AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise

Diabetes

Volumn 50, Issue 5, 2001, Pages 921-927

  Musi, Nicolas ^a   Fujii, Nobuharu ^a   Hirshman, Michael F ^a   Ekberg, Ingvar ^b   Fröberg, Sven ^b   Ljungqvist, Olle ^b,c   Thorell, Anders ^b   Goodyear, Laurie J ^a,d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b ERSTA HOSPITAL   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d JOSLIN DIABETES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MESSENGER RNA; PROTEIN KINASE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BICYCLE ERGOMETER; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EXERCISE; GLUCOSE BLOOD LEVEL; HUMAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASTUS LATERALIS MUSCLE;

EID: 0035039274     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.5.921     Document Type: Article

References (57)

1. Diabetes mellitus and exercise
2. Regulation of glucose transport into skeletal muscle
3. Exercise regulation of glucose transport in skeletal muscle
4. Exercise, glucose transport, and insulin sensitivity
5. Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes
6. Insulin receptor phosphorylation, IRS-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects
7. Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation
8. Insulin action in skeletal muscle from patients with NIDDM
9. Insulin resistance in obese Zucker rat (fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation
10. Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM
11. Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance
12. Contraction-activated glucose uptake is normal in insulin-resistant muscle of the obese Zucker rat
13. Exercise, unlike insulin, promotes glucose transporter translocation in obese Zucker rat muscle
14. Glucose uptake and GLUT-4 protein distribution in skeletal muscle of obese Zucker rat
15. Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes
16. AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
17. Evidence for 5′ AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport
18. Effect of AMPK activation on muscle glucose metabolism in conscious rats
19. Malonyl-CoA, fuel sensing, and insulin resistance
20. The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
21. Dealing with energy demand: The AMP-activated protein kinase
22. Metabolic stress and altered glucose transport: Activation of AMP-activated protein kinase as a unifying coupling mechanism
23. Effect of exercise intensity on skeletal muscle malonyl-CoA and acetyl-CoA carboxylase
24. Postexercise recovery of skeletal muscle malonyl-CoA, acetyl-CoA carboxylase, and AMP-activated protein kinase
25. Electrical stimulation inactivates muscle acetyl-CoA carboxylase and increases AMP-activated protein kinase
26. Contraction-induced changes in acetyl-CoA carboxylase and 5′-AMP-activated kinase in skeletal muscle
27. Effect of tension on contraction-induced glucose transport in rat skeletal muscle
28. Exercise induces isoform-specific increases in 5′AMP-activated protein kinase activity in human skeletal muscle
29. Isoform-specific and exercise intensity-dependent activation of 5′-AMP-activated protein kinase in human skeletal muscle
30. Mammalian AMP-activated protein kinase subfamily
31. 5-Aminoimidazole-4-carboxamide ribonucleoside: A specific method for activating AMP-activated protein kinase in intact cells?
32. Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR
33. 5′ AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle
34. Chronic activation of 5′-AMP-activated protein kinase increases GLUT4, hexokinase, and glycogen in muscle
35. Increased expression of GLUT-4 and hexokinase in rat epitrochlearis muscles exposed to AICAR in vitro
36. AMP-activated protein kinase, a metabolic master switch: Possible roles in type 2 diabetes
37. Report of the expert committee on the diagnosis and classification of diabetes mellitus
38. Physical working capacity determined by different types of bicycle exercise tests
39. Muscle electrolytes in man
40. Use of glucose oxidase and O-dianisidin in determinations of blood and urinary glucose
41. Rapid micromeasurement of lactate in whole blood
42. Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay
43. Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus
44. Glucose transporters and insulin action: Implications for insulin resistance and diabetes mellitus
45. The effect of AMP-activated protine kinase (AMPK) stimulation on whole body glucose metabolism in awake lean and zucker diabetic fatty (ZDF) rats
46. Pharmacological activation of 5′AMP-activated protein kinase (AMPK) in vivo acutely decreases blood glucose and chronically increases muscle GLUT4 in normal and diabetic animals
47. Hypoglycaemic effect of AICAriboside in mice
48. Inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside in isolated rat hepatocytes
49. Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside: Evidence for involvement of amp-activated protein kinase
50. Apoptosis induced by growth factor withdrawal in fibroblasts overproducing fructose 2,6-bisphosphate
51. Splanchnic and leg exchange of glucose, amino acids, and free fatty acids during exercise in diabetes mellitus
52. Splanchnic and muscle metabolism during exercise in NIDDM patients
53. Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise
54. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle
55. AMP-activated protein kinase: Greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform
56. The α1 and α2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro
57. AMPK signaling in contracting human skeletal muscle: Acetyl-CoA carboxylase and NO synthase phosphorylation