Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage

Journal of Biological Chemistry

Volumn 274, Issue 34, 1999, Pages 24176-24186

  Jilani, Arshad ^a,b   Ramotar, Dindial ^c   Slack, Carolyn ^a,b   Ong, Colin ^a,b   Yang, Xiao Ming ^c   Scherer, Stephen W ^d   Lasko, Dana D ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; CELL ENZYME; COMPLEMENTARY DNA; PHOSPHATASE; PHOSPHOTRANSFERASE; POLYNUCLEOTIDE 5' HYDROXYL KINASE; POLYNUCLEOTIDE 5' KINASE 3' PHOSPHATASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL PROTECTION; CONTROLLED STUDY; DNA DETERMINATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME LOCALIZATION; ENZYME MECHANISM; EXCISION REPAIR; GENE FUNCTION; GENE LOCATION; HUMAN; IONIZING RADIATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; TISSUE DISTRIBUTION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOTTING, SOUTHERN; CATTLE; CHROMOSOME MAPPING; CLONING, MOLECULAR; DNA DAMAGE; DNA REPAIR; DNA, COMPLEMENTARY; HUMANS; HYDROGEN PEROXIDE; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PHOSPHORIC MONOESTER HYDROLASES; POLYNUCLEOTIDE 5'-HYDROXYL-KINASE;

BACTERIA (MICROORGANISMS); BOVINAE; CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; ESCHERICHIA COLI; MAMMALIA; MELANOGASTER; MURINAE; SCHIZOSACCHAROMYCES POMBE;

EID: 0033588161     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.34.24176     Document Type: Article

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