-
1
-
-
0031850369
-
New diagnostic criteria and classification of diabetes-again?
-
Alberti KG, Zimmet PZ (1998) New diagnostic criteria and classification of diabetes-again? Diabet Med15:535-536.
-
(1998)
Diabet Med
, vol.15
, pp. 535-536
-
-
Alberti, K.G.1
Zimmet, P.Z.2
-
2
-
-
1842582870
-
AMP-activated protein kinase plays a role in the control of food intake
-
Andersson U, Filipsson K et al (2004) AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem279:12005-12008.
-
(2004)
J Biol Chem
, vol.279
, pp. 12005-12008
-
-
Andersson, U.1
Filipsson, K.2
-
3
-
-
33645884425
-
Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin
-
Andreelli F, Foretz M et al (2006) Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin. Endocrinology147:2432-2441.
-
(2006)
Endocrinology
, vol.147
, pp. 2432-2441
-
-
Andreelli, F.1
Foretz, M.2
-
4
-
-
2642614548
-
Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro
-
Anthonsen MW, Ronnstrand L et al (1998) Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro. J Biol Chem273:215-221.
-
(1998)
J Biol Chem
, vol.273
, pp. 215-221
-
-
Anthonsen, M.W.1
Ronnstrand, L.2
-
5
-
-
27144483324
-
AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats
-
Assifi MM, Suchankova G et al (2005) AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats. Am J Physiol Endocrinol Metab 289:E794-E800.
-
(2005)
Am J Physiol Endocrinol Metab
, vol.289
, pp. E794-E800
-
-
Assifi, M.M.1
Suchankova, G.2
-
6
-
-
10744225368
-
Regulation of fasted blood glucose by resistin
-
Banerjee RR, Rangwala SM et al (2004) Regulation of fasted blood glucose by resistin. Science303:1195-1198.
-
(2004)
Science
, vol.303
, pp. 1195-1198
-
-
Banerjee, R.R.1
Rangwala, S.M.2
-
7
-
-
52749091816
-
SirT1 gain of function increases energy efficiency and prevents diabetes in mice
-
Banks AS, Kon N et al (2008) SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab8:333-341.
-
(2008)
Cell Metab
, vol.8
, pp. 333-341
-
-
Banks, A.S.1
Kon, N.2
-
8
-
-
4644309036
-
The 50-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle
-
Barnes BR, Marklund S et al (2004) The 50-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle. J Biol Chem279:38441-38447.
-
(2004)
J Biol Chem
, vol.279
, pp. 38441-38447
-
-
Barnes, B.R.1
Marklund, S.2
-
9
-
-
33751072349
-
Resveratrol improves health and survival of mice on a highcalorie diet
-
Baur JA, Pearson KJ et al (2006) Resveratrol improves health and survival of mice on a highcalorie diet. Nature444:337-342.
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
-
10
-
-
0032966874
-
Effect of AMPK activation on muscle glucose metabolism in conscious rats
-
Bergeron R, Russell RR 3rd et al (1999) Effect of AMPK activation on muscle glucose metabolism in conscious rats. Am J Physiol276:E938-E944.
-
(1999)
Am J Physiol
, vol.276
, pp. E938-E944
-
-
Bergeron, R.1
Russell, R.R.2
-
11
-
-
0035029874
-
Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats
-
Bergeron R, Previs SF et al (2001a) Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats. Diabetes50:1076-1082.
-
(2001)
Diabetes
, vol.50
, pp. 1076-1082
-
-
Bergeron, R.1
Previs, S.F.2
-
12
-
-
0035665594
-
Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis
-
Bergeron R, Ren JM et al (2001b) Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis. Am J Physiol Endocrinol Metab281:E1340-E1346.
-
(2001)
Am J Physiol Endocrinol Metab
, vol.281
, pp. E1340-E1346
-
-
Bergeron, R.1
Ren, J.M.2
-
13
-
-
51249103805
-
Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients
-
Boon H, Bosselaar M et al (2008) Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients. Diabetologia 51:1893-1900.
-
(2008)
Diabetologia
, vol.51
, pp. 1893-1900
-
-
Boon, H.1
Bosselaar, M.2
-
14
-
-
33244486764
-
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells
-
Bordone L, Motta MC et al (2006) Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol4:e31.
-
(2006)
PLoS Biol
, vol.4
-
-
Bordone, L.1
Motta, M.C.2
-
15
-
-
33644699965
-
The stimulatory effect of globular adiponectin on insulinstimulated glucose uptake and fatty acid oxidation is impaired in skeletal muscle from obese subjects
-
Bruce CR, Mertz VA et al (2005) The stimulatory effect of globular adiponectin on insulinstimulated glucose uptake and fatty acid oxidation is impaired in skeletal muscle from obese subjects. Diabetes54:3154-3160.
-
(2005)
Diabetes
, vol.54
, pp. 3154-3160
-
-
Bruce, C.R.1
Mertz, V.A.2
-
16
-
-
0036307179
-
Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome
-
Buhl ES, Jessen N et al (2002) Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome. Diabetes51:2199-2206.
-
(2002)
Diabetes
, vol.51
, pp. 2199-2206
-
-
Buhl, E.S.1
Jessen, N.2
-
17
-
-
0037219411
-
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
-
Butler AE, Janson J et al (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes52:102-110.
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
-
18
-
-
67349276169
-
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
-
Canto C, Gerhart-Hines Z et al (2009) AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature458:1056-1060.
-
(2009)
Nature
, vol.458
, pp. 1056-1060
-
-
Canto, C.1
Gerhart-Hines, Z.2
-
19
-
-
77249156847
-
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
-
Canto C, Jiang LQ et al (2010) Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab11:213-219.
-
(2010)
Cell Metab
, vol.11
, pp. 213-219
-
-
Canto, C.1
Jiang, L.Q.2
-
20
-
-
23744492591
-
Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells
-
Carattino MD, Edinger RS et al (2005) Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells. J Biol Chem280:17608-17616.
-
(2005)
J Biol Chem
, vol.280
, pp. 17608-17616
-
-
Carattino, M.D.1
Edinger, R.S.2
-
21
-
-
0036776903
-
Effect of rosiglitazone on insulin sensitivity and body composition in type 2 diabetic patients [corrected]
-
Carey DG, Cowin GJ et al (2002) Effect of rosiglitazone on insulin sensitivity and body composition in type 2 diabetic patients [corrected]. Obes Res10:1008-1015.
-
(2002)
Obes Res
, vol.10
, pp. 1008-1015
-
-
Carey, D.G.1
Cowin, G.J.2
-
22
-
-
33750859187
-
Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase
-
Carey AL, Steinberg GR et al (2006) Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes55:2688-2697.
-
(2006)
Diabetes
, vol.55
, pp. 2688-2697
-
-
Carey, A.L.1
Steinberg, G.R.2
-
23
-
-
0033036636
-
AMP-activated protein kinase phosphorylation of endothelial NO synthase
-
Chen ZP, Mitchelhill KI et al (1999) AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett443:285-289.
-
(1999)
FEBS Lett
, vol.443
, pp. 285-289
-
-
Chen, Z.P.1
Mitchelhill, K.I.2
-
24
-
-
0033667964
-
AMPK signaling in contracting human skeletal muscle: Acetyl-CoA carboxylase and NO synthase phosphorylation
-
Chen ZP, McConell GK et al (2000) AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation. Am J Physiol Endocrinol Metab279:E1202-E1206.
-
(2000)
Am J Physiol Endocrinol Metab
, vol.279
, pp. E1202-E1206
-
-
Chen, Z.P.1
McConell, G.K.2
-
25
-
-
61949165795
-
AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633
-
Chen Z, Peng IC et al (2009) AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633. Circ Res104:496-505.
-
(2009)
Circ Res
, vol.104
, pp. 496-505
-
-
Chen, Z.1
Peng, I.C.2
-
26
-
-
0025310576
-
Regulation of HMG-CoA reductase: Identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver
-
Clarke PR, Hardie DG (1990) Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver. EMBO J9:2439-2446.
-
(1990)
EMBO J
, vol.9
, pp. 2439-2446
-
-
Clarke, P.R.1
Hardie, D.G.2
-
27
-
-
35648944317
-
Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 50-AMP-activated protein kinase
-
Collins QF, Liu HY et al (2007) Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 50-AMP-activated protein kinase. J Biol Chem282:30143-30149.
-
(2007)
J Biol Chem
, vol.282
, pp. 30143-30149
-
-
Collins, Q.F.1
Liu, H.Y.2
-
28
-
-
33744514139
-
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
-
Cool B, Zinker B et al (2006) Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab3:403-416.
-
(2006)
Cell Metab
, vol.3
, pp. 403-416
-
-
Cool, B.1
Zinker, B.2
-
30
-
-
0038584871
-
Role for AMP-activated protein kinase in glucosestimulated insulin secretion and preproinsulin gene expression
-
daSilva Xavier G, Leclerc I et al (2003) Role for AMP-activated protein kinase in glucosestimulated insulin secretion and preproinsulin gene expression. Biochem J371:761-774.
-
(2003)
Biochem J
, vol.371
, pp. 761-774
-
-
daSilva Xavier, G.1
Leclerc, I.2
-
31
-
-
34249846128
-
Resveratrol stimulates AMP kinase activity in neurons
-
Dasgupta B, Milbrandt J (2007) Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci USA104:7217-7222.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 7217-7222
-
-
Dasgupta, B.1
Milbrandt, J.2
-
32
-
-
21644455008
-
Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes
-
Daval M, Diot-Dupuy F et al (2005) Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes. J Biol Chem280:25250-25257.
-
(2005)
J Biol Chem
, vol.280
, pp. 25250-25257
-
-
Daval, M.1
Diot-Dupuy, F.2
-
33
-
-
33644747421
-
Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase
-
Davis BJ, Xie Z et al (2006) Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. Diabetes 55:496-505.
-
(2006)
Diabetes
, vol.55
, pp. 496-505
-
-
Davis, B.J.1
Xie, Z.2
-
34
-
-
75549085755
-
Skeletal muscle insulin resistance is the primary defect in type 2 diabetes
-
De Fronzo RA, Tripathy D (2009) Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes Care 32(Suppl2):S157-S163.
-
(2009)
Diabetes Care
, vol.32
, pp. S157-S163
-
-
De Fronzo, R.A.1
Tripathy, D.2
-
35
-
-
33644747390
-
Mechanisms of beta-cell death in type 2 diabetes
-
Donath MY, Ehses JA et al (2005) Mechanisms of beta-cell death in type 2 diabetes. Diabetes 54(Suppl2):S108-S113.
-
(2005)
Diabetes
, vol.54
, pp. S108-S113
-
-
Donath, M.Y.1
Ehses, J.A.2
-
36
-
-
57349197971
-
Resistance exercise increases human skeletal muscle AS160/TBC1D4 phosphorylation in association with enhanced leg glucose uptake during postexercise recovery
-
Dreyer HC, Drummond MJ et al (2008) Resistance exercise increases human skeletal muscle AS160/TBC1D4 phosphorylation in association with enhanced leg glucose uptake during postexercise recovery. J Appl Physiol105:1967-1974.
-
(2008)
J Appl Physiol
, vol.105
, pp. 1967-1974
-
-
Dreyer, H.C.1
Drummond, M.J.2
-
37
-
-
33745204925
-
AMPK alterations in cardiac physiology and pathology: Enemy or ally?
-
Dyck JR, Lopaschuk GD (2006) AMPK alterations in cardiac physiology and pathology: enemy or ally? J Physiol574:95-112.
-
(2006)
J Physiol
, vol.574
, pp. 95-112
-
-
Dyck, J.R.1
Lopaschuk, G.D.2
-
38
-
-
17144380822
-
The metabolic syndrome
-
Eckel RH, Grundy SM et al (2005) The metabolic syndrome. Lancet365:1415-1428.
-
(2005)
Lancet
, vol.365
, pp. 1415-1428
-
-
Eckel, R.H.1
Grundy, S.M.2
-
39
-
-
0042922453
-
Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death
-
El-Assaad W, Buteau J et al (2003) Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. Endocrinology144:4154-4163.
-
(2003)
Endocrinology
, vol.144
, pp. 4154-4163
-
-
El-Assaad, W.1
Buteau, J.2
-
40
-
-
0036894375
-
Genetic manipulations of fatty acid metabolism in beta-cells are associated with dysregulated insulin secretion
-
Eto K, Yamashita T et al (2002) Genetic manipulations of fatty acid metabolism in beta-cells are associated with dysregulated insulin secretion. Diabetes 51(Suppl3):S414-S420.
-
(2002)
Diabetes
, vol.51
, pp. S414-S420
-
-
Eto, K.1
Yamashita, T.2
-
41
-
-
29244463866
-
Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to calcium signaling in O2-sensing cells?
-
Evans AM, Mustard KJ et al (2005) Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to calcium signaling in O2-sensing cells? J Biol Chem280:41504-41511.
-
(2005)
J Biol Chem
, vol.280
, pp. 41504-41511
-
-
Evans, A.M.1
Mustard, K.J.2
-
42
-
-
22244477735
-
Contraction-induced myokine production and release: Is skeletal muscle an endocrine organ?
-
Febbraio MA, Pedersen BK (2005) Contraction-induced myokine production and release: is skeletal muscle an endocrine organ? Exerc Sport Sci Rev33:114-119.
-
(2005)
Exerc Sport Sci Rev
, vol.33
, pp. 114-119
-
-
Febbraio, M.A.1
Pedersen, B.K.2
-
43
-
-
0036078863
-
Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin
-
Fisher JS, Gao J et al (2002) Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin. Am J Physiol Endocrinol Metab282:E18-E23.
-
(2002)
Am J Physiol Endocrinol Metab
, vol.282
, pp. E18-E23
-
-
Fisher, J.S.1
Gao, J.2
-
44
-
-
75549090118
-
Defining and characterizing the progression of type 2 diabetes
-
Fonseca VA (2009) Defining and characterizing the progression of type 2 diabetes. Diabetes Care 32(Suppl2):S151-S156.
-
(2009)
Diabetes Care
, vol.32
, pp. S151-S156
-
-
Fonseca, V.A.1
-
45
-
-
0032511053
-
AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes
-
Foretz M, Carling D et al (1998) AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes. J Biol Chem273:14767-14771.
-
(1998)
J Biol Chem
, vol.273
, pp. 14767-14771
-
-
Foretz, M.1
Carling, D.2
-
46
-
-
17844368938
-
Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver
-
Foretz M, Ancellin N et al (2005) Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes54:1331-1339.
-
(2005)
Diabetes
, vol.54
, pp. 1331-1339
-
-
Foretz, M.1
Ancellin, N.2
-
47
-
-
14044249254
-
Inhibition of the Na-K-2Cl cotransporter by novel interaction with the metabolic sensor AMP-activated protein kinase
-
Fraser SA, Mount PF et al (2003) Inhibition of the Na-K-2Cl cotransporter by novel interaction with the metabolic sensor AMP-activated protein kinase. J Am Soc Nephrol14:545A.
-
(2003)
J Am Soc Nephrol
, vol.14
, pp. 545A
-
-
Fraser, S.A.1
Mount, P.F.2
-
48
-
-
0037067666
-
The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
-
Fryer LG, Parbu-Patel A et al (2002) The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem277:25226-25232.
-
(2002)
J Biol Chem
, vol.277
, pp. 25226-25232
-
-
Fryer, L.G.1
Parbu-Patel, A.2
-
49
-
-
58149348480
-
Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice
-
Fujii N, Ho RC et al (2008) Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice. Diabetes57:2958-2966.
-
(2008)
Diabetes
, vol.57
, pp. 2958-2966
-
-
Fujii, N.1
Ho, R.C.2
-
50
-
-
0025330929
-
Identification and role of the basal phosphorylation site on hormone-sensitive lipase
-
Garton AJ, Yeaman SJ (1990) Identification and role of the basal phosphorylation site on hormone-sensitive lipase. Eur J Biochem191:245-250.
-
(1990)
Eur J Biochem
, vol.191
, pp. 245-250
-
-
Garton, A.J.1
Yeaman, S.J.2
-
51
-
-
0024516569
-
Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism
-
Garton AJ, Campbell DG et al (1989) Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism. Eur J Biochem 179:249-254.
-
(1989)
Eur J Biochem
, vol.179
, pp. 249-254
-
-
Garton, A.J.1
Campbell, D.G.2
-
52
-
-
35348865444
-
Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols
-
Gledhill JR, Montgomery MG et al (2007) Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols. Proc Natl Acad Sci USA104:13632-13637.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 13632-13637
-
-
Gledhill, J.R.1
Montgomery, M.G.2
-
53
-
-
34249682779
-
Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle
-
Glund S, Deshmukh A et al (2007) Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle. Diabetes56:1630-1637.
-
(2007)
Diabetes
, vol.56
, pp. 1630-1637
-
-
Glund, S.1
Deshmukh, A.2
-
54
-
-
59649119311
-
Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle
-
Glund S, Treebak JT et al (2009) Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle. Endocrinology150:600-606.
-
(2009)
Endocrinology
, vol.150
, pp. 600-606
-
-
Glund, S.1
Treebak, J.T.2
-
55
-
-
50949116173
-
Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function
-
Hammer S, Snel M et al (2008) Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function. J Am Coll Cardiol52:1006-1012.
-
(2008)
J Am Coll Cardiol
, vol.52
, pp. 1006-1012
-
-
Hammer, S.1
Snel, M.2
-
56
-
-
0031849916
-
Evidence for 50 AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport
-
Hayashi T, Hirshman MF et al (1998) Evidence for 50 AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport. Diabetes47:1369-1373.
-
(1998)
Diabetes
, vol.47
, pp. 1369-1373
-
-
Hayashi, T.1
Hirshman, M.F.2
-
57
-
-
0033613181
-
Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats
-
Higa M, Zhou YT et al (1999) Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats. Proc Natl Acad Sci USA96:11513-11518.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 11513-11518
-
-
Higa, M.1
Zhou, Y.T.2
-
58
-
-
0032704115
-
Chronic activation of 50-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle
-
Holmes BF, Kurth-Kraczek EJ et al (1999) Chronic activation of 50-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle. J Appl Physiol87:1990-1995.
-
(1999)
J Appl Physiol
, vol.87
, pp. 1990-1995
-
-
Holmes, B.F.1
Kurth-Kraczek, E.J.2
-
59
-
-
4544386858
-
AMP kinase is not required for the GLUT4 response to exercise and denervation in skeletal muscle
-
Holmes BF, Lang DB et al (2004) AMP kinase is not required for the GLUT4 response to exercise and denervation in skeletal muscle. Am J Physiol Endocrinol Metab287:E739-E743.
-
(2004)
Am J Physiol Endocrinol Metab
, vol.287
, pp. E739-E743
-
-
Holmes, B.F.1
Lang, D.B.2
-
60
-
-
50649112638
-
SIRT1 regulates hepatocyte lipid metabolism through activating AMPactivated protein kinase
-
Hou X, Xu S et al (2008) SIRT1 regulates hepatocyte lipid metabolism through activating AMPactivated protein kinase. J Biol Chem283:20015-20026.
-
(2008)
J Biol Chem
, vol.283
, pp. 20015-20026
-
-
Hou, X.1
Xu, S.2
-
61
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
Howitz KT, Bitterman KJ et al (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature425:191-196.
-
(2003)
Nature
, vol.425
, pp. 191-196
-
-
Howitz, K.T.1
Bitterman, K.J.2
-
62
-
-
0036788292
-
AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats
-
Iglesias MA, Ye JM et al (2002) AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats. Diabetes51:2886-2894.
-
(2002)
Diabetes
, vol.51
, pp. 2886-2894
-
-
Iglesias, M.A.1
Ye, J.M.2
-
63
-
-
34547545892
-
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
-
Jager S, Handschin C et al (2007) AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci USA104:12017-12022.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 12017-12022
-
-
Jager, S.1
Handschin, C.2
-
64
-
-
37549054706
-
Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients
-
Jazet IM, Schaart G et al (2008) Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients. Diabetologia51:309-319.
-
(2008)
Diabetologia
, vol.51
, pp. 309-319
-
-
Jazet, I.M.1
Schaart, G.2
-
65
-
-
21744463063
-
Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle
-
Jorgensen SB, Wojtaszewski JF et al (2005) Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle. FASEB J19:1146-1148.
-
(2005)
FASEB J
, vol.19
, pp. 1146-1148
-
-
Jorgensen, S.B.1
Wojtaszewski, J.F.2
-
66
-
-
33845881411
-
Mechanisms linking obesity to insulin resistance and type 2 diabetes
-
Kahn SE, Hull RL et al (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature444:840-846.
-
(2006)
Nature
, vol.444
, pp. 840-846
-
-
Kahn, S.E.1
Hull, R.L.2
-
67
-
-
0038825044
-
Glucotoxicity and beta-cell failure in type 2 diabetes mellitus
-
Kaiser N, Leibowitz G et al (2003) Glucotoxicity and beta-cell failure in type 2 diabetes mellitus. J Pediatr Endocrinol Metab16:5-22.
-
(2003)
J Pediatr Endocrinol Metab
, vol.16
, pp. 5-22
-
-
Kaiser, N.1
Leibowitz, G.2
-
68
-
-
0030847432
-
Acute stimulation of glucose metabolism in mice by leptin treatment
-
Kamohara S, Burcelin R et al (1997) Acute stimulation of glucose metabolism in mice by leptin treatment. Nature389:374-377.
-
(1997)
Nature
, vol.389
, pp. 374-377
-
-
Kamohara, S.1
Burcelin, R.2
-
69
-
-
0043025606
-
Increased visceral fat and serum levels of triglyceride are associated with insulin resistance in Japanese metabolically obese, normal weight subjects with normal glucose tolerance
-
Katsuki A, Sumida Y et al (2003) Increased visceral fat and serum levels of triglyceride are associated with insulin resistance in Japanese metabolically obese, normal weight subjects with normal glucose tolerance. Diabetes Care26:2341-2344.
-
(2003)
Diabetes Care
, vol.26
, pp. 2341-2344
-
-
Katsuki, A.1
Sumida, Y.2
-
70
-
-
0038363852
-
AMP-activated protein kinase can induce apoptosis of insulinproducing MIN6 cells through stimulation of c-Jun-N-terminal kinase
-
Kefas BA, Cai Y et al (2003a) AMP-activated protein kinase can induce apoptosis of insulinproducing MIN6 cells through stimulation of c-Jun-N-terminal kinase. J Mol Endocrinol30:151-161.
-
(2003)
J Mol Endocrinol
, vol.30
, pp. 151-161
-
-
Kefas, B.A.1
Cai, Y.2
-
71
-
-
0037301056
-
AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase
-
Kefas BA, Heimberg H et al (2003b) AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase. Diabetologia46:250-254.
-
(2003)
Diabetologia
, vol.46
, pp. 250-254
-
-
Kefas, B.A.1
Heimberg, H.2
-
72
-
-
2942748289
-
AMPK activity is diminished in tissues of IL-6 knockout mice: The effect of exercise
-
Kelly M, Keller C et al (2004) AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise. Biochem Biophys Res Commun320:449-454.
-
(2004)
Biochem Biophys Res Commun
, vol.320
, pp. 449-454
-
-
Kelly, M.1
Keller, C.2
-
73
-
-
3142677140
-
Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase
-
Kim MS, Park JY et al (2004) Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med10:727-733.
-
(2004)
Nat Med
, vol.10
, pp. 727-733
-
-
Kim, M.S.1
Park, J.Y.2
-
74
-
-
33847009048
-
AICAR potentiates ROS production induced by chronic high glucose: Roles of AMPK in pancreatic beta-cell apoptosis
-
Kim WH, Lee JW et al (2007) AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis. Cell Signal19:791-805.
-
(2007)
Cell Signal
, vol.19
, pp. 791-805
-
-
Kim, W.H.1
Lee, J.W.2
-
75
-
-
0037034257
-
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
-
Knowler WC, Barrett-Connor E et al (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med346:393-403.
-
(2002)
N Engl J Med
, vol.346
, pp. 393-403
-
-
Knowler, W.C.1
Barrett-Connor, E.2
-
76
-
-
0242600806
-
5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes
-
Koistinen HA, Galuska D et al (2003) 5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. Diabetes52:1066-1072.
-
(2003)
Diabetes
, vol.52
, pp. 1066-1072
-
-
Koistinen, H.A.1
Galuska, D.2
-
77
-
-
21644453934
-
Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase
-
Kola B, Hubina E et al (2005) Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. J Biol Chem 280:25196-25201.
-
(2005)
J Biol Chem
, vol.280
, pp. 25196-25201
-
-
Kola, B.1
Hubina, E.2
-
78
-
-
27144506185
-
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
-
Koo SH, Flechner L et al (2005) The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature437:1109-1111.
-
(2005)
Nature
, vol.437
, pp. 1109-1111
-
-
Koo, S.H.1
Flechner, L.2
-
79
-
-
0037135523
-
Disruption of adiponectin causes insulin resistance and neointimal formation
-
Kubota N, Terauchi Y et al (2002) Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem277:25863-25866.
-
(2002)
J Biol Chem
, vol.277
, pp. 25863-25866
-
-
Kubota, N.1
Terauchi, Y.2
-
80
-
-
0032765396
-
50 AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle
-
Kurth-Kraczek EJ, Hirshman MF et al (1999) 50 AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle. Diabetes48:1667-1671.
-
(1999)
Diabetes
, vol.48
, pp. 1667-1671
-
-
Kurth-Kraczek, E.J.1
Hirshman, M.F.2
-
81
-
-
33845399894
-
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
-
Lagouge M, Argmann C et al (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell127:1109-1122.
-
(2006)
Cell
, vol.127
, pp. 1109-1122
-
-
Lagouge, M.1
Argmann, C.2
-
82
-
-
55549096745
-
SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation
-
Lan F, Cacicedo JM et al (2008) SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J Biol Chem283:27628-27635.
-
(2008)
J Biol Chem
, vol.283
, pp. 27628-27635
-
-
Lan, F.1
Cacicedo, J.M.2
-
83
-
-
33746419647
-
Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects
-
Larson-Meyer DE, Heilbronn LK et al (2006) Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects. Diabetes Care29:1337-1344.
-
(2006)
Diabetes Care
, vol.29
, pp. 1337-1344
-
-
Larson-Meyer, D.E.1
Heilbronn, L.K.2
-
84
-
-
0347560375
-
nNOS and eNOS modulate cGMP formation and vascular response in contracting fast-twitch skeletal muscle
-
Lau KS, Grange RW et al (2000) nNOS and eNOS modulate cGMP formation and vascular response in contracting fast-twitch skeletal muscle. Physiol Genomics2:21-27.
-
(2000)
Physiol Genomics
, vol.2
, pp. 21-27
-
-
Lau, K.S.1
Grange, R.W.2
-
85
-
-
0032541083
-
The 50-AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex
-
Leclerc I, Kahn A et al (1998) The 50-AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex. FEBS Lett431:180-184.
-
(1998)
FEBS Lett
, vol.431
, pp. 180-184
-
-
Leclerc, I.1
Kahn, A.2
-
86
-
-
0035406121
-
Hepatocyte nuclear factor-4alpha involved in type 1 maturityonset diabetes of the young is a novel target of AMP-activated protein kinase
-
Leclerc I, Lenzner C et al (2001) Hepatocyte nuclear factor-4alpha involved in type 1 maturityonset diabetes of the young is a novel target of AMP-activated protein kinase. Diabetes50:1515-1521.
-
(2001)
Diabetes
, vol.50
, pp. 1515-1521
-
-
Leclerc, I.1
Lenzner, C.2
-
87
-
-
2442691889
-
Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: Impact on glucose-stimulated insulin secretion
-
Leclerc I, Woltersdorf WW et al (2004) Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab286:E1023-E1031.
-
(2004)
Am J Physiol Endocrinol Metab
, vol.286
, pp. E1023-E1031
-
-
Leclerc, I.1
Woltersdorf, W.W.2
-
88
-
-
33644802810
-
Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase
-
Lee WJ, Lee IK et al (2005a) Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase. Arterioscler Thromb Vasc Biol25:2488-2494.
-
(2005)
Arterioscler Thromb Vasc Biol
, vol.25
, pp. 2488-2494
-
-
Lee, W.J.1
Lee, I.K.2
-
89
-
-
19744372144
-
Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle
-
Lee WJ, Song KH et al (2005b) Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. Biochem Biophys Res Commun332:885-891.
-
(2005)
Biochem Biophys Res Commun
, vol.332
, pp. 885-891
-
-
Lee, W.J.1
Song, K.H.2
-
90
-
-
69949129312
-
Skeletal muscle AMP-activated protein kinase is essential for the metabolic response to exercise in vivo
-
Lee-Young RS, Griffee SR et al (2009) Skeletal muscle AMP-activated protein kinase is essential for the metabolic response to exercise in vivo. J Biol Chem284:23925-23934.
-
(2009)
J Biol Chem
, vol.284
, pp. 23925-23934
-
-
Lee-Young, R.S.1
Griffee, S.R.2
-
91
-
-
77951727854
-
Endothelial nitric oxide synthase is central to skeletal muscle metabolic regulation and enzymatic signaling during exercise in vivo
-
Lee-Young RS, Ayala JE et al (2010) Endothelial nitric oxide synthase is central to skeletal muscle metabolic regulation and enzymatic signaling during exercise in vivo. Am J Physiol Regul Integr Comp Physiol298:R1399-R1408.
-
(2010)
Am J Physiol Regul Integr Comp Physiol
, vol.298
, pp. R1399-R1408
-
-
Lee-Young, R.S.1
Ayala, J.E.2
-
92
-
-
22744449914
-
Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism
-
Liao Y, Takashima S et al (2005) Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism. Cardiovasc Res67:705-713.
-
(2005)
Cardiovasc Res
, vol.67
, pp. 705-713
-
-
Liao, Y.1
Takashima, S.2
-
93
-
-
1642335469
-
AICAR stimulates adiponectin and inhibits cytokines in adipose tissue
-
Lihn AS, Jessen N et al (2004) AICAR stimulates adiponectin and inhibits cytokines in adipose tissue. Biochem Biophys Res Commun316:853-858.
-
(2004)
Biochem Biophys Res Commun
, vol.316
, pp. 853-858
-
-
Lihn, A.S.1
Jessen, N.2
-
94
-
-
0012785395
-
Metformin reverses fatty liver disease in obese, leptin-deficient mice
-
Lin HZ, Yang SQ et al (2000) Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat Med6:998-1003.
-
(2000)
Nat Med
, vol.6
, pp. 998-1003
-
-
Lin, H.Z.1
Yang, S.Q.2
-
95
-
-
35148827677
-
Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle
-
Lira VA, Soltow QA et al (2007) Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle. Am J Physiol Endocrinol Metab293:E1062-E1068.
-
(2007)
Am J Physiol Endocrinol Metab
, vol.293
, pp. E1062-E1068
-
-
Lira, V.A.1
Soltow, Q.A.2
-
96
-
-
0034074153
-
5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase
-
Lochhead PA, Salt IP et al (2000) 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase. Diabetes49:896-903.
-
(2000)
Diabetes
, vol.49
, pp. 896-903
-
-
Lochhead, P.A.1
Salt, I.P.2
-
97
-
-
12844281251
-
AMPK, the metabolic syndrome and cancer
-
Luo Z, Saha AK et al (2005) AMPK, the metabolic syndrome and cancer. Trends Pharmacol Sci26:69-76.
-
(2005)
Trends Pharmacol Sci
, vol.26
, pp. 69-76
-
-
Luo, Z.1
Saha, A.K.2
-
98
-
-
0036318319
-
Lipotoxicity in human pancreatic islets and the protective effect of metformin
-
Lupi R, Del Guerra S et al (2002) Lipotoxicity in human pancreatic islets and the protective effect of metformin. Diabetes 51(Suppl1):S134-S137.
-
(2002)
Diabetes
, vol.51
, pp. S134-S137
-
-
Lupi, R.1
Del Guerra, S.2
-
99
-
-
0035462629
-
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein
-
Maeda N, Takahashi M et al (2001) PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes50:2094-2099.
-
(2001)
Diabetes
, vol.50
, pp. 2094-2099
-
-
Maeda, N.1
Takahashi, M.2
-
100
-
-
33646070557
-
Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin-induced diabetic rats
-
Majithiya JB, Balaraman R (2006) Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin-induced diabetic rats. Life Sci78:2615-2624.
-
(2006)
Life Sci
, vol.78
, pp. 2615-2624
-
-
Majithiya, J.B.1
Balaraman, R.2
-
101
-
-
33745224043
-
Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle
-
Martin TL, Alquier T et al (2006) Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle. J Biol Chem281:18933-18941.
-
(2006)
J Biol Chem
, vol.281
, pp. 18933-18941
-
-
Martin, T.L.1
Alquier, T.2
-
102
-
-
3042593895
-
Possible involvement of AMP-activated protein kinase in obesity resistance induced by respiratory uncoupling in white fat
-
Matejkova O, Mustard KJ et al (2004) Possible involvement of AMP-activated protein kinase in obesity resistance induced by respiratory uncoupling in white fat. FEBS Lett569:245-248.
-
(2004)
FEBS Lett
, vol.569
, pp. 245-248
-
-
Matejkova, O.1
Mustard, K.J.2
-
103
-
-
0032575337
-
Limb blood flow during exercise is dependent on nitric oxide
-
Maxwell AJ, Schauble E et al (1998) Limb blood flow during exercise is dependent on nitric oxide. Circulation98:369-374.
-
(1998)
Circulation
, vol.98
, pp. 369-374
-
-
Maxwell, A.J.1
Schauble, E.2
-
104
-
-
0031425839
-
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
-
Merrill GF, Kurth EJ et al (1997) AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol273:E1107-E1112.
-
(1997)
Am J Physiol
, vol.273
, pp. E1107-E1112
-
-
Merrill, G.F.1
Kurth, E.J.2
-
105
-
-
0035957375
-
Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1
-
Michael LF, Wu Z et al (2001) Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1. Proc Natl Acad Sci USA98:3820-3825.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3820-3825
-
-
Michael, L.F.1
Wu, Z.2
-
106
-
-
36749087548
-
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
-
Milne JC, Lambert PD et al (2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature450:712-716.
-
(2007)
Nature
, vol.450
, pp. 712-716
-
-
Milne, J.C.1
Lambert, P.D.2
-
107
-
-
0032971214
-
Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats
-
Minokoshi Y, Haque MS et al (1999) Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats. Diabetes48:287-291.
-
(1999)
Diabetes
, vol.48
, pp. 287-291
-
-
Minokoshi, Y.1
Haque, M.S.2
-
108
-
-
0037122766
-
Leptin stimulates fatty-acid oxidation by activating AMPactivated protein kinase
-
Minokoshi Y, Kim YB et al (2002) Leptin stimulates fatty-acid oxidation by activating AMPactivated protein kinase. Nature415:339-343.
-
(2002)
Nature
, vol.415
, pp. 339-343
-
-
Minokoshi, Y.1
Kim, Y.B.2
-
109
-
-
1842484296
-
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
-
Minokoshi Y, Alquier T et al (2004) AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature428:569-574.
-
(2004)
Nature
, vol.428
, pp. 569-574
-
-
Minokoshi, Y.1
Alquier, T.2
-
110
-
-
0038054341
-
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
-
Mootha VK, Lindgren CM et al (2003) PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet34:267-273.
-
(2003)
Nat Genet
, vol.34
, pp. 267-273
-
-
Mootha, V.K.1
Lindgren, C.M.2
-
111
-
-
0031731021
-
The activation of p38 MAPK by the beta-adrenergic agonist isoproterenol in rat epididymal fat cells
-
Moule SK, Denton RM (1998) The activation of p38 MAPK by the beta-adrenergic agonist isoproterenol in rat epididymal fat cells. FEBS Lett439:287-290.
-
(1998)
FEBS Lett
, vol.439
, pp. 287-290
-
-
Moule, S.K.1
Denton, R.M.2
-
112
-
-
25144454432
-
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice
-
Moynihan KA, Grimm AA et al (2005) Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metab2:105-117.
-
(2005)
Cell Metab
, vol.2
, pp. 105-117
-
-
Moynihan, K.A.1
Grimm, A.A.2
-
113
-
-
0033559856
-
AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: Evidence that sn-glycerol-3-phosphate acyltransferase is a novel target
-
Muoio DM, Seefeld K et al (1999) AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem J 338(Pt3):783-791.
-
(1999)
Biochem J
, vol.338
, pp. 783-791
-
-
Muoio, D.M.1
Seefeld, K.2
-
114
-
-
0022970945
-
Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
-
Murry CE, Jennings RB et al (1986) Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation74:1124-1136.
-
(1986)
Circulation
, vol.74
, pp. 1124-1136
-
-
Murry, C.E.1
Jennings, R.B.2
-
115
-
-
0035039274
-
AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise
-
Musi N, Fujii N et al (2001) AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise. Diabetes50:921-927.
-
(2001)
Diabetes
, vol.50
, pp. 921-927
-
-
Musi, N.1
Fujii, N.2
-
116
-
-
48449094498
-
AMPK and PPARdelta agonists are exercise mimetics
-
Narkar VA, Downes M et al (2008) AMPK and PPARdelta agonists are exercise mimetics. Cell134:405-415.
-
(2008)
Cell
, vol.134
, pp. 405-415
-
-
Narkar, V.A.1
Downes, M.2
-
117
-
-
57349160286
-
Medical management of hyperglycaemia in type 2 diabetes mellitus: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
-
Nathan DM, Buse JB et al (2009) Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia52:17-30.
-
(2009)
Diabetologia
, vol.52
, pp. 17-30
-
-
Nathan, D.M.1
Buse, J.B.2
-
118
-
-
33646346627
-
Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists
-
Nawrocki AR, Rajala MW et al (2006) Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. J Biol Chem281:2654-2660.
-
(2006)
J Biol Chem
, vol.281
, pp. 2654-2660
-
-
Nawrocki, A.R.1
Rajala, M.W.2
-
119
-
-
0038644536
-
Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference
-
Neuschwander-Tetri BA, Caldwell SH (2003) Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology37:1202-1219.
-
(2003)
Hepatology
, vol.37
, pp. 1202-1219
-
-
Neuschwander-Tetri, B.A.1
Caldwell, S.H.2
-
120
-
-
58149345626
-
Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle
-
Nieto-Vazquez I, Fernandez-Veledo S et al (2008) Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle. Diabetes57:3211-3221.
-
(2008)
Diabetes
, vol.57
, pp. 3211-3221
-
-
Nieto-Vazquez, I.1
Fernandez-Veledo, S.2
-
121
-
-
1142297593
-
Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection
-
Nishino Y, Miura T et al (2004) Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection. Cardiovasc Res61:610-619.
-
(2004)
Cardiovasc Res
, vol.61
, pp. 610-619
-
-
Nishino, Y.1
Miura, T.2
-
122
-
-
55749090598
-
AMP-activated protein kinase agonist dose dependently improves function and reduces apoptosis in glucotoxic beta-cells without changing triglyceride levels
-
Nyblom HK, Sargsyan E et al (2008) AMP-activated protein kinase agonist dose dependently improves function and reduces apoptosis in glucotoxic beta-cells without changing triglyceride levels. J Mol Endocrinol41:187-194.
-
(2008)
J Mol Endocrinol
, vol.41
, pp. 187-194
-
-
Nyblom, H.K.1
Sargsyan, E.2
-
123
-
-
1242274390
-
Rapid transformation of white adipocytes into fat-oxidizing machines
-
Orci L, Cook WS et al (2004) Rapid transformation of white adipocytes into fat-oxidizing machines. Proc Natl Acad Sci USA101:2058-2063.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 2058-2063
-
-
Orci, L.1
Cook, W.S.2
-
124
-
-
0035957040
-
Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages
-
Ouchi N, Kihara S et al (2001) Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation103:1057-1063.
-
(2001)
Circulation
, vol.103
, pp. 1057-1063
-
-
Ouchi, N.1
Kihara, S.2
-
125
-
-
77950246109
-
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
-
Pacholec M, Bleasdale JE et al (2010) SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem285:8340-8351.
-
(2010)
J Biol Chem
, vol.285
, pp. 8340-8351
-
-
Pacholec, M.1
Bleasdale, J.E.2
-
126
-
-
24144459843
-
Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistin
-
Palanivel R, Sweeney G (2005) Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistin. FEBS Lett579:5049-5054.
-
(2005)
FEBS Lett
, vol.579
, pp. 5049-5054
-
-
Palanivel, R.1
Sweeney, G.2
-
127
-
-
0030935652
-
Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study
-
Pan XR, Li GW et al (1997) Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care20:537-544.
-
(1997)
Diabetes Care
, vol.20
, pp. 537-544
-
-
Pan, X.R.1
Li, G.W.2
-
128
-
-
0037031840
-
Coordinate regulation of malonyl-CoA decarboxylase, snglycerol- 3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise
-
Park H, Kaushik VK et al (2002) Coordinate regulation of malonyl-CoA decarboxylase, snglycerol- 3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. J Biol Chem277:32571-32577.
-
(2002)
J Biol Chem
, vol.277
, pp. 32571-32577
-
-
Park, H.1
Kaushik, V.K.2
-
129
-
-
0038025371
-
Mitochondrial dysfunction in the elderly: Possible role in insulin resistance
-
Petersen KF, Befroy D et al (2003) Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science300:1140-1142.
-
(2003)
Science
, vol.300
, pp. 1140-1142
-
-
Petersen, K.F.1
Befroy, D.2
-
130
-
-
0037342120
-
Modulation of circulating and adipose tissue adiponectin levels by antidiabetic therapy
-
Phillips SA, Ciaraldi TP et al (2003) Modulation of circulating and adipose tissue adiponectin levels by antidiabetic therapy. Diabetes52:667-674.
-
(2003)
Diabetes
, vol.52
, pp. 667-674
-
-
Phillips, S.A.1
Ciaraldi, T.P.2
-
131
-
-
3042681042
-
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
-
Picard F, Kurtev M et al (2004) Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature429:771-776.
-
(2004)
Nature
, vol.429
, pp. 771-776
-
-
Picard, F.1
Kurtev, M.2
-
132
-
-
1842864234
-
Plasma adiponectin levels and risk of myocardial infarction in men
-
Pischon T, Girman CJ et al (2004) Plasma adiponectin levels and risk of myocardial infarction in men. JAMA291:1730-1737.
-
(2004)
JAMA
, vol.291
, pp. 1730-1737
-
-
Pischon, T.1
Girman, C.J.2
-
133
-
-
20144386698
-
Long-term AICAR administration and exercise prevents diabetes in ZDF rats
-
Pold R, Jensen LS et al (2005) Long-term AICAR administration and exercise prevents diabetes in ZDF rats. Diabetes54:928-934.
-
(2005)
Diabetes
, vol.54
, pp. 928-934
-
-
Pold, R.1
Jensen, L.S.2
-
134
-
-
0036896505
-
Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: Role in beta-cell adaptation and failure in the etiology of diabetes
-
Prentki M, Joly E et al (2002) Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes. Diabetes 51(Suppl 3):S405-S413.
-
(2002)
Diabetes
, vol.51
, pp. S405-S413
-
-
Prentki, M.1
Joly, E.2
-
135
-
-
12344323484
-
Type 2 diabetes-a matter of beta-cell life and death?
-
Rhodes CJ (2005) Type 2 diabetes-a matter of beta-cell life and death? Science307:380-384.
-
(2005)
Science
, vol.307
, pp. 380-384
-
-
Rhodes, C.J.1
-
136
-
-
40749090482
-
Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity
-
Riboulet-Chavey A, Diraison F et al (2008) Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity. Diabetes57:415-423.
-
(2008)
Diabetes
, vol.57
, pp. 415-423
-
-
Riboulet-Chavey, A.1
Diraison, F.2
-
137
-
-
28044464932
-
Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo
-
Richards SK, Parton LE et al (2005) Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo. J Endocrinol187:225-235.
-
(2005)
J Endocrinol
, vol.187
, pp. 225-235
-
-
Richards, S.K.1
Parton, L.E.2
-
138
-
-
0032856430
-
Acute exercise increases nitric oxide synthase activity in skeletal muscle
-
Roberts CK, Barnard RJ et al (1999) Acute exercise increases nitric oxide synthase activity in skeletal muscle. Am J Physiol277:E390-E394.
-
(1999)
Am J Physiol
, vol.277
, pp. E390-E394
-
-
Roberts, C.K.1
Barnard, R.J.2
-
139
-
-
34547906123
-
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1
-
Rodgers JT, Puigserver P (2007) Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci USA104:12861-12866.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 12861-12866
-
-
Rodgers, J.T.1
Puigserver, P.2
-
140
-
-
18244386043
-
Expression of the uncoupling protein 1 from the aP2 gene promoter stimulates mitochondrial biogenesis in unilocular adipocytes in vivo
-
Rossmeisl M, Barbatelli G et al (2002) Expression of the uncoupling protein 1 from the aP2 gene promoter stimulates mitochondrial biogenesis in unilocular adipocytes in vivo. Eur J Biochem269:19-28.
-
(2002)
Eur J Biochem
, vol.269
, pp. 19-28
-
-
Rossmeisl, M.1
Barbatelli, G.2
-
141
-
-
11144283703
-
Metabolic activation of AMP kinase in vascular smooth muscle
-
Rubin LJ, Magliola L et al (2005) Metabolic activation of AMP kinase in vascular smooth muscle. J Appl Physiol 98:296-306.
-
(2005)
J Appl Physiol
, vol.98
, pp. 296-306
-
-
Rubin, L.J.1
Magliola, L.2
-
142
-
-
78149279712
-
AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury
-
Russell RR3rd, Li J et al (2004) AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. J Clin Invest114:495-503.
-
(2004)
J Clin Invest
, vol.114
, pp. 495-503
-
-
Russell, R.R.1
Li, J.2
-
143
-
-
0346374720
-
Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo
-
Saha AK, Avilucea PR et al (2004) Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo. Biochem Biophys Res Commun314:580-585.
-
(2004)
Biochem Biophys Res Commun
, vol.314
, pp. 580-585
-
-
Saha, A.K.1
Avilucea, P.R.2
-
144
-
-
0035856949
-
Insulin signalling and the regulation of glucose and lipid metabolism
-
Saltiel AR, Kahn CR (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature414:799-806.
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
145
-
-
34147152841
-
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade
-
Sanders MJ, Grondin PO et al (2007) Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem J403:139-148.
-
(2007)
Biochem J
, vol.403
, pp. 139-148
-
-
Sanders, M.J.1
Grondin, P.O.2
-
146
-
-
33645938915
-
Cytokine secretion by human adipocytes is differentially regulated by adiponectin, AICAR, and troglitazone
-
Sell H, Dietze-Schroeder D et al (2006) Cytokine secretion by human adipocytes is differentially regulated by adiponectin, AICAR, and troglitazone. Biochem Biophys Res Commun 343:700-706.
-
(2006)
Biochem Biophys Res Commun
, vol.343
, pp. 700-706
-
-
Sell, H.1
Dietze-Schroeder, D.2
-
147
-
-
28844433635
-
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
-
Shaw RJ, Lamia KA et al (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science310:1642-1646.
-
(2005)
Science
, vol.310
, pp. 1642-1646
-
-
Shaw, R.J.1
Lamia, K.A.2
-
148
-
-
19944369735
-
Adiponectin-mediated modulation of hypertrophic signals in the heart
-
Shibata R, Ouchi N et al (2004a) Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med10:1384-1389.
-
(2004)
Nat Med
, vol.10
, pp. 1384-1389
-
-
Shibata, R.1
Ouchi, N.2
-
149
-
-
3142616447
-
Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling
-
Shibata R, Ouchi N et al (2004b) Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling. J Biol Chem 279:28670-28674.
-
(2004)
J Biol Chem
, vol.279
, pp. 28670-28674
-
-
Shibata, R.1
Ouchi, N.2
-
150
-
-
27144457438
-
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms
-
Shibata R, Sato K et al (2005) Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med11:1096-1103.
-
(2005)
Nat Med
, vol.11
, pp. 1096-1103
-
-
Shibata, R.1
Sato, K.2
-
151
-
-
21044443195
-
AMP kinase activation with AICAR further increases fatty acid oxidation and blunts triacylglycerol hydrolysis in contracting rat soleus muscle
-
Smith AC, Bruce CR et al (2005) AMP kinase activation with AICAR further increases fatty acid oxidation and blunts triacylglycerol hydrolysis in contracting rat soleus muscle. J Physiol565:547-553.
-
(2005)
J Physiol
, vol.565
, pp. 547-553
-
-
Smith, A.C.1
Bruce, C.R.2
-
152
-
-
0036165489
-
5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice
-
Song XM, Fiedler M et al (2002) 5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice. Diabetologia 45:56-65.
-
(2002)
Diabetologia
, vol.45
, pp. 56-65
-
-
Song, X.M.1
Fiedler, M.2
-
153
-
-
67650914230
-
AMPK in health and disease
-
Steinberg GR, Kemp BE (2009) AMPK in health and disease. Physiol Rev89:1025-1078.
-
(2009)
Physiol Rev
, vol.89
, pp. 1025-1078
-
-
Steinberg, G.R.1
Kemp, B.E.2
-
154
-
-
33751552452
-
Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling
-
Steinberg GR, Michell BJ et al (2006) Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metab4:465-474.
-
(2006)
Cell Metab
, vol.4
, pp. 465-474
-
-
Steinberg, G.R.1
Michell, B.J.2
-
155
-
-
0036088360
-
Progressive increase in human skeletal muscle AMPKalpha2 activity and ACC phosphorylation during exercise
-
Stephens TJ, Chen ZP et al (2002) Progressive increase in human skeletal muscle AMPKalpha2 activity and ACC phosphorylation during exercise. Am J Physiol Endocrinol Metab 282:E688-E694.
-
(2002)
Am J Physiol Endocrinol Metab
, vol.282
, pp. E688-E694
-
-
Stephens, T.J.1
Chen, Z.P.2
-
156
-
-
0036889017
-
AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle
-
Stoppani J, Hildebrandt AL et al (2002) AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle. Am J Physiol Endocrinol Metab 283:E1239-E1248.
-
(2002)
Am J Physiol Endocrinol Metab
, vol.283
, pp. E1239-E1248
-
-
Stoppani, J.1
Hildebrandt, A.L.2
-
157
-
-
0028073143
-
Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase
-
Sullivan JE, Brocklehurst KJ et al (1994) Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase. FEBS Lett353:33-36.
-
(1994)
FEBS Lett
, vol.353
, pp. 33-36
-
-
Sullivan, J.E.1
Brocklehurst, K.J.2
-
158
-
-
34548857700
-
SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B
-
Sun C, Zhang F et al (2007) SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab6:307-319.
-
(2007)
Cell Metab
, vol.6
, pp. 307-319
-
-
Sun, C.1
Zhang, F.2
-
159
-
-
77952095690
-
Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo
-
Sun G, Tarasov AI et al (2010) Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo. Diabetologia53(5):924-936.
-
(2010)
Diabetologia
, vol.53
, Issue.5
, pp. 924-936
-
-
Sun, G.1
Tarasov, A.I.2
-
160
-
-
33845949733
-
Dissecting the role of 50-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase
-
Suter M, Riek U et al (2006) Dissecting the role of 50-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. J Biol Chem281:32207-32216.
-
(2006)
J Biol Chem
, vol.281
, pp. 32207-32216
-
-
Suter, M.1
Riek, U.2
-
161
-
-
34250182374
-
Leptin stimulates fatty acid oxidation and peroxisome proliferator- activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase
-
Suzuki A, Okamoto S et al (2007) Leptin stimulates fatty acid oxidation and peroxisome proliferator- activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase. Mol Cell Biol27:4317-4327.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 4317-4327
-
-
Suzuki, A.1
Okamoto, S.2
-
162
-
-
0037059013
-
Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation
-
Tomas E, Tsao TS et al (2002) Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci USA99:16309-16313.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 16309-16313
-
-
Tomas, E.1
Tsao, T.S.2
-
163
-
-
33947173689
-
AS160 phosphorylation is associated with activation of alpha2- beta2gamma1- but not alpha2beta2gamma3-AMPK trimeric complex in skeletal muscle during exercise in humans
-
Treebak JT, Birk JB et al (2007) AS160 phosphorylation is associated with activation of alpha2- beta2gamma1- but not alpha2beta2gamma3-AMPK trimeric complex in skeletal muscle during exercise in humans. Am J Physiol Endocrinol Metab292:E715-E722.
-
(2007)
Am J Physiol Endocrinol Metab
, vol.292
, pp. E715-E722
-
-
Treebak, J.T.1
Birk, J.B.2
-
164
-
-
0035799806
-
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
-
Tuomilehto J, Lindstrom J et al (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med344:1343-1350.
-
(2001)
N Engl J Med
, vol.344
, pp. 1343-1350
-
-
Tuomilehto, J.1
Lindstrom, J.2
-
165
-
-
0028817815
-
U.K. prospective diabetes study. Overview of 6 years' therapy of type II diabetes: A progressive disease
-
U.K. Prospective Diabetes Study Group (1995) U.K. prospective diabetes study 16: Overview of 6 years' therapy of type II diabetes: a progressive disease. Diabetes44:1249-1258.
-
(1995)
Diabetes
, vol.44
, pp. 1249-1258
-
-
-
166
-
-
77950348878
-
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol
-
Um JH, Park SJ et al (2010) AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes59:554-563.
-
(2010)
Diabetes
, vol.59
, pp. 554-563
-
-
Um, J.H.1
Park, S.J.2
-
167
-
-
0029151863
-
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
-
Unger RH (1995) Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 44:863-870.
-
(1995)
Diabetes
, vol.44
, pp. 863-870
-
-
Unger, R.H.1
-
168
-
-
33845914986
-
Mechanisms linking obesity with cardiovascular disease
-
Van Gaal LF, Mertens IL et al (2006) Mechanisms linking obesity with cardiovascular disease. Nature444:875-880.
-
(2006)
Nature
, vol.444
, pp. 875-880
-
-
Van Gaal, L.F.1
Mertens, I.L.2
-
169
-
-
33744544094
-
Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression
-
Viana AY, Sakoda H et al (2006) Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression. Diabetes Res Clin Pract73:135-142.
-
(2006)
Diabetes Res Clin Pract
, vol.73
, pp. 135-142
-
-
Viana, A.Y.1
Sakoda, H.2
-
170
-
-
0037326307
-
Physiological role of AMP-activated protein kinase (AMPK): Insights from knockout mouse models
-
Viollet B, Andreelli F et al (2003) Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models. Biochem Soc Trans31:216-219.
-
(2003)
Biochem Soc Trans
, vol.31
, pp. 216-219
-
-
Viollet, B.1
Andreelli, F.2
-
171
-
-
34250665869
-
Troglitazone acutely activates AMP-activated protein kinase and inhibits insulin secretion from beta cells
-
Wang X, Zhou L et al (2007) Troglitazone acutely activates AMP-activated protein kinase and inhibits insulin secretion from beta cells. Life Sci81:160-165.
-
(2007)
Life Sci
, vol.81
, pp. 160-165
-
-
Wang, X.1
Zhou, L.2
-
172
-
-
33645093212
-
Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue
-
Watt MJ, Holmes AG et al (2006) Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue. Am J Physiol Endocrinol Metab290:E500-E508.
-
(2006)
Am J Physiol Endocrinol Metab
, vol.290
, pp. E500-E508
-
-
Watt, M.J.1
Holmes, A.G.2
-
173
-
-
33750908045
-
Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: A randomized controlled trial
-
Weiss EP, Racette SB et al (2006) Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. Am J Clin Nutr84:1033-1042.
-
(2006)
Am J Clin Nutr
, vol.84
, pp. 1033-1042
-
-
Weiss, E.P.1
Racette, S.B.2
-
174
-
-
0033527025
-
Guidelines for healthy weight
-
Willett WC, Dietz WH et al (1999) Guidelines for healthy weight. N Engl J Med341:427-434.
-
(1999)
N Engl J Med
, vol.341
, pp. 427-434
-
-
Willett, W.C.1
Dietz, W.H.2
-
175
-
-
0032792665
-
AMP-activated protein kinase, a metabolic master switch: Possible roles in type 2 diabetes
-
Winder WW, Hardie DG (1999) AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol277:E1-E10.
-
(1999)
Am J Physiol
, vol.277
, pp. E1-E10
-
-
Winder, W.W.1
Hardie, D.G.2
-
176
-
-
0033949848
-
Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle
-
Winder WW, Holmes BF et al (2000) Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle. J Appl Physiol88:2219-2226.
-
(2000)
J Appl Physiol
, vol.88
, pp. 2219-2226
-
-
Winder, W.W.1
Holmes, B.F.2
-
177
-
-
0035132417
-
Behavioral science research in diabetes: Lifestyle changes related to obesity, eating behavior, and physical activity
-
Wing RR, Goldstein MG et al (2001) Behavioral science research in diabetes: lifestyle changes related to obesity, eating behavior, and physical activity. Diabetes Care24:117-123.
-
(2001)
Diabetes Care
, vol.24
, pp. 117-123
-
-
Wing, R.R.1
Goldstein, M.G.2
-
178
-
-
0028275189
-
Hepatic 5'-AMP-activated protein kinase: Zonal distribution and relationship to acetyl-CoA carboxylase activity in varying nutritional states
-
Witters LA, Gao G et al (1994) Hepatic 5'-AMP-activated protein kinase: zonal distribution and relationship to acetyl-CoA carboxylase activity in varying nutritional states. Arch Biochem Biophys308:413-419.
-
(1994)
Arch Biochem Biophys
, vol.308
, pp. 413-419
-
-
Witters, L.A.1
Gao, G.2
-
179
-
-
0033815967
-
Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase
-
Woods A, Azzout-Marniche D et al (2000) Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase. Mol Cell Biol20:6704-6711.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 6704-6711
-
-
Woods, A.1
Azzout-Marniche, D.2
-
180
-
-
0041302377
-
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
-
Xu A, Wang Y et al (2003) The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest112:91-100.
-
(2003)
J Clin Invest
, vol.112
, pp. 91-100
-
-
Xu, A.1
Wang, Y.2
-
181
-
-
17944365228
-
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
-
Yamauchi T, Kamon J et al (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med7:941-946.
-
(2001)
Nat Med
, vol.7
, pp. 941-946
-
-
Yamauchi, T.1
Kamon, J.2
-
182
-
-
0036851817
-
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
-
Yamauchi T, Kamon J et al (2002) Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med8:1288-1295.
-
(2002)
Nat Med
, vol.8
, pp. 1288-1295
-
-
Yamauchi, T.1
Kamon, J.2
-
183
-
-
0037462684
-
Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis
-
Yamauchi T, Kamon J et al (2003) Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem278:2461-2468.
-
(2003)
J Biol Chem
, vol.278
, pp. 2461-2468
-
-
Yamauchi, T.1
Kamon, J.2
-
184
-
-
33749349202
-
Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice
-
Zang M, Xu S et al (2006) Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes 55:2180-2191.
-
(2006)
Diabetes
, vol.55
, pp. 2180-2191
-
-
Zang, M.1
Xu, S.2
-
185
-
-
33845416894
-
Role of the alpha2 isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia
-
Zarrinpashneh E, Carjaval K et al (2006) Role of the alpha2 isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia. Am J Physiol Heart Circ Physiol291(6):H2875-H2883.
-
(2006)
Am J Physiol Heart Circ Physiol
, vol.291
, Issue.6
, pp. H2875-H2883
-
-
Zarrinpashneh, E.1
Carjaval, K.2
-
186
-
-
55549135363
-
Identification of nitric oxide as an endogenous activator of the AMPactivated protein kinase in vascular endothelial cells
-
Zhang J, Xie Z et al (2008) Identification of nitric oxide as an endogenous activator of the AMPactivated protein kinase in vascular endothelial cells. J Biol Chem283:27452-27461.
-
(2008)
J Biol Chem
, vol.283
, pp. 27452-27461
-
-
Zhang, J.1
Xie, Z.2
-
187
-
-
0033830770
-
UCP-3 expression in skeletal muscle: Effects of exercise, hypoxia, and AMP-activated protein kinase
-
Zhou M, Lin BZ et al (2000) UCP-3 expression in skeletal muscle: effects of exercise, hypoxia, and AMP-activated protein kinase. Am J Physiol Endocrinol Metab279:E622-E629.
-
(2000)
Am J Physiol Endocrinol Metab
, vol.279
, pp. E622-E629
-
-
Zhou, M.1
Lin, B.Z.2
-
188
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
Zhou G, Myers R et al (2001) Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest108:1167-1174.
-
(2001)
J Clin Invest
, vol.108
, pp. 1167-1174
-
-
Zhou, G.1
Myers, R.2
-
189
-
-
50449090523
-
Berberine acutely inhibits insulin secretion from beta-cells through 30, 50-cyclic adenosine 50-monophosphate signaling pathway
-
Zhou L, Wang X et al (2008) Berberine acutely inhibits insulin secretion from beta-cells through 30, 50-cyclic adenosine 50-monophosphate signaling pathway. Endocrinology149:4510-4518.
-
(2008)
Endocrinology
, vol.149
, pp. 4510-4518
-
-
Zhou, L.1
Wang, X.2
-
190
-
-
0037058977
-
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
-
Zong H, Ren JM et al (2002) AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci USA99:15983-15987.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 15983-15987
-
-
Zong, H.1
Ren, J.M.2
-
191
-
-
57649180479
-
AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise
-
Zwetsloot KA, Westerkamp LM et al (2008) AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise. J Physiol586:6021-6035.
-
(2008)
J Physiol
, vol.586
, pp. 6021-6035
-
-
Zwetsloot, K.A.1
Westerkamp, L.M.2
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