Neprilysin-sensitive synapse-associated amyloid-β peptide oligomers impair neuronal plasticity and cognitive function

Journal of Biological Chemistry

Volumn 281, Issue 26, 2006, Pages 17941-17951

  Huang, Shu Ming ^a   Mouri, Akihiro ^b   Kokubo, Hideko ^a,c   Nakajima, Ryuichi ^a   Suemoto, Takahiro ^a   Higuchi, Makoto ^a,d   Staufenbiel, Matthias ^e   Noda, Yukihiro ^b,f   Yamaguchi, Haruyasu ^a,c   Nabeshima, Toshitaka ^b   Saido, Takaomi C ^a   Iwata, Nobuhisa ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c GUNMA UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^e NOVARTIS PHARMA AG   (Switzerland)

^f MEIJO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; DISEASE CONTROL; DISEASES; ENZYMES; PATHOLOGY; PLASTICITY;

ALZHEIMER DISEASE; CATABOLIC ACTIVITIES; NEPRILYSIN ACTIVITY; SYNAPTIC PLASTICITY;

OLIGOMERS;

AMYLOID BETA PROTEIN; MEMBRANE METALLOENDOPEPTIDASE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; COGNITION; ENZYME ACTIVITY; LEARNING; MAZE TEST; MEMORY; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; UPREGULATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; COGNITION; FEMALE; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; NEPRILYSIN; NEURONAL PLASTICITY; PEPTIDE FRAGMENTS; SYNAPSES;

MUS MUSCULUS;

EID: 33745808762     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M601372200     Document Type: Article

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