메뉴 건너뛰기




Volumn 8, Issue 9, 2010, Pages 629-635

Parp inhibitors in breast cancer

Author keywords

Brca; Bsi 201; Dna repair; Olaparib; Poly (adp ribose) polymerase (parp) inhibitor; Triple negative breast cancer

Indexed keywords

4 IODO 3 NITROBENZAMIDE; 8 FLUORO 3,4 DIHYDRO 2 [4 (METHYLAMINOMETHYL)PHENYL]PYRROLO[3,4,5 E,F][2]BENZAZEPIN 6(5H) ONE; BRCA1 PROTEIN; BRCA2 PROTEIN; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DNA; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; GEMCITABINE; HISTONE H2AX; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; OLAPARIB; PACLITAXEL; PF 01367338; PROGESTERONE RECEPTOR; RAD51 PROTEIN; SAR 240550; UNCLASSIFIED DRUG; VELIPARIB;

EID: 79251541469     PISSN: 15430790     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (44)

References (27)
  • 1
    • 77954452202 scopus 로고    scopus 로고
    • DNA damage response pathways and cancer
    • In: Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, McKenna WG, 4th ed: Philadelphia, PA: Churchill Livingston
    • Ford JM, Kastan MB. DNA damage response pathways and cancer. In: Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, McKenna WG. Abeloff's Clinical Oncology. 4th ed: Philadelphia, PA: Churchill Livingston; 2008.
    • (2008) Abeloff's Clinical Oncology
    • Ford, J.M.1    Kastan, M.B.2
  • 2
    • 0018906390 scopus 로고
    • (ADP-ribose)n participates in DNA excision repair
    • Durkacz BW, Omidiji O, Gray DA, Shall S. (ADP-ribose)n participates in DNA excision repair. Nature. 1980;283:593-596.
    • (1980) Nature , vol.283 , pp. 593-596
    • Durkacz, B.W.1    Omidiji, O.2    Gray, D.A.3    Shall, S.4
  • 4
    • 0035104990 scopus 로고    scopus 로고
    • Establishment of a chemical synthetic lethality screen in cultured human cells
    • Simons A, Dafni N, Dotan I, et al. Establishment of a chemical synthetic lethality screen in cultured human cells. Genome Res. 2001;11:266-273.
    • (2001) Genome Res , vol.11 , pp. 266-273
    • Simons, A.1    Dafni, N.2    Dotan, I.3
  • 5
    • 6044261241 scopus 로고    scopus 로고
    • Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair
    • Veuger SJ, Curtin NJ, Smith GC, Durkacz BW. Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair. Oncogene. 2004;23:7322-7329.
    • (2004) Oncogene , vol.23 , pp. 7322-7329
    • Veuger, S.J.1    Curtin, N.J.2    Smith, G.C.3    Durkacz, B.W.4
  • 6
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer H, McCabe N, Lord CJ, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature. 2005;434:917-921.
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3
  • 7
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
    • Bryant HE, Schultz N, Thomas HD, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature. 2005;434: 913-917.
    • (2005) Nature , vol.434 , pp. 913-917
    • Bryant, H.E.1    Schultz, N.2    Thomas, H.D.3
  • 8
    • 25444497278 scopus 로고    scopus 로고
    • The concept of synthetic lethality in the context of anticancer therapy
    • Kaelin WG Jr. The concept of synthetic lethality in the context of anticancer therapy. Nat Rev Cancer. 2005;5:689-698.
    • (2005) Nat Rev Cancer , vol.5 , pp. 689-698
    • Kaelin Jr., W.G.1
  • 9
    • 0036724986 scopus 로고    scopus 로고
    • BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair
    • Hartman AR, Ford JM. BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair. Nat Genet. 2002;32:180-184.
    • (2002) Nat Genet , vol.32 , pp. 180-184
    • Hartman, A.R.1    Ford, J.M.2
  • 10
    • 65949124480 scopus 로고    scopus 로고
    • Defective repair of oxidative DNA damage in triple-negative breast cancer confers sensitivity to inhibition of poly(ADP-ribose) polymerase
    • Alli E, Sharma VB, Sunderesakumar P, Ford JM. Defective repair of oxidative DNA damage in triple-negative breast cancer confers sensitivity to inhibition of poly(ADP-ribose) polymerase. Cancer Res. 2009;69:3589-3596.
    • (2009) Cancer Res , vol.69 , pp. 3589-3596
    • Alli, E.1    Sharma, V.B.2    Sunderesakumar, P.3    Ford, J.M.4
  • 11
    • 0035853295 scopus 로고    scopus 로고
    • DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells
    • Arnaudeau C, Lundin C, Helleday T. DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells. J Mol Biol. 2001;307: 1235-1245.
    • (2001) J Mol Biol , vol.307 , pp. 1235-1245
    • Arnaudeau, C.1    Lundin, C.2    Helleday, T.3
  • 12
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong PC, Boss DS, Yap TA, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med. 2009;361:123-134.
    • (2009) N Engl J Med , vol.361 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3
  • 13
    • 77955019276 scopus 로고    scopus 로고
    • Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof of concept trial
    • Tutt A, Robson M, Garber JE, et al. Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof of concept trial. Lancet. 2010;376:235-244.
    • (2010) Lancet , vol.376 , pp. 235-244
    • Tutt, A.1    Robson, M.2    Garber, J.E.3
  • 14
    • 77955019962 scopus 로고    scopus 로고
    • Can we define tumors that will respond to PARP inhibitors? A phase II correlative study of olaparib in advanced serous ovarian cancer and triple-negative breast cancer
    • Abstract 3002
    • Gelmon KA, Hirte HW, Robidoux A, et al. Can we define tumors that will respond to PARP inhibitors? A phase II correlative study of olaparib in advanced serous ovarian cancer and triple-negative breast cancer. J Clin Oncol (ASCO Annual Meeting Abstracts). 2010;28:Abstract 3002.
    • (2010) J Clin Oncol (ASCO Annual Meeting Abstracts) , vol.28
    • Gelmon, K.A.1    Hirte, H.W.2    Robidoux, A.3
  • 15
    • 0037478605 scopus 로고    scopus 로고
    • Repeated observation of breast tumor subtypes in independent gene expression data sets
    • Sorlie T, Tibshirani R, Parker J, et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci U S A. 2003;100:8418-8423.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8418-8423
    • Sorlie, T.1    Tibshirani, R.2    Parker, J.3
  • 16
    • 33847136743 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Therapeutic options
    • Cleator S, Heller W, Coombes RC. Triple-negative breast cancer: therapeutic options. Lancet Oncol. 2007;8:235-244.
    • (2007) Lancet Oncol , vol.8 , pp. 235-244
    • Cleator, S.1    Heller, W.2    Coombes, R.C.3
  • 17
    • 58149359842 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Risk factors to potential targets
    • Schneider BP, Winer EP, Foulkes WD, et al. Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res. 2008;14:8010-8018.
    • (2008) Clin Cancer Res , vol.14 , pp. 8010-8018
    • Schneider, B.P.1    Winer, E.P.2    Foulkes, W.D.3
  • 18
    • 77957555168 scopus 로고    scopus 로고
    • Synergistic chemosensitivity of triple-negative breast cancer cell lines to PARP inhibition, gemcitabine and cisplatin
    • [published online ahead of print August 26 2010]
    • Hastak K, Alli E, Ford JM. Synergistic chemosensitivity of triple-negative breast cancer cell lines to PARP inhibition, gemcitabine and cisplatin. [published online ahead of print August 26 2010]. Cancer Res. 2010.
    • (2010) Cancer Res
    • Hastak, K.1    Alli, E.2    Ford, J.M.3
  • 19
    • 79251556323 scopus 로고    scopus 로고
    • Triple negative breast cancer: A phase 2, multi-center, open-label, randomized trial of gemcitabine/carboplatin (G/C), with or without BSI-201, a PARP inhibitor
    • December 10-14, San Antonio, TX. Abstract 2120
    • O'Shaughnessy J, Osborne C, Blum J, et al. Triple negative breast cancer: a phase 2, multi-center, open-label, randomized trial of gemcitabine/carboplatin (G/C), with or without BSI-201, a PARP inhibitor. Paper presented at: 31st Annual San Antonio Breast Cancer Symposium; December 10-14, 2008; San Antonio, TX. Abstract 2120.
    • (2008) Paper Presented At: 31st Annual San Antonio Breast Cancer Symposium
    • O'Shaughnessy, J.1    Osborne, C.2    Blum, J.3
  • 20
    • 68449096428 scopus 로고    scopus 로고
    • Efficacy of BSI-201, a poly (ADP-ribose) polymerase-1 (PARP1) inhibitor, in combination with gemcitabine/ carboplatin (G/C) in patients with metastatic triple-negative breast cancer (TNBC): Results of a randomized phase II trial
    • Abstract 3
    • O'Shaughnessy J, Osborne C, Pippen J, et al. Efficacy of BSI-201, a poly (ADP-ribose) polymerase-1 (PARP1) inhibitor, in combination with gemcitabine/ carboplatin (G/C) in patients with metastatic triple-negative breast cancer (TNBC): results of a randomized phase II trial. J Clin Oncol (ASCO Annual Meeting Abstracts). 2009;27: Abstract 3.
    • (2009) J Clin Oncol (ASCO Annual Meeting Abstracts) , vol.27
    • O'Shaughnessy, J.1    Osborne, C.2    Pippen, J.3
  • 21
    • 77949686134 scopus 로고    scopus 로고
    • Final results of a randomized phase II study demonstrating efficacy and safety of BSI-201, a poly (ADP-Ribose) polymerase (PARP) inhibitor, in combination with gemcitabine/carboplatin (G/C) in metastatic triple negative breast cancer (TNBC)
    • Abstract 3122
    • O'Shaughnessy J, Osborne C, Pippen J, et al. Final results of a randomized phase II study demonstrating efficacy and safety of BSI-201, a poly (ADP-Ribose) polymerase (PARP) inhibitor, in combination with gemcitabine/carboplatin (G/C) in metastatic triple negative breast cancer (TNBC). Cancer Res. 2009;69: Abstract 3122.
    • (2009) Cancer Res , vol.69
    • O'Shaughnessy, J.1    Osborne, C.2    Pippen, J.3
  • 22
    • 77149157867 scopus 로고    scopus 로고
    • Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors
    • Mendes-Pereira AM, Martin SA, Brough R, et al. Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors. EMBO Mol Med. 2009;1:315-322.
    • (2009) EMBO Mol Med , vol.1 , pp. 315-322
    • Mendes-Pereira, A.M.1    Martin, S.A.2    Brough, R.3
  • 23
    • 79251584394 scopus 로고    scopus 로고
    • PARP is expressed in all subtypes of early breast cancer and is a predictive factor for response to neoadjuvant chemotherapy
    • April, Barcelona, Spain
    • Von Minckwitz G, Muller B, Loibl S, et al. PARP is expressed in all subtypes of early breast cancer and is a predictive factor for response to neoadjuvant chemotherapy. Presented at: European Breast Cancer Conference; April 2010; Barcelona, Spain.
    • (2010) Presented At: European Breast Cancer Conference
    • von Minckwitz, G.1    Muller, B.2    Loibl, S.3
  • 25
    • 66149190689 scopus 로고    scopus 로고
    • GammaH2AX expression in tumors exposed to cisplatin and fractionated irradiation
    • Banuelos CA, Banath JP, Kim JY, et al. GammaH2AX expression in tumors exposed to cisplatin and fractionated irradiation. Clin Cancer Res. 2009;15: 3344-3353.
    • (2009) Clin Cancer Res , vol.15 , pp. 3344-3353
    • Banuelos, C.A.1    Banath, J.P.2    Kim, J.Y.3
  • 26
    • 69449090092 scopus 로고    scopus 로고
    • Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies
    • Willers H, Taghian AG, Luo CM, et al. Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies. Mol Cancer Res. 2009;7:1304-1309.
    • (2009) Mol Cancer Res , vol.7 , pp. 1304-1309
    • Willers, H.1    Taghian, A.G.2    Luo, C.M.3
  • 27
    • 77956633760 scopus 로고    scopus 로고
    • Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins
    • Asakawa H, Koizumi H, Koike A, et al. Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins. Breast Cancer Res. 2010;12:R17.
    • (2010) Breast Cancer Res , vol.12
    • Asakawa, H.1    Koizumi, H.2    Koike, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.