A combination Alzheimer's therapy targeting BACE1 and neprilysin in 5XFAD transgenic mice

Molecular Brain

Volumn 8, Issue 1, 2015, Pages

  Devi, Latha ^a   Ohno, Masuo ^a,b  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5XFAD; Alzheimer's disease; Amyloid ; BACE1; C99; Cholinergic neuron; Fear conditioning; Learning and memory; Neprilysin; Secretase

Indexed keywords

AMYLOID BETA PROTEIN; BETA SECRETASE; BETA SECRETASE 1; INITIATION FACTOR 2ALPHA; MEMBRANE METALLOENDOPEPTIDASE; ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; SECRETASE;

5XFAD MOUSE; ALZHEIMER DISEASE; AMNESIA; AMYLOIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; CROSS BREEDING; ENZYME ACTIVITY; GENE DOSAGE; GENE FREQUENCY; HAPLOINSUFFICIENCY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TARGETING; UPREGULATION; WILD TYPE; ANIMAL; GENETICS; MEMORY DISORDER; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PROTEIN PROCESSING; TRANSGENIC MOUSE; WESTERN BLOTTING;

MUS; MUS MUSCULUS;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BLOTTING, WESTERN; CHOLINERGIC NEURONS; HAPLOINSUFFICIENCY; MEMORY DISORDERS; MICE, TRANSGENIC; MOLECULAR TARGETED THERAPY; NEPRILYSIN; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 84927591073     PISSN: None     EISSN: 17566606     Source Type: Journal    
DOI: 10.1186/s13041-015-0110-5     Document Type: Article

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