Potential Capacity of Aptamers to Trigger Immune Activation in Human Blood

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Avci Adali, Meltem ^a   Steinle, Heidrun ^a   Michel, Tatjana ^a   Schlensak, Christian ^a   Wendel, Hans P ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; APTAMER; BETA INTERFERON; CD83 ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; CXCL11 CHEMOKINE; ENDOTOXIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 3; PHOSPHATASE AND ACTIN REGULATOR 1; PLASMINOGEN ACTIVATOR INHIBITOR 2; PYROGEN; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR LIKE 1; SINGLE STRANDED DNA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD; BLOOD SAMPLING; CCL2 GENE; CCL7 GENE; CCL8 GENE; CD22 GENE; CD80 GENE; CD83 GENE; CELL MATURATION; CIRCULATION; CONTROLLED STUDY; CXCL10 GENE; CXCL11 GENE; CYTOKINE PRODUCTION; DENDRITIC CELL; DNA SYNTHESIS; DOWN REGULATION; ENZYME ACTIVITY; F2RL1 GENE; FEMALE; GENE; GENE EXPRESSION REGULATION; GENETIC STABILITY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; ICAM1 GENE; IFNA5 GENE; IFNB1 GENE; IL4I1 GENE; IL6 GENE; IMMUNE RESPONSE; IMMUNOSTIMULATION; INCUBATION TEMPERATURE; INFLAMMATION; INNATE IMMUNITY; KEGG GENE; MALE; MICROARRAY ANALYSIS; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PLAU GENE; PROTEIN STABILITY; PTPN7 GENE; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RGL1 GENE; RNA ISOLATION; SERPINB2 GENE; SIGNAL TRANSDUCTION; TLR GENE; TLR1 GENE; TLR2 GENE; TLR3 GENE; TLR5 GENE; TLR7 GENE; TLR8 GENE; TLR9 GENE; TNFSF15 GENE; TRANSCRIPTION REGULATION; UPREGULATION;

ADULT; APTAMERS, NUCLEOTIDE; BLOOD CELL COUNT; CELL DIFFERENTIATION; DENDRITIC CELLS; ENDOTOXINS; FEMALE; GENE EXPRESSION PROFILING; GENE ONTOLOGY; HUMANS; IMMUNITY; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OLIGONUCLEOTIDES; PYROGENS; REAL-TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; UP-REGULATION;

EID: 84880704185     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068810     Document Type: Article

References (41)

1. Shangguan D, Li Y, Tang Z, Cao ZC, Chen HW, et al. (2006) Aptamers evolved from live cells as effective molecular probes for cancer study. Proc Natl Acad Sci U S A 103: 11838-11843.
2. Rusconi CP, Roberts JD, Pitoc GA, Nimjee SM, White RR, et al. (2004) Antidote-mediated control of an anticoagulant aptamer in vivo. Nat Biotechnol 22: 1423-1428.
3. Ng EW, Shima DT, Calias P, Cunningham ET Jr, Guyer DR, et al. (2006) Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease. Nat Rev Drug Discov 5: 123-132.
4. Charlton J, Sennello J, Smith D, (1997) In vivo imaging of inflammation using an aptamer inhibitor of human neutrophil elastase. Chem Biol 4: 809-816.
5. Schäfer R, Wiskirchen J, Guo K, Neumann B, Kehlbach R, et al. (2007) Aptamer-based isolation and subsequent imaging of mesenchymal stem cells in ischemic myocard by magnetic resonance imaging. Rofo 179: 1009-1015.
6. Bates PJ, Laber DA, Miller DM, Thomas SD, Trent JO, (2009) Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer. Exp Mol Pathol 86: 151-164.
7. Pichlmair A, Schulz O, Tan CP, Naslund TI, Liljestrom P, et al. (2006) RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates. Science 314: 997-1001.
8. Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, et al. (2006) A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol 7: 40-48.
9. Chiu YH, Macmillan JB, Chen ZJ, (2009) RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 138: 576-591.
10. Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, et al. (2007) DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 448: 501-505.
11. Yang P, An H, Liu X, Wen M, Zheng Y, et al. (2010) The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat Immunol 11: 487-494.
12. Burckstummer T, Baumann C, Bluml S, Dixit E, Durnberger G, et al. (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol 10: 266-272.
13. Kim T, Pazhoor S, Bao M, Zhang Z, Hanabuchi S, et al. (2010) Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells. Proc Natl Acad Sci U S A 107: 15181-15186.
14. Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, et al. (2010) IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol 11: 997-1004.
15. Chandler AB, (1958) In vitro thrombotic coagulation of the blood; a method for producing a thrombus. Lab Invest 7: 110-114.
16. Schroeder A, Mueller O, Stocker S, Salowsky R, Leiber M, et al. (2006) The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol Biol 7: 3.
17. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, et al. (2004) Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5: R80.
18. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, et al. (2003) Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 31: e15.
19. Smyth GK, (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: Article3.
20. Benjamini Y, Hochberg Y, (1995) Controlling the False Discovery Rate: a Practical and Powerful Approach to Multiple Testing. J R Statist Soc B 57: 289-300.
21. Jilma-Stohlawetz P, Gilbert JC, Gorczyca ME, Knobl P, Jilma B, (2011) A dose ranging phase I/II trial of the von Willebrand factor inhibiting aptamer ARC1779 in patients with congenital thrombotic thrombocytopenic purpura. Thromb Haemost 106: 539-547.
22. Shi H, Tang Z, Kim Y, Nie H, Huang YF, et al. (2010) In vivo fluorescence imaging of tumors using molecular aptamers generated by cell-SELEX. Chem Asian J 5: 2209-2213.
23. Hong H, Goel S, Zhang Y, Cai W, (2011) Molecular imaging with nucleic acid aptamers. Curr Med Chem 18: 4195-4205.
24. Avci-Adali M, Perle N, Ziemer G, Wendel HP, (2011) Current concepts and new developments for autologous in vivo endothelialisation of biomaterials for intravascular applications. Eur Cell Mater 21: 157-176.
25. Hartmann G, Battiany J, Poeck H, Wagner M, Kerkmann M, et al. (2003) Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells. Eur J Immunol 33: 1633-1641.
26. Hornung V, Rothenfusser S, Britsch S, Krug A, Jahrsdorfer B, et al. (2002) Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 168: 4531-4537.
27. El Kebir D, Jozsef L, Filep JG, (2008) Neutrophil recognition of bacterial DNA and Toll-like receptor 9-dependent and-independent regulation of neutrophil function. Arch Immunol Ther Exp (Warsz) 56: 41-53.
28. Paul A, Avci-Adali M, Neumann B, Guo K, Straub A, et al. (2010) Aptamers influence the hemostatic system by activating the intrinsic coagulation pathway in an in vitro Chandler-Loop model. Clin Appl Thromb Hemost 16: 161-169.
29. Flo TH, Halaas O, Torp S, Ryan L, Lien E, et al. (2001) Differential expression of Toll-like receptor 2 in human cells. J Leukoc Biol 69: 474-481.
30. Akira S, Takeda K, (2004) Toll-like receptor signalling. Nat Rev Immunol 4: 499-511.
31. Nilsen N, Nonstad U, Khan N, Knetter CF, Akira S, et al. (2004) Lipopolysaccharide and double-stranded RNA up-regulate toll-like receptor 2 independently of myeloid differentiation factor 88. J Biol Chem 279: 39727-39735.
32. Ablasser A, Bauernfeind F, Hartmann G, Latz E, Fitzgerald KA, et al. (2009) RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat Immunol 10: 1065-1072.
33. Petrilli V, Dostert C, Muruve DA, Tschopp J, (2007) The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol 19: 615-622.
34. Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES, (2009) AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458: 509-513.
35. Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, et al. (2009) AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458: 514-518.
36. Karbach J, Neumann A, Wahle C, Brand K, Gnjatic S, et al. (2012) Therapeutic Administration of a Synthetic CpG Oligodeoxynucleotide Triggers Formation of Anti-CpG Antibodies. Cancer Res 72: 4304-4310.
37. Shimosato T, Kimura T, Tohno M, Iliev ID, Katoh S, et al. (2006) Strong immunostimulatory activity of AT-oligodeoxynucleotide requires a six-base loop with a self-stabilized 5′-C.G-3′-stem structure. Cell Microbiol 8: 485-495.
38. Vollmer J, Weeratna RD, Jurk M, Samulowitz U, McCluskie MJ, et al. (2004) Oligodeoxynucleotides lacking CpG dinucleotides mediate Toll-like receptor 9 dependent T helper type 2 biased immune stimulation. Immunology 113: 212-223.
39. Yasuda K, Rutz M, Schlatter B, Metzger J, Luppa PB, et al. (2006) CpG motif-independent activation of TLR9 upon endosomal translocation of "natural" phosphodiester DNA. Eur J Immunol 36: 431-436.
40. Levy-Nissenbaum E, Radovic-Moreno AF, Wang AZ, Langer R, Farokhzad OC, (2008) Nanotechnology and aptamers: applications in drug delivery. Trends Biotechnol 26: 442-449.
41. Wu CC, Sabet M, Hayashi T, Tawatao R, Fierer J, et al. (2008) In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection model. Cell Immunol 251: 78-85.