New paradigms in the repair of oxidative damage in human genome: Mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins

Cellular and Molecular Life Sciences

Volumn 72, Issue 9, 2015, Pages 1679-1698

  Dutta, Arijit ^a,b   Yang, Chunying ^a   Sengupta, Shiladitya ^a   Mitra, Sankar ^a,b   Hegde, Muralidhar L ^a  

^a HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Base excision repair; DNA glycosylase; NEIL1; Non canonical proteins; Oxidized DNA bases; Pre replicative repair of oxidized bases; Reactive oxygen species; Single strand break repair

Indexed keywords

5 HYDROXYURACIL; BASE EXCISION PROTEIN; CYCLINE; CYTOSINE; DNA GLYCOSYLTRANSFERASE; DNA POLYMERASE; FLAP ENDONUCLEASE 1; GENOMIC DNA; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U; HIGH MOBILITY GROUP B1 PROTEIN; NEI ENDONUCLEASE VIII; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 3; PROTEIN HUS1; PROTEIN RAD1; PROTEIN RAD9; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REPLICATION FACTOR C; SCAFFOLD PROTEIN; SINGLE STRANDED RNA; UNCLASSIFIED DRUG; XRCC1 PROTEIN; Y BOX BINDING PROTEIN 1; DNA; NEIL1 PROTEIN, HUMAN; RNA BINDING PROTEIN;

AEROBIC CELL CULTURE; AMINO TERMINAL SEQUENCE; BASE EXCISION REPAIR DEFICIENCY; BER GENE; BINDING AFFINITY; BREAST CANCER; CARBOXY TERMINAL SEQUENCE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; DEAMINATION; DNA ADDUCT; DNA DAMAGE; DNA METABOLISM; DNA PROTEIN COMPLEX; DNA REPAIR; DNA REPLICATION; DNA STRAND; DNA SYNTHESIS; DNA TEMPLATE; DNA TRANSCRIPTION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME SUBSTRATE; EXCISION REPAIR; GENE MUTATION; GENOME; GENOMIC INTEGRITY; GENOTOXICITY; HUMAN; LETHALITY; MAMMAL CELL; MISMATCH REPAIR; NONHUMAN; OVARIAN SEROUS CARCINOMA; OXIDATIVE STRESS; PARP1 GENE; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REVIEW; RNA BINDING; SIGNAL TRANSDUCTION; SINGLE STRANDED DNA BREAK; SSBR GENE; TRANSCRIPTION REGULATION; XRCC1 DEFICIENCY; CHEMISTRY; GENETIC TRANSCRIPTION; GENETICS; HUMAN GENOME; METABOLISM; MUTATION;

MAMMALIA;

DNA; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; DNA REPLICATION; GENOME, HUMAN; HUMANS; MUTATION; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN INTERACTION MAPS; RNA-BINDING PROTEINS; TRANSCRIPTION, GENETIC;

EID: 84928579535     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-014-1820-z     Document Type: Review

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