Preliminary development of DNA aptamer-Fc conjugate opsonins

Journal of Biomedical Materials Research - Part A

Volumn 90, Issue 4, 2009, Pages 1152-1161

  Bruno, John G ^a   Carrillo, Maria P ^a   Crowell, Randy ^a  

^a Operational Technologies Corporation   (United States)

Author keywords

Anthrax; Aptamer; Capsule; Macrophage; Phagocytosis

Indexed keywords

ANTHRACIS; ANTHRAX; APTAMER; APTAMER SEQUENCES; APTAMERS; BACILLUS ANTHRACIS; CAPSULE; CONJUGATE ADDITION; DNA APTAMERS; GLUTAMIC ACID; IMAGE ANALYSIS TECHNIQUES; MAGNETIC BEADS; MURINE MACROPHAGES; PHAGOCYTOSIS; PROOF OF CONCEPT; VIRULENT STRAINS;

ANTIBODIES; ANTIGEN-ANTIBODY REACTIONS; BACTERIOLOGY; DNA; GENES; IMAGE ANALYSIS; MACROPHAGES; NUCLEIC ACIDS;

BACTERIA;

APTAMER; DNA; GLUTAMIC ACID; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; OPSONIN; POLY(GAMMA DEXTRO GLUTAMIC ACID); UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACILLUS ANTHRACIS; BACTERIAL MEMBRANE; CONTROLLED STUDY; IMAGE ANALYSIS; MACROPHAGE; MOUSE; NONHUMAN; PHAGOCYTOSIS; SPECTROFLUOROMETRY;

ANIMALS; APTAMERS, NUCLEOTIDE; BACILLUS ANTHRACIS; CELL LINE; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; MACROPHAGES; MICE; MODELS, BIOLOGICAL; OPSONIN PROTEINS; PHAGOCYTOSIS; POLYGLUTAMIC ACID; PROTEINS;

EID: 68249142782     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32182     Document Type: Article

References (25)

1. Ezzell JW, Welkos SL. The capsule of Bacillus anthracis, a review. J Appl Microbiol 1999;87:250.
2. Fouet A, Mesnage S. Bacillus anthracis cell envelope components. Curr Top Microbiol Immunol 2002;271:87-113.
3. Gordon SB, Irving GR, Lawson RA, Lee ME, Read RC. Intracellular trafficking and killing of Streptococcus pneumoniae by human alveolar macrophages are influenced by opsonins. Infect Immun 2000;68:2286-2293.
4. Kocianova S, Vuong C, Yao JM, Voyich ER, Fischer FR, DeLeo FR, Otto M. Key role of poly-gamma-DL-glutamic acid in immune evasion and virulence of Staphylococcus epidermidis. J Clin Invest 2005;115:688-694.
5. Scorpio A, Chabot DJ, Day WA, O'Brien DK, Vietri NJ, Itoh Y, Mohammadzadeh M, Friedlander AM. Poly-gamma-glutamate capsule-degrading enzyme treatment enhances phagocytosis and killing of encapsulated Bacillus anthracis. Antimicrob Agents Chemother 2007;51:215-222.
6. Brittingham KC, Ruthel G, Panchal RG. Dendritic cells endocytose Bacillus anthracis spores: Implications for anthrax pathogenesis. J Immunol 2005;174:5545-5552.
7. Cote CK, Rooijen V, Welkos SL. Roles of macrophages and neutrophils in the early host response to Bacillus anthracis spores in a mouse model of infection. Infect Immun 2006;74:469-480.
8. Drysdale M. Heninger S, Hutt J, Chen Y, Lyons CR, Koehler TM. Capsule synthesis by Bacillus anthracis is required for dissemination in murine inhalation anthrax. EMBO J 2005;24:221-227.
9. Rhie GE, Roehrl MH, Mourez M, Collier RJ, Mekalanos JJ, Wang JY. A dually active anthrax vaccine that confers protection against both bacilli and toxins. Proc Natl Acad Sci USA 2003;100:10925-10930.
10. Kubler-Kielb J, Liu TY, Mocca C, Majadly F, Robbins JB, Schneerson R. Additional conjugation methods and immunogenicity of Bacillus anthracis poly-γ-D-glutamic acid-protein conjugates. Infect Immun 2006;74:4744-4749.
11. Ferrara N, Hillan KJ, Novotny W. Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy. Biochem Biophys Res Commun 2005;333:328-335.
12. Jayasena SD. Aptamers: An emerging class of molecules that rival antibodies in diagnostics. Clin Chem 1999;45:1628-1650.
13. Bruno JG, Kiel JL. Use of magnetic beads in selection and detection of biotoxin aptamers by ECL and enzymatic methods. Biotechniques 2002;32:178-183.
14. Cload ST, McCauley TG, Keefe AD, Healy JM, Wilson C. Chap. 17 - Properties of therapeutic aptamers. In: Klussmann S, editor. The Aptamer Handbook. Weinheim, Germany: WILEY-VCH Verlag GmBH & Co. KgaA; 2006. p 363-416.
15. Healy JM, Lewis SD, Kurz M, Boomer RM, Thompson KM, Wilson C, McCauley TG. Pharmacokinetics and biodistribution of novel aptamer compositions. Pharm Res 2004;21:2234-2246.
16. Dougan H, Lyster DM, Vo CV, Stafford A, Weitz JI, Hobbs JB. Extending the lifetime of anticoagulant oligodeoxynucleotide aptamers in blood. Nucl Med Biol 2000;27:289-297.
17. Bruno JG, Carrillo MP, Phillips T. Effects of immobilization chemistry on enzyme-linked aptamer assays for Leishmania surface antigens. J Clin Ligand Assay 2007;30:37-43.
18. Farrell S, Halsall HB, Heineman WR. Bacillus globigii bugbeads: A model stimulant of a bacterial spore. Anal Chem 2005;77:549-555.
19. Welkos S, Little S, Friedlander A, Fritz D, Fellows P. The role of antibodies to Bacillus anthracis and anthrax toxin components in inhibiting the early stages of infection of anthrax spores. Microbiology 2001;147:1677-1685.
20. Hofacker IL. Vienna RNA secondary structure server. Nucl Acids Res 2003;31:3429-3431.
21. SantaLucia J. A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. Proc Natl Acad Sci USA 1998;95:1460-1465.
22. Van de Water L, Schroeder S, Crenshaw EB, Hynes RO. Phagocytosis of gelatin-latex particles by a murine macrophage line is dependent on fibronectin and heparin. J Cell Biol 1981;90:32-39.
23. De Weger RA, Van Loveren H, Van Basten CDH, Oskam R, Van Der Zeijst BAM, Den Otter W. Functional activities of the NCTC 1469 macrophage-like cell line: Comparison of the NCTC 1469 cell line with various other macrophage-like cell lines. J Reticuloendoth Soc 1983;33:55-66.
24. Steel RGD, Torrie JH. Principles and Procedures of Statistics with Special Reference to the Biological Sciences. New York: MacGraw-Hill; 1960. p 103-107.
25. Chu TC, Marks JW, Lavery LA, Faulkner S, Rosenblum MG, Ellington AD, Levy M. Aptamer:toxin conjugates that specifically target prostate tumor cells. Cancer Res 2006;66:5989-5992.