Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy

American Journal of Pathology

Volumn 171, Issue 1, 2007, Pages 241-251

  Farris, Wesley ^a,f,g   Schütz, Sonja G ^a   Cirrito, John R ^b   Shankar, Ganesh M ^a   Sun, Xiaoyan ^c   George, Ana ^a   Leissring, Malcolm A ^d   Walsh, Dominic M ^e   Wei, Qiao Qiu ^c   Holtzman, David M ^b   Selkoe, Dennis J ^a,h  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e UNIVERSITY COLLEGE DUBLIN   (Ireland)

^f UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^g VETERANS AFFAIRS MEDICAL CENTER   (United States)

^h HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; BRAIN PROTEIN; DIMER; MEMBRANE METALLOENDOPEPTIDASE;

AGING; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE DISRUPTION; GENE SILENCING; HIPPOCAMPUS; IN VIVO STUDY; INTERSTITIAL FLUID; MOUSE; NEUROPATHOLOGY; NONHUMAN; PLAQUE FORMING CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN FUNCTION; VASCULAR AMYLOIDOSIS; ANIMAL; BLOOD; BRAIN; CHEMISTRY; DISEASE MODEL; GENETICS; HALF LIFE TIME; HUMAN; METABOLISM; PATHOLOGY; SENILE PLAQUE; TRANSGENIC MOUSE; VASCULARIZATION;

AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; CEREBRAL AMYLOID ANGIOPATHY; DISEASE MODELS, ANIMAL; HALF-LIFE; HIPPOCAMPUS; HUMANS; MICE; MICE, TRANSGENIC; NEPRILYSIN; SENILE PLAQUES;

EID: 34547693437     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2007.070105     Document Type: Article

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