PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease

Neurobiology of Aging

Volumn 35, Issue 10, 2014, Pages 2272-2281

  Devi, Latha ^a   Ohno, Masuo ^a,b  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

5XFAD; Amyloid ; ATF4; BACE1; Cholinergic neuron; CREB; ElF2 ; Fear conditioning; Learning and memory; PERK

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; AMYLOID BETA PROTEIN; BETA SECRETASE 1; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; INITIATION FACTOR 2ALPHA; PROTEIN KINASE; PROTEIN KINASE RNA LIKE ENDOPLASMIC RETICULUM KINASE; UNCLASSIFIED DRUG; ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; CREB1 PROTEIN, MOUSE; INITIATION FACTOR 2; PERK KINASE; PROTEIN KINASE R; SECRETASE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLINERGIC NERVE CELL; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; HAPLOINSUFFICIENCY; MALE; MEMORY DISORDER; MOUSE; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SENILE PLAQUE; UPREGULATION; ANIMAL; C57BL MOUSE; DISEASE MODEL; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DISEASE MODELS, ANIMAL; EIF-2 KINASE; EUKARYOTIC INITIATION FACTOR-2; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE DEGENERATION; PHOSPHORYLATION;

EID: 84903814520     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2014.04.031     Document Type: Article

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