Damage response of XRCC1 at sites of DNA single strand breaks is regulated by phosphorylation and ubiquitylation after degradation of poly(ADP-ribose)

Journal of Cell Science

Volumn 126, Issue 19, 2013, Pages 4414-4423

  Wei, Leizhen ^a   Nakajima, Satoshi ^a   Hsieh, Ching Lung ^a   Kanno, Shinichiro ^b   Masutani, Mitsuko ^c   Levine, Arthur S ^a   Yasui, Akira ^b   Lan, Li ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b TOHOKU UNIVERSITY   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Damage response; Phosphorylation; Polyadp ribosylation; Single strand breaks; Ubiquitylation; Xrcc1

Indexed keywords

CYCLINE; DNA DIRECTED DNA POLYMERASE BETA; GLYCOSIDASE; LIGASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); POLYNUCLEOTIDE 5' HYDROXYL KINASE; PROTEIN; SINGLE STRANDED DNA; XRCC1 PROTEIN;

ANIMAL CELL; ARTICLE; BINDING KINETICS; CONTROLLED STUDY; DISSOCIATION; DNA REPAIR; DNA STRUCTURE; EMBRYO; FEMALE; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SINGLE STRANDED DNA BREAK; UBIQUITINATION; UPREGULATION; WILD TYPE;

DAMAGE RESPONSE; PHOSPHORYLATION; POLYADP-RIBOSYLATION; SINGLE STRAND BREAKS; UBIQUITYLATION; XRCC1;

DNA BREAKS, SINGLE-STRANDED; DNA LIGASES; DNA REPAIR; DNA-BINDING PROTEINS; HEK293 CELLS; HELA CELLS; HUMANS; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN STRUCTURE, TERTIARY; TRANSFECTION; UBIQUITINATION;

EID: 84885436181     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.128272     Document Type: Article

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