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Volumn 39, Issue 3, 2014, Pages 638-650

7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease

Author keywords

7,8 Dihydroxyflavone; Alzheimer's disease; neuroprotection; Synapse; TrkB

Indexed keywords

7,8 DIHYDROXYFLAVONE; AMYLOID BETA PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR;

EID: 84892680431     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2013.243     Document Type: Article
Times cited : (201)

References (47)
  • 1
    • 84857208654 scopus 로고    scopus 로고
    • 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats
    • Andero R, Daviu N, Escorihuela RM, Nadal R, Armario A (2012). 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats. Hippocampus 22: 399-408.
    • (2012) Hippocampus , vol.22 , pp. 399-408
    • Andero, R.1    Daviu, N.2    Escorihuela, R.M.3    Nadal, R.4    Armario, A.5
  • 2
    • 79952728977 scopus 로고    scopus 로고
    • Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning
    • Andero R, Heldt SA, Ye K, Liu X, Armario A, Ressler KJ (2011). Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning. Am J Psychiatry 168: 163-172.
    • (2011) Am J Psychiatry , vol.168 , pp. 163-172
    • Andero, R.1    Heldt, S.A.2    Ye, K.3    Liu, X.4    Armario, A.5    Ressler, K.J.6
  • 3
    • 84877805363 scopus 로고    scopus 로고
    • Probing the ability of presynaptic tyrosine kinase receptors to regulate striatal dopamine dynamics
    • Apawu AK, Maina FK, Taylor JR, Mathews TA (2013). Probing the ability of presynaptic tyrosine kinase receptors to regulate striatal dopamine dynamics. ACS Chem Neurosci 4: 895-904.
    • (2013) ACS Chem Neurosci , vol.4 , pp. 895-904
    • Apawu, A.K.1    Maina, F.K.2    Taylor, J.R.3    Mathews, T.A.4
  • 4
    • 49349113732 scopus 로고    scopus 로고
    • Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats
    • Arancibia S, Silhol M, Mouliere F, Meffre J, Hollinger I, Maurice T et al (2008). Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats. Neurobiol Dis 31: 316-326.
    • (2008) Neurobiol Dis , vol.31 , pp. 316-326
    • Arancibia, S.1    Silhol, M.2    Mouliere, F.3    Meffre, J.4    Hollinger, I.5    Maurice, T.6
  • 5
    • 0036851840 scopus 로고    scopus 로고
    • Food intake, water intake, and drinking spout side preference of 28 mouse strains
    • Bachmanov AA, Reed DR, Beauchamp GK, Tordoff MG (2002). Food intake, water intake, and drinking spout side preference of 28 mouse strains. Behav Genet 32: 435-443.
    • (2002) Behav Genet , vol.32 , pp. 435-443
    • Bachmanov, A.A.1    Reed, D.R.2    Beauchamp, G.K.3    Tordoff, M.G.4
  • 8
    • 14444285507 scopus 로고    scopus 로고
    • Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: Relation of histologic markers to dementia severity, age, sex, and apolipoprotein e genotype
    • Berg L, McKeel DW Jr, Miller JP, Storandt M, Rubin EH, Morris JC et al (1998). Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype. Arch Neurol 55: 326-335.
    • (1998) Arch Neurol , vol.55 , pp. 326-335
    • Berg, L.1    McKeel Jr., D.W.2    Miller, J.P.3    Storandt, M.4    Rubin, E.H.5    Morris, J.C.6
  • 10
    • 79958051229 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex
    • Chan CB, Liu X, Pradoldej S, Hao C, An J, Yepes M et al (2011). Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex. J Neurosci 31: 8083-8092.
    • (2011) J Neurosci , vol.31 , pp. 8083-8092
    • Chan, C.B.1    Liu, X.2    Pradoldej, S.3    Hao, C.4    An, J.5    Yepes, M.6
  • 12
    • 77249140499 scopus 로고    scopus 로고
    • Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear
    • Choi DC, Maguschak KA, Ye K, Jang SW, Myers KM, Ressler KJ (2010). Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear. Proc Natl Acad Sci USA 107: 2675-2680.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 2675-2680
    • Choi, D.C.1    Maguschak, K.A.2    Ye, K.3    Jang, S.W.4    Myers, K.M.5    Ressler, K.J.6
  • 13
    • 5344272541 scopus 로고    scopus 로고
    • A focus on the synapse for neuroprotection in Alzheimer disease and other dementias
    • Coleman P, Federoff H, Kurlan R (2004). A focus on the synapse for neuroprotection in Alzheimer disease and other dementias. Neurology 63: 1155-1162.
    • (2004) Neurology , vol.63 , pp. 1155-1162
    • Coleman, P.1    Federoff, H.2    Kurlan, R.3
  • 14
    • 84856059838 scopus 로고    scopus 로고
    • 7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease
    • Devi L, Ohno M (2012). 7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease. Neuropsychopharmacology 37: 434-444.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 434-444
    • Devi, L.1    Ohno, M.2
  • 15
    • 84855904096 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and Alzheimer's disease: Physiopathology and beyond
    • Diniz BS, Teixeira AL (2011). Brain-derived neurotrophic factor and Alzheimer's disease: physiopathology and beyond. Neuromolecular Med 13: 217-222.
    • (2011) Neuromolecular Med , vol.13 , pp. 217-222
    • Diniz, B.S.1    Teixeira, A.L.2
  • 16
    • 33750950147 scopus 로고    scopus 로고
    • The dynamic distribution of TrkB receptors before, during, and after synapse formation between cortical neurons
    • Gomes RA, Hampton C, El-Sabeawy F, Sabo SL, McAllister AK (2006). The dynamic distribution of TrkB receptors before, during, and after synapse formation between cortical neurons. J Neurosci 26: 11487-11500.
    • (2006) J Neurosci , vol.26 , pp. 11487-11500
    • Gomes, R.A.1    Hampton, C.2    El-Sabeawy, F.3    Sabo, S.L.4    McAllister, A.K.5
  • 17
    • 84871948613 scopus 로고    scopus 로고
    • Protective effects of 7,8-dihydroxyflavone on retinal ganglion and RGC-5 cells against excitotoxic and oxidative stress
    • Gupta VK, You Y, Li JC, Klistorner A, Graham SL (2013). Protective effects of 7,8-dihydroxyflavone on retinal ganglion and RGC-5 cells against excitotoxic and oxidative stress. J Mol Neurosci 49: 96-104.
    • (2013) J Mol Neurosci , vol.49 , pp. 96-104
    • Gupta, V.K.1    You, Y.2    Li, J.C.3    Klistorner, A.4    Graham, S.L.5
  • 18
    • 84873087532 scopus 로고    scopus 로고
    • NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
    • Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A et al (2013). NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 493: 674-678.
    • (2013) Nature , vol.493 , pp. 674-678
    • Heneka, M.T.1    Kummer, M.P.2    Stutz, A.3    Delekate, A.4    Schwartz, S.5    Vieira-Saecker, A.6
  • 19
    • 84878152890 scopus 로고    scopus 로고
    • Neurotrophin and Wnt signaling cooperatively regulate dendritic spine formation
    • Hiester BG, Galati DF, Salinas PC, Jones KR (2013). Neurotrophin and Wnt signaling cooperatively regulate dendritic spine formation. Mol Cell Neurosci 56C: 115-127.
    • (2013) Mol Cell Neurosci , vol.56 C , pp. 115-127
    • Hiester, B.G.1    Galati, D.F.2    Salinas, P.C.3    Jones, K.R.4
  • 20
    • 84870228676 scopus 로고    scopus 로고
    • SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease
    • Hong Y, Chan CB, Kwon IS, Li X, Song M, Lee HP et al (2012). SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease. J Neurosci 32: 17262-17272.
    • (2012) J Neurosci , vol.32 , pp. 17262-17272
    • Hong, Y.1    Chan, C.B.2    Kwon, I.S.3    Li, X.4    Song, M.5    Lee, H.P.6
  • 21
    • 78651483724 scopus 로고    scopus 로고
    • PKC epsilon activation prevents synaptic loss, Abeta elevation, and cognitive deficits in Alzheimer's disease transgenic mice
    • Hongpaisan J, Sun MK, Alkon DL (2011). PKC epsilon activation prevents synaptic loss, Abeta elevation, and cognitive deficits in Alzheimer's disease transgenic mice. J Neurosci 31: 630-643.
    • (2011) J Neurosci , vol.31 , pp. 630-643
    • Hongpaisan, J.1    Sun, M.K.2    Alkon, D.L.3
  • 22
    • 77249168715 scopus 로고    scopus 로고
    • A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
    • Jang SW, Liu X, Yepes M, Shepherd KR, Miller GW, Liu Y et al (2010). A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci USA 107: 2687-2692.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 2687-2692
    • Jang, S.W.1    Liu, X.2    Yepes, M.3    Shepherd, K.R.4    Miller, G.W.5    Liu, Y.6
  • 24
    • 58149479368 scopus 로고    scopus 로고
    • Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model
    • Kimura R, Ohno M (2009). Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model. Neurobiol Dis 33: 229-235.
    • (2009) Neurobiol Dis , vol.33 , pp. 229-235
    • Kimura, R.1    Ohno, M.2
  • 25
    • 78649857797 scopus 로고    scopus 로고
    • A Synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect
    • Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K et al (2010). A Synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. J Med Chem 53: 8274-8286.
    • (2010) J Med Chem , vol.53 , pp. 8274-8286
    • Liu, X.1    Chan, C.B.2    Jang, S.W.3    Pradoldej, S.4    Huang, J.5    He, K.6
  • 26
    • 84874263260 scopus 로고    scopus 로고
    • O-methylated metabolite of 7,8-dihydroxyflavone activates TrkB receptor and displays antidepressant activity
    • Liu X, Qi Q, Xiao G, Li J, Luo HR, Ye K (2013). O-methylated metabolite of 7,8-dihydroxyflavone activates TrkB receptor and displays antidepressant activity. Pharmacology 91: 185-200.
    • (2013) Pharmacology , vol.91 , pp. 185-200
    • Liu, X.1    Qi, Q.2    Xiao, G.3    Li, J.4    Luo, H.R.5    Ye, K.6
  • 27
    • 84878227058 scopus 로고    scopus 로고
    • BDNFbased synaptic repair as a disease-modifying strategy for neurodegenerative diseases
    • Lu B, Nagappan G, Guan X, Nathan PJ, Wren P (2013). BDNFbased synaptic repair as a disease-modifying strategy for neurodegenerative diseases. Nat Rev Neurosci 14: 401-416.
    • (2013) Nat Rev Neurosci , vol.14 , pp. 401-416
    • Lu, B.1    Nagappan, G.2    Guan, X.3    Nathan, P.J.4    Wren, P.5
  • 28
    • 84855836040 scopus 로고    scopus 로고
    • The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission
    • Mantilla CB, Ermilov LG (2012). The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission. Muscle Nerve 45: 274-276.
    • (2012) Muscle Nerve , vol.45 , pp. 274-276
    • Mantilla, C.B.1    Ermilov, L.G.2
  • 30
    • 0032890036 scopus 로고    scopus 로고
    • An immunohistochemical study of the distribution of brain-derived neurotrophic factor in the adult human brain, with particular reference to Alzheimer's disease
    • Murer MG, Boissiere F, Yan Q, Hunot S, Villares J, Faucheux B et al (1999). An immunohistochemical study of the distribution of brain-derived neurotrophic factor in the adult human brain, with particular reference to Alzheimer's disease. Neuroscience 88: 1015-1032.
    • (1999) Neuroscience , vol.88 , pp. 1015-1032
    • Murer, M.G.1    Boissiere, F.2    Yan, Q.3    Hunot, S.4    Villares, J.5    Faucheux, B.6
  • 31
    • 0035239020 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
    • Murer MG, Yan Q, Raisman-Vozari R (2001). Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Prog Neurobiol 63: 71-124.
    • (2001) Prog Neurobiol , vol.63 , pp. 71-124
    • Murer, M.G.1    Yan, Q.2    Raisman-Vozari, R.3
  • 32
    • 62049083420 scopus 로고    scopus 로고
    • Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
    • Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM et al (2009). Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med 15: 331-337.
    • (2009) Nat Med , vol.15 , pp. 331-337
    • Nagahara, A.H.1    Merrill, D.A.2    Coppola, G.3    Tsukada, S.4    Schroeder, B.E.5    Shaked, G.M.6
  • 33
    • 0030451939 scopus 로고    scopus 로고
    • Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease
    • Narisawa-Saito M, Wakabayashi K, Tsuji S, Takahashi H, Nawa H (1996). Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease. Neuroreport 7: 2925-2928.
    • (1996) Neuroreport , vol.7 , pp. 2925-2928
    • Narisawa-Saito, M.1    Wakabayashi, K.2    Tsuji, S.3    Takahashi, H.4    Nawa, H.5
  • 34
    • 33749521100 scopus 로고    scopus 로고
    • Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: Potential factors in amyloid plaque formation
    • Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J et al (2006). Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci 26: 10129-10140.
    • (2006) J Neurosci , vol.26 , pp. 10129-10140
    • Oakley, H.1    Cole, S.L.2    Logan, S.3    Maus, E.4    Shao, P.5    Craft, J.6
  • 35
    • 0034208461 scopus 로고    scopus 로고
    • A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis
    • Ochs G, Penn RD, York M, Giess R, Beck M, Tonn J et al (2000). A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 1: 201-206.
    • (2000) Amyotroph Lateral Scler Other Motor Neuron Disord , vol.1 , pp. 201-206
    • Ochs, G.1    Penn, R.D.2    York, M.3    Giess, R.4    Beck, M.5    Tonn, J.6
  • 36
    • 0042697305 scopus 로고    scopus 로고
    • Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
    • Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R et al (2003). Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39: 409-421.
    • (2003) Neuron , vol.39 , pp. 409-421
    • Oddo, S.1    Caccamo, A.2    Shepherd, J.D.3    Murphy, M.P.4    Golde, T.E.5    Kayed, R.6
  • 38
    • 84881396465 scopus 로고    scopus 로고
    • Site-specific inhibitory mechanism for amyloidbeta42 aggregation by catechol-type flavonoids targeting the Lys residues
    • Sato M, Murakami K, Uno M, Nakagawa Y, Katayama S, Akagi KI et al (2013). Site-specific inhibitory mechanism for amyloidbeta42 aggregation by catechol-type flavonoids targeting the Lys residues. J Biol Chem 188: 23212-23224.
    • (2013) J Biol Chem , vol.188 , pp. 23212-23224
    • Sato, M.1    Murakami, K.2    Uno, M.3    Nakagawa, Y.4    Katayama, S.5    Akagi, K.I.6
  • 39
    • 79957872121 scopus 로고    scopus 로고
    • Synaptic loss in the inferior temporal gyrus in mild cognitive impairment and Alzheimer's disease
    • Scheff SW, Price DA, Schmitt FA, Scheff MA, Mufson EJ (2011). Synaptic loss in the inferior temporal gyrus in mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis 24: 547-557.
    • (2011) J Alzheimers Dis , vol.24 , pp. 547-557
    • Scheff, S.W.1    Price, D.A.2    Schmitt, F.A.3    Scheff, M.A.4    Mufson, E.J.5
  • 40
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • Selkoe DJ (2002). Alzheimer's disease is a synaptic failure. Science 298: 789-791.
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 41
    • 0030872413 scopus 로고    scopus 로고
    • Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease
    • Sze CI, Troncoso JC, Kawas C, Mouton P, Price DL, Martin LJ (1997). Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease. J Neuropathol Exp Neurol 56: 933-944.
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 933-944
    • Sze, C.I.1    Troncoso, J.C.2    Kawas, C.3    Mouton, P.4    Price, D.L.5    Martin, L.J.6
  • 42
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R et al (1991). Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30: 572-580.
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    Deteresa, R.5    Hill, R.6
  • 43
    • 45249087489 scopus 로고    scopus 로고
    • Functional consequences of locus coeruleus degeneration in Alzheimer's disease
    • Weinshenker D (2008). Functional consequences of locus coeruleus degeneration in Alzheimer's disease. Curr Alzheimer Res 5: 342-345.
    • (2008) Curr Alzheimer Res , vol.5 , pp. 342-345
    • Weinshenker, D.1
  • 44
    • 84864124228 scopus 로고    scopus 로고
    • 7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats
    • Zeng Y, Lv F, Li L, Yu H, Dong M, Fu Q (2012). 7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats. J Neurochem 122: 800-811.
    • (2012) J Neurochem , vol.122 , pp. 800-811
    • Zeng, Y.1    Lv, F.2    Li, L.3    Yu, H.4    Dong, M.5    Fu, Q.6
  • 45
    • 83055185674 scopus 로고    scopus 로고
    • Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging
    • Zeng Y, Tan M, Kohyama J, Sneddon M, Watson JB, Sun YE et al (2011). Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging. J Neurosci 31: 17800-17810.
    • (2011) J Neurosci , vol.31 , pp. 17800-17810
    • Zeng, Y.1    Tan, M.2    Kohyama, J.3    Sneddon, M.4    Watson, J.B.5    Sun, Y.E.6
  • 46
    • 72949089907 scopus 로고    scopus 로고
    • Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: Implications for neuritic plaque development
    • Zhang XM, Cai Y, Xiong K, Cai H, Luo XG, Feng JC et al (2009). Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development. Eur J Neurosci 30: 2271-2283.
    • (2009) Eur J Neurosci , vol.30 , pp. 2271-2283
    • Zhang, X.M.1    Cai, Y.2    Xiong, K.3    Cai, H.4    Luo, X.G.5    Feng, J.C.6
  • 47
    • 68849083063 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in neurodegenerative diseases
    • Zuccato C, Cattaneo E (2009). Brain-derived neurotrophic factor in neurodegenerative diseases. Nat Rev Neurol 5: 311-322.
    • (2009) Nat Rev Neurol , vol.5 , pp. 311-322
    • Zuccato, C.1    Cattaneo, E.2


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