-
1
-
-
0026640577
-
Fatty infiltration of the liver: Analysis of prevalence, radiological and clinical findings
-
el-Hassan, A.V., Ibrahim, E.M., al-Mulhim, F.A., Nabhan, A.A. & Chammas, M.Y. Fatty infiltration of the liver: analysis of prevalence, radiological and clinical findings. Br. J. Radiol. 65, 774-778 (1992).
-
(1992)
Br. J. Radiol.
, vol.65
, pp. 774-778
-
-
El-Hassan, A.V.1
Ibrahim, E.M.2
Al-Mulhim, F.A.3
Nabhan, A.A.4
Chammas, M.Y.5
-
2
-
-
0027999941
-
Prevalence of chronic liver disease in the general population of Northern Italy: The dionysis study
-
Bellentani, S. et al. Prevalence of chronic liver disease in the general population of Northern Italy: The Dionysis study. Hepatology 20, 1442-1449 (1994).
-
(1994)
Hepatology
, vol.20
, pp. 1442-1449
-
-
Bellentani, S.1
-
3
-
-
0033231294
-
Association of nonalcoholic fatty liver disease with insulin resistance
-
Marchesini, G. et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am. J. Med. 107, 450-455 (1999)
-
(1999)
Am. J. Med.
, vol.107
, pp. 450-455
-
-
Marchesini, G.1
-
4
-
-
0031038055
-
Nonalcoholic steatohepatitis
-
Sheth, S.G., Cordon, F.D. & Chopar, S. Nonalcoholic steatohepatitis. Ann. Intern. Med. 126, 137-145 (1997).
-
(1997)
Ann. Intern. Med.
, vol.126
, pp. 137-145
-
-
Sheth, S.G.1
Cordon, F.D.2
Chopar, S.3
-
5
-
-
0033038672
-
Nonalcoholic fatty liver disease: A spectrum of clinical pathological severity
-
Matteoni, C., Younossi, Z.M. & McCullough, A. Nonalcoholic fatty liver disease: a spectrum of clinical pathological severity. Gastroenterology 116, 1413-1419 (1999).
-
(1999)
Gastroenterology
, vol.116
, pp. 1413-1419
-
-
Matteoni, C.1
Younossi, Z.M.2
McCullough, A.3
-
6
-
-
0033329864
-
Liver pathology and metabolic syndrome X in severe obesity
-
Marceau, P. et al. Liver pathology and metabolic syndrome X in severe obesity. J Clin. Endocrinol. Metab. 84, 1513-1517 (1999).
-
(1999)
J Clin. Endocrinol. Metab.
, vol.84
, pp. 1513-1517
-
-
Marceau, P.1
-
7
-
-
0001513966
-
Obesity increases sensitivity of endotoxin liver injury: Implications for pathogenesis of steatohepatitis
-
Yang, S.Q., Lin, H.Z., Lane, M.D., Clemens, M. & Diehl, A.M. Obesity increases sensitivity of endotoxin liver injury: implications for pathogenesis of steatohepatitis. Proc. Natl. Acad. Sci. USA 94, 2557-2562 (1997).
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 2557-2562
-
-
Yang, S.Q.1
Lin, H.Z.2
Lane, M.D.3
Clemens, M.4
Diehl, A.M.5
-
8
-
-
0032417697
-
Obesity and mild hyperinsulinemia found in neuropeptide Y-U1 receptor deficient mice
-
Kushi, A. et al. Obesity and mild hyperinsulinemia found in neuropeptide Y-U1 receptor deficient mice. Proc. Natl. Acad. Sci USA 95, 15659-15664 (1998).
-
(1998)
Proc. Natl. Acad. Sci USA
, vol.95
, pp. 15659-15664
-
-
Kushi, A.1
-
9
-
-
0032532152
-
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: Model for congenital generalized lipodystrophy
-
Shimomura, I. et al. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev. 12, 3182-3194 (1998).
-
(1998)
Genes Dev.
, vol.12
, pp. 3182-3194
-
-
Shimomura, I.1
-
10
-
-
0025837055
-
Mechanism of metformin action in obese and lean non-insulin dependent diabetics subjects
-
DeFronzo, R.A., Barzilai, N. & Simonson, D.C. Mechanism of metformin action in obese and lean non-insulin dependent diabetics subjects. J. Clin. Endocrinol. Metab. 73, 1294-1301 (1991).
-
(1991)
J. Clin. Endocrinol. Metab.
, vol.73
, pp. 1294-1301
-
-
DeFronzo, R.A.1
Barzilai, N.2
Simonson, D.C.3
-
11
-
-
0029133235
-
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus
-
Stumvoll, M., Nurjhan, N., Perriello, C., Dailey, G. & Gerich, J.E. Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N. Engl. J. Med. 333, 550-554 (1995).
-
(1995)
N. Engl. J. Med.
, vol.333
, pp. 550-554
-
-
Stumvoll, M.1
Nurjhan, N.2
Perriello, C.3
Dailey, G.4
Gerich, J.E.5
-
12
-
-
0029819936
-
Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus
-
Cusi, K., Consoli, A. & DeFronzo, R.A. Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus. J. Clin. Endocrinol Metab. 81, 4059-4067 (1996).
-
(1996)
J. Clin. Endocrinol Metab.
, vol.81
, pp. 4059-4067
-
-
Cusi, K.1
Consoli, A.2
DeFronzo, R.A.3
-
13
-
-
0032697674
-
The anti-hyperglycemic effect of metformin
-
Wiernsperger, N.F. & Bailey, C.J. The anti-hyperglycemic effect of metformin. Drugs 58, 31-39 (1999).
-
(1999)
Drugs
, vol.58
, pp. 31-39
-
-
Wiernsperger, N.F.1
Bailey, C.J.2
-
14
-
-
0027847677
-
Anti hyperglycemic actions of guanidenoalkanoic acids: 3-guanidinopropionic acid ameliorates hyperglycemia in diabetic KKAy and C57BL-6J ob/ob mice and increases glucose disappearance in rhesus monkeys
-
Meglasson, M.D. et al. Anti hyperglycemic actions of guanidenoalkanoic acids: 3-guanidinopropionic acid ameliorates hyperglycemia in diabetic KKAy and C57BL-6J ob/ob mice and increases glucose disappearance in rhesus monkeys. J. Pharmacol. Exp. Ther. 266, 1454-1462 (1993).
-
(1993)
J. Pharmacol. Exp. Ther.
, vol.266
, pp. 1454-1462
-
-
Meglasson, M.D.1
-
15
-
-
0030756346
-
Protection from obesity-induced insulin-resistance in mice lacking TNFα function
-
Uysal, K.T., Wiesbrock, S.M., Marino, M.W. & Hotamisligil, G.S. Protection from obesity-induced insulin-resistance in mice lacking TNFα function. Nature 389, 610-614 (1997).
-
(1997)
Nature
, vol.389
, pp. 610-614
-
-
Uysal, K.T.1
Wiesbrock, S.M.2
Marino, M.W.3
Hotamisligil, G.S.4
-
16
-
-
0030467446
-
The OB protein (leptin) pathway - A link between adipose tissue mass and central neural networks
-
Campfield, L.A., Smith, F.J. & Burn, P. The OB protein (leptin) pathway - a link between adipose tissue mass and central neural networks. Horm. Metab. Res. 28, 619-632 (1996).
-
(1996)
Horm. Metab. Res.
, vol.28
, pp. 619-632
-
-
Campfield, L.A.1
Smith, F.J.2
Burn, P.3
-
17
-
-
0026506222
-
Subchronic treatment with metformin produces anorectic effect and reduces hyperinsulinemia in genetically obese Zucker rats
-
Rouru, J., Pesonen, V. & Koulu, M. Subchronic treatment with metformin produces anorectic effect and reduces hyperinsulinemia in genetically obese Zucker rats. Life Sci. 50, 1813-1820 (1992)
-
(1992)
Life Sci.
, vol.50
, pp. 1813-1820
-
-
Rouru, J.1
Pesonen, V.2
Koulu, M.3
-
18
-
-
0031869676
-
Effect of metformin on food intake in obese subjects
-
Paolisso, G. et al. Effect of metformin on food intake in obese subjects. Eur. J. Clin. Invest. 28, 441-446 (1998).
-
(1998)
Eur. J. Clin. Invest.
, vol.28
, pp. 441-446
-
-
Paolisso, G.1
-
19
-
-
0033536157
-
Cellular mechanisms of insulin resistance in humans
-
Shulman, G.I. Cellular mechanisms of insulin resistance in humans. Am. J. Cordiol. 84, 3J-10J (1999).
-
(1999)
Am. J. Cordiol.
, vol.84
-
-
Shulman, G.I.1
-
20
-
-
0026040202
-
Effects of metformin on glucose, insulin and lipid metabolism in patients with mild hypertriglyceridemia and non-insulin dependent diabetes by glucose tolerance test criteria
-
Holleneck, C.B., Johnston, P., Varasteh, B.B., Chen, V.D. & Reaven, G.M. Effects of metformin on glucose, insulin and lipid metabolism in patients with mild hypertriglyceridemia and non-insulin dependent diabetes by glucose tolerance test criteria. Diabete Metab. 17, 483-489 (1991).
-
(1991)
Diabete Metab.
, vol.17
, pp. 483-489
-
-
Holleneck, C.B.1
Johnston, P.2
Varasteh, B.B.3
Chen, V.D.4
Reaven, G.M.5
-
21
-
-
0027483152
-
Metformin and liver glycogen synthase activity in obese Zucker rats
-
Huupponen, R., Pyykko, K., Koulu, M. & Rouru, J. Metformin and liver glycogen synthase activity in obese Zucker rats. Res. Commun. Chem. Pathol. Pharmacol. 79, 219-227 (1993).
-
(1993)
Res. Commun. Chem. Pathol. Pharmacol.
, vol.79
, pp. 219-227
-
-
Huupponen, R.1
Pyykko, K.2
Koulu, M.3
Rouru, J.4
-
22
-
-
0031799223
-
Neonatal brown adipose tissue, UCP-1 and the novel uncoupling proteins
-
Ricquier, D. Neonatal brown adipose tissue, UCP-1 and the novel uncoupling proteins. Biochem. Soc. Trans. 26, 120-123 (1998).
-
(1998)
Biochem. Soc. Trans.
, vol.26
, pp. 120-123
-
-
Ricquier, D.1
-
23
-
-
0030739844
-
Pioglitazone and metformin reverse insulin resistance induced by tumor necrosis factor-alpha in liver cells
-
Solomon, S. S., Mishra, S.K., Cwik, C., Rajanna, B. & Postlethwaite, A.E. Pioglitazone and metformin reverse insulin resistance induced by tumor necrosis factor-alpha in liver cells. Horm. Metab. Res. 29, 379-382 (1997).
-
(1997)
Horm. Metab. Res.
, vol.29
, pp. 379-382
-
-
Solomon, S.S.1
Mishra, S.K.2
Cwik, C.3
Rajanna, B.4
Postlethwaite, A.E.5
-
24
-
-
0344624846
-
Bacterial lipopolysaccharide induces uncoupling protein-2 in hepatocytes via a tumor necrosis factor alpha-dependent mechanism
-
Cortez-Pinto, H. et al. Bacterial lipopolysaccharide induces uncoupling protein-2 in hepatocytes via a tumor necrosis factor alpha-dependent mechanism. Biochem. Biophys. Res. Commun. 251, 313-319 (1998).
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.251
, pp. 313-319
-
-
Cortez-Pinto, H.1
-
25
-
-
0032570828
-
Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 through the actions of neutral sphingomyleinase
-
Lawler, J.F., Yin, M., Diehl, A.M., Roberts, E. & Chatterjee, S. Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 through the actions of neutral sphingomyleinase. J. Biol. Chem. 273, 5053-5059 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5053-5059
-
-
Lawler, J.F.1
Yin, M.2
Diehl, A.M.3
Roberts, E.4
Chatterjee, S.5
-
26
-
-
0033605261
-
Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion
-
Chavin, K. et al. Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. J. Biol. Chem. 274, 5692-5700 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 5692-5700
-
-
Chavin, K.1
-
27
-
-
0029098097
-
Metformin induces an agonist-specific increase in albumin production by primary cultured rat hepatocytes
-
Zaibi, M.D. et al. Metformin induces an agonist-specific increase in albumin production by primary cultured rat hepatocytes. Biochem. Pharmacol. 50, 775-780 (1995).
-
(1995)
Biochem. Pharmacol.
, vol.50
, pp. 775-780
-
-
Zaibi, M.D.1
-
28
-
-
0033570119
-
Increased nuclear levels of SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus
-
Shimomura, I., Bashmakow, Y. & Horton, J.D. Increased nuclear levels of SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J. Biol. Chem. 274, 30028-30032 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 30028-30032
-
-
Shimomura, I.1
Bashmakow, Y.2
Horton, J.D.3
-
29
-
-
0028342565
-
Acute anti hyperglycemic actions of metformin in NIDDM. Evidence for suppression of lipid oxidation and hepatic glucose production
-
Perriello, C. et al. Acute anti hyperglycemic actions of metformin in NIDDM. Evidence for suppression of lipid oxidation and hepatic glucose production. Diabetes 43, 920-928 (1994).
-
(1994)
Diabetes
, vol.43
, pp. 920-928
-
-
Perriello, C.1
-
30
-
-
0023684548
-
Metformin enhances certain insulin actions in cultured rat hepatoma cells
-
Purrello, F. et al. Metformin enhances certain insulin actions in cultured rat hepatoma cells. Diabetologia 31, 385-389 (1988).
-
(1988)
Diabetologia
, vol.31
, pp. 385-389
-
-
Purrello, F.1
-
31
-
-
0025155412
-
Dual effect of metformin in cultured rat hepatocytes. Potentiation of insulin action and prevention of insulin-induced resistance
-
Melin, B. et al. Dual effect of metformin in cultured rat hepatocytes. potentiation of insulin action and prevention of insulin-induced resistance. Metabolism 39, 1089-1095 (1990).
-
(1990)
Metabolism
, vol.39
, pp. 1089-1095
-
-
Melin, B.1
-
32
-
-
0030061922
-
IRS-I mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance
-
Hotamisligil, C.S. et al. IRS-I mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance. Science 271, 665-668 (1996).
-
(1996)
Science
, vol.271
, pp. 665-668
-
-
Hotamisligil, C.S.1
-
33
-
-
0027243948
-
Cytokines and alcoholic liver disease
-
McClain, C.J., Hill, D.B., Schmidt, J. & Diehl, A.M. Cytokines and alcoholic liver disease. Semin. Liv. Dis. 13, 170-182 (1993).
-
(1993)
Semin. Liv. Dis.
, vol.13
, pp. 170-182
-
-
McClain, C.J.1
Hill, D.B.2
Schmidt, J.3
Diehl, A.M.4
-
34
-
-
0032835529
-
Essential role of tumor necrosis factor-alpha in alcohol-induced liver injury in mice
-
Yin, M. et al. Essential role of tumor necrosis factor-alpha in alcohol-induced liver injury in mice. Castroenterology 117, 942-952 (1999).
-
(1999)
Castroenterology
, vol.117
, pp. 942-952
-
-
Yin, M.1
-
35
-
-
0033570119
-
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
-
Shimomura, E., Bashmakov, Y. & Horton, J.D. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. J. Biol. Chem. 274, 30028-30032 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 30028-30032
-
-
Shimomura, E.1
Bashmakov, Y.2
Horton, J.D.3
-
36
-
-
0032959236
-
Lipids upregulate uncoupling protein-2 expression in rat hepatocytes
-
Cortez-Pinto, H., Lin, H.Z., Yang, S.Q., Odwin da Costa, S. & Diehl, A.M. Lipids upregulate uncoupling protein-2 expression in rat hepatocytes. Gastroenterology 116, 1184-1193 (1999).
-
(1999)
Gastroenterology
, vol.116
, pp. 1184-1193
-
-
Cortez-Pinto, H.1
Lin, H.Z.2
Yang, S.Q.3
Odwin Da Costa, S.4
Diehl, A.M.5
-
37
-
-
23444453884
-
Co-mitogenic effects of estrogens on DNA synthesis induced by various growth factors in cultured female hepatocytes
-
Ni, N. & Yager, J. Co-mitogenic effects of estrogens on DNA synthesis induced by various growth factors in cultured female hepatocytes. Hepatohgy 19, 182-190 (1994).
-
(1994)
Hepatohgy
, vol.19
, pp. 182-190
-
-
Ni, N.1
Yager, J.2
-
38
-
-
0028518860
-
Tumor necrosis factor induces c-jun during the regenerative response to liver injury
-
Diehl, A.M. et al. Tumor necrosis factor induces c-jun during the regenerative response to liver injury. Am. J. Physiol. 267, G552-G561 (1994).
-
(1994)
Am. J. Physiol.
, vol.267
-
-
Diehl, A.M.1
-
39
-
-
0034650757
-
Malonyl-coenzyme A is a potential mediator of cytotoxicity induced by fatty acid synthase inhibition in human breast cancer cells and xenografts
-
Pizer, E.S. et al. Malonyl-coenzyme A is a potential mediator of cytotoxicity induced by fatty acid synthase inhibition in human breast cancer cells and xenografts. Cancer Res. 60, 213-218 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 213-218
-
-
Pizer, E.S.1
-
40
-
-
0023277545
-
Single step method of RNA isolation by acid guanidine thiocyanate-phenol-chloroform extraction
-
Chomczynski, P., Sacchi, N. Single step method of RNA isolation by acid guanidine thiocyanate-phenol-chloroform extraction. Anal. Biochem 162, 156-161 (1987).
-
(1987)
Anal. Biochem
, vol.162
, pp. 156-161
-
-
Chomczynski, P.1
Sacchi, N.2
-
41
-
-
0034659814
-
Mitochondrial adaptations to oxidative stress in obesity-related fatty livers
-
Yang, S.Q. et al. Mitochondrial adaptations to oxidative stress in obesity-related fatty livers. Arch, Biochem. Biophys. 378, 259-268 (2000).
-
(2000)
Arch, Biochem. Biophys.
, vol.378
, pp. 259-268
-
-
Yang, S.Q.1
-
42
-
-
0027428137
-
Circadian transcription of the 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP
-
Lavery, D.J. & Schibler, U. Circadian transcription of the 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP. Genes Dev. 7, 1871-1884 (1993).
-
(1993)
Genes Dev.
, vol.7
, pp. 1871-1884
-
-
Lavery, D.J.1
Schibler, U.2
-
43
-
-
0023867357
-
Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor SP1
-
Dawson, P.A. et al. Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor SP1. J. Biol. Chem. 263, 3372-3379 (1988).
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 3372-3379
-
-
Dawson, P.A.1
-
44
-
-
0030063936
-
Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients
-
Alo, P.L. Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients. Cancer 77, 474-482 (1996).
-
(1996)
Cancer
, vol.77
, pp. 474-482
-
-
Alo, P.L.1
|