Selection is more intelligent than design: Improving the affinity of a bivalent ligand through directed evolution

Nucleic Acids Research

Volumn 40, Issue 22, 2012, Pages 11777-11783

  Ahmad, Kareem M ^a   Xiao, Yi ^a,b   Tom Soh, H ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APTAMER; BIVALENT APTAMER; MOLECULAR SCAFFOLD; THROMBIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; DIRECTED MOLECULAR EVOLUTION; DISSOCIATION CONSTANT; DNA SEQUENCE; IN VITRO STUDY; MICROFLUIDICS; MOLECULAR INTERACTION; PRIORITY JOURNAL;

APTAMERS, NUCLEOTIDE; DIRECTED MOLECULAR EVOLUTION; DNA, SINGLE-STRANDED; LIGANDS; MICROFLUIDIC ANALYTICAL TECHNIQUES; NUCLEIC ACID CONFORMATION; THROMBIN;

EID: 84871246567     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gks899     Document Type: Article

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