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Volumn 56, Issue 6, 2007, Pages 1630-1637

Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 6; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN S6; STAT3 PROTEIN;

EID: 34249682779     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db06-1733     Document Type: Article
Times cited : (177)

References (51)
  • 1
    • 12344266697 scopus 로고    scopus 로고
    • How obesity causes diabetes: Not a tall tale
    • Lazar MA: How obesity causes diabetes: not a tall tale. Science 307:373-375, 2005
    • (2005) Science , vol.307 , pp. 373-375
    • Lazar, M.A.1
  • 4
    • 33846883060 scopus 로고    scopus 로고
    • Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis
    • Pedersen BK, Febbraio MA, Mooney RA: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis. J Appl Physiol 102:814-819, 2007
    • (2007) J Appl Physiol , vol.102 , pp. 814-819
    • Pedersen, B.K.1    Febbraio, M.A.2    Mooney, R.A.3
  • 5
    • 0035023128 scopus 로고    scopus 로고
    • Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
    • Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G: Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 280:E745-E751, 2001
    • (2001) Am J Physiol Endocrinol Metab , vol.280
    • Kern, P.A.1    Ranganathan, S.2    Li, C.3    Wood, L.4    Ranganathan, G.5
  • 8
    • 27744503664 scopus 로고    scopus 로고
    • Plasma IL-6 concentration is inversely related to insulin sensitivity, and acute-phase proteins associate with glucose and lipid metabolism in healthy subjects
    • Heliovaara MK, Teppo AM, Karonen SL, Tuominen JA, Ebeling P: Plasma IL-6 concentration is inversely related to insulin sensitivity, and acute-phase proteins associate with glucose and lipid metabolism in healthy subjects. Diabetes Obes Metab 7:729-736, 2005
    • (2005) Diabetes Obes Metab , vol.7 , pp. 729-736
    • Heliovaara, M.K.1    Teppo, A.M.2    Karonen, S.L.3    Tuominen, J.A.4    Ebeling, P.5
  • 9
    • 3142710172 scopus 로고    scopus 로고
    • Interleukin-6 and tumor necrosis factor-a are not increased in patients with type 2 diabetes: Evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness
    • Carey AL, Bruce CR, Sacchetti M, Anderson MJ, Olsen DB, Saltin B, Hawley JA, Febbraio MA: Interleukin-6 and tumor necrosis factor-a are not increased in patients with type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness. Diabetologia 47:1029-1037, 2004
    • (2004) Diabetologia , vol.47 , pp. 1029-1037
    • Carey, A.L.1    Bruce, C.R.2    Sacchetti, M.3    Anderson, M.J.4    Olsen, D.B.5    Saltin, B.6    Hawley, J.A.7    Febbraio, M.A.8
  • 10
    • 22244477735 scopus 로고    scopus 로고
    • Contraction-induced myokine production and release: Is skeletal muscle an endocrine organ?
    • Febbraio MA, Pedersen BK: Contraction-induced myokine production and release: is skeletal muscle an endocrine organ? Exerc Sport Sci Rev 33:114-119, 2005
    • (2005) Exerc Sport Sci Rev , vol.33 , pp. 114-119
    • Febbraio, M.A.1    Pedersen, B.K.2
  • 11
    • 0031895668 scopus 로고    scopus 로고
    • Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running
    • Ostrowski K, Rohde T, Zacho M, Asp S, Pedersen BK: Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running. J Physiol (Lond) 508:949-953, 1998
    • (1998) J Physiol (Lond) , vol.508 , pp. 949-953
    • Ostrowski, K.1    Rohde, T.2    Zacho, M.3    Asp, S.4    Pedersen, B.K.5
  • 12
    • 23044448763 scopus 로고    scopus 로고
    • Muscle-derived interleukin-6: A possible link between skeletal muscle, adipose tissue, liver, and brain
    • Pedersen BK, Febbraio M: Muscle-derived interleukin-6: a possible link between skeletal muscle, adipose tissue, liver, and brain Brain Behav Immun 19:371-376, 2005
    • (2005) Brain Behav Immun , vol.19 , pp. 371-376
    • Pedersen, B.K.1    Febbraio, M.2
  • 13
    • 0036720342 scopus 로고    scopus 로고
    • Muscle-derived interleukin-6: Mechanisms for activation and possible biological roles
    • Febbraio MA, Pedersen BK: Muscle-derived interleukin-6: mechanisms for activation and possible biological roles. FASEB J 16:1335-1347, 2002
    • (2002) FASEB J , vol.16 , pp. 1335-1347
    • Febbraio, M.A.1    Pedersen, B.K.2
  • 14
    • 0042591426 scopus 로고    scopus 로고
    • Skeletal muscle interleukin-6 and tumor necrosis factor-alpha release in healthy subjects and patients with type 2 diabetes at rest and during exercise
    • Febbraio MA, Steensberg A, Starkie RL, McConell GK, Kingwell BA: Skeletal muscle interleukin-6 and tumor necrosis factor-alpha release in healthy subjects and patients with type 2 diabetes at rest and during exercise. Metabolism 52:939-944, 2003
    • (2003) Metabolism , vol.52 , pp. 939-944
    • Febbraio, M.A.1    Steensberg, A.2    Starkie, R.L.3    McConell, G.K.4    Kingwell, B.A.5
  • 15
    • 0037853260 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
    • Senn JJ, Klover PJ, Nowak IA, Zimmers TA, Koniaris LG, Furlanetto RW, Mooney RA: Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. J Bio Chem 278:13740-13746, 2003
    • (2003) J Bio Chem , vol.278 , pp. 13740-13746
    • Senn, J.J.1    Klover, P.J.2    Nowak, I.A.3    Zimmers, T.A.4    Koniaris, L.G.5    Furlanetto, R.W.6    Mooney, R.A.7
  • 16
    • 0036894360 scopus 로고    scopus 로고
    • Interleukin-6 induces cellular insulin resistance in hepatocytes
    • Senn JJ, Klover PJ, Nowak IA, Mooney RA: Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes 51:3391-3399, 2002
    • (2002) Diabetes , vol.51 , pp. 3391-3399
    • Senn, J.J.1    Klover, P.J.2    Nowak, I.A.3    Mooney, R.A.4
  • 17
    • 0242580711 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects
    • Rotter V, Nagaev I, Smith U: Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem 278:45777-45784, 2003
    • (2003) J Biol Chem , vol.278 , pp. 45777-45784
    • Rotter, V.1    Nagaev, I.2    Smith, U.3
  • 20
    • 33751501694 scopus 로고    scopus 로고
    • Signalling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle
    • Al-Khalili L, Bouzakri K, Glund S, Lönnqvist F, Koistinen HA, Krook A: Signalling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle. Mol Endocrinol 12:3364-3375, 2006
    • (2006) Mol Endocrinol , vol.12 , pp. 3364-3375
    • Al-Khalili, L.1    Bouzakri, K.2    Glund, S.3    Lönnqvist, F.4    Koistinen, H.A.5    Krook, A.6
  • 22
    • 12144274058 scopus 로고    scopus 로고
    • Short-term infusion of interleukin-6 does not induce insulin resistance in vivo or impair insulin signalling in rats
    • Rotter Sopasakis V, Larsson BM, Johansson A, Holmäng A, Smith U: Short-term infusion of interleukin-6 does not induce insulin resistance in vivo or impair insulin signalling in rats. Diabetologia 47:1879-1887, 2004
    • (2004) Diabetologia , vol.47 , pp. 1879-1887
    • Rotter Sopasakis, V.1    Larsson, B.M.2    Johansson, A.3    Holmäng, A.4    Smith, U.5
  • 24
    • 0029438723 scopus 로고
    • In vitro studies of human skeletal muscle: Hormonal and metabolic regulation of glucose transport
    • Zierath JR: In vitro studies of human skeletal muscle: hormonal and metabolic regulation of glucose transport. Acta Physiol Scand 155:1-96, 1995
    • (1995) Acta Physiol Scand , vol.155 , pp. 1-96
    • Zierath, J.R.1
  • 26
    • 0017109461 scopus 로고
    • Decreased basal, noninsulin-stimulated glucose uptake and metabolism by skeletal soleus muscle isolated from obese-hyperglycemic (ob/ob) mice
    • Cuendet GS, Loten EG, Jeanrenaud B, Renold AE: Decreased basal, noninsulin-stimulated glucose uptake and metabolism by skeletal soleus muscle isolated from obese-hyperglycemic (ob/ob) mice. J Clin Invest 58:1078-1088, 1976
    • (1976) J Clin Invest , vol.58 , pp. 1078-1088
    • Cuendet, G.S.1    Loten, E.G.2    Jeanrenaud, B.3    Renold, A.E.4
  • 27
    • 0029927839 scopus 로고    scopus 로고
    • Two naturally occurring mutant insulin receptors phosphorylate insulin receptor substrate-1 (IRS-1) but fail to mediate the biological effects of insulin
    • Krook A, Moller DE, Dib K, O'Rahilly S: Two naturally occurring mutant insulin receptors phosphorylate insulin receptor substrate-1 (IRS-1) but fail to mediate the biological effects of insulin. J Biol Chem 271:7134-7140, 1996
    • (1996) J Biol Chem , vol.271 , pp. 7134-7140
    • Krook, A.1    Moller, D.E.2    Dib, K.3    O'Rahilly, S.4
  • 29
    • 0032189103 scopus 로고    scopus 로고
    • The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis
    • Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S, Woo P: The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 102:1369-1376, 1998
    • (1998) J Clin Invest , vol.102 , pp. 1369-1376
    • Fishman, D.1    Faulds, G.2    Jeffery, R.3    Mohamed-Ali, V.4    Yudkin, J.S.5    Humphries, S.6    Woo, P.7
  • 30
    • 23044499225 scopus 로고    scopus 로고
    • Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt
    • Weigert C, Hennige AM, Brodbeck K, Haring HU, Schleicher ED: Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt. Am J Physiol Endocrinol Metab 289:E251-E257, 2005
    • (2005) Am J Physiol Endocrinol Metab , vol.289
    • Weigert, C.1    Hennige, A.M.2    Brodbeck, K.3    Haring, H.U.4    Schleicher, E.D.5
  • 31
    • 1542297244 scopus 로고    scopus 로고
    • IL-6 signal transduction and its physiological roles: The signal orchestration model
    • Kamimura D, Ishihara K, Hirano T: IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev Physiol Biochem Pharmacol 149:1-38, 2003
    • (2003) Rev Physiol Biochem Pharmacol , vol.149 , pp. 1-38
    • Kamimura, D.1    Ishihara, K.2    Hirano, T.3
  • 32
    • 23044468612 scopus 로고    scopus 로고
    • Interleukin-6 depletion selectively improves hepatic insulin action in obesity
    • Klover PJ, Clementi AH, Mooney RA: Interleukin-6 depletion selectively improves hepatic insulin action in obesity. Endocrinology 146:3417-3427, 2005
    • (2005) Endocrinology , vol.146 , pp. 3417-3427
    • Klover, P.J.1    Clementi, A.H.2    Mooney, R.A.3
  • 35
    • 33745836687 scopus 로고    scopus 로고
    • Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR
    • Williamson DL, Bolster DR, Kimball SR, Jefferson LS: Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR. Am J Physiol Endocrinol Metab 291:E80-E89, 2006
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Williamson, D.L.1    Bolster, D.R.2    Kimball, S.R.3    Jefferson, L.S.4
  • 36
    • 3543008912 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte
    • Chan AYM, Soltys CLM, Young ME, Proud CG, Dyck JRB: Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte. J Biol Chem 279:32771-32779, 2004
    • (2004) J Biol Chem , vol.279 , pp. 32771-32779
    • Chan, A.Y.M.1    Soltys, C.L.M.2    Young, M.E.3    Proud, C.G.4    Dyck, J.R.B.5
  • 37
    • 0036364274 scopus 로고    scopus 로고
    • Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes
    • Krause U, Bertrand L, Hue L: Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes. Eur J Biochem 269:3751-3759, 2002
    • (2002) Eur J Biochem , vol.269 , pp. 3751-3759
    • Krause, U.1    Bertrand, L.2    Hue, L.3
  • 39
    • 27744469758 scopus 로고    scopus 로고
    • Tendon healing in interleukin-4 and interleukin-6 knockout mice
    • Lin TW, Cardenas L, Glaser DL, Soslowsky LJ: Tendon healing in interleukin-4 and interleukin-6 knockout mice. J Biomech 39:61-69, 2006
    • (2006) J Biomech , vol.39 , pp. 61-69
    • Lin, T.W.1    Cardenas, L.2    Glaser, D.L.3    Soslowsky, L.J.4
  • 40
    • 1642423481 scopus 로고    scopus 로고
    • p38 MAPK-induced nuclear factor-kappa B activity is required for skeletal muscle differentiation: Role of interleukin-6
    • Baeza-Raja B, Munoz-Canoves P: p38 MAPK-induced nuclear factor-kappa B activity is required for skeletal muscle differentiation: role of interleukin-6. Mol Biol Cell 15:2013-2026, 2004
    • (2004) Mol Biol Cell , vol.15 , pp. 2013-2026
    • Baeza-Raja, B.1    Munoz-Canoves, P.2
  • 41
    • 35148886207 scopus 로고    scopus 로고
    • Plasma levels of interleukin-6 and C-reactive protein are associated with physical inactivity independent of obesity
    • In press
    • Fischer CP, Berntsen A, Perstrup LB, Eskildsen P, Pedersen BK: Plasma levels of interleukin-6 and C-reactive protein are associated with physical inactivity independent of obesity. Scand J Med Sci Sports. In press
    • Scand J Med Sci Sports
    • Fischer, C.P.1    Berntsen, A.2    Perstrup, L.B.3    Eskildsen, P.4    Pedersen, B.K.5
  • 42
    • 28044442051 scopus 로고    scopus 로고
    • The effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle
    • Keller C, Steensberg A, Hansen AK, Fischer CP, Plomgaard P, Pedersen BK: The effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle. J Appl Physiol 99:2075-2079, 2005
    • (2005) J Appl Physiol , vol.99 , pp. 2075-2079
    • Keller, C.1    Steensberg, A.2    Hansen, A.K.3    Fischer, C.P.4    Plomgaard, P.5    Pedersen, B.K.6
  • 43
    • 0345700727 scopus 로고    scopus 로고
    • Inflammatory cytokines and the risk to develop type 2 diabetes: Results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    • Spranger J, Kroke A, Mohlig M, Hoffmann K, Bergmann MM, Ristow M, Boeing H, Pfeiffer AFH: Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes 52:812-817, 2003
    • (2003) Diabetes , vol.52 , pp. 812-817
    • Spranger, J.1    Kroke, A.2    Mohlig, M.3    Hoffmann, K.4    Bergmann, M.M.5    Ristow, M.6    Boeing, H.7    Pfeiffer, A.F.H.8
  • 45
    • 0031956922 scopus 로고    scopus 로고
    • Proinflammatory mediator release after total hip arthroplasty
    • Hill GE, Whitten CW: Proinflammatory mediator release after total hip arthroplasty. Anesthesiology 88:1407-1408, 1998
    • (1998) Anesthesiology , vol.88 , pp. 1407-1408
    • Hill, G.E.1    Whitten, C.W.2
  • 46
    • 18144402800 scopus 로고    scopus 로고
    • Emerging biologic therapies in rheumatoid arthritis: Cell targets and cytokines
    • Singh R, Robinson DB, El-Gabalawy HS: Emerging biologic therapies in rheumatoid arthritis: cell targets and cytokines. Curr Opin Rheumatol 17:274-279, 2005
    • (2005) Curr Opin Rheumatol , vol.17 , pp. 274-279
    • Singh, R.1    Robinson, D.B.2    El-Gabalawy, H.S.3
  • 47
    • 0037236935 scopus 로고    scopus 로고
    • The effect of graded exercise on IL-6 release and glucose uptake in human skeletal muscle
    • Helge JW, Stallknecht B, Pedersen BK, Galbo H, Kiens B, Richter EA: The effect of graded exercise on IL-6 release and glucose uptake in human skeletal muscle. J Physiol 546:299-305, 2003
    • (2003) J Physiol , vol.546 , pp. 299-305
    • Helge, J.W.1    Stallknecht, B.2    Pedersen, B.K.3    Galbo, H.4    Kiens, B.5    Richter, E.A.6
  • 51
    • 24344509287 scopus 로고    scopus 로고
    • Effect of the interleukin-6 (-174) G/C promoter polymorphism on adiponectin and insulin sensitivity
    • Yang X, Jansson P-A, Pellme F, Laakso M, Smith U: Effect of the interleukin-6 (-174) G/C promoter polymorphism on adiponectin and insulin sensitivity. Obesity Res 13:813-817, 2005
    • (2005) Obesity Res , vol.13 , pp. 813-817
    • Yang, X.1    Jansson, P.-A.2    Pellme, F.3    Laakso, M.4    Smith, U.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.