The β-secretase, BACE: A prime drug target for Alzheimer's disease

Journal of Molecular Neuroscience

Volumn 17, Issue 2, 2001, Pages 157-170

  Vassar, R ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

amyloid; Secretase; A peptide; Alzheimer's disease; APP processing; BACE

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BETA SECRETASE; BETA SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1; BETA SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 2; ENZYME INHIBITOR; GAMMA SECRETASE; MEMBRANE ENZYME; MESSENGER RNA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL MODEL; ARTICLE; BRAIN DISEASE; DEGENERATIVE DISEASE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; KNOCKOUT MOUSE; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN DEGRADATION;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; ENDOPEPTIDASES; HUMANS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA;

ANIMALIA;

EID: 0035159756     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:17:2:157     Document Type: Article

References (63)

1. The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region
2. Post-translational processing of β-secretase (β-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-β production
3. Expression analysis of BACE2 in brain and peripheral tissues
4. A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's β-secretase
5. A splice variant of β-secretase deficient in the amyloidogenic processing of the amyloid precursor protein
6. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the alzheimer amyloid protein precursor
7. BACE1 is the major β-secretase for generation of Aβ peptides by neurons
8. Maturation and pro-peptide cleavage of β-secretase
9. Characterization of the glycosylation profiles of Alzheimer's β-secretase protein Asp-2 expressed in a variety of cell lines
10. Inhibition of amyloid β-protein production in neural cells by the serine protease inhibitor AEBSF
11. Generation of amyloid β-protein from its precursor is sequence specific
12. Processing of β-secretase by furin and other members of the proprotein convertase family
13. BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein
14. Amyloidogenesis in Alzheimer's disease: Some possible therapeutic opportunities
15. Design of potent inhibitors for human brain memapsin 2 (β-secretase)
16. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
17. Generation and regulation of β-amyloid peptide variants by neurons
18. The vacuolar H+ ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type β-amyloid precursor protein
19. β-amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms
20. The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway
21. Amyloid β-peptide is produced by cultured cells during normal metabolism
22. Charaterization of Alzheimer's β-secretase protein BACE
23. Structure of the protease domain of memapsin 2 (β-secretase) complexed with inhibitor
24. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
25. Maturation and endosomal targeting of β-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease β-secretase
26. Prodomain processing of Asp1 (BACE2) is autocatalytic
27. Identification of a novel aspartic protease (Asp 2) as β-Secretase
28. ASP1 (BACE2) cleaves the amyloid precursor protein at the β-secretase site
29. Genetics of Alzheimer's disease
30. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
31. Cell-type and amyloid precursor protein-type specific inhibition of Aβ release by bafilomycin A1, a selective inhibitor of vacuolar ATPases
32. Evidence that production and release of amyloid β-protein involves the endocytic pathway
33. Constitutive and regulated alpha-secretase cleavage of alzheimer's amyloid precursor protein by a disintegrin metalloprotease
34. A68. A major subunit of paired helical filaments and derivatized forms of normal tau
35. Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein
36. Constitutive α-secretase cleavage of the β-amyloid precursor protein in the furin-deficient LoVo cell line: Involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10
37. Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation
38. Mechanism of inhibition of β-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide
39. Coordinated expression of β-amyloid precursor protein and the putative β-secretase BACE and α-secretase ADAM10 in mouse and human brain
40. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of β-amyloid
41. The BACE gene: Genomic structure and candidate gene study in late-onset Alzheimer's disease
42. Amino-terminal deletions enhance aggregation of β-amyloid peptides in vitro
43. BACE knockout mice are healthy despite lacking the primary β-secretase activity in brain: Implications for Alzheimer's disease therapeutics
44. Structural alterations in the peptide backbone of β-amyloid core protein may account for its deposition and stability in Alzheimer's disease
45. Modeling of substrate specificity of the Alzheimer's disease amyloid precursor protein β-secretase
46. BACE maps to chromosome 11 and a BACE homolog, BACE2, reside in the obligate Down syndrome region of chromosome 21
47. Alzheimer's disease: Genes, proteins, and therapy
48. Secretion of β-amyloid precursor protein cleaved at the amino-terminus of the β-amyloid peptide
49. The pro domain of β-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain
50. Purification and cloning of amyloid precursor protein β-secretase from human brain
51. Function and dysfunction of the presenilins
52. A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein β-secretase
53. Amyloid β-protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
54. The neuropathology of Alzheimer disease and the structural basis of its cognitive alterations
55. β-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
56. Aβ-generating enzymes: Recent advances in β- and γ-secretase research
57. Phosphorylation regulates intracellular trafficking of β-secretase
58. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease
59. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
60. Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity
61. BACE2 functions as an alternative α-secretase in cells
62. The role of A beta 42 in Alzheimer's disease
63. β-Secretase processing of the β-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes