The absence of Ku but not defects in classical non-homologous end-joining is required to trigger PARP1-dependent end-joining

DNA Repair

Volumn 12, Issue 12, 2013, Pages 1134-1142

  Mansour, Wael Y ^a,c   Borgmann, K ^a   Petersen, C ^b   Dikomey, Ekkehard ^a   Dahm Daphi, Jochen ^a  

^a Laboratory of Radiobiology and oExperimental Radiooncology   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c CAIRO UNIVERSITY   (Egypt)

Author keywords

Alternative end joining; DSB repair; Non homologous end joining; PARP1 dependent end joining

Indexed keywords

KU ANTIGEN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; OLAPARIB; XRCC4 PROTEIN;

ANIMAL CELL; ARTICLE; CHROMATIN; COLONY FORMATION; DNA DAMAGE; DNA END JOINING REPAIR; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; GENOMIC INSTABILITY; HAMSTER; IONIZING RADIATION; MOLECULAR RECOGNITION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; TRANSIENT TRANSFECTION;

MAMMALIA;

ALTERNATIVE END-JOINING; DSB REPAIR; NON-HOMOLOGOUS END-JOINING; PARP1-DEPENDENT END-JOINING;

ANIMALS; ANTIGENS, NUCLEAR; CHO CELLS; CHROMATIN; CRICETULUS; DNA BREAKS, DOUBLE-STRANDED; DNA END-JOINING REPAIR; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; MUTATION; NUCLEAR PROTEINS; POLY(ADP-RIBOSE) POLYMERASES; PURINES; PYRIMIDINONES; THIONES;

EID: 84888130820     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2013.10.005     Document Type: Article

References (50)

1. Grabarz A., et al. Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining. Am. J. Cancer Res. 2012, 2(3):249-268.
2. Helleday T., et al. DNA double-strand break repair: from mechanistic understanding to cancer treatment. DNA Repair (Amst.) 2007, 6(7):923-935.
3. Khanna K.K., Jackson S.P. DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet. 2001, 27(3):247-254.
4. Lieber M.R., Yu K., Raghavan S.C. Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations. DNA Repair 2006, 5(9-10):1234-1245.
5. Mansour W.Y., et al. Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks. Nucleic Acids Res. 2008, 36(12):4088-4098.
6. Hefferin M.L., Tomkinson A.E. Mechanism of DNA double-strand break repair by non-homologous end joining. DNA Repair (Amst.) 2005, 4(6):639-648.
7. Dahm-Daphi J., Dikomey E. Non-reparable DNA strand breaks and cell killing studied in CHO cells after X-irradiation at different passage numbers. Int. J. Radiat. Biol. 1994, 66(5):553-555.
8. Dikomey E., et al. Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mammalian cell lines. Int. J. Radiat. Biol. 1998, 73(3):269-278.
9. Jeggo P.A. Identification of genes involved in repair of DNA double-strand breaks in mammalian cells. Radiat. Res. 1998, 150(5 Suppl):S80-S91.
10. Audebert M., Salles B., Calsou P. Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J. Biol. Chem. 2004, 279(53):55117-55126.
11. Nussenzweig A., Nussenzweig M.C. A backup DNA repair pathway moves to the forefront. Cell 2007, 131(2):223-225.
12. Iliakis G. Backup pathways of NHEJ in cells of higher eukaryotes: cell cycle dependence. Radiother. Oncol. 2009, 92(3):310-315.
13. Mansour W.Y., Rhein T., Dahm-Daphi J. The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies. Nucleic Acids Res. 2010, 38(18):6065-6077.
14. Valeria Ossovskaya I.C.K., Eric P.Kaldjian, Christopher Alvares, Barry M.Sherman Upregulation of poly(ADP-ribose) polymerase-1 (PARP1) in triple-negative breast cancer and other primary human tumor types. Genes Cancer 2010, I(8):10.
15. Boboila C., et al. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc. Nat. Acad. Sci. USA 2010, 107(7):3034-3039.
16. Ferguson D.O., Alt F.W. DNA double strand break repair and chromosomal translocation: lessons from animal models. Oncogene 2001, 20(40):5572-5579.
17. Weinstock D.M., Brunet E., Jasin M. Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70. Nat. Cell Biol. 2007, 9(8):978-981.
18. Bentley J., et al. DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining. Nucleic Acids Res. 2004, 32(17):5249-5259.
19. Shin K.H., Abnormal D.N.A., et al. end-joining activity in human head and neck cancer. Int. J. Med. Mol. Adv. Sc.i 2006, 17(5):917-924.
20. Weterings E., Chen D.J. The endless tale of non-homologous end-joining. Cell Res. 2008, 18(1):114-124.
21. Wang H., et al. DNA ligase III as a candidate component of backup pathways of nonhomologous end joining. Cancer Res. 2005, 65(10):4020-4030.
22. Davis A.J., Chen D.J. A role for ATM kinase activity and Mre11 in microhomology-mediated end-joining. Cell Cycle 2010, 9(16):3147-3148.
23. Jia Q., et al. Poly(ADP-ribose)polymerases are involved in microhomology mediated back-up non-homologous end joining in Arabidopsis thaliana. Plant Mol. Biol. 2013.
24. Lee-Theilen M., et al. CtIP promotes microhomology-mediated alternative end joining during class-switch recombination. Nat. Struct. Mol. Biol. 2011, 18(1):75-79.
25. Liang L., Human D.N.A., et al. ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks. Nucleic Acids Res. 2008, 36(10):3297-3310.
26. Rahal E.A., et al. ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining. Cell Cycle 2010, 9(14):2866-2877.
27. Truong L.N., et al. Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells. Proc. Nat. Acad. Sci. USA 2013, 110(19):7720-7725.
28. Zhong Q., et al. BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks. J. Biol. Chem. 2002, 277(32):28641-28647.
29. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227(5259):680-685.
30. Berkovich E., Monnat R.J., Kastan M.B. Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat. Cell Biol. 2007, 9(6):683-690.
31. Wang M., et al. PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res. 2006, 34(21):6170-6182.
32. Decottignies A. Alternative end-joining mechanisms: a historical perspective. Front Genet. 2013, 4:48.
33. Rositsa Dueva G.I. Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer. Transl. Cancer Res. 2013, 2(3):163-177. 2(3): p. 15.
34. Pierce A.J., Ku D.N.A., et al. end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev. 2001, 15(24):3237-3242.
35. Mari P.O., et al. Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4. Proc. Nat. Acad. Sci. USA 2006, 103(49):18597-18602.
36. Walker J.R., Corpina R.A., Goldberg J. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 2001, 412(6847):607-614.
37. Adachi N., et al. DNA ligase IV-deficient cells are more resistant to ionizing radiation in the absence of Ku70: Implications for DNA double-strand break repair. Proc. Nat. Acad. Sci. USA 2001, 98(21):12109-12113.
38. Karanjawala Z.E., et al. The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants. DNA Repair 2002, 1(12):1017-1026.
39. Henrie M.S., et al. Lethality in PARP-1/Ku80 double mutant mice reveals physiological synergy during early embryogenesis. DNA Repair 2003, 2(2):151-158.
40. Cheng Q., et al. Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks. Nucleic Acids Res. 2011, 39(22):9605-9619.
41. Wang H., et al. Biochemical evidence for Ku-independent backup pathways of NHEJ. Nucleic Acids Res. 2003, 31(18):5377-5388.
42. Haince J.F., et al. PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites. J. Biol. Chem. 2008, 283(2):1197-1208.
43. Callagy G.M., et al. Bcl-2 is a prognostic marker in breast cancer independently of the Nottingham Prognostic Index. Clin. Cancer Res. 2006, 12(8):2468-2475.
44. Leber B., et al. Drugs targeting Bcl-2 family members as an emerging strategy in cancer. Expert. Rev. Mol. Med. 2010, 12:pe28.
45. Tsujimoto Y., et al. Involvement of the bcl-2 gene in human follicular lymphoma. Science 1985, 228(4706):1440-1443.
46. Ye D., et al. bcl-2/bax expression and p53 gene status in human bladder cancer: relationship to early recurrence with intravesical chemotherapy after resection. J. Urol. 1998, 160(6 Pt 1):2025-2028. discussion 2029.
47. Chen M.K., et al. Expression of bcl-2 correlates with poor prognosis and modulates migration of nasopharyngeal carcinoma cells. Clin. Chim. Acta 2010, 411(5-6):400-405.
48. Karakas T., et al. High expression of bcl-2 mRNA as a determinant of poor prognosis in acute myeloid leukemia. Ann. Oncology: Off. J. Eur. Soc. Med. Oncol./ESMO 1998, 9(2):159-165.
49. Tawfik K., et al. Prognostic significance of Bcl-2 in invasive mammary carcinomas: a comparative clinicopathologic study between "triple-negative" and non-"triple-negative" tumors. Hum. Pathol. 2012, 43(1):23-30.
50. Rojo F., et al. Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer. Ann. Oncol.: Off. J. Eur. Soc. Med. Oncol./ESMO 2012, 23(5):1156-1164.