-
1
-
-
0037219411
-
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
-
Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC: Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102-110, 2003
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
2
-
-
0036163156
-
Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese type II diabetic patients
-
Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S: Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese type II diabetic patients. Diabetologia 45:85-96, 2002
-
(2002)
Diabetologia
, vol.45
, pp. 85-96
-
-
Sakuraba, H.1
Mizukami, H.2
Yagihashi, N.3
Wada, R.4
Hanyu, C.5
Yagihashi, S.6
-
3
-
-
0038707331
-
Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea
-
Yoon KH, Ko SH, Cho JH, Lee JM, Ahn YB, Song KH, Yoo SJ, Kang MI, Cha BY, Lee KW, Son HY, Kang SK, Kim HS, Lee IK, Bonner-Weir S: Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab 88:2300-2308, 2003
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 2300-2308
-
-
Yoon, K.H.1
Ko, S.H.2
Cho, J.H.3
Lee, J.M.4
Ahn, Y.B.5
Song, K.H.6
Yoo, S.J.7
Kang, M.I.8
Cha, B.Y.9
Lee, K.W.10
Son, H.Y.11
Kang, S.K.12
Kim, H.S.13
Lee, I.K.14
Bonner-Weir, S.15
-
4
-
-
0033660085
-
Obesity, increased linear growth, and risk of type 1 diabetes in children
-
Hypponen E, Virtanen SM, Kenward MG, Knip M, Akerblom HK: Obesity, increased linear growth, and risk of type 1 diabetes in children. Diabetes Care 23:1755-1760, 2000
-
(2000)
Diabetes Care
, vol.23
, pp. 1755-1760
-
-
Hypponen, E.1
Virtanen, S.M.2
Kenward, M.G.3
Knip, M.4
Akerblom, H.K.5
-
5
-
-
11144298970
-
Insulin resistance is a risk factor for progression to type 1 diabetes
-
Fourlanos S, Narendran P, Byrnes GB, Colman PG, Harrison LC: Insulin resistance is a risk factor for progression to type 1 diabetes. Diabetologia 47:1661-1667, 2004
-
(2004)
Diabetologia
, vol.47
, pp. 1661-1667
-
-
Fourlanos, S.1
Narendran, P.2
Byrnes, G.B.3
Colman, P.G.4
Harrison, L.C.5
-
6
-
-
0041828484
-
Inflammatory mediators and islet beta-cell failure: A link between type 1 and type 2 diabetes
-
Donath MY, Storling J, Maedler K, Mandrup-Poulsen T: Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes. J Mol Med 81:455-470, 2003
-
(2003)
J Mol Med
, vol.81
, pp. 455-470
-
-
Donath, M.Y.1
Storling, J.2
Maedler, K.3
Mandrup-Poulsen, T.4
-
7
-
-
1842844414
-
Decreased beta-cell mass in diabetes: Significance, mechanisms and therapeutic implications
-
Donath MY, Halban PA: Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications. Diabetologia 47:581-589, 2004
-
(2004)
Diabetologia
, vol.47
, pp. 581-589
-
-
Donath, M.Y.1
Halban, P.A.2
-
8
-
-
11844299586
-
Diagnosis and classification of diabetes mellitus
-
American Diabetes Association: Diagnosis and classification of diabetes mellitus. Diabetes Care 28 (Suppl. 1):S37-S42, 2005
-
(2005)
Diabetes Care
, vol.28
, Issue.1 SUPPL.
-
-
-
9
-
-
0014802883
-
Studies in the diabetic mutant mouse. 3. Physiological factors associated with alterations in beta cell proliferation
-
Chick WL, Like AA: Studies in the diabetic mutant mouse. 3. Physiological factors associated with alterations in beta cell proliferation. Diabetologia 6:243-251, 1970
-
(1970)
Diabetologia
, vol.6
, pp. 243-251
-
-
Chick, W.L.1
Like, A.A.2
-
10
-
-
0033034807
-
Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes
-
Donath MY, Gross DJ, Cerasi E, Kaiser N: Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes. Diabetes 48:738-744, 1999
-
(1999)
Diabetes
, vol.48
, pp. 738-744
-
-
Donath, M.Y.1
Gross, D.J.2
Cerasi, E.3
Kaiser, N.4
-
11
-
-
0035432491
-
Glucose induces beta-cell apoptosis via upregulation of the Fas-receptor in human islets
-
Maedler K, Spinas GA, Lehmann R, Sergeev P, Weber M, Fontana A, Kaiser N, Donath MY: Glucose induces beta-cell apoptosis via upregulation of the Fas-receptor in human islets. Diabetes 50:1683-1690, 2001
-
(2001)
Diabetes
, vol.50
, pp. 1683-1690
-
-
Maedler, K.1
Spinas, G.A.2
Lehmann, R.3
Sergeev, P.4
Weber, M.5
Fontana, A.6
Kaiser, N.7
Donath, M.Y.8
-
12
-
-
0032509446
-
2+ concentration
-
2+ concentration. J Biol Chem 273:33501-33507, 1998
-
(1998)
J Biol Chem
, vol.273
, pp. 33501-33507
-
-
Efanova, I.B.1
Zaitsev, S.V.2
Zhivotovsky, B.3
Kohler, M.4
Efendic, S.5
Orrenius, S.6
Berggren, P.O.7
-
13
-
-
0029797603
-
Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program
-
Hoorens A, Van de Casteele M, Kloppel G, Pipeleers D: Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program. J Clin Invest 98:1568-1574, 1996
-
(1996)
J Clin Invest
, vol.98
, pp. 1568-1574
-
-
Hoorens, A.1
Van De Casteele, M.2
Kloppel, G.3
Pipeleers, D.4
-
14
-
-
0034982387
-
High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: A potential role for regulation of specific Bcl family genes toward an apoptotic cell death program
-
Federici M, Hribal M, Perego L, Ranalli M, Caradonna Z, Perego C, Usellini L, Nano R, Bonini P, Bertuzzi F, Marlier LN, Davalli AM, Carandente O, Pontiroli AE, Melino G, Marchetti P, Lauro R, Sesti G, Folli F: High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program. Diabetes 50:1290-1301, 2001
-
(2001)
Diabetes
, vol.50
, pp. 1290-1301
-
-
Federici, M.1
Hribal, M.2
Perego, L.3
Ranalli, M.4
Caradonna, Z.5
Perego, C.6
Usellini, L.7
Nano, R.8
Bonini, P.9
Bertuzzi, F.10
Marlier, L.N.11
Davalli, A.M.12
Carandente, O.13
Pontiroli, A.E.14
Melino, G.15
Marchetti, P.16
Lauro, R.17
Sesti, G.18
Folli, F.19
-
15
-
-
9444242665
-
Five stages of evolving beta-cell dysfunction during progression to diabetes
-
Weir GC, Bonner-Weir S: Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes 53 (Suppl. 3):S16-S21, 2004
-
(2004)
Diabetes
, vol.53
, Issue.3 SUPPL.
-
-
Weir, G.C.1
Bonner-Weir, S.2
-
16
-
-
0033513455
-
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
-
Xu G, Stoffers DA, Habener JF, Bonner-Weir S: Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48:2270-2276, 1999
-
(1999)
Diabetes
, vol.48
, pp. 2270-2276
-
-
Xu, G.1
Stoffers, D.A.2
Habener, J.F.3
Bonner-Weir, S.4
-
17
-
-
0037062429
-
FLIP switches Fas-mediated glucose signaling in human pancreatic β cells from apoptosis to cell replication
-
Maedler K, Fontana A, Ris F, Sergeev P, Toso C, Oberholzer J, Lehmann R, Bachmann F, Tasinato A, Spinas GA, Halban PA, Donath MY: FLIP switches Fas-mediated glucose signaling in human pancreatic β cells from apoptosis to cell replication. Proc Natl Acad Sci U S A 99:8236-8241, 2002
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 8236-8241
-
-
Maedler, K.1
Fontana, A.2
Ris, F.3
Sergeev, P.4
Toso, C.5
Oberholzer, J.6
Lehmann, R.7
Bachmann, F.8
Tasinato, A.9
Spinas, G.A.10
Halban, P.A.11
Donath, M.Y.12
-
18
-
-
0345354674
-
Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function
-
Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY: Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Diabetes 52:726-733, 2003
-
(2003)
Diabetes
, vol.52
, pp. 726-733
-
-
Maedler, K.1
Oberholzer, J.2
Bucher, P.3
Spinas, G.A.4
Donath, M.Y.5
-
19
-
-
2542541353
-
Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets
-
Maedler K, Sergeev P, Ehses JA, Mathe Z, Bosco D, Berney T, Dayer JM, Reinecke M, Halban PA, Donath MY: Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets. Proc Natl Acad Sci U S A 101:8138-8143, 2004
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 8138-8143
-
-
Maedler, K.1
Sergeev, P.2
Ehses, J.A.3
Mathe, Z.4
Bosco, D.5
Berney, T.6
Dayer, J.M.7
Reinecke, M.8
Halban, P.A.9
Donath, M.Y.10
-
20
-
-
0036738398
-
Glucose-induced beta-cell production of interleukin-1beta contributes to glucotoxicity in human pancreatic islets
-
Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY: Glucose-induced beta-cell production of interleukin-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 110:851-860, 2002
-
(2002)
J Clin Invest
, vol.110
, pp. 851-860
-
-
Maedler, K.1
Sergeev, P.2
Ris, F.3
Oberholzer, J.4
Joller-Jemelka, H.I.5
Spinas, G.A.6
Kaiser, N.7
Halban, P.A.8
Donath, M.Y.9
-
21
-
-
0034042959
-
Islet growth and development in the adult
-
Bonner-Weir S: Islet growth and development in the adult. J Mol Endocrinol 24:297-302, 2000
-
(2000)
J Mol Endocrinol
, vol.24
, pp. 297-302
-
-
Bonner-Weir, S.1
-
22
-
-
0037474332
-
Critical reduction in beta-cell mass results in two distinct outcomes over time: Adaptation with impaired glucose tolerance or decompensated diabetes
-
Laybutt DR, Glandt M, Xu G, Ahn YB, Trivedi N, Bonner-Weir S, Weir GC: Critical reduction in beta-cell mass results in two distinct outcomes over time: adaptation with impaired glucose tolerance or decompensated diabetes. J Biol Chem 278:2997-3005, 2003
-
(2003)
J Biol Chem
, vol.278
, pp. 2997-3005
-
-
Laybutt, D.R.1
Glandt, M.2
Xu, G.3
Ahn, Y.B.4
Trivedi, N.5
Bonner-Weir, S.6
Weir, G.C.7
-
23
-
-
33644787182
-
Gene expression profile in the pancreatic islets of Goto-Kakizaki (GK) rats with repeated postprandial hyperglycemia
-
Mine T, Miura K, Okutsu T, Mitsui A, Kitahara Y: Gene expression profile in the pancreatic islets of Goto-Kakizaki (GK) rats with repeated postprandial hyperglycemia. Diabetes 53 (Suppl. 2):2475A, 2004
-
(2004)
Diabetes
, vol.53
, Issue.2 SUPPL.
-
-
Mine, T.1
Miura, K.2
Okutsu, T.3
Mitsui, A.4
Kitahara, Y.5
-
24
-
-
2542581025
-
Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): A new model for type 2 diabetes
-
Butler AE, Jang J, Gurlo T, Carty MD, Soeller WC, Butler PC: Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes. Diabetes 53:1509-1516, 2004
-
(2004)
Diabetes
, vol.53
, pp. 1509-1516
-
-
Butler, A.E.1
Jang, J.2
Gurlo, T.3
Carty, M.D.4
Soeller, W.C.5
Butler, P.C.6
-
25
-
-
12344270191
-
High glucose potentiates cytokine- And streptozotocin-induced apoptosis of rat islet cells: Effect on apoptosis-related genes
-
Mellado-Gil JM, Aguilar-Diosdado M: High glucose potentiates cytokine- and streptozotocin-induced apoptosis of rat islet cells: effect on apoptosis-related genes. J Endocrinol 183:155-162, 2004
-
(2004)
J Endocrinol
, vol.183
, pp. 155-162
-
-
Mellado-Gil, J.M.1
Aguilar-Diosdado, M.2
-
26
-
-
0019510244
-
Islet secretion in a new experimental model for non-insulin-dependent diabetes
-
Weir GC, Clore ET, Zmachinski CJ, Bonner-Weir S: Islet secretion in a new experimental model for non-insulin-dependent diabetes. Diabetes 30:590-595, 1981
-
(1981)
Diabetes
, vol.30
, pp. 590-595
-
-
Weir, G.C.1
Clore, E.T.2
Zmachinski, C.J.3
Bonner-Weir, S.4
-
27
-
-
0021961644
-
Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: Implications for the management of diabetes
-
Unger RH, Grundy S: Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes. Diabetologia 28:119-121, 1985
-
(1985)
Diabetologia
, vol.28
, pp. 119-121
-
-
Unger, R.H.1
Grundy, S.2
-
28
-
-
0024351557
-
Type II diabetes, glucose "non-sense," and islet desensitization
-
Robertson RP: Type II diabetes, glucose "non-sense," and islet desensitization. Diabetes 38:1501-1505, 1989
-
(1989)
Diabetes
, vol.38
, pp. 1501-1505
-
-
Robertson, R.P.1
-
29
-
-
0022522943
-
Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion: A study in normal rats using chronic in vivo glucose infusions
-
Leahy JL, Cooper HE, Deal DA, Weir GC: Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion: a study in normal rats using chronic in vivo glucose infusions. J Clin Invest 77:908-915, 1986
-
(1986)
J Clin Invest
, vol.77
, pp. 908-915
-
-
Leahy, J.L.1
Cooper, H.E.2
Deal, D.A.3
Weir, G.C.4
-
30
-
-
0023865083
-
Evolution of abnormal insulin secretory responses during 48-h in vivo hyperglycemia
-
Leahy JL, Weir GC: Evolution of abnormal insulin secretory responses during 48-h in vivo hyperglycemia. Diabetes 37:217-222, 1988
-
(1988)
Diabetes
, vol.37
, pp. 217-222
-
-
Leahy, J.L.1
Weir, G.C.2
-
31
-
-
0035156817
-
Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function
-
Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY: Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function. Diabetes 50:69-76, 2001
-
(2001)
Diabetes
, vol.50
, pp. 69-76
-
-
Maedler, K.1
Spinas, G.A.2
Dyntar, D.3
Moritz, W.4
Kaiser, N.5
Donath, M.Y.6
-
32
-
-
0035462571
-
Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes
-
Dyntar D, Eppenberger-Eberhardt M, Maedler K, Pruschy M, Eppenberger HM, Spinas GA, Donath MY: Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes. Diabetes 50:2105-2113, 2001
-
(2001)
Diabetes
, vol.50
, pp. 2105-2113
-
-
Dyntar, D.1
Eppenberger-Eberhardt, M.2
Maedler, K.3
Pruschy, M.4
Eppenberger, H.M.5
Spinas, G.A.6
Donath, M.Y.7
-
33
-
-
0036721312
-
Low density lipoprotein can cause death of islet beta-cells by its cellular uptake and oxidative modification
-
Cnop M, Hannaert JC, Grupping AY, Pipeleers DG: Low density lipoprotein can cause death of islet beta-cells by its cellular uptake and oxidative modification. Endocrinology 143:3449-3453, 2002
-
(2002)
Endocrinology
, vol.143
, pp. 3449-3453
-
-
Cnop, M.1
Hannaert, J.C.2
Grupping, A.Y.3
Pipeleers, D.G.4
-
34
-
-
0038381515
-
Insulin-secreting beta-cell dysfunction induced by human lipoproteins
-
Roehrich ME, Mooser V, Lenain V, Herz J, Nimpf J, Azhar S, Bideau M, Capponi A, Nicod P, Haefliger JA, Waeber G: Insulin-secreting beta-cell dysfunction induced by human lipoproteins. J Biol Chem 278:18368-18375, 2003
-
(2003)
J Biol Chem
, vol.278
, pp. 18368-18375
-
-
Roehrich, M.E.1
Mooser, V.2
Lenain, V.3
Herz, J.4
Nimpf, J.5
Azhar, S.6
Bideau, M.7
Capponi, A.8
Nicod, P.9
Haefliger, J.A.10
Waeber, G.11
-
35
-
-
0042922453
-
Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death
-
El-Assaad W, Buteau J, Peyot ML, Nolan C, Roduit R, Hardy S, Joly E, Dbaibo G, Rosenberg L, Prentki M: Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. Endocrinology 144:4154-4163, 2003
-
(2003)
Endocrinology
, vol.144
, pp. 4154-4163
-
-
El-Assaad, W.1
Buteau, J.2
Peyot, M.L.3
Nolan, C.4
Roduit, R.5
Hardy, S.6
Joly, E.7
Dbaibo, G.8
Rosenberg, L.9
Prentki, M.10
-
36
-
-
0036153256
-
Minireview: Secondary beta-cell failure in type 2 diabetes: a convergence of glucotoxicity and lipotoxicity
-
Poitout V, Robertson RP: Minireview: secondary beta-cell failure in type 2 diabetes: a convergence of glucotoxicity and lipotoxicity. Endocrinology 143:339-342, 2002
-
(2002)
Endocrinology
, vol.143
, pp. 339-342
-
-
Poitout, V.1
Robertson, R.P.2
-
37
-
-
11844253254
-
Leptin, from fat to inflammation: Old questions and new insights
-
Otero M, Lago R, Lago F, Casanueva FF, Dieguez C, Gomez-Reino JJ, Gualillo O: Leptin, from fat to inflammation: old questions and new insights. FEBS Lett 579:295-301, 2005
-
(2005)
FEBS Lett
, vol.579
, pp. 295-301
-
-
Otero, M.1
Lago, R.2
Lago, F.3
Casanueva, F.F.4
Dieguez, C.5
Gomez-Reino, J.J.6
Gualillo, O.7
-
38
-
-
0036312494
-
Leptin accelerates autoimmune diabetes in female NOD mice
-
Matarese G, Sanna V, Lechler RI, Sarvetnick N, Fontana S, Zappacosta S, La Cava A: Leptin accelerates autoimmune diabetes in female NOD mice. Diabetes 51:1356-1361, 2002
-
(2002)
Diabetes
, vol.51
, pp. 1356-1361
-
-
Matarese, G.1
Sanna, V.2
Lechler, R.I.3
Sarvetnick, N.4
Fontana, S.5
Zappacosta, S.6
La Cava, A.7
-
39
-
-
0031768795
-
Elevated plasma leptin concentrations in early stages of experimental intestinal inflammation in rats
-
Barbier M, Cherbut C, Aube AC, Blottiere HM, Galmiche JP: Elevated plasma leptin concentrations in early stages of experimental intestinal inflammation in rats. Gut 43:783-790, 1998
-
(1998)
Gut
, vol.43
, pp. 783-790
-
-
Barbier, M.1
Cherbut, C.2
Aube, A.C.3
Blottiere, H.M.4
Galmiche, J.P.5
-
40
-
-
0037241113
-
Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses
-
Sanna V, Di Giacomo A, La Cava A, Lechler RI, Fontana S, Zappacosta S, Matarese G: Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. J Clin Invest 111:241-250, 2003
-
(2003)
J Clin Invest
, vol.111
, pp. 241-250
-
-
Sanna, V.1
Di Giacomo, A.2
La Cava, A.3
Lechler, R.I.4
Fontana, S.5
Zappacosta, S.6
Matarese, G.7
-
41
-
-
0033974348
-
The adipoinsular axis: Effects of leptin on pancreatic beta-cells
-
Kieffer TJ, Habener JF: The adipoinsular axis: effects of leptin on pancreatic beta-cells. Am J Physiol Endocrinol Metab 278:E1-E14, 2000
-
(2000)
Am J Physiol Endocrinol Metab
, vol.278
-
-
Kieffer, T.J.1
Habener, J.F.2
-
42
-
-
0031590317
-
Inhibition of glucose-induced insulin secretion by long-term preexposure of pancreatic islets to leptin
-
Roduit R, Thorens B: Inhibition of glucose-induced insulin secretion by long-term preexposure of pancreatic islets to leptin. FEBS Lett 415:179-182, 1997
-
(1997)
FEBS Lett
, vol.415
, pp. 179-182
-
-
Roduit, R.1
Thorens, B.2
-
43
-
-
0345618266
-
Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes
-
Hennige AM, Burks DJ, Ozcan U, Kulkarni RN, Ye J, Park S, Schubert M, Fisher TL, Dow MA, Leshan R, Zakaria M, Mossa-Basha M, White MF: Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J Clin Invest 112:1521-1532, 2003
-
(2003)
J Clin Invest
, vol.112
, pp. 1521-1532
-
-
Hennige, A.M.1
Burks, D.J.2
Ozcan, U.3
Kulkarni, R.N.4
Ye, J.5
Park, S.6
Schubert, M.7
Fisher, T.L.8
Dow, M.A.9
Leshan, R.10
Zakaria, M.11
White Mf, M.M.12
-
44
-
-
12344323484
-
Type 2 diabetes: A matter of beta-cell life and death?
-
Rhodes CJ: Type 2 diabetes: a matter of beta-cell life and death? Science 307:380-384, 2005
-
(2005)
Science
, vol.307
, pp. 380-384
-
-
Rhodes, C.J.1
-
45
-
-
0028973284
-
Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: Evidence for the involvement of nuclear factor kappa B in the signaling mechanism
-
Kwon G, Corbett JA, Rodi CP, Sullivan P, McDaniel ML: Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: evidence for the involvement of nuclear factor kappa B in the signaling mechanism. Endocrinology 136:4790-4795, 1995
-
(1995)
Endocrinology
, vol.136
, pp. 4790-4795
-
-
Kwon, G.1
Corbett, J.A.2
Rodi, C.P.3
Sullivan, P.4
McDaniel, M.L.5
-
46
-
-
6344265234
-
Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta
-
Zeender E, Maedler K, Bosco D, Berney T, Donath MY, Halban PA: Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta. J Clin Endocrinol Metab 89:5059-5066, 2004
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 5059-5066
-
-
Zeender, E.1
Maedler, K.2
Bosco, D.3
Berney, T.4
Donath, M.Y.5
Halban, P.A.6
-
47
-
-
0034711250
-
Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Ikappa B repressor
-
Giannoukakis N, Rudert WA, Trucco M, Robbins PD: Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Ikappa B repressor. J Biol Chem 275:36509-36513, 2000
-
(2000)
J Biol Chem
, vol.275
, pp. 36509-36513
-
-
Giannoukakis, N.1
Rudert, W.A.2
Trucco, M.3
Robbins, P.D.4
-
48
-
-
0346880505
-
Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- And diet-induced insulin resistance
-
Shoelson SE, Lee J, Yuan M: Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. Int J Obes Relat Metab Disord 27 (Suppl. 3):S49-S52, 2003
-
(2003)
Int J Obes Relat Metab Disord
, vol.27
, Issue.3 SUPPL.
-
-
Shoelson, S.E.1
Lee, J.2
Yuan, M.3
-
49
-
-
0036460073
-
Invited comment on W. Ebstein: On the therapy of diabetes mellitus, in particular on the application of sodium salicylate
-
Shoelson S: Invited comment on W. Ebstein: on the therapy of diabetes mellitus, in particular on the application of sodium salicylate. J Mol Med 80:618-619, 2002
-
(2002)
J Mol Med
, vol.80
, pp. 618-619
-
-
Shoelson, S.1
-
50
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
-
Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE: Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 11:183-190, 2005
-
(2005)
Nat Med
, vol.11
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
Melendez, P.A.4
Hansen, L.5
Lee, J.6
Shoelson, S.E.7
-
51
-
-
20044387026
-
IKK-beta links inflammation to obesity-induced insulin resistance
-
Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M: IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11:191-198, 2005
-
(2005)
Nat Med
, vol.11
, pp. 191-198
-
-
Arkan, M.C.1
Hevener, A.L.2
Greten, F.R.3
Maeda, S.4
Li, Z.W.5
Long, J.M.6
Wynshaw-Boris, A.7
Poli, G.8
Olefsky, J.9
Karin, M.10
-
52
-
-
1542284737
-
Adiponectin counteracts cytokine- And fatty acid-induced apoptosis in the pancreatic beta-cell line INS-1
-
Rakatzi I, Mueller H, Ritzeler O, Tennagels N, Eckel J: Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line INS-1. Diabetologia 47:249-258, 2004
-
(2004)
Diabetologia
, vol.47
, pp. 249-258
-
-
Rakatzi, I.1
Mueller, H.2
Ritzeler, O.3
Tennagels, N.4
Eckel, J.5
-
53
-
-
0036796875
-
Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes
-
Evans JL, Goldfine ID, Maddux BA, Grodsky GM: Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 23:599-622, 2002
-
(2002)
Endocr Rev
, vol.23
, pp. 599-622
-
-
Evans, J.L.1
Goldfine, I.D.2
Maddux, B.A.3
Grodsky, G.M.4
-
54
-
-
12144279068
-
Nuclear factor-κB activity in β-cells is required for glucose-stimulated insulin secretion
-
Norlin S, Ahlgren U, Edlund H: Nuclear factor-κB activity in β-cells is required for glucose-stimulated insulin secretion. Diabetes 54:125-132, 2005
-
(2005)
Diabetes
, vol.54
, pp. 125-132
-
-
Norlin, S.1
Ahlgren, U.2
Edlund, H.3
-
55
-
-
0037312881
-
Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse
-
Izumi T, Yokota-Hashimoto H, Zhao S, Wang J, Halban PA, Takeuchi T: Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse. Diabetes 52:409-416, 2003
-
(2003)
Diabetes
, vol.52
, pp. 409-416
-
-
Izumi, T.1
Yokota-Hashimoto, H.2
Zhao, S.3
Wang, J.4
Halban, P.A.5
Takeuchi, T.6
-
56
-
-
0036895383
-
Endoplasmic reticulum stress and the development of diabetes: A review
-
Harding HP, Ron D: Endoplasmic reticulum stress and the development of diabetes: a review. Diabetes 51 (Suppl. 3):S455-S461, 2002
-
(2002)
Diabetes
, vol.51
, Issue.3 SUPPL.
-
-
Harding, H.P.1
Ron, D.2
-
57
-
-
0037288692
-
Endoplasmic reticulum stress and diabetes mellitus
-
Araki E, Oyadomari S, Mori M: Endoplasmic reticulum stress and diabetes mellitus. Intern Med 42:7-14, 2003
-
(2003)
Intern Med
, vol.42
, pp. 7-14
-
-
Araki, E.1
Oyadomari, S.2
Mori, M.3
-
58
-
-
8544267219
-
PPARgamma ligands induce ER stress in pancreatic beta-cells: ER stress activation results in attenuation of cytokine signaling
-
Weber SM, Chambers KT, Bensch KG, Scarim AL, Corbett JA: PPARgamma ligands induce ER stress in pancreatic beta-cells: ER stress activation results in attenuation of cytokine signaling. Am J Physiol Endocrinol Metab 287:E1171-E1177, 2004
-
(2004)
Am J Physiol Endocrinol Metab
, vol.287
-
-
Weber, S.M.1
Chambers, K.T.2
Bensch, K.G.3
Scarim, A.L.4
Corbett, J.A.5
-
59
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS: Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306:457-461, 2004
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Gorgun, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
60
-
-
12344305124
-
Mitochondrial dysfunction and type 2 diabetes
-
Lowell BB, Shulman GI: Mitochondrial dysfunction and type 2 diabetes. Science 307:384-387, 2005
-
(2005)
Science
, vol.307
, pp. 384-387
-
-
Lowell, B.B.1
Shulman, G.I.2
-
61
-
-
0037192799
-
Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion
-
Brissova M, Shiota M, Nicholson WE, Gannon M, Knobel SM, Piston DW, Wright CV, Powers AC: Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem 277:11225-11232, 2002
-
(2002)
J Biol Chem
, vol.277
, pp. 11225-11232
-
-
Brissova, M.1
Shiota, M.2
Nicholson, W.E.3
Gannon, M.4
Knobel, S.M.5
Piston, D.W.6
Wright, C.V.7
Powers, A.C.8
-
62
-
-
3843101644
-
Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets
-
Gauthier BR, Brun T, Sarret EJ, Ishihara H, Schaad O, Descombes P, Wollheim CB: Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets. J Biol Chem 279:31121-31130, 2004
-
(2004)
J Biol Chem
, vol.279
, pp. 31121-31130
-
-
Gauthier, B.R.1
Brun, T.2
Sarret, E.J.3
Ishihara, H.4
Schaad, O.5
Descombes, P.6
Wollheim, C.B.7
-
63
-
-
0035078830
-
Uncoupling protein 2: A possible link between fatty acid excess and impaired glucose-induced insulin secretion?
-
Lameloise N, Muzzin P, Prentki M, Assimacopoulos-Jeannet F: Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion? Diabetes 50:803-809, 2001
-
(2001)
Diabetes
, vol.50
, pp. 803-809
-
-
Lameloise, N.1
Muzzin, P.2
Prentki, M.3
Assimacopoulos-Jeannet, F.4
-
64
-
-
9644268967
-
PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance
-
Kulkarni RN, Jhala US, Winnay JN, Krajewski S, Montminy M, Kahn CR: PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest 114:828-836, 2004
-
(2004)
J Clin Invest
, vol.114
, pp. 828-836
-
-
Kulkarni, R.N.1
Jhala, U.S.2
Winnay, J.N.3
Krajewski, S.4
Montminy, M.5
Kahn, C.R.6
-
65
-
-
0242584873
-
Increased islet apoptosis in Pdx1+/- Mice
-
Johnson JD, Ahmed NT, Luciani DS, Han Z, Tran H, Fujita J, Misler S, Edlund H, Polonsky KS: Increased islet apoptosis in Pdx1+/- mice. J Clin Invest 111:1147-1160, 2003
-
(2003)
J Clin Invest
, vol.111
, pp. 1147-1160
-
-
Johnson, J.D.1
Ahmed, N.T.2
Luciani, D.S.3
Han, Z.4
Tran, H.5
Fujita, J.6
Misler, S.7
Edlund, H.8
Polonsky, K.S.9
-
66
-
-
0842284799
-
Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes
-
Robertson RP, Harmon J, Tran PO, Poitout V: Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 53 (Suppl. 1):S119-S124, 2004
-
(2004)
Diabetes
, vol.53
, Issue.1 SUPPL.
-
-
Robertson, R.P.1
Harmon, J.2
Tran, P.O.3
Poitout, V.4
-
67
-
-
0842328003
-
Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes
-
Green K, Brand MD, Murphy MP: Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes 53 (Suppl. 1):S110-S118, 2004
-
(2004)
Diabetes
, vol.53
, Issue.1 SUPPL.
-
-
Green, K.1
Brand, M.D.2
Murphy, M.P.3
-
68
-
-
0037219409
-
Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?
-
Evans JL, Goldfine ID, Maddux BA, Grodsky GM: Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes 52:1-8, 2003
-
(2003)
Diabetes
, vol.52
, pp. 1-8
-
-
Evans, J.L.1
Goldfine, I.D.2
Maddux, B.A.3
Grodsky, G.M.4
-
69
-
-
0034630757
-
Sustained enhancement of Ca(2+) influx by glibenclamide induces apoptosis in RINm5F cells
-
Iwakura T, Fujimoto S, Kagimoto S, Inada A, Kubota A, Someya Y, Ihara Y, Yamada Y, Seino Y: Sustained enhancement of Ca(2+) influx by glibenclamide induces apoptosis in RINm5F cells. Biochem Biophys Res Commun 271:422-428, 2000
-
(2000)
Biochem Biophys Res Commun
, vol.271
, pp. 422-428
-
-
Iwakura, T.1
Fujimoto, S.2
Kagimoto, S.3
Inada, A.4
Kubota, A.5
Someya, Y.6
Ihara, Y.7
Yamada, Y.8
Seino, Y.9
-
70
-
-
12244287074
-
Sulfonylurea induced beta-cell apoptosis in cultured human islets
-
Maedler K, Carr RD, Bosco D, Zuellig RA, Berney T, Donath MY: Sulfonylurea induced beta-cell apoptosis in cultured human islets. J Clin Endocrinol Metab 90:501-506, 2005
-
(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 501-506
-
-
Maedler, K.1
Carr, R.D.2
Bosco, D.3
Zuellig, R.A.4
Berney, T.5
Donath, M.Y.6
-
71
-
-
11844298435
-
Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human islets
-
Del Guerra S, Marselli L, Lupi R, Boggi U, Mosca F, Benzi L, Del Prato S, Marchetti P: Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human islets. J Diabetes Complications 19:60-64, 2005
-
(2005)
J Diabetes Complications
, vol.19
, pp. 60-64
-
-
Del Guerra, S.1
Marselli, L.2
Lupi, R.3
Boggi, U.4
Mosca, F.5
Benzi, L.6
Del Prato, S.7
Marchetti, P.8
-
72
-
-
0041523870
-
Beneficial effects of insulin versus sulphonylurea on insulin secretion and metabolic control in recently diagnosed type 2 diabetic patients
-
Alvarsson M, Sundkvist G, Lager I, Henricsson M, Berntorp K, Fernqvist-Forbes E, Steen L, Westermark G, Westermark P, Orn T, Grill V: Beneficial effects of insulin versus sulphonylurea on insulin secretion and metabolic control in recently diagnosed type 2 diabetic patients. Diabetes Care 26:2231-2237, 2003
-
(2003)
Diabetes Care
, vol.26
, pp. 2231-2237
-
-
Alvarsson, M.1
Sundkvist, G.2
Lager, I.3
Henricsson, M.4
Berntorp, K.5
Fernqvist-Forbes, E.6
Steen, L.7
Westermark, G.8
Westermark, P.9
Orn, T.10
Grill, V.11
-
73
-
-
0028817815
-
U.K. Prospective Diabetes Study 16: Overview of 6 years' therapy of type II diabetes: A progressive disease
-
U.K. Prospective Diabetes Study Group: U.K. Prospective Diabetes Study 16: Overview of 6 years' therapy of type II diabetes: a progressive disease. Diabetes 44:1249-1258, 1995
-
(1995)
Diabetes
, vol.44
, pp. 1249-1258
-
-
-
74
-
-
3042825017
-
Glucose- And interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets
-
Maedler K, Storling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY: Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets. Diabetes 53:1706-1713, 2004
-
(2004)
Diabetes
, vol.53
, pp. 1706-1713
-
-
Maedler, K.1
Storling, J.2
Sturis, J.3
Zuellig, R.A.4
Spinas, G.A.5
Arkhammar, P.O.6
Mandrup-Poulsen, T.7
Donath, M.Y.8
-
75
-
-
1442327747
-
Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose
-
Ritzel RA, Hansen JB, Veldhuis JD, Butler PC: Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose. J Clin Endocrinol Metab 89:795-805, 2004
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 795-805
-
-
Ritzel, R.A.1
Hansen, J.B.2
Veldhuis, J.D.3
Butler, P.C.4
-
76
-
-
0017239486
-
Improvement in insulin secretion in diabetes after diazoxide
-
Greenwood RH, Mahler RF, Hales CN: Improvement in insulin secretion in diabetes after diazoxide. Lancet 1:444-447, 1976
-
(1976)
Lancet
, vol.1
, pp. 444-447
-
-
Greenwood, R.H.1
Mahler, R.F.2
Hales, C.N.3
-
77
-
-
0029784458
-
Diazoxide treatment at onset preserves residual insulin secretion in adults with autoimmune diabetes
-
Bjork E, Berne C, Kampe O, Wibell L, Oskarsson P, Karlsson FA: Diazoxide treatment at onset preserves residual insulin secretion in adults with autoimmune diabetes. Diabetes 45:1427-1430, 1996
-
(1996)
Diabetes
, vol.45
, pp. 1427-1430
-
-
Bjork, E.1
Berne, C.2
Kampe, O.3
Wibell, L.4
Oskarsson, P.5
Karlsson, F.A.6
-
78
-
-
0036934184
-
Improved beta cell function after short-term treatment with diazoxide in obese subjects with type 2 diabetes
-
Guldstrand M, Grill V, Bjorklund A, Lins PE, Adamson U: Improved beta cell function after short-term treatment with diazoxide in obese subjects with type 2 diabetes. Diabete Metab 28:448-456, 2002
-
(2002)
Diabete Metab
, vol.28
, pp. 448-456
-
-
Guldstrand, M.1
Grill, V.2
Bjorklund, A.3
Lins, P.E.4
Adamson, U.5
-
79
-
-
0345257136
-
Glucagon-like peptide-1 and the islet beta-cell: Augmentation of cell proliferation and inhibition of apoptosis
-
Drucker DJ: Glucagon-like peptide-1 and the islet beta-cell: augmentation of cell proliferation and inhibition of apoptosis. Endocrinology 144:5145-5148, 2003
-
(2003)
Endocrinology
, vol.144
, pp. 5145-5148
-
-
Drucker, D.J.1
-
80
-
-
0037414781
-
Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis
-
Li Y, Hansotia T, Yusta B, Ris F, Halban PA, Drucker DJ: Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem 278:471-478, 2003
-
(2003)
J Biol Chem
, vol.278
, pp. 471-478
-
-
Li, Y.1
Hansotia, T.2
Yusta, B.3
Ris, F.4
Halban, P.A.5
Drucker, D.J.6
-
81
-
-
0035856952
-
Beta-cell death during progression to diabetes
-
Mathis D, Vence L, Benoist C: Beta-cell death during progression to diabetes. Nature 414:792-798, 2001
-
(2001)
Nature
, vol.414
, pp. 792-798
-
-
Mathis, D.1
Vence, L.2
Benoist, C.3
-
82
-
-
0031297434
-
Processing of engulfed apoptotic bodies yields T cell epitopes
-
Bellone M, Iezzi G, Rovere P, Galati G, Ronchetti A, Protti MP, Davoust J, Rugarli C, Manfredi AA: Processing of engulfed apoptotic bodies yields T cell epitopes. J Immunol 159:5391-5399, 1997
-
(1997)
J Immunol
, vol.159
, pp. 5391-5399
-
-
Bellone, M.1
Iezzi, G.2
Rovere, P.3
Galati, G.4
Ronchetti, A.5
Protti, M.P.6
Davoust, J.7
Rugarli, C.8
Manfredi, A.A.9
-
83
-
-
0033985277
-
Neonatal beta-cell apoptosis: A trigger for autoimmune diabetes?
-
Trudeau JD, Dutz JP, Arany E, Hill DJ, Fieldus WE, Finegood DT: Neonatal beta-cell apoptosis: a trigger for autoimmune diabetes? Diabetes 49:1-7, 2000
-
(2000)
Diabetes
, vol.49
, pp. 1-7
-
-
Trudeau, J.D.1
Dutz, J.P.2
Arany, E.3
Hill, D.J.4
Fieldus, W.E.5
Finegood, D.T.6
-
84
-
-
4043171124
-
Islet amyloid: A critical entity in the pathogenesis of type 2 diabetes
-
Hull RL, Westermark GT, Westermark P, Kahn SE: Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes. J Clin Endocrinol Metab 89:3629-3643, 2004
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 3629-3643
-
-
Hull, R.L.1
Westermark, G.T.2
Westermark, P.3
Kahn, S.E.4
|