Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase

Molecular and Cellular Biology

Volumn 20, Issue 18, 2000, Pages 6704-6711

  Woods, A ^a   Azzout Marniche, D ^a   Foretz, M ^a   Stein, S C ^a   Lemarchand, P ^a   Ferre, P ^a   Foufelle, F ^a   Carling, D ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; CYCLIC AMP; FATTY ACID SYNTHASE; GLUCOSE; PROTEIN KINASE; PYRUVATE KINASE;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE TRANSFER; GLUCOSE METABOLISM; LIPID METABOLISM; LIVER CELL; MUTANT; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSCRIPTION REGULATION;

ACETYL-COA CARBOXYLASE; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; FATTY ACID SYNTHETASE COMPLEX; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE; HUMANS; LIVER; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PYRUVATE KINASE; RATS; RATS, WISTAR; TRANSCRIPTION FACTORS;

EID: 0033815967     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.18.6704-6711.2000     Document Type: Article

References (53)

1. Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism
2. Mutational analysis of the Saccharomyces cerevisiae SNF1 protein kinase and evidence for functional interaction with the SNF4 protein
3. A yeast gene that is essential for release from glucose repression encodes a protein kinase
4. Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding
5. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
6. 5-Aminoimidazole-4-carboxamide ribonucleoside - A specific method for activating AMP-activated protein kinase in intact cells
7. Lipogenic enzyme activities and mRNA in rat adipose tissue at weaning
8. Functional domains of the α1 catalytic subunit of the AMP-activated protein kinase
9. Similar substrate recognition motifs for mammalian AMP-activated protein kinase, higher-plant HMG-CoA reductase kinase-A, yeast Snf1, and mammalian calmodulin-dependent protein kinase-I
10. Regulation of the expression of the L-type pyruvate kinase gene in adult rat hepatocytes in primary culture
11. A double recombinant adenovirus expressing the costimulatory molecule B7-1 (murine) and human IL-2 induces complete tumor regression in a murine breast adenocarcinoma model
12. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product
13. AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes
14. ADD1/SREBP1c is required in the activation of hepatic lipogenic gene expression by glucose
15. Mechanisms by which carbohydrates regulate expression of genes for glycolytic and lipogenic enzymes
16. The AMP-activated protein kinase: Fuel gauge of the mammalian cell?
17. The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
18. The AMP-activated protein kinase - A multisubstrate regulator of lipid metabolism
19. AMP-activated protein kinase: An ultrasensitive system for monitoring cellular energy charge
20. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase
21. Evidence for AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport
22. A simplified system for generating recombinant adenoviruses
23. Chronic activation of 5'-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle
24. Sequences within the 5'-flanking region of the S14 gene confer responsiveness to glucose in primary hepatocytes
25. Cell-type specificity of inhibition of glycolysis by 5-amino-4 imidazolecarboxamide riboside. Lack of effect in rabbit cardiomyocytes and human erythrocytes, and inhibition in FTO-2B rat hepatoma cells
26. Active and inactive protein kinases: Structural basis for regulation
27. Feasting, fasting and fermenting: Glucose sensing in yeast and other cells
28. Dealing with energy demand: The AMP-activated protein kinase
29. High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase
30. Vasomotor dysfunction early after exposure of normal rabbit arteries to an adenoviral vector
31. The AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex
32. Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase
33. Induction of fatty acid synthase and S14 gene expression by glucose, xylitol and dihydroxyacetone in cultured rat hepatocytes is closely correlated with glucose 6-phosphate concentrations
34. AMP-activated protein kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: Evidence that sn-glycerol-3-phosphate acyltransferase is a novel target
35. Exercise induces a transient increase in transcription of the GLUT4 gene in skeletal muscle
36. Lack of evidence of phenotypic complementation of E1A/E1B-deleted adenovirus upon superinfection by wild-type virus in the cotton rat
37. 5-Amino-4-imidazole-carboxamide riboside (Z-riboside) metabolism in eukaryotic cells
38. AMP-activated protein kinase: Greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform
39. AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic β cells, and may regulate insulin release
40. Mammalian 5'-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase
41. The regulation of AMP-activated protein kinase by phosphorylation
42. Two glucose signalling pathways in S14 gene transcription in primary hepatocytes: A common role of protein phosphorylation
43. Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase
44. Characterization of AMP-activated protein kinase in human liver using specific peptide substrates and the effects of AMP analogs on enzyme activity
45. Regulation of the expression of lipogenic enzymes by carbohydrates
46. Glucose repression in the yeast Saccharomyces cerevisiae
47. Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscle
48. Control of hepatic fatty acid oxidation by 5'-AMP-activated protein kinase involves a malonyl-CoA-dependent and a malonyl-CoA-independent mechanism
49. Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components
50. Glucose repression/derepression in budding yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio
51. Characterization of AMP-activated protein kinase β subunit and γ subunit - Assembly of the heterotrimeric complex in vitro
52. Yeast Snf1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo
53. The α1 and α2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro