Nature 465: 227-230.
    • (2010) Nature , vol.465 , pp. 227-230
    • Pastor, F.1    Kolonias, D.2    Giangrande, P.H.3    Gilboa, E.4
  • 60
    • 48349105059 scopus 로고    scopus 로고
    • Novel dual inhibitory function aptamersiRNA delivery system for HIV-1 therapy
    • Zhou, J, Li, H, Li, S, Zaia, J and Rossi, JJ (2008). Novel dual inhibitory function aptamersiRNA delivery system for HIV-1 therapy. Mol Ther 16: 1481-1489.
    • (2008) Mol Ther , vol.16 , pp. 1481-1489
    • Zhou, J.1    Li, H.2    Li, S.3    Zaia, J.4    Rossi, J.J.5
  • 61
    • 78751667739 scopus 로고    scopus 로고
    • An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice
    • Neff, CP, Zhou, J, Remling, L, Kuruvilla, J, Zhang, J, Li, H et al. (2011). An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice. Sci Transl Med 3: 66ra66.
    • (2011) Sci Transl Med , vol.3
    • Neff, C.P.1    Zhou, J.2    Remling, L.3    Kuruvilla, J.4    Zhang, J.5    Li, H.6
  • 62
    • 79957905425 scopus 로고    scopus 로고
    • Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras
    • Wheeler, LA, Trifonova, R, Vrbanac, V, Basar, E, McKernan, S, Xu, Z et al. (2011). Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. J Clin Invest 121: 2401-2412.
    • (2011) J Clin Invest , vol.121 , pp. 2401-2412
    • Wheeler, L.A.1    Trifonova, R.2    Vrbanac, V.3    Basar, E.4    McKernan, S.5    Xu, Z.6
  • 63
    • 79957920185 scopus 로고    scopus 로고
    • Prostatetargeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts
    • Ni, X, Zhang, Y, Ribas, J, Chowdhury, WH, Castanares, M, Zhang, Z et al. (2011). Prostatetargeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts. J Clin Invest. 121: 2383-2390.
    • (2011) J Clin Invest. , vol.121 , pp. 2383-2390
    • Ni, X.1    Zhang, Y.2    Ribas, J.3    Chowdhury, W.H.4    Castanares, M.5    Zhang, Z.6
  • 64
    • 55449127119 scopus 로고    scopus 로고
    • Cell-specific induction of apoptosis by rationally designed bivalent aptamer-siRNA transcripts silencing eukaryotic elongation factor 2
    • Wullner, U, Neef, I, Eller, A, Kleines, M, Tur, MK and Barth, S (2008). Cell-specific induction of apoptosis by rationally designed bivalent aptamer-siRNA transcripts silencing eukaryotic elongation factor 2. Curr Cancer Drug Targets 8: 554-565.
    • (2008) Curr Cancer Drug Targets , vol.8 , pp. 554-565
    • Wullner, U.1    Neef, I.2    Eller, A.3    Kleines, M.4    Tur, M.K.5    Barth, S.6
  • 65
    • 84867997347 scopus 로고    scopus 로고
    • Inhibition of HIV-1 protease expression in T cells owing to DNA aptamer-mediated specific delivery of siRNA
    • Zhu, Q, Shibata, T, Kabashima, T and Kai, M (2012). Inhibition of HIV-1 protease expression in T cells owing to DNA aptamer-mediated specific delivery of siRNA. Eur J Med Chem 56: 396-399.
    • (2012) Eur J Med Chem , vol.56 , pp. 396-399
    • Zhu, Q.1    Shibata, T.2    Kabashima, T.3    Kai, M.4
  • 66
    • 84885351606 scopus 로고    scopus 로고
    • Solubilization of flurbiprofen into aptamer-modified PEG-PLA micelles for targeted delivery to brain-derived endothelial cells in vitro
    • Mu, C, Dave, N, Hu, J, Desai, P, Pauletti, G, Bai, S et al. (2013). Solubilization of flurbiprofen into aptamer-modified PEG-PLA micelles for targeted delivery to brain-derived endothelial cells in vitro. J Microencapsul 30: 701-708.
    • (2013) J Microencapsul , vol.30 , pp. 701-708
    • Mu, C.1    Dave, N.2    Hu, J.3    Desai, P.4    Pauletti, G.5    Bai, S.6
  • 67
    • 77951296766 scopus 로고    scopus 로고
    • Insulin like growth factor-1 prevents 1-mentyl-4-phenylphyridinium- induced apoptosis in PC12 cells through activation of glycogen synthase kinase-3beta
    • Sun, X, Huang, L, Zhang, M, Sun, S and Wu, Y (2010). Insulin like growth factor-1 prevents 1-mentyl-4-phenylphyridinium-induced apoptosis in PC12 cells through activation of glycogen synthase kinase-3beta. Toxicology 271: 5-12.
    • (2010) Toxicology , vol.271 , pp. 5-12
    • Sun, X.1    Huang, L.2    Zhang, M.3    Sun, S.4    Wu, Y.5
  • 70
    • 84877039892 scopus 로고    scopus 로고
    • Aptamerconjugated and doxorubicin-loaded unimolecular micelles for targeted therapy of prostate cancer
    • Xu, W, Siddiqui, IA, Nihal, M, Pilla, S, Rosenthal, K, Mukhtar, H et al. (2013). Aptamerconjugated and doxorubicin-loaded unimolecular micelles for targeted therapy of prostate cancer. Biomaterials 34: 5244-5253.
    • (2013) Biomaterials , vol.34 , pp. 5244-5253
    • Xu, W.1    Siddiqui, I.A.2    Nihal, M.3    Pilla, S.4    Rosenthal, K.5    Mukhtar, H.6
  • 72
    • 67349167635 scopus 로고    scopus 로고
    • Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer
    • Bates, PJ, Laber, DA, Miller, DM, Thomas, SD and Trent, JO (2009). Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer. Exp Mol Pathol 86: 151-164.
    • (2009) Exp Mol Pathol , vol.86 , pp. 151-164
    • Bates, P.J.1    Laber, D.A.2    Miller, D.M.3    Thomas, S.D.4    Trent, J.O.5
  • 73
    • 0033543548 scopus 로고    scopus 로고
    • Antiproliferative activity of G-rich oligonucleotides correlates with protein binding
    • Bates, PJ, Kahlon, JB, Thomas, SD, Trent, JO and Miller, DM (1999). Antiproliferative activity of G-rich oligonucleotides correlates with protein binding. J Biol Chem 274: 26369-26377.
    • (1999) J Biol Chem , vol.274 , pp. 26369-26377
    • Bates, P.J.1    Kahlon, J.B.2    Thomas, S.D.3    Trent, J.O.4    Miller, D.M.5
  • 75
    • 84871919249 scopus 로고    scopus 로고
    • Functional in vivo delivery of multiplexed anti-HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge
    • Zhou, J, Neff, CP, Swiderski, P, Li, H, Smith, DD, Aboellail, T et al. (2013). Functional in vivo delivery of multiplexed anti-HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge. Mol Ther 21: 192-200.
    • (2013) Mol Ther , vol.21 , pp. 192-200
    • Zhou, J.1    Neff, C.P.2    Swiderski, P.3    Li, H.4    Smith, D.D.5    Aboellail, T.6
  • 76
    • 84888321871 scopus 로고    scopus 로고
    • Nucleolin targeting AS1411 modified protein nanoparticle for antitumor drugs delivery
    • Wu, J, Song, C, Jiang, C, Shen, X, Qiao, Q and Hu, Y (2013). Nucleolin targeting AS1411 modified protein nanoparticle for antitumor drugs delivery. Mol Pharm 10: 3555-3563.
    • (2013) Mol Pharm , vol.10 , pp. 3555-3563
    • Wu, J.1    Song, C.2    Jiang, C.3    Shen, X.4    Qiao, Q.5    Hu, Y.6
  • 77
    • 84874912010 scopus 로고    scopus 로고
    • Use of oligonucleotide aptamer ligands to modulate the function of immune receptors
    • Gilboa, E, McNamara, J, 2nd and Pastor, F (2013). Use of oligonucleotide aptamer ligands to modulate the function of immune receptors. Clin Cancer Res 19: 1054-1062.
    • (2013) Clin Cancer Res , vol.19 , pp. 1054-1062
    • Gilboa, E.1    McNamara, I.I.J.2    Pastor, F.3
  • 78
    • 80053576818 scopus 로고    scopus 로고
    • Targeting 4-1BB costimulation to disseminated tumor lesions with bi-specific oligonucleotide aptamers
    • Pastor, F, Kolonias, D, McNamara, JO, 2nd and Gilboa, E (2011). Targeting 4-1BB costimulation to disseminated tumor lesions with bi-specific oligonucleotide aptamers. Mol Ther 19: 1878-1886.
    • (2011) Mol Ther , vol.19 , pp. 1878-1886
    • Pastor, F.1    Kolonias, D.2    McNamara, I.I.J.O.3    Gilboa, E.4
  • 79
    • 38149096315 scopus 로고    scopus 로고
    • Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice
    • McNamara, JO, Kolonias, D, Pastor, F, Mittler, RS, Chen, L, Giangrande, PH et al. (2008). Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice. J Clin Invest 118: 376-386.
    • (2008) J Clin Invest , vol.118 , pp. 376-386
    • McNamara, J.O.1    Kolonias, D.2    Pastor, F.3    Mittler, R.S.4    Chen, L.5    Giangrande, P.H.6
  • 80
    • 65549102827 scopus 로고    scopus 로고
    • Molecular assembly of an aptamer-drug conjugate for targeted drug delivery to tumor cells
    • Huang, YF, Shangguan, D, Liu, H, Phillips, JA, Zhang, X, Chen, Y et al. (2009). Molecular assembly of an aptamer-drug conjugate for targeted drug delivery to tumor cells. Chembiochem 10: 862-868.
    • (2009) Chembiochem , vol.10 , pp. 862-868
    • Huang, Y.F.1    Shangguan, D.2    Liu, H.3    Phillips, J.A.4    Zhang, X.5    Chen, Y.6
  • 81
    • 46049108242 scopus 로고    scopus 로고
    • Cell-specific internalization study of an aptamer from whole cell selection
    • Xiao, Z, Shangguan, D, Cao, Z, Fang, X and Tan, W (2008). Cell-specific internalization study of an aptamer from whole cell selection. Chemistry 14: 1769-1775.
    • (2008) Chemistry , vol.14 , pp. 1769-1775
    • Xiao, Z.1    Shangguan, D.2    Cao, Z.3    Fang, X.4    Tan, W.5
  • 82
    • 84862894295 scopus 로고    scopus 로고
    • Whole-cell SELEX aptamerfunctionalised poly(ethyleneglycol)-poly(epsilon- caprolactone) nanoparticles for enhanced targeted glioblastoma therapy
    • Gao, H, Qian, J, Yang, Z, Pang, Z, Xi, Z, Cao, S et al. (2012). Whole-cell SELEX aptamerfunctionalised poly(ethyleneglycol)-poly(epsilon- caprolactone) nanoparticles for enhanced targeted glioblastoma therapy. Biomaterials 33: 6264-6272.
    • (2012) Biomaterials , vol.33 , pp. 6264-6272
    • Gao, H.1    Qian, J.2    Yang, Z.3    Pang, Z.4    Xi, Z.5    Cao, S.6
  • 85
    • 33845723241 scopus 로고    scopus 로고
    • An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform
    • DOI 10.1002/anie.200602251
    • Bagalkot, V, Farokhzad, OC, Langer, R and Jon, S (2006). An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform. Angew Chem Int Ed Engl 45: 8149-8152. (Pubitemid 44974149)
    • (2006) Angewandte Chemie - International Edition , vol.45 , Issue.48 , pp. 8149-8152
    • Bagalkot, V.1    Farokhzad, O.C.2    Langer, R.3    Jon, S.4
  • 86
    • 84863145260 scopus 로고    scopus 로고
    • Novel MUC1 aptamer selectively delivers cytotoxic agent to cancer cells in vitro
    • Hu, Y, Duan, J, Zhan, Q, Wang, F, Lu, X and Yang, XD (2012). Novel MUC1 aptamer selectively delivers cytotoxic agent to cancer cells in vitro. PLoS One 7: e31970.
    • (2012) PLoS One , vol.7
    • Hu, Y.1    Duan, J.2    Zhan, Q.3    Wang, F.4    Lu, X.5    Yang, X.D.6
  • 87
    • 84867754001 scopus 로고    scopus 로고
    • Novel HER2 aptamer selectively delivers cytotoxic drug to HER2-positive breast cancer cells in vitro
    • Liu, Z, Duan, JH, Song, YM, Ma, J, Wang, FD, Lu, X et al. (2012). Novel HER2 aptamer selectively delivers cytotoxic drug to HER2-positive breast cancer cells in vitro. J Transl Med 10: 148.
    • (2012) J Transl Med , vol.10 , pp. 148
    • Liu, Z.1    Duan, J.H.2    Song, Y.M.3    Ma, J.4    Wang, F.D.5    Lu, X.6
  • 88
    • 84864304921 scopus 로고    scopus 로고
    • Designer tridentate mucin 1 aptamer for targeted drug delivery
    • Tan, L, Gee Neoh, K, Kang, ET, Choe, WS and Su, X (2012). Designer tridentate mucin 1 aptamer for targeted drug delivery. J Pharm Sci 101: 1672-1677.
    • (2012) J Pharm Sci , vol.101 , pp. 1672-1677
    • Tan, L.1    Gee Neoh, K.2    Kang, E.T.3    Choe, W.S.4    Su, X.5
  • 89
    • 77950145605 scopus 로고    scopus 로고
    • Aptamer-based tumor-targeted drug delivery for photodynamic therapy
    • Shieh, YA, Yang, SJ, Wei, MF and Shieh, MJ (2010). Aptamer-based tumor-targeted drug delivery for photodynamic therapy. ACS Nano 4: 1433-1442.
    • (2010) ACS Nano , vol.4 , pp. 1433-1442
    • Shieh, Y.A.1    Yang, S.J.2    Wei, M.F.3    Shieh, M.J.4
  • 90
    • 84858590366 scopus 로고    scopus 로고
    • Monolayer coated gold nanoparticles for delivery applications
    • Rana, S, Bajaj, A, Mout, R and Rotello, VM (2012). Monolayer coated gold nanoparticles for delivery applications. Adv Drug Deliv Rev 64: 200-216.
    • (2012) Adv Drug Deliv Rev , vol.64 , pp. 200-216
    • Rana, S.1    Bajaj, A.2    Mout, R.3    Rotello, V.M.4
  • 91
    • 80054972260 scopus 로고    scopus 로고
    • Release of photoactivatable drugs from plasmonic nanoparticles for targeted cancer therapy
    • Luo, YL, Shiao, YS and Huang, YF (2011). Release of photoactivatable drugs from plasmonic nanoparticles for targeted cancer therapy. ACS Nano 5: 7796-7804.
    • (2011) ACS Nano , vol.5 , pp. 7796-7804
    • Luo, Y.L.1    Shiao, Y.S.2    Huang, Y.F.3
  • 92
    • 84862840610 scopus 로고    scopus 로고
    • Assembly of aptamer switch probes and photosensitizer on gold nanorods for targeted photothermal and photodynamic cancer therapy
    • Wang, J, Zhu, G, You, M, Song, E, Shukoor, MI, Zhang, K et al. (2012). Assembly of aptamer switch probes and photosensitizer on gold nanorods for targeted photothermal and photodynamic cancer therapy. ACS Nano 6: 5070-5077.
    • (2012) ACS Nano , vol.6 , pp. 5070-5077
    • Wang, J.1    Zhu, G.2    You, M.3    Song, E.4    Shukoor, M.I.5    Zhang, K.6
  • 93
    • 84886092247 scopus 로고    scopus 로고
    • An ultra pH-sensitive and aptamerequipped nanoscale drug-delivery system for selective killing of tumor cells
    • Zhao, N, You, J, Zeng, Z, Li, C and Zu, Y (2013). An ultra pH-sensitive and aptamerequipped nanoscale drug-delivery system for selective killing of tumor cells. Small 9: 3477-3484.
    • (2013) Small , vol.9 , pp. 3477-3484
    • Zhao, N.1    You, J.2    Zeng, Z.3    Li, C.4    Zu, Y.5
  • 94
    • 54849404705 scopus 로고    scopus 로고
    • Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy
    • Wang, AZ, Bagalkot, V, Vasilliou, CC, Gu, F, Alexis, F, Zhang, L et al. (2008). Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy. Chem Med Chem 3: 1311-1315.
    • (2008) Chem Med Chem , vol.3 , pp. 1311-1315
    • Wang, A.Z.1    Bagalkot, V.2    Vasilliou, C.C.3    Gu, F.4    Alexis, F.5    Zhang, L.6
  • 95
    • 83555177197 scopus 로고    scopus 로고
    • Single walled carbon nanotubes as drug delivery vehicles: Targeting doxorubicin to tumors
    • Meng, L, Zhang, X, Lu, Q, Fei, Z and Dyson, PJ (2012). Single walled carbon nanotubes as drug delivery vehicles: targeting doxorubicin to tumors. Biomaterials 33: 1689-1698.
    • (2012) Biomaterials , vol.33 , pp. 1689-1698
    • Meng, L.1    Zhang, X.2    Lu, Q.3    Fei, Z.4    Dyson, P.J.5
  • 96
    • 79551561775 scopus 로고    scopus 로고
    • Reversible targeting and controlled release delivery of daunorubicin to cancer cells by aptamer-wrapped carbon nanotubes
    • Taghdisi, SM, Lavaee, P, Ramezani, M and Abnous, K (2011). Reversible targeting and controlled release delivery of daunorubicin to cancer cells by aptamer-wrapped carbon nanotubes. Eur J Pharm Biopharm 77: 200-206.
    • (2011) Eur J Pharm Biopharm , vol.77 , pp. 200-206
    • Taghdisi, S.M.1    Lavaee, P.2    Ramezani, M.3    Abnous, K.4
  • 97
    • 50249133647 scopus 로고    scopus 로고
    • Regulation of singlet oxygen generation using single-walled carbon nanotubes
    • Zhu, Z, Tang, Z, Phillips, JA, Yang, R, Wang, H and Tan, W (2008). Regulation of singlet oxygen generation using single-walled carbon nanotubes. J Am Chem Soc 130: 10856-10857.
    • (2008) J Am Chem Soc , vol.130 , pp. 10856-10857
    • Zhu, Z.1    Tang, Z.2    Phillips, J.A.3    Yang, R.4    Wang, H.5    Tan, W.6
  • 98
    • 84861809558 scopus 로고    scopus 로고
    • Near-infrared light-triggered, targeted drug delivery to cancer cells by aptamer gated nanovehicles
    • Yang, X, Liu, X, Liu, Z, Pu, F, Ren, J and Qu, X (2012). Near-infrared light-triggered, targeted drug delivery to cancer cells by aptamer gated nanovehicles. Adv Mater 24: 2890-2895.
    • (2012) Adv Mater , vol.24 , pp. 2890-2895
    • Yang, X.1    Liu, X.2    Liu, Z.3    Pu, F.4    Ren, J.5    Qu, X.6
  • 99
    • 82855175161 scopus 로고    scopus 로고
    • Molecular imaging of a cancertargeting theragnostics probe using a nucleolin aptamer-and microRNA-221 molecular beacon-conjugated nanoparticle
    • Kim, JK, Choi, KJ, Lee, M, Jo, MH and Kim, S (2012). Molecular imaging of a cancertargeting theragnostics probe using a nucleolin aptamer-and microRNA-221 molecular beacon-conjugated nanoparticle. Biomaterials 33: 207-217.
    • (2012) Biomaterials , vol.33 , pp. 207-217
    • Kim, J.K.1    Choi, K.J.2    Lee, M.3    Jo, M.H.4    Kim, S.5
  • 100
    • 79960078032 scopus 로고    scopus 로고
    • Tumor targeted quantum dot-mucin 1 aptamer-doxorubicin conjugate for imaging and treatment of cancer
    • Savla, R, Taratula, O, Garbuzenko, O and Minko, T (2011). Tumor targeted quantum dot-mucin 1 aptamer-doxorubicin conjugate for imaging and treatment of cancer. J Control Release 153: 16-22.
    • (2011) J Control Release , vol.153 , pp. 16-22
    • Savla, R.1    Taratula, O.2    Garbuzenko, O.3    Minko, T.4
  • 101
    • 84861194242 scopus 로고    scopus 로고
    • Nanovector delivery of siRNA for cancer therapy
    • Shen, H, Sun, T and Ferrari, M (2012). Nanovector delivery of siRNA for cancer therapy. Cancer Gene Ther 19: 367-373.
    • (2012) Cancer Gene Ther , vol.19 , pp. 367-373
    • Shen, H.1    Sun, T.2    Ferrari, M.3
  • 102
    • 75649089648 scopus 로고    scopus 로고
    • A liposome-based nanostructure for aptamer directed delivery
    • Kang, H, O'Donoghue, MB, Liu, H and Tan, W (2010). A liposome-based nanostructure for aptamer directed delivery. Chem Commun (Camb) 46: 249-251.
    • (2010) Chem Commun (Camb) , vol.46 , pp. 249-251
    • Kang, H.1    O'Donoghue, M.B.2    Liu, H.3    Tan, W.4
  • 103
    • 70349898026 scopus 로고    scopus 로고
    • Reversible cellspecific drug delivery with aptamer-functionalized liposomes
    • Cao, Z, Tong, R, Mishra, A, Xu, W, Wong, GC, Cheng, J et al. (2009). Reversible cellspecific drug delivery with aptamer-functionalized liposomes. Angew Chem Int Ed Engl 48: 6494-6498.
    • (2009) Angew Chem Int Ed Engl , vol.48 , pp. 6494-6498
    • Cao, Z.1    Tong, R.2    Mishra, A.3    Xu, W.4    Wong, G.C.5    Cheng, J.6
  • 105
    • 84880849719 scopus 로고    scopus 로고
    • Engineering of switchable aptamer micelle flares for molecular imaging in living cells
    • Wu, C, Chen, T, Han, D, You, M, Peng, L, Cansiz, S et al. (2013). Engineering of switchable aptamer micelle flares for molecular imaging in living cells. ACS Nano 7: 5724-5731.
    • (2013) ACS Nano , vol.7 , pp. 5724-5731
    • Wu, C.1    Chen, T.2    Han, D.3    You, M.4    Peng, L.5    Cansiz, S.6
  • 106
    • 76249127542 scopus 로고    scopus 로고
    • DNA aptamer-micelle as an efficient detection/delivery vehicle toward cancer cells
    • Wu, Y, Sefah, K, Liu, H, Wang, R and Tan, W (2010). DNA aptamer-micelle as an efficient detection/delivery vehicle toward cancer cells. Proc Natl Acad Sci USA 107: 5-10.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 5-10
    • Wu, Y.1    Sefah, K.2    Liu, H.3    Wang, R.4    Tan, W.5
  • 107
    • 84862016955 scopus 로고    scopus 로고
    • Prodrug strategy for PSMA-targeted delivery of TGX-221 to prostate cancer cells
    • Zhao, Y, Duan, S, Zeng, X, Liu, C, Davies, NM, Li, B et al. (2012). Prodrug strategy for PSMA-targeted delivery of TGX-221 to prostate cancer cells. Mol Pharm 9: 1705-1716.
    • (2012) Mol Pharm , vol.9 , pp. 1705-1716
    • Zhao, Y.1    Duan, S.2    Zeng, X.3    Liu, C.4    Davies, N.M.5    Li, B.6
  • 108
    • 84875073935 scopus 로고    scopus 로고
    • Targeted in vitro photodynamic therapy via aptamerlabeled, porphyrin-loaded virus capsids
    • Cohen, BA and Bergkvist, M (2013). Targeted in vitro photodynamic therapy via aptamerlabeled, porphyrin-loaded virus capsids. J Photochem Photobiol B 121: 67-74.
    • (2013) J Photochem Photobiol B , vol.121 , pp. 67-74
    • Cohen, B.A.1    Bergkvist, M.2
  • 109
    • 84889581080 scopus 로고    scopus 로고
    • A universal protein tag for delivery of SiRNA-aptamer chimeras
    • Liu, HY and Gao, X (2013). A universal protein tag for delivery of SiRNA-aptamer chimeras. Sci Rep 3: 3129.
    • (2013) Sci Rep , vol.3 , pp. 3129
    • Liu, H.Y.1    Gao, X.2
  • 110
    • 84881146974 scopus 로고    scopus 로고
    • Smart ligand: Aptamer-mediated targeted delivery of chemotherapeutic drugs and siRNA for cancer therapy
    • Li, X, Zhao, Q and Qiu, L (2013). Smart ligand: aptamer-mediated targeted delivery of chemotherapeutic drugs and siRNA for cancer therapy. J Control Release 171: 152-162.
    • (2013) J Control Release , vol.171 , pp. 152-162
    • Li, X.1    Zhao, Q.2    Qiu, L.3
  • 111
    • 7444223607 scopus 로고    scopus 로고
    • Nanoparticle-aptamer bioconjugates: A new approach for targeting prostate cancer cells
    • DOI 10.1158/0008-5472.CAN-04-2550
    • Farokhzad, OC, Jon, S, Khademhosseini, A, Tran, TN, Lavan, DA and Langer, R (2004). Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells. Cancer Res 64: 7668-7672. (Pubitemid 39446893)
    • (2004) Cancer Research , vol.64 , Issue.21 , pp. 7668-7672
    • Farokhzad, O.C.1    Jon, S.2    Khademhosseini, A.3    Tran, T.-N.T.4    LaVan, D.A.5    Langer, R.6
  • 113
    • 56249097260 scopus 로고    scopus 로고
    • Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles
    • Dhar, S, Gu, FX, Langer, R, Farokhzad, OC and Lippard, SJ (2008). Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. Proc Natl Acad Sci USA 105: 17356-17361.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 17356-17361
    • Dhar, S.1    Gu, F.X.2    Langer, R.3    Farokhzad, O.C.4    Lippard, S.J.5
  • 116
    • 84866759245 scopus 로고    scopus 로고
    • AS1411 aptamer tagged PLGA-lecithin-PEG nanoparticles for tumor cell targeting and drug delivery
    • Aravind, A, Jeyamohan, P, Nair, R, Veeranarayanan, S, Nagaoka, Y, Yoshida, Y et al. (2012). AS1411 aptamer tagged PLGA-lecithin-PEG nanoparticles for tumor cell targeting and drug delivery. Biotechnol Bioeng 109: 2920-2931.
    • (2012) Biotechnol Bioeng , vol.109 , pp. 2920-2931
    • Aravind, A.1    Jeyamohan, P.2    Nair, R.3    Veeranarayanan, S.4    Nagaoka, Y.5    Yoshida, Y.6
  • 117
    • 79251568958 scopus 로고    scopus 로고
    • A nanocomplex that is both tumor cell-selective and cancer gene-specific for anaplastic large cell lymphoma
    • Zhao, N, Bagaria, HG, Wong, MS and Zu, Y (2011). A nanocomplex that is both tumor cell-selective and cancer gene-specific for anaplastic large cell lymphoma. J Nanobiotechnology 9: 2.
    • (2011) J Nanobiotechnology , vol.9 , pp. 2
    • Zhao, N.1    Bagaria, H.G.2    Wong, M.S.3    Zu, Y.4
  • 119
    • 84866641974 scopus 로고    scopus 로고
    • Prostate-targeted biodegradable nanoparticles loaded with androgen receptor silencing constructs eradicate xenograft tumors in mice
    • Yang, J, Xie, SX, Huang, Y, Ling, M, Liu, J, Ran, Y et al. (2012). Prostate-targeted biodegradable nanoparticles loaded with androgen receptor silencing constructs eradicate xenograft tumors in mice. Nanomedicine (Lond) 7: 1297-1309.
    • (2012) Nanomedicine (Lond) , vol.7 , pp. 1297-1309
    • Yang, J.1    Xie, S.X.2    Huang, Y.3    Ling, M.4    Liu, J.5    Ran, Y.6
  • 120
    • 80055004444 scopus 로고    scopus 로고
    • SiRNA-aptamer chimeras on nanoparticles: Preserving targeting functionality for effective gene silencing
    • Bagalkot, V and Gao, X (2011). siRNA-aptamer chimeras on nanoparticles: preserving targeting functionality for effective gene silencing. ACS Nano 5: 8131-8139.
    • (2011) ACS Nano , vol.5 , pp. 8131-8139
    • Bagalkot, V.1    Gao, X.2
  • 122
    • 80054681184 scopus 로고    scopus 로고
    • Targeted chemoimmunotherapy using drug-loaded aptamer-dendrimer bioconjugates
    • Lee, IH, An, S, Yu, MK, Kwon, HK, Im, SH and Jon, S (2011). Targeted chemoimmunotherapy using drug-loaded aptamer-dendrimer bioconjugates. J Control Release 155: 435-441.
    • (2011) J Control Release , vol.155 , pp. 435-441
    • Lee, I.H.1    An, S.2    Yu, M.K.3    Kwon, H.K.4    Im, S.H.5    Jon, S.6
  • 123
    • 84862833395 scopus 로고    scopus 로고
    • Second-generation aptamer-conjugated PSMA-targeted delivery system for prostate cancer therapy
    • Wu, X, Ding, B, Gao, J, Wang, H, Fan, W, Wang, X et al. (2011). Second-generation aptamer-conjugated PSMA-targeted delivery system for prostate cancer therapy. Int J Nanomedicine 6: 1747-1756.
    • (2011) Int J Nanomedicine , vol.6 , pp. 1747-1756
    • Wu, X.1    Ding, B.2    Gao, J.3    Wang, H.4    Fan, W.5    Wang, X.6
  • 124
    • 42349106952 scopus 로고    scopus 로고
    • Codelivery of hydrophobic and hydrophilic drugs from nanoparticle-aptamer bioconjugates
    • Zhang, L, Radovic-Moreno, AF, Alexis, F, Gu, FX, Basto, PA, Bagalkot, V et al. (2007). Codelivery of hydrophobic and hydrophilic drugs from nanoparticle-aptamer bioconjugates. Chem Med Chem 2: 1268-1271.
    • (2007) Chem Med Chem , vol.2 , pp. 1268-1271
    • Zhang, L.1    Radovic-Moreno, A.F.2    Alexis, F.3    Gu, F.X.4    Basto, P.A.5    Bagalkot, V.6
  • 125
    • 77950051368 scopus 로고    scopus 로고
    • Prostate cancer cell death produced by the co-delivery of Bcl-xL shRNA and doxorubicin using an aptamerconjugated polyplex
    • Kim, E, Jung, Y, Choi, H, Yang, J, Suh, JS, Huh, YM et al. (2010). Prostate cancer cell death produced by the co-delivery of Bcl-xL shRNA and doxorubicin using an aptamerconjugated polyplex. Biomaterials 31: 4592-4599.
    • (2010) Biomaterials , vol.31 , pp. 4592-4599
    • Kim, E.1    Jung, Y.2    Choi, H.3    Yang, J.4    Suh, J.S.5    Huh, Y.M.6


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