Coordination of DNA repair by NEIL1 and PARP-1: A possible link to aging

Aging

Volumn 4, Issue 10, 2012, Pages 674-685

  Noren Hooten, Nicole ^a   Fitzpatrick, Megan ^a   Kompaniez, Kari ^a   Jacob, Kimberly D ^a   Moore, Brittany R ^a   Nagle, Julia ^a   Barnes, Janice ^a   Lohani, Althaf ^a   Evans, Michele K ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Aging; Base excision repair; Dna damage; Glycosylase; Oxidative stress; Parp

Indexed keywords

EID: 84872524849     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100492     Document Type: Article

References (53)

1. Svilar D, Goellner EM, Almeida KH and Sobol RW. Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage. Antioxidants&redox signaling. 2011; 14:2491-2507.
2. Barnes DE and Lindahl T. Repair and genetic consequences of endogenous DNA base damage in mammalian cells. Annual review of genetics. 2004; 38:445-476.
3. Bjelland S and Seeberg E. Mutagenicity, toxicity and repair of DNA base damage induced by oxidation. Mutat Res. 2003; 531:37-80.
4. Dizdaroglu M, Jaruga P, Birincioglu M and Rodriguez H. Free radical-induced damage to DNA: mechanisms and measurement. Free Radic Biol Med. 2002; 32:1102-1115.
5. Hegde ML, Mantha AK, Hazra TK, Bhakat KK, Mitra S and Szczesny B. Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases. Mechanisms of ageing and development. 2012; 133:157-168.
6. Caldecott KW. Single-strand break repair and genetic disease. Nat Rev Genet. 2008; 9:619-631.
7. Maynard S, Schurman SH, Harboe C, de Souza-Pinto NC and Bohr VA. Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis. 2009; 30:2-10.
8. David SS, O'Shea VL and Kundu S. Base-excision repair of oxidative DNA damage. Nature. 2007; 447:941-950.
9. Berquist BR and Wilson DM, 3rd. Pathways for repairing and tolerating the spectrum of oxidative DNA lesions. Cancer letters. 2012; 327:61-72.
10. Dizdaroglu M. Base-excision repair of oxidative DNA damage by DNA glycosylases. Mutat Res. 2005; 591:45-59.
11. Sampath H, McCullough AK and Lloyd RS. Regulation of DNA glycosylases and their role in limiting disease. Free radical research. 2012; 46:460-478.
12. Hegde ML, Hazra TK and Mitra S. Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells. Cell research. 2008; 18:27-47.
13. Sung JS and Demple B. Roles of base excision repair subpathways in correcting oxidized abasic sites in DNA. The FEBS journal. 2006; 273:1620-1629.
14. Hazra TK, Izumi T, Boldogh I, Imhoff B, Kow YW, Jaruga P, Dizdaroglu M and Mitra S. Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA. Proc Natl Acad Sci U S A. 2002; 99:3523-3528.
15. Dallosso AR, Dolwani S, Jones N, Jones S, Colley J, Maynard J, Idziaszczyk S, Humphreys V, Arnold J, Donaldson A, Eccles D, Ellis A, Evans DG, et al. Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3. Gut. 2008; 57:1252-1255.
16. Shinmura K, Tao H, Goto M, Igarashi H, Taniguchi T, Maekawa M, Takezaki T and Sugimura H. Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer. Carcinogenesis. 2004; 25:2311-2317.
17. Vartanian V, Lowell B, Minko IG, Wood TG, Ceci JD, George S, Ballinger SW, Corless CL, McCullough AK and Lloyd RS. The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. Proc Natl Acad Sci U S A. 2006; 103:1864-1869.
18. Sampath H, Batra AK, Vartanian V, Carmical JR, Prusak D, King IB, Lowell B, Earley LF, Wood TG, Marks DL, McCullough AK and L RS. Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1- deficient mice. American journal of physiology. 2011; 300:E724-734.
19. Das A, Boldogh I, Lee JW, Harrigan JA, Hegde ML, Piotrowski J, de Souza Pinto N, Ramos W, Greenberg MM, Hazra TK, Mitra S and Bohr VA. The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1. J Biol Chem. 2007; 282:26591-26602.
20. Dou H, Theriot CA, Das A, Hegde ML, Matsumoto Y, Boldogh I, Hazra TK, Bhakat KK and Mitra S. Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes. J Biol Chem. 2008; 283:3130-3140.
21. Hegde ML, Theriot CA, Das A, Hegde PM, Guo Z, Gary RK, Hazra TK, Shen B and Mitra S. Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1. J Biol Chem. 2008; 283:27028-27037.
22. Guan X, Bai H, Shi G, Theriot CA, Hazra TK, Mitra S and Lu AL. The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates NEIL1 glycosylase. Nucleic Acids Res. 2007; 35:2463-2472.
23. Theriot CA, Hegde ML, Hazra TK and Mitra S. RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures. DNA Repair (Amst). 2010; 9:643-652.
24. Wiederhold L, Leppard JB, Kedar P, Karimi-Busheri F, Rasouli-Nia A, Weinfeld M, Tomkinson AE, Izumi T, Prasad R, Wilson SH, Mitra S and Hazra TK. AP endonuclease-independent DNA base excision repair in human cells. Molecular cell. 2004; 15:209-220.
25. Noren Hooten N, Kompaniez K, Barnes J, Lohani A and Evans MK. Poly(ADP-ribose) polymerase 1 (PARP-1) binds to 8- oxoguanine-DNA glycosylase (OGG1). J Biol Chem. 2011; 286:44679-44690.
26. Burkle A. DNA repair and PARP in aging. Free radical research. 2006; 40:1295-1302.
27. Luo X and Kraus WL. On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1. Genes&development. 2012; 26:417-432.
28. Schreiber V, Dantzer F, Ame JC and de Murcia G. Poly(ADPribose): novel functions for an old molecule. Nature reviews. 2006; 7:517-528.
29. Mangerich A, Herbach N, Hanf B, Fischbach A, Popp O, Moreno-Villanueva M, Bruns OT and Burkle A. Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1. Mechanisms of ageing and development. 2012; 131:389-404.
30. Chevanne M, Calia C, Zampieri M, Cecchinelli B, Caldini R, Monti D, Bucci L, Franceschi C and Caiafa P. Oxidative DNA damage repair and parp 1 and parp 2 expression in Epstein-Barr virus-immortalized B lymphocyte cells from young subjects, old subjects, and centenarians. Rejuvenation research. 2007; 10:191-204.
31. Muiras ML, Muller M, Schachter F and Burkle A. Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians. J Mol Med (Berl). 1998; 76:346-354.
32. Piskunova TS, Yurova MN, Ovsyannikov AI, Semenchenko AV, Zabezhinski MA, Popovich IG, Wang ZQ and Anisimov VN. Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice. Current gerontology and geriatrics research. 2008:754190.
33. Dizdaroglu M. Substrate specificities and excision kinetics of DNA glycosylases involved in base-excision repair of oxidative DNA damage. Mutat Res. 2003; 531:109-126.
34. Hu J, de Souza-Pinto NC, Haraguchi K, Hogue BA, Jaruga P, Greenberg MM, Dizdaroglu M and Bohr VA. Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes. J Biol Chem. 2005; 280:40544-40551.
35. Ame JC, Hakme A, Quenet D, Fouquerel E, Dantzer F and Schreiber V. Detection of the Nuclear Poly(ADP-ribose)- Metabolizing Enzymes and Activities in Response to DNA Damage. Methods in molecular biology (Clifton, NJ. 2009; 464:267-283.
36. Bohr VA, Ottersen OP and Tonjum T. Genome instability and DNA repair in brain, ageing and neurological disease. Neuroscience. 2007; 145:1183-1186.
37. Gorbunova V, Seluanov A, Mao Z and Hine C. Changes in DNA repair during aging. Nucleic Acids Res. 2007; 35:7466-7474.
38. Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M and Alt FW. DNA repair, genome stability, and aging. Cell. 2005; 120:497-512.
39. Grube K and Burkle A. Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span. Proc Natl Acad Sci U S A. 1992; 89:11759-11763.
40. Hegde ML, Hazra TK and Mitra S. Functions of disordered regions in mammalian early base excision repair proteins. Cell Mol Life Sci. 2010; 67:3573-3587.
41. Wilson DM, 3rd, Kim D, Berquist BR and Sigurdson AJ. Variation in base excision repair capacity. Mutat Res. 2011; 711:100-12.
42. Bouchard VJ, Rouleau M and Poirier GG. PARP-1, a determinant of cell survival in response to DNA damage. Experimental hematology. 2003; 31:446-454.
43. El-Khamisy SF, Masutani M, Suzuki H and Caldecott KW. A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. Nucleic Acids Res. 2003; 31:5526-5533.
44. Bruner SD, Norman DP and Verdine GL. Structural basis for recognition and repair of the endogenous mutagen 8- oxoguanine in DNA. Nature. 2000; 403:859-866.
45. Doublie S, Bandaru V, Bond JP and Wallace SS. The crystal structure of human endonuclease VIII-like 1 (NEIL1) reveals a zincless finger motif required for glycosylase activity. Proc Natl Acad Sci U S A. 2004; 101:10284-10289.
46. Masson M, Niedergang C, Schreiber V, Muller S, Menissierde Murcia J and de Murcia G. XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage. Mol Cell Biol. 1998; 18:3563-3571.
47. Huber A, Bai P, de Murcia JM and de Murcia G. PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development. DNA Repair (Amst). 2004; 3:1103-1108.
48. Dou H, Mitra S and Hazra TK. Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2. J Biol Chem. 2003; 278:49679-49684.
49. Hanssen-Bauer A, Solvang-Garten K, Sundheim O, Pena-Diaz J, Andersen S, Slupphaug G, Krokan HE, Wilson DM, 3rd, Akbari M and Otterlei M. XRCC1 coordinates disparate responses and multiprotein repair complexes depending on the nature and context of the DNA damage. Environ Mol Mutagen. 2011; 52:623-635.
50. Rouleau M, Patel A, Hendzel MJ, Kaufmann SH and Poirier GG. PARP inhibition: PARP1 and beyond. Nat Rev Cancer. 2010; 10:293-301.
51. Zaremba T and Curtin NJ. PARP inhibitor development for systemic cancer targeting. Anti-cancer agents in medicinal chemistry. 2007; 7:515-523.
52. Noren NK, Liu BP, Burridge K and Kreft B. p120 catenin regulates the actin cytoskeleton via Rho family GTPases. The Journal of cell biology. 2000; 150:567-580.
53. Nyaga SG, Lohani A and Evans MK. Deficient repair of 8- hydroxyguanine in the BxPC-3 pancreatic cancer cell line. Biochem Biophys Res Commun. 2008; 376:336-340.