Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice

Journal of Neurochemistry

Volumn 113, Issue 1, 2010, Pages 248-261

  Kimura, Ryoichi ^a   Devi, Latha ^a   Ohno, Masuo ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

secretase; Amyloid ; Brain derived neurotrophic factor; Fear conditioning; Knockout; Long term potentiation

Indexed keywords

BETA SECRETASE; BETA SECRETASE 1; BRAIN DERIVED NEUROTROPHIC FACTOR; PROTEIN TYROSINE KINASE; TYROSINE KINASE B; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CARBOXY TERMINAL SEQUENCE; CEREBRAL BLINDNESS; COGNITIVE DEFECT; CONDITIONING; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME REPRESSION; FEAR; HIPPOCAMPUS; KNOCKOUT MOUSE; LONG TERM POTENTIATION; MAZE TEST; MEMORY; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SYNAPSE; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANALYSIS OF VARIANCE; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CONDITIONING, CLASSICAL; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXCITATORY POSTSYNAPTIC POTENTIALS; FEAR; GENE EXPRESSION REGULATION; HUMANS; LONG-TERM POTENTIATION; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; MUTATION; NEURONAL PLASTICITY; PATCH-CLAMP TECHNIQUES; PEPTIDE FRAGMENTS; PRESENILIN-1;

MUS; MUS MUSCULUS;

EID: 77749289454     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06608.x     Document Type: Article

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