-
1
-
-
0041803006
-
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
-
Andorfer C, Kress Y, Espinoza M, de Silva R, Tucker KL, Barde YA, Duff K, Davies P (2003) Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. J Neurochem 86:582-590.
-
(2003)
J Neurochem
, vol.86
, pp. 582-590
-
-
Andorfer, C.1
Kress, Y.2
Espinoza, M.3
de Silva, R.4
Tucker, K.L.5
Barde, Y.A.6
Duff, K.7
Davies, P.8
-
2
-
-
42249102801
-
Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease
-
Basun H, Bogdanovic N, Ingelsson M, Almkvist O, Näslund J, Axelman K, Bird TD, Nochlin D, Schellenberg GD, Wahlund LO, Lannfelt L (2008) Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease. Arch Neurol 65:499-505.
-
(2008)
Arch Neurol
, vol.65
, pp. 499-505
-
-
Basun, H.1
Bogdanovic, N.2
Ingelsson, M.3
Almkvist, O.4
Näslund, J.5
Axelman, K.6
Bird, T.D.7
Nochlin, D.8
Schellenberg, G.D.9
Wahlund, L.O.10
Lannfelt, L.11
-
3
-
-
14644442872
-
Intraneu-ronal Abeta causes the onset ofearly Alzheimer's disease-related cognitive deficits in transgenic mice
-
Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM (2005) Intraneu-ronal Abeta causes the onset ofearly Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 45:675-688.
-
(2005)
Neuron
, vol.45
, pp. 675-688
-
-
Billings, L.M.1
Oddo, S.2
Green, K.N.3
McGaugh, J.L.4
Laferla, F.M.5
-
4
-
-
69449091994
-
Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease
-
Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Müller FJ, Loring JF, Yamasaki TR, Poon WW, Green KN, LaFerla FM (2009) Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci USA 106:13594-13599.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 13594-13599
-
-
Blurton-Jones, M.1
Kitazawa, M.2
Martinez-Coria, H.3
Castello, N.A.4
Müller, F.J.5
Loring, J.F.6
Yamasaki, T.R.7
Poon, W.W.8
Green, K.N.9
Laferla, F.M.10
-
5
-
-
9144272296
-
Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation
-
Cheng IH, Palop JJ, Esposito LA, Bien-Ly N, Yan F, Mucke L (2004) Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation. Nat Med 10:1190-1192.
-
(2004)
Nat Med
, vol.10
, pp. 1190-1192
-
-
Cheng, I.H.1
Palop, J.J.2
Esposito, L.A.3
Bien-Ly, N.4
Yan, F.5
Mucke, L.6
-
6
-
-
33745268224
-
Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons
-
Deshpande A, Mina E, Glabe C, Busciglio J (2006) Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons. J Neurosci 26:6011-6018.
-
(2006)
J Neurosci
, vol.26
, pp. 6011-6018
-
-
Deshpande, A.1
Mina, E.2
Glabe, C.3
Busciglio, J.4
-
7
-
-
0034016093
-
Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes
-
Duff K, Knight H, Refolo LM, Sanders S, Yu X, Picciano M, Malester B, Hutton M, Adamson J, Goedert M, Burki K, Davies P (2000) Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes. Neurobiol Dis 7:87-98.
-
(2000)
Neurobiol Dis
, vol.7
, pp. 87-98
-
-
Duff, K.1
Knight, H.2
Refolo, L.M.3
Sanders, S.4
Yu, X.5
Picciano, M.6
Malester, B.7
Hutton, M.8
Adamson, J.9
Goedert, M.10
Burki, K.11
Davies, P.12
-
8
-
-
57649148788
-
Structural classification of toxic amyloid oligomers
-
Glabe CG (2008) Structural classification of toxic amyloid oligomers. J Biol Chem 283:29639-29643.
-
(2008)
J Biol Chem
, vol.283
, pp. 29639-29643
-
-
Glabe, C.G.1
-
9
-
-
0035943436
-
Formationof neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
-
Götz J, Chen F, van Dorpe J, Nitsch RM (2001) Formationof neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science 293:1491-1495.
-
(2001)
Science
, vol.293
, pp. 1491-1495
-
-
Götz, J.1
Chen, F.2
van Dorpe, J.3
Nitsch, R.M.4
-
10
-
-
77955322042
-
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models
-
Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, Wölfing H, Chieng BC, Christie MJ, Napier IA, Eckert A, Staufenbiel M, Hardeman E, Götz J (2010) Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell 142:387-397.
-
(2010)
Cell
, vol.142
, pp. 387-397
-
-
Ittner, L.M.1
Ke, Y.D.2
Delerue, F.3
Bi, M.4
Gladbach, A.5
van Eersel, J.6
Wölfing, H.7
Chieng, B.C.8
Christie, M.J.9
Napier, I.A.10
Eckert, A.11
Staufenbiel, M.12
Hardeman, E.13
Götz, J.14
-
11
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG (2003) Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300:486-489.
-
(2003)
Science
, vol.300
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
McIntire, T.M.4
Milton, S.C.5
Cotman, C.W.6
Glabe, C.G.7
-
12
-
-
36749078121
-
Fibril specific, conformation dependent antibodies recognize a generic epitope common toamyloid fibrils and fibrillar oligomers thatisabsent in prefibrillar oligomers
-
Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG (2007) Fibril specific, conformation dependent antibodies recognize a generic epitope common toamyloid fibrils and fibrillar oligomers thatisabsent in prefibrillar oligomers. Mol Neurodegener 2:18.
-
(2007)
Mol Neurodegener
, vol.2
, pp. 18
-
-
Kayed, R.1
Head, E.2
Sarsoza, F.3
Saing, T.4
Cotman, C.W.5
Necula, M.6
Margol, L.7
Wu, J.8
Breydo, L.9
Thompson, J.L.10
Rasool, S.11
Gurlo, T.12
Butler, P.13
Glabe, C.G.14
-
13
-
-
20844458090
-
Syn-aptic targeting by Alzheimer's-related amyloid beta oligomers
-
Lacor PN, Buniel MC, Chang L, Fernandez SJ, Gong Y, Viola KL, Lambert MP, Velasco PT, Bigio EH, Finch CE, Krafft GA, Klein WL (2004) Syn-aptic targeting by Alzheimer's-related amyloid beta oligomers. J Neurosci 24:10191-10200.
-
(2004)
J Neurosci
, vol.24
, pp. 10191-10200
-
-
Lacor, P.N.1
Buniel, M.C.2
Chang, L.3
Fernandez, S.J.4
Gong, Y.5
Viola, K.L.6
Lambert, M.P.7
Velasco, P.T.8
Bigio, E.H.9
Finch, C.E.10
Krafft, G.A.11
Klein, W.L.12
-
14
-
-
33645038471
-
A specific amyloid-beta protein assembly in the brain impairs memory
-
Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH (2006) A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440:352-357.
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesné, S.1
Koh, M.T.2
Kotilinek, L.3
Kayed, R.4
Glabe, C.G.5
Yang, A.6
Gallagher, M.7
Ashe, K.H.8
-
15
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
-
Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, Yen SH, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E (2001) Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 293:1487-1491.
-
(2001)
Science
, vol.293
, pp. 1487-1491
-
-
Lewis, J.1
Dickson, D.W.2
Lin, W.L.3
Chisholm, L.4
Corral, A.5
Jones, G.6
Yen, S.H.7
Sahara, N.8
Skipper, L.9
Yager, D.10
Eckman, C.11
Hardy, J.12
Hutton, M.13
McGowan, E.14
-
16
-
-
27744512118
-
The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice
-
Lord A, Kalimo H, Eckman C, Zhang XQ, Lannfelt L, Nilsson LN (2006) The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice. Neurobiol Aging 27:67-77.
-
(2006)
Neurobiol Aging
, vol.27
, pp. 67-77
-
-
Lord, A.1
Kalimo, H.2
Eckman, C.3
Zhang, X.Q.4
Lannfelt, L.5
Nilsson, L.N.6
-
17
-
-
34548847452
-
Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP transgenic mice
-
McConlogue L, Buttini M, Anderson JP, Brigham EF, Chen KS, Freedman SB, Games D, Johnson-Wood K, Lee M, Zeller M, Liu W, Motter R, Sinha S (2007) Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP transgenic mice. J Biol Chem 282: 26326-26334.
-
(2007)
J Biol Chem
, vol.282
, pp. 26326-26334
-
-
McConlogue, L.1
Buttini, M.2
Anderson, J.P.3
Brigham, E.F.4
Chen, K.S.5
Freedman, S.B.6
Games, D.7
Johnson-Wood, K.8
Lee, M.9
Zeller, M.10
Liu, W.11
Motter, R.12
Sinha, S.13
-
18
-
-
0032590054
-
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
-
McLean CA, Cherny RA, Fraser FW, Fuller SJ, Smith MJ, Beyreuther K, Bush AI, Masters CL (1999) Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol 46: 860-866.
-
(1999)
Ann Neurol
, vol.46
, pp. 860-866
-
-
McLean, C.A.1
Cherny, R.A.2
Fraser, F.W.3
Fuller, S.J.4
Smith, M.J.5
Beyreuther, K.6
Bush, A.I.7
Masters, C.L.8
-
19
-
-
0038117796
-
Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
-
Näslund J, Haroutunian V, Mohs R, Davis KL, Davies P, Greengard P, Bux-baum JD (2000) Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA 283:1571-1577.
-
(2000)
JAMA
, vol.283
, pp. 1571-1577
-
-
Näslund, J.1
Haroutunian, V.2
Mohs, R.3
Davis, K.L.4
Davies, P.5
Greengard, P.6
Bux-Baum, J.D.7
-
20
-
-
0042697305
-
Triple-transgenic modelof Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
-
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Mether-ate R, Mattson MP, Akbari Y, LaFerla FM (2003) Triple-transgenic modelof Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39:409-421.
-
(2003)
Neuron
, vol.39
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
Murphy, M.P.4
Golde, T.E.5
Kayed, R.6
Mether-Ate, R.7
Mattson, M.P.8
Akbari, Y.9
Laferla, F.M.10
-
21
-
-
4043167747
-
Abeta immu-notherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
-
Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM (2004) Abeta immu-notherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 43:321-332.
-
(2004)
Neuron
, vol.43
, pp. 321-332
-
-
Oddo, S.1
Billings, L.2
Kesslak, J.P.3
Cribbs, D.H.4
Laferla, F.M.5
-
22
-
-
58149388879
-
Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: A mechanistic link between Abeta and tau pathology
-
Oddo S, Caccamo A, Tseng B, Cheng D, Vasilevko V, Cribbs DH, LaFerla FM (2008) Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology. J Neurosci 28:12163-12175.
-
(2008)
J Neurosci
, vol.28
, pp. 12163-12175
-
-
Oddo, S.1
Caccamo, A.2
Tseng, B.3
Cheng, D.4
Vasilevko, V.5
Cribbs, D.H.6
Laferla, F.M.7
-
23
-
-
12344306018
-
Characterizationofadouble (amyloid precursor protein-tau) transgenic: Tau phosphorylation and aggregation
-
Perez M, Ribe E, Rubio A, Lim F, Moran MA, Ramos PG, Ferrer I, Isla MT, Avila J (2005) Characterizationofadouble (amyloid precursor protein-tau) transgenic: tau phosphorylation and aggregation. Neuroscience 130:339-347.
-
(2005)
Neuroscience
, vol.130
, pp. 339-347
-
-
Perez, M.1
Ribe, E.2
Rubio, A.3
Lim, F.4
Moran, M.A.5
Ramos, P.G.6
Ferrer, I.7
Isla, M.T.8
Avila, J.9
-
25
-
-
17344388652
-
BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: Implications for Alzheimer's disease therapeutics
-
Roberds SL, Anderson J, Basi G, Bienkowski MJ, Branstetter DG, Chen KS, Freedman SB, Frigon NL, Games D, Hu K, Johnson-Wood K, Kappen-man KE, Kawabe TT, Kola I, Kuehn R, Lee M, Liu W, Motter R, Nichols NF, Power M, et al. (2001) BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum Mol Genet 10:1317-1324.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 1317-1324
-
-
Roberds, S.L.1
Anderson, J.2
Basi, G.3
Bienkowski, M.J.4
Branstetter, D.G.5
Chen, K.S.6
Freedman, S.B.7
Frigon, N.L.8
Games, D.9
Hu, K.10
Johnson-Wood, K.11
Kappen-Man, K.E.12
Kawabe, T.T.13
Kola, I.14
Kuehn, R.15
Lee, M.16
Liu, W.17
Motter, R.18
Nichols, N.F.19
Power, M.20
more..
-
26
-
-
84863859181
-
AlmkvistO, GraffC, NordbergA (2012) Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers
-
Scholl M, Wall A, Thordardottir S, Ferreira D, Bogdanovic N, Långstrom B, AlmkvistO, GraffC, NordbergA (2012) Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers. Neurology 79:229-236.
-
Neurology
, vol.79
, pp. 229-236
-
-
Scholl, M.1
Wall, A.2
Thordardottir, S.3
Ferreira, D.4
Bogdanovic, N.5
Långstrom, B.6
-
27
-
-
51449096696
-
Abeta inhibits the proteasome and enhances amyloid and tau accumulation
-
Tseng BP, Green KN, Chan JL, Blurton-Jones M, LaFerla FM (2008) Abeta inhibits the proteasome and enhances amyloid and tau accumulation. Neurobiol Aging 29:1607-1618.
-
(2008)
Neurobiol Aging
, vol.29
, pp. 1607-1618
-
-
Tseng, B.P.1
Green, K.N.2
Chan, J.L.3
Blurton-Jones, M.4
Laferla, F.M.5
-
28
-
-
79957653811
-
Intraneuronal APP, not free Abeta peptides in 3xTg-AD mice: Implications for tau versus Abeta-mediated Alzheimer neurodegen-eration
-
Winton MJ, Lee EB, Sun E, Wong MM, Leight S, Zhang B, Trojanowski JQ, Lee VM (2011) Intraneuronal APP, not free Abeta peptides in 3xTg-AD mice: implications for tau versus Abeta-mediated Alzheimer neurodegen-eration. J Neurosci 31:7691-7699.
-
(2011)
J Neurosci
, vol.31
, pp. 7691-7699
-
-
Winton, M.J.1
Lee, E.B.2
Sun, E.3
Wong, M.M.4
Leight, S.5
Zhang, B.6
Trojanowski, J.Q.7
Lee, V.M.8
-
29
-
-
77949905345
-
Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation
-
Wu JW, Breydo L, Isas JM, Lee J, Kuznetsov YG, Langen R, Glabe C (2010) Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation. J Biol Chem 285:6071-6079.
-
(2010)
J Biol Chem
, vol.285
, pp. 6071-6079
-
-
Wu, J.W.1
Breydo, L.2
Isas, J.M.3
Lee, J.4
Kuznetsov, Y.G.5
Langen, R.6
Glabe, C.7
-
30
-
-
77956587739
-
Abeta oligomers cause localized Ca(2 +) elevation, missorting of endogenous tau into dendrites, tau phosphorylation, and destruction of microtubules and spines
-
Zempel H, Thies E, Mandelkow E, Mandelkow EM (2010) Abeta oligomers cause localized Ca(2 +) elevation, missorting of endogenous tau into dendrites, tau phosphorylation, and destruction of microtubules and spines. J Neurosci 30:11938-11950.
-
(2010)
J Neurosci
, vol.30
, pp. 11938-11950
-
-
Zempel, H.1
Thies, E.2
Mandelkow, E.3
Mandelkow, E.M.4
-
31
-
-
2442642836
-
Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopa-thy
-
Zhang B, Higuchi M, Yoshiyama Y, Ishihara T, Forman MS, Martinez D, Joyce S, Trojanowski JQ, Lee VM (2004) Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopa-thy. J Neurosci 24:4657-4667.
-
(2004)
J Neurosci
, vol.24
, pp. 4657-4667
-
-
Zhang, B.1
Higuchi, M.2
Yoshiyama, Y.3
Ishihara, T.4
Forman, M.S.5
Martinez, D.6
Joyce, S.7
Trojanowski, J.Q.8
Lee, V.M.9
|