메뉴 건너뛰기




Volumn 83, Issue 1, 2015, Pages 120-131

Potential role of growth factors in the management of spinal cord injury

Author keywords

Growth factor; Recovery; Spinal cord injury

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GROWTH FACTOR; NEUROTROPHIN 3; NEUROTROPHIN 4; NERVE GROWTH FACTOR;

EID: 84923535682     PISSN: 18788750     EISSN: 18788769     Source Type: Journal    
DOI: 10.1016/j.wneu.2013.01.042     Document Type: Review
Times cited : (45)

References (170)
  • 1
    • 0017177655 scopus 로고
    • Potential of Schwann cells from unmyelinated nerves to produce myelin: A quantitative ultrastructural and radiographic study
    • A.J. Aguayo, L. Charron, and G.M. Bray Potential of Schwann cells from unmyelinated nerves to produce myelin: a quantitative ultrastructural and radiographic study J Neurocytol 5 1976 565 573
    • (1976) J Neurocytol , vol.5 , pp. 565-573
    • Aguayo, A.J.1    Charron, L.2    Bray, G.M.3
  • 3
    • 69449094846 scopus 로고    scopus 로고
    • Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury
    • L.T. Alto, L.A. Havton, J.M. Conner, E.R. Hollis 2nd, A. Blesch, and M.H. Tuszynski Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury Nature Neurosci 12 2009 1106 1113
    • (2009) Nature Neurosci , vol.12 , pp. 1106-1113
    • Alto, L.T.1    Havton, L.A.2    Conner, J.M.3    Hollis, E.R.4    Blesch, A.5    Tuszynski, M.H.6
  • 4
    • 0036939722 scopus 로고    scopus 로고
    • Fibroblast growth factors and neuroprotection
    • C. Alzheimer, and S. Werner Fibroblast growth factors and neuroprotection Adv Exp Med Biol 513 2002 335 351
    • (2002) Adv Exp Med Biol , vol.513 , pp. 335-351
    • Alzheimer, C.1    Werner, S.2
  • 5
    • 0023928594 scopus 로고
    • Basic FGF prevents death of lesioned cholinergic neurons in vivo
    • K.J. Anderson, D. Dam, S. Lee, and C.W. Cotman Basic FGF prevents death of lesioned cholinergic neurons in vivo Nature 332 1988 360 361
    • (1988) Nature , vol.332 , pp. 360-361
    • Anderson, K.J.1    Dam, D.2    Lee, S.3    Cotman, C.W.4
  • 6
    • 0034948264 scopus 로고    scopus 로고
    • Pegylated brain-derived neurotrophic factor shows improved distribution into the spinal cord and stimulates locomotor activity and morphological changes after injury
    • D.P. Ankeny, D.M. McTigue, Z. Guan, Q. Yan, O. Kinstler, B.T. Stokes, and L.B. Jakeman Pegylated brain-derived neurotrophic factor shows improved distribution into the spinal cord and stimulates locomotor activity and morphological changes after injury Exp Neurol 170 2001 85 100
    • (2001) Exp Neurol , vol.170 , pp. 85-100
    • Ankeny, D.P.1    McTigue, D.M.2    Guan, Z.3    Yan, Q.4    Kinstler, O.5    Stokes, B.T.6    Jakeman, L.B.7
  • 7
    • 5044220530 scopus 로고    scopus 로고
    • Bone marrow transplants provide tissue protection and directional guidance for axons after contusive spinal cord injury in rats
    • D.P. Ankeny, D.M. McTigue, and L.B. Jakeman Bone marrow transplants provide tissue protection and directional guidance for axons after contusive spinal cord injury in rats Exp Neurol 90 2004 17 31
    • (2004) Exp Neurol , vol.90 , pp. 17-31
    • Ankeny, D.P.1    McTigue, D.M.2    Jakeman, L.B.3
  • 8
    • 0029584686 scopus 로고
    • GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo
    • E. Arenas, M. Trupp, P. Akerud, and C.F. Ibanez GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo Neuron 15 1995 1465 1473
    • (1995) Neuron , vol.15 , pp. 1465-1473
    • Arenas, E.1    Trupp, M.2    Akerud, P.3    Ibanez, C.F.4
  • 9
    • 65649113921 scopus 로고    scopus 로고
    • Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis
    • L. Bai, D.P. Lennon, V. Eaton, K. Maier, A.I. Caplan, S.D. Miller, and R.H. Miller Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis Glia 57 2009 1192 1203
    • (2009) Glia , vol.57 , pp. 1192-1203
    • Bai, L.1    Lennon, D.P.2    Eaton, V.3    Maier, K.4    Caplan, A.I.5    Miller, S.D.6    Miller, R.H.7
  • 10
    • 31944433392 scopus 로고    scopus 로고
    • Lumbar puncture delivery of bone marrow stromal cells in spinal cord contusion: A novel method for minimally invasive cell transplantation
    • A. Bakshi, A.L. Barshinger, S.A. Swanger, V. Madhavani, J.S. Shumsky, B. Neuhuber, and I. Fischer Lumbar puncture delivery of bone marrow stromal cells in spinal cord contusion: a novel method for minimally invasive cell transplantation J Neurotrauma 23 2006 55 65
    • (2006) J Neurotrauma , vol.23 , pp. 55-65
    • Bakshi, A.1    Barshinger, A.L.2    Swanger, S.A.3    Madhavani, V.4    Shumsky, J.S.5    Neuhuber, B.6    Fischer, I.7
  • 11
    • 0020338405 scopus 로고
    • Purification of a new neurotrophic factor from mammalian brain
    • Y.A. Barde, D. Edgar, and H. Thoenen Purification of a new neurotrophic factor from mammalian brain EMBO J 1 1982 549 553
    • (1982) EMBO J , vol.1 , pp. 549-553
    • Barde, Y.A.1    Edgar, D.2    Thoenen, H.3
  • 12
    • 0028341483 scopus 로고
    • Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus
    • T. Beck, D. Lindholm, E. Castren, and A. Wree Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus J Cereb Blood Flow Metab 14 1994 689 692
    • (1994) J Cereb Blood Flow Metab , vol.14 , pp. 689-692
    • Beck, T.1    Lindholm, D.2    Castren, E.3    Wree, A.4
  • 14
    • 0036098072 scopus 로고    scopus 로고
    • Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair
    • A. Blesch, P. Lu, and M.H. Tuszynski Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair Brain Res Bull 57 2002 833 838
    • (2002) Brain Res Bull , vol.57 , pp. 833-838
    • Blesch, A.1    Lu, P.2    Tuszynski, M.H.3
  • 15
    • 58149512333 scopus 로고    scopus 로고
    • Spinal cord injury: Plasticity, regeneration and the challenge of translational drug development
    • A. Blesch, and M.H. Tuszynski Spinal cord injury: plasticity, regeneration and the challenge of translational drug development Trends Neurosci 32 2009 41 47
    • (2009) Trends Neurosci , vol.32 , pp. 41-47
    • Blesch, A.1    Tuszynski, M.H.2
  • 16
    • 5644264890 scopus 로고    scopus 로고
    • Axonal responses to cellularly delivered NT-4/5 after spinal cord injury
    • A. Blesch, H. Yang, N. Weidner, A. Hoang, and D. Otero Axonal responses to cellularly delivered NT-4/5 after spinal cord injury Mol Cell Neurosci 27 2004 190 201
    • (2004) Mol Cell Neurosci , vol.27 , pp. 190-201
    • Blesch, A.1    Yang, H.2    Weidner, N.3    Hoang, A.4    Otero, D.5
  • 17
    • 58149512333 scopus 로고    scopus 로고
    • Spinal cord injury: Plasticity, regeneration and the challenge of translational during development
    • A. Blesch, and M.H. Tuszynski Spinal cord injury: plasticity, regeneration and the challenge of translational during development Trends Neurosci 32 2009 41 47
    • (2009) Trends Neurosci , vol.32 , pp. 41-47
    • Blesch, A.1    Tuszynski, M.H.2
  • 19
    • 0141448981 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor sustain the axonal regeneration of chronically axotomized motoneurons in vivo
    • J.G. Boyd, and T. Gordon Glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor sustain the axonal regeneration of chronically axotomized motoneurons in vivo Exp Neurol 183 2003 610 619
    • (2003) Exp Neurol , vol.183 , pp. 610-619
    • Boyd, J.G.1    Gordon, T.2
  • 20
    • 0032722126 scopus 로고    scopus 로고
    • NT-3 promotes growth of lesioned adult rat sensory axons ascending in the dorsal columns of the spinal cord
    • E.J. Bradbury, S. Khemani, V.R. King, J.V. Priestley, and S.B. McMahon NT-3 promotes growth of lesioned adult rat sensory axons ascending in the dorsal columns of the spinal cord Eur J Neurosci 11 1999 3873 3883
    • (1999) Eur J Neurosci , vol.11 , pp. 3873-3883
    • Bradbury, E.J.1    Khemani, S.2    King, V.R.3    Priestley, J.V.4    McMahon, S.B.5
  • 21
    • 0031427410 scopus 로고    scopus 로고
    • Neurotrophic factors increase axonal growth after spinal cord injury and transplantation in the adult rat
    • B.S. Bregman, M. McAtee, H.N. Dai, and P.L. Kuhn Neurotrophic factors increase axonal growth after spinal cord injury and transplantation in the adult rat Exp Neurol 148 1997 475 494
    • (1997) Exp Neurol , vol.148 , pp. 475-494
    • Bregman, B.S.1    McAtee, M.2    Dai, H.N.3    Kuhn, P.L.4
  • 22
    • 0028884522 scopus 로고
    • GDNF is an age-specific survival factor for sensory and autonomic neurons
    • A. Buj-Bello, V.L. Buchman, A. Horton, A. Rosenthal, and A.M. Davies GDNF is an age-specific survival factor for sensory and autonomic neurons Neuron 15 1995 821 828
    • (1995) Neuron , vol.15 , pp. 821-828
    • Buj-Bello, A.1    Buchman, V.L.2    Horton, A.3    Rosenthal, A.4    Davies, A.M.5
  • 23
    • 0034911949 scopus 로고    scopus 로고
    • Bridging areas of injury in the spinal cord
    • M.B. Bunge Bridging areas of injury in the spinal cord Neuroscientist 7 2001 325 339
    • (2001) Neuroscientist , vol.7 , pp. 325-339
    • Bunge, M.B.1
  • 24
    • 31844433193 scopus 로고    scopus 로고
    • Delivery of autologous bone marrow precursor cells into the spinal cord via lumbar puncture technique in patients with spinal cord injury: A preliminary safety study
    • F. Callera, and do Nascimento Delivery of autologous bone marrow precursor cells into the spinal cord via lumbar puncture technique in patients with spinal cord injury: a preliminary safety study Exp Hematol 34 2006 130 131
    • (2006) Exp Hematol , vol.34 , pp. 130-131
    • Callera, F.1    Nascimento, D.2
  • 25
    • 0029021457 scopus 로고
    • P75 and Trk: A two-receptor system
    • M.V. Chao, and B.L. Hempstead p75 and Trk: a two-receptor system Trends Neurosci 18 1995 321 326
    • (1995) Trends Neurosci , vol.18 , pp. 321-326
    • Chao, M.V.1    Hempstead, B.L.2
  • 26
    • 0041336932 scopus 로고    scopus 로고
    • Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat
    • J. Chen, Y. Li, M. Katakowski, X. Chen, L. Wang, D. Lu, M. Lu, S.C. Gautam, and M. Chopp Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat J Neurosci Res 73 2003 778 786
    • (2003) J Neurosci Res , vol.73 , pp. 778-786
    • Chen, J.1    Li, Y.2    Katakowski, M.3    Chen, X.4    Wang, L.5    Lu, D.6    Lu, M.7    Gautam, S.C.8    Chopp, M.9
  • 28
    • 5444230191 scopus 로고    scopus 로고
    • Spinal cord repair with acidic fibroblast growth factor as a treatment for a patient with chronic paraplegia
    • H. Cheng, K.K. Liao, S.F. Liao, T.Y. Chuang, and Y.H. Shih Spinal cord repair with acidic fibroblast growth factor as a treatment for a patient with chronic paraplegia Spine 29 2004 E284 E288
    • (2004) Spine , vol.29 , pp. E284-E288
    • Cheng, H.1    Liao, K.K.2    Liao, S.F.3    Chuang, T.Y.4    Shih, Y.H.5
  • 29
    • 0034637810 scopus 로고    scopus 로고
    • Spinal cord injury in rat: Treatment with bone marrow stromal cell transplantation
    • M. Chopp, X.H. Zhang, Y. Li, L. Wang, J. Chen, D. Lu, M. Lu, and M. Rosenblum Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation Neuroreport 11 2000 3001 3005
    • (2000) Neuroreport , vol.11 , pp. 3001-3005
    • Chopp, M.1    Zhang, X.H.2    Li, Y.3    Wang, L.4    Chen, J.5    Lu, D.6    Lu, M.7    Rosenblum, M.8
  • 31
    • 33845534557 scopus 로고    scopus 로고
    • Transplants of human mesenchymal stem cells improve functional recovery after spinal cord injury in the rat
    • D. Cízková, J. Rosocha, I. Vanický, S. Jergová, and M. Cízek Transplants of human mesenchymal stem cells improve functional recovery after spinal cord injury in the rat Cell Mol Neurobiol 26 2006 1167 1180
    • (2006) Cell Mol Neurobiol , vol.26 , pp. 1167-1180
    • Cízková, D.1    Rosocha, J.2    Vanický, I.3    Jergová, S.4    Cízek, M.5
  • 32
    • 77949700751 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and the development of structural neuronal connectivity
    • S. Cohen-Cory, A.H. Kidane, N.J. Shirkey, and S. Marshak Brain-derived neurotrophic factor and the development of structural neuronal connectivity Dev Neurobiol 70 2010 271 288
    • (2010) Dev Neurobiol , vol.70 , pp. 271-288
    • Cohen-Cory, S.1    Kidane, A.H.2    Shirkey, N.J.3    Marshak, S.4
  • 34
    • 53749099516 scopus 로고    scopus 로고
    • Treatment of chronic spinal cord injured patients with autologous bone marrow-derived hematopoietic stem cell transplantation: 1-year follow-up
    • H. Deda, M.C. Inci, A.E. Kürekçi, K. Kayihan, E. Ozgün, G.E. Ustünsoy, and S. Kocabay Treatment of chronic spinal cord injured patients with autologous bone marrow-derived hematopoietic stem cell transplantation: 1-year follow-up Cytotherapy 10 2008 565 574
    • (2008) Cytotherapy , vol.10 , pp. 565-574
    • Deda, H.1    Inci, M.C.2    Kürekçi, A.E.3    Kayihan, K.4    Ozgün, E.5    Ustünsoy, G.E.6    Kocabay, S.7
  • 35
    • 79956109364 scopus 로고    scopus 로고
    • GDNF modifies reactive astrogliosis allowing robust axonal regeneration through Schwann cell-seeded guidance channels after spinal cord injury
    • L.X. Deng, J. Hu, N. Liu, X. Wang, G.M. Smith, X. Wen, and X.M. Xu GDNF modifies reactive astrogliosis allowing robust axonal regeneration through Schwann cell-seeded guidance channels after spinal cord injury Exp Neurol 229 2011 238 250
    • (2011) Exp Neurol , vol.229 , pp. 238-250
    • Deng, L.X.1    Hu, J.2    Liu, N.3    Wang, X.4    Smith, G.M.5    Wen, X.6    Xu, X.M.7
  • 36
    • 33646576505 scopus 로고    scopus 로고
    • Functional considerations of stem cell transplantation therapy for spinal cord repair
    • G.U. Enzmann, R.L. Benton, J.F. Talbott, Q. Cao, and S.R. Whittemore Functional considerations of stem cell transplantation therapy for spinal cord repair J Neurotrauma 23 2006 479 495
    • (2006) J Neurotrauma , vol.23 , pp. 479-495
    • Enzmann, G.U.1    Benton, R.L.2    Talbott, J.F.3    Cao, Q.4    Whittemore, S.R.5
  • 39
    • 33646672406 scopus 로고    scopus 로고
    • Overcoming inhibition in the damaged spinal cord
    • J.W. Fawcett Overcoming inhibition in the damaged spinal cord J Neurotrauma 23 2006 371 383
    • (2006) J Neurotrauma , vol.23 , pp. 371-383
    • Fawcett, J.W.1
  • 40
    • 21344461953 scopus 로고    scopus 로고
    • Current status of clinical trials for acute spinal cord injury
    • M.G. Fehlings, and D.C. Baptiste Current status of clinical trials for acute spinal cord injury Injury 36 2005 B113 B122
    • (2005) Injury , vol.36 , pp. B113-B122
    • Fehlings, M.G.1    Baptiste, D.C.2
  • 42
    • 0035109207 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat
    • I. Ferrer, J. Krupinski, E. Goutan, E. Martí, S. Ambrosio, and E. Arenas Brain-derived neurotrophic factor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat Acta Neuropathol 101 2001 229 238
    • (2001) Acta Neuropathol , vol.101 , pp. 229-238
    • Ferrer, I.1    Krupinski, J.2    Goutan, E.3    Martí, E.4    Ambrosio, S.5    Arenas, E.6
  • 43
    • 0029970008 scopus 로고    scopus 로고
    • Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus
    • A. Figurov, L.D. Pozzo-Miller, P. Olafsson, T. Wang, and B. Lu Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus Nature 381 1996 706 709
    • (1996) Nature , vol.381 , pp. 706-709
    • Figurov, A.1    Pozzo-Miller, L.D.2    Olafsson, P.3    Wang, T.4    Lu, B.5
  • 44
    • 0141499228 scopus 로고    scopus 로고
    • Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS
    • M.T. Filbin Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS Nat Rev Neurosci 4 2003 703 713
    • (2003) Nat Rev Neurosci , vol.4 , pp. 703-713
    • Filbin, M.T.1
  • 45
    • 38649112309 scopus 로고    scopus 로고
    • CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure
    • M.T. Fitch, and J. Silver CNS injury, glial scars, and inflammation: inhibitory extracellular matrices and regeneration failure Exp Neurol 209 2008 294 301
    • (2008) Exp Neurol , vol.209 , pp. 294-301
    • Fitch, M.T.1    Silver, J.2
  • 47
    • 57749120457 scopus 로고    scopus 로고
    • Design of a conformationally defined and proteolytically stable circular mimetic of brain-derived neurotrophic factor
    • J.M. Fletcher, C.J. Morton, R.A. Zwar, S.S. Murray, P.D. O'Leary, and R.A. Hughes Design of a conformationally defined and proteolytically stable circular mimetic of brain-derived neurotrophic factor J Biol Chem 283 2008 33375 33383
    • (2008) J Biol Chem , vol.283 , pp. 33375-33383
    • Fletcher, J.M.1    Morton, C.J.2    Zwar, R.A.3    Murray, S.S.4    O'Leary, P.D.5    Hughes, R.A.6
  • 48
    • 84862877006 scopus 로고    scopus 로고
    • Recent therapeutic strategies for spinal cord injury treatment: Possible role of stem cells
    • D. Garbossa, M. Boido, M. Fontanella, C. Fronda, A. Ducati, and A. Vercelli Recent therapeutic strategies for spinal cord injury treatment: possible role of stem cells Neurosurg Rev 35 2012 293 311
    • (2012) Neurosurg Rev , vol.35 , pp. 293-311
    • Garbossa, D.1    Boido, M.2    Fontanella, M.3    Fronda, C.4    Ducati, A.5    Vercelli, A.6
  • 49
    • 83055160902 scopus 로고    scopus 로고
    • Chondroitinase ABC combined with neurotrophin NT-3 secretion and NR2D expression promotes axonal plasticity and functional recovery in rats with lateral hemisection of the spinal cord
    • G. García-Alías, H.A. Petrosyan, L. Schnell, P.J. Horner, W.J. Bowers, L.M. Mendell, J.W. Fawcett, and V.L. Arvanian Chondroitinase ABC combined with neurotrophin NT-3 secretion and NR2D expression promotes axonal plasticity and functional recovery in rats with lateral hemisection of the spinal cord J Neurosci 31 2011 17788 17799
    • (2011) J Neurosci , vol.31 , pp. 17788-17799
    • García-Alías, G.1    Petrosyan, H.A.2    Schnell, L.3    Horner, P.J.4    Bowers, W.J.5    Mendell, L.M.6    Fawcett, J.W.7    Arvanian, V.L.8
  • 50
    • 33846011117 scopus 로고    scopus 로고
    • Striatal delivery of neurturin by CERE-120, an AAV2 vector for the treatment of dopaminergic neuron degeneration in Parkinson's disease
    • M. Gasmi, C.D. Herzog, E.P. Brandon, J.J. Cunningham, G.A. Ramirez, E.T. Ketchum, and R.T. Bartus Striatal delivery of neurturin by CERE-120, an AAV2 vector for the treatment of dopaminergic neuron degeneration in Parkinson's disease Mol Ther 15 2007 62 68
    • (2007) Mol Ther , vol.15 , pp. 62-68
    • Gasmi, M.1    Herzog, C.D.2    Brandon, E.P.3    Cunningham, J.J.4    Ramirez, G.A.5    Ketchum, E.T.6    Bartus, R.T.7
  • 51
    • 62549145360 scopus 로고    scopus 로고
    • Administration of autologous bone marrow stem cells into spinal cord injury patients via multiple routes is safe and improves their quality of life: Comprehensive case studies
    • L.F. Geffner, P. Santacruz, M. Izurieta, L. Flor, B. Maldonado, A.H. Auad, X. Montenegro, R. Gonzalez, and F. Silva Administration of autologous bone marrow stem cells into spinal cord injury patients via multiple routes is safe and improves their quality of life: comprehensive case studies Cell Transplant 17 2008 1277 1293
    • (2008) Cell Transplant , vol.17 , pp. 1277-1293
    • Geffner, L.F.1    Santacruz, P.2    Izurieta, M.3    Flor, L.4    Maldonado, B.5    Auad, A.H.6    Montenegro, X.7    Gonzalez, R.8    Silva, F.9
  • 52
    • 0029989784 scopus 로고    scopus 로고
    • BDNF and NT-3, but not NGF, prevent axotomy-induced death of rat corticospinal neurons in vivo
    • K.M. Giehl, and W. Tetzlaff BDNF and NT-3, but not NGF, prevent axotomy-induced death of rat corticospinal neurons in vivo Eur J Neurosci 8 1996 1167 1175
    • (1996) Eur J Neurosci , vol.8 , pp. 1167-1175
    • Giehl, K.M.1    Tetzlaff, W.2
  • 54
    • 0347984998 scopus 로고    scopus 로고
    • Experimental strategies to promote functional recovery after peripheral nerve injuries
    • T. Gordon, O. Sulaiman, and J.G. Boyd Experimental strategies to promote functional recovery after peripheral nerve injuries J. Peripher Nerv Syst 8 2003 236 250
    • (2003) J. Peripher Nerv Syst , vol.8 , pp. 236-250
    • Gordon, T.1    Sulaiman, O.2    Boyd, J.G.3
  • 55
    • 0035987408 scopus 로고    scopus 로고
    • Ecdysone-controlled expression of transgenes
    • L.D. Graham Ecdysone-controlled expression of transgenes Expert Opin Biol Ther 2 2002 525 535
    • (2002) Expert Opin Biol Ther , vol.2 , pp. 525-535
    • Graham, L.D.1
  • 56
    • 0033842612 scopus 로고    scopus 로고
    • Angiogenesis induced by the implantation of self-bone marrow cells: A new material for therapeutic angiogenesis
    • K. Hamano, T.S. Li, T. Kobayashi, S. Kobayashi, M. Matsuzaki, and K. Esato Angiogenesis induced by the implantation of self-bone marrow cells: a new material for therapeutic angiogenesis Cell Transplant 9 2000 439 443
    • (2000) Cell Transplant , vol.9 , pp. 439-443
    • Hamano, K.1    Li, T.S.2    Kobayashi, T.3    Kobayashi, S.4    Matsuzaki, M.5    Esato, K.6
  • 57
    • 0033588533 scopus 로고    scopus 로고
    • BDNF, but not NT-3, promotes long-term survival of axotomized adult rat corticospinal neurons in vivo
    • E.N. Hammond, W. Tetzlaff, P. Mestres, and K.M. Giehl BDNF, but not NT-3, promotes long-term survival of axotomized adult rat corticospinal neurons in vivo Neuroreport 10 1999 2671 2675
    • (1999) Neuroreport , vol.10 , pp. 2671-2675
    • Hammond, E.N.1    Tetzlaff, W.2    Mestres, P.3    Giehl, K.M.4
  • 59
    • 0038340422 scopus 로고    scopus 로고
    • Post-traumatic inflammation following spinal cord injury
    • O.N. Hausmann Post-traumatic inflammation following spinal cord injury Spinal Cord 41 2003 369 378
    • (2003) Spinal Cord , vol.41 , pp. 369-378
    • Hausmann, O.N.1
  • 62
    • 0037100178 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor applied to the motor cortex promotes sprouting of corticospinal fibers but not regeneration into a peripheral nerve transplant
    • G.W. Hiebert, K. Khodarahmi, J. McGraw, J.D. Steeves, and W. Tetzlaff Brain-derived neurotrophic factor applied to the motor cortex promotes sprouting of corticospinal fibers but not regeneration into a peripheral nerve transplant J Neurosci Res 69 2002 160 168
    • (2002) J Neurosci Res , vol.69 , pp. 160-168
    • Hiebert, G.W.1    Khodarahmi, K.2    McGraw, J.3    Steeves, J.D.4    Tetzlaff, W.5
  • 64
    • 0036144945 scopus 로고    scopus 로고
    • A decline in glial cell-line-derived neurotrophic factor expression is associated with impaired regeneration after long-term Schwann cell denervation
    • A. Hoke, T. Gordon, D.W. Zochodne, and O.A. Sulaiman A decline in glial cell-line-derived neurotrophic factor expression is associated with impaired regeneration after long-term Schwann cell denervation Exp Neurol 173 2002 77 85
    • (2002) Exp Neurol , vol.173 , pp. 77-85
    • Hoke, A.1    Gordon, T.2    Zochodne, D.W.3    Sulaiman, O.A.4
  • 65
    • 66349113194 scopus 로고    scopus 로고
    • Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation
    • E.R. Hollis, P. Jamshidi, K. Low, A. Blesch, and M.H. Tuszynski Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation Proc Natl Acad Sci USA 106 2009 7215 7220
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 7215-7220
    • Hollis, E.R.1    Jamshidi, P.2    Low, K.3    Blesch, A.4    Tuszynski, M.H.5
  • 66
    • 0034927081 scopus 로고    scopus 로고
    • Neurotrophins: Roles in neuronal development and function
    • E.J. Huang, and L.F. Reichardt Neurotrophins: roles in neuronal development and function Annu Rev Neurosci 24 2001 677 736
    • (2001) Annu Rev Neurosci , vol.24 , pp. 677-736
    • Huang, E.J.1    Reichardt, L.F.2
  • 67
    • 0141560588 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor-enriched bridging transplants promote propriospinal axonal regeneration and enhance myelination after spinal cord injury
    • C. Iannotti, H. Li, P. Yan, X. Lu, L. Wirthlin, and X.-M. Xu Glial cell line-derived neurotrophic factor-enriched bridging transplants promote propriospinal axonal regeneration and enhance myelination after spinal cord injury Exp Neurol 183 2003 379 393
    • (2003) Exp Neurol , vol.183 , pp. 379-393
    • Iannotti, C.1    Li, H.2    Yan, P.3    Lu, X.4    Wirthlin, L.5    Xu, X.-M.6
  • 68
    • 4544308191 scopus 로고    scopus 로고
    • A neuroprotective role of glial cell line-derived neurotrophic factor following moderate spinal cord contusion injury
    • C. Iannotti, Y.P. Zhang, C.B. Shields, Y. Han, D.A. Burke, and X.-M. Xu A neuroprotective role of glial cell line-derived neurotrophic factor following moderate spinal cord contusion injury Exp Neurol 189 2004 317 332
    • (2004) Exp Neurol , vol.189 , pp. 317-332
    • Iannotti, C.1    Zhang, Y.P.2    Shields, C.B.3    Han, Y.4    Burke, D.A.5    Xu, X.-M.6
  • 69
    • 1942535132 scopus 로고    scopus 로고
    • A therapeutic window for intravenous administration of autologous bone marrow after cerebral ischemia in adult rats
    • S. Iihoshi, O. Honmou, K. Houkin, K. Hashi, and J.D. Kocsis A therapeutic window for intravenous administration of autologous bone marrow after cerebral ischemia in adult rats Brain Res 8 2004 1 9
    • (2004) Brain Res , vol.8 , pp. 1-9
    • Iihoshi, S.1    Honmou, O.2    Houkin, K.3    Hashi, K.4    Kocsis, J.D.5
  • 70
    • 0025236296 scopus 로고
    • Intracerebral NGF infusion induces hyperinnervation of cerebral blood vessels
    • L.G. Isaacson, B.N. Saffran, and K.A. Crutcher Intracerebral NGF infusion induces hyperinnervation of cerebral blood vessels Neurobiol Aging 11 1990 51 55
    • (1990) Neurobiol Aging , vol.11 , pp. 51-55
    • Isaacson, L.G.1    Saffran, B.N.2    Crutcher, K.A.3
  • 71
    • 24944520789 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor-induced signaling in Schwann cells
    • T. Iwase, C.G. Jung, H. Bae, M. Zhang, and B. Soliven Glial cell line-derived neurotrophic factor-induced signaling in Schwann cells J Neurochem 94 2005 1488 1499
    • (2005) J Neurochem , vol.94 , pp. 1488-1499
    • Iwase, T.1    Jung, C.G.2    Bae, H.3    Zhang, M.4    Soliven, B.5
  • 73
    • 79952155086 scopus 로고    scopus 로고
    • Neurotrophic factors
    • J.H. Kordower, M.H. Tuszynski, Academic Press San Diego
    • E.M. Johnson Jr., and M.H. Tuszynski Neurotrophic factors J.H. Kordower, M.H. Tuszynski, CNS Regeneration 2008 Academic Press San Diego 95 144
    • (2008) CNS Regeneration , pp. 95-144
    • Johnson, Jr.E.M.1    Tuszynski, M.H.2
  • 74
    • 0035866993 scopus 로고    scopus 로고
    • Neurotrophic factors, cellular bridges and gene therapy for spinal cord injury
    • L.L. Jones, M. Oudega, M.B. Bunge, and M.H. Tuszynski Neurotrophic factors, cellular bridges and gene therapy for spinal cord injury J Physiol 533 2001 83 89
    • (2001) J Physiol , vol.533 , pp. 83-89
    • Jones, L.L.1    Oudega, M.2    Bunge, M.B.3    Tuszynski, M.H.4
  • 75
    • 16244384670 scopus 로고    scopus 로고
    • Inflammatory-mediated injury and repair in the traumatically injured spinal cord
    • T.B. Jones, E.E. McDaniel, and P.G. Popovich Inflammatory-mediated injury and repair in the traumatically injured spinal cord Curr Pharm Des 11 2005 1223 1236
    • (2005) Curr Pharm des , vol.11 , pp. 1223-1236
    • Jones, T.B.1    McDaniel, E.E.2    Popovich, P.G.3
  • 76
    • 13244277654 scopus 로고    scopus 로고
    • Transplantation of bone marrow stromal cell-derived Schwann cells promotes axonal regeneration and functional recovery after complete transection of adult rat spinal cord
    • T. Kamada, M. Koda, M. Dezawa, K. Yoshinaga, M. Hashimoto, S. Koshizuka, Y. Nishio, H. Moriya, and M. Yamazaki Transplantation of bone marrow stromal cell-derived Schwann cells promotes axonal regeneration and functional recovery after complete transection of adult rat spinal cord J Neuropathol Exp Neurol 64 2005 37 45
    • (2005) J Neuropathol Exp Neurol , vol.64 , pp. 37-45
    • Kamada, T.1    Koda, M.2    Dezawa, M.3    Yoshinaga, K.4    Hashimoto, M.5    Koshizuka, S.6    Nishio, Y.7    Moriya, H.8    Yamazaki, M.9
  • 77
    • 0029794770 scopus 로고    scopus 로고
    • A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity
    • H. Kang, and E.M. Schuman A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity Science 273 1996 1402 1406
    • (1996) Science , vol.273 , pp. 1402-1406
    • Kang, H.1    Schuman, E.M.2
  • 78
    • 84861327454 scopus 로고    scopus 로고
    • Chondroitinase and growth factors enhance activation and oligodendrocyte differentiation of endogenous neural precursor cells after spinal cord injury
    • S. Karimi-Abdolrezaee, D. Schut, J. Wang, and M.G. Fehlings Chondroitinase and growth factors enhance activation and oligodendrocyte differentiation of endogenous neural precursor cells after spinal cord injury PLoS One 7 2012 e37589
    • (2012) PLoS One , vol.7 , pp. e37589
    • Karimi-Abdolrezaee, S.1    Schut, D.2    Wang, J.3    Fehlings, M.G.4
  • 79
    • 0028325455 scopus 로고
    • Neurological recovery after conservative treatment of cervical cord injuries
    • S. Katoh, and W. El Masri Neurological recovery after conservative treatment of cervical cord injuries J Bone Joint Surg Br 76B 1994 225 228
    • (1994) J Bone Joint Surg Br , vol.76 B , pp. 225-228
    • Katoh, S.1    El Masri, W.2
  • 80
    • 74449093066 scopus 로고    scopus 로고
    • Cyclophosphamide promotes cell survival via activation of intracellular signaling in cultured cortical neurons
    • H. Kitazawa, T. Numakawa, N. Adachi, E. Kumamaru, T. Tuerxun, M. Kudo, and H. Kunugi Cyclophosphamide promotes cell survival via activation of intracellular signaling in cultured cortical neurons Neurosci Lett 470 2010 139 144
    • (2010) Neurosci Lett , vol.470 , pp. 139-144
    • Kitazawa, H.1    Numakawa, T.2    Adachi, N.3    Kumamaru, E.4    Tuerxun, T.5    Kudo, M.6    Kunugi, H.7
  • 82
    • 0031467240 scopus 로고    scopus 로고
    • BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Talpha1-tubulin mRNA expression, and promote axonal regeneration
    • N.R. Kobayashi, D.P. Fan, K.M. Giehl, A.M. Bedard, S.J. Wiegand, and W. Tetzlaff BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Talpha1-tubulin mRNA expression, and promote axonal regeneration J Neurosci 17 1997 9583 9595
    • (1997) J Neurosci , vol.17 , pp. 9583-9595
    • Kobayashi, N.R.1    Fan, D.P.2    Giehl, K.M.3    Bedard, A.M.4    Wiegand, S.J.5    Tetzlaff, W.6
  • 83
    • 37248999868 scopus 로고    scopus 로고
    • Adenovirus vector-mediated ex vivo gene transfer of brain-derived neurotrophic factor to bone marrow stromal cells promotes axonal regeneration after transplantation in completely transected adult rat spinal cord
    • M. Koda, T. Kamada, M. Hashimoto, M. Murakami, H. Shirasawa, S. Sakao, H. Ino, K. Yoshinaga, S. Koshizuka, H. Moriya, and M. Yamazaki Adenovirus vector-mediated ex vivo gene transfer of brain-derived neurotrophic factor to bone marrow stromal cells promotes axonal regeneration after transplantation in completely transected adult rat spinal cord Eur Spine J 16 2007 2206 2214
    • (2007) Eur Spine J , vol.16 , pp. 2206-2214
    • Koda, M.1    Kamada, T.2    Hashimoto, M.3    Murakami, M.4    Shirasawa, H.5    Sakao, S.6    Ino, H.7    Yoshinaga, K.8    Koshizuka, S.9    Moriya, H.10    Yamazaki, M.11
  • 88
    • 34248326047 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor gene transfer with adeno-associated viral and lentiviral vectors prevents rubrospinal neuronal atrophy and stimulates regeneration-associated gene expression after acute cervical spinal cord injury
    • B.K. Kwon, J. Liu, C. Lam, W. Plunet, L.W. Oschipok, W. Hauswirth, A. Di Polo, A. Blesch, and W. Tetzlaff Brain-derived neurotrophic factor gene transfer with adeno-associated viral and lentiviral vectors prevents rubrospinal neuronal atrophy and stimulates regeneration-associated gene expression after acute cervical spinal cord injury Spine 32 2007 1164 1173
    • (2007) Spine , vol.32 , pp. 1164-1173
    • Kwon, B.K.1    Liu, J.2    Lam, C.3    Plunet, W.4    Oschipok, L.W.5    Hauswirth, W.6    Di Polo, A.7    Blesch, A.8    Tetzlaff, W.9
  • 89
    • 0036907505 scopus 로고    scopus 로고
    • Transplant mediated repair of the central nervous system: An imminent solution?
    • A. Lakatos, and R.J. Franklin Transplant mediated repair of the central nervous system: an imminent solution? Curr Opin Neurol 15 2002 701 705
    • (2002) Curr Opin Neurol , vol.15 , pp. 701-705
    • Lakatos, A.1    Franklin, R.J.2
  • 92
    • 0033504237 scopus 로고    scopus 로고
    • Evidence for neuroprotective effects of endogenous brain-derived neurotrophic factor after global forebrain ischemia in rats
    • E. Larsson, A. Nanobashvili, Z. Kokaia, and O. Lindvall Evidence for neuroprotective effects of endogenous brain-derived neurotrophic factor after global forebrain ischemia in rats J Cereb Blood Flow Metab 19 1999 1220 1228
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 1220-1228
    • Larsson, E.1    Nanobashvili, A.2    Kokaia, Z.3    Lindvall, O.4
  • 93
    • 76549235314 scopus 로고
    • Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo
    • R. Levi-Montalcini, and V. Hamburger Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo J Exp Zool 116 1951 321 361
    • (1951) J Exp Zool , vol.116 , pp. 321-361
    • Levi-Montalcini, R.1    Hamburger, V.2
  • 95
    • 0029898339 scopus 로고    scopus 로고
    • The FGF receptor-1 is necessary for the induction of neurite outgrowth in PC12 cells by aFGF
    • H.Y. Lin, J. Xu, D.M. Ornitz, S. Halegoua, and M.J. Hayman The FGF receptor-1 is necessary for the induction of neurite outgrowth in PC12 cells by aFGF J Neurosci 16 1996 4579 4587
    • (1996) J Neurosci , vol.16 , pp. 4579-4587
    • Lin, H.Y.1    Xu, J.2    Ornitz, D.M.3    Halegoua, S.4    Hayman, M.J.5
  • 96
    • 0033151593 scopus 로고    scopus 로고
    • Transplants of fibroblasts genetically modified to express BDNF promote regeneration of adult rat rubrospinal axons and recovery of forelimb function
    • Y. Liu, D. Kim, B.T. Himes, S.Y. Chow, T. Schallert, M. Murray, A. Tessler, and I. Fischer Transplants of fibroblasts genetically modified to express BDNF promote regeneration of adult rat rubrospinal axons and recovery of forelimb function J Neurosci 19 1999 4370 4387
    • (1999) J Neurosci , vol.19 , pp. 4370-4387
    • Liu, Y.1    Kim, D.2    Himes, B.T.3    Chow, S.Y.4    Schallert, T.5    Murray, M.6    Tessler, A.7    Fischer, I.8
  • 97
    • 0035817425 scopus 로고    scopus 로고
    • Neurotrophism without neurotropism: BDNF promotes survival but not growth of lesioned corticospinal neurons
    • P. Lu, A. Blesch, and M.H. Tuszynski Neurotrophism without neurotropism: BDNF promotes survival but not growth of lesioned corticospinal neurons J Comp Neurol 436 2001 456 470
    • (2001) J Comp Neurol , vol.436 , pp. 456-470
    • Lu, P.1    Blesch, A.2    Tuszynski, M.H.3
  • 98
    • 11844273931 scopus 로고    scopus 로고
    • BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury
    • P. Lu, L.L. Jones, and M.H. Tuszynski BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury Exp Neurol 191 2005 344 360
    • (2005) Exp Neurol , vol.191 , pp. 344-360
    • Lu, P.1    Jones, L.L.2    Tuszynski, M.H.3
  • 99
    • 38649126573 scopus 로고    scopus 로고
    • Growth factors and combinatorial therapies for CNS regeneration
    • P. Lu, and M.H. Tuszynski Growth factors and combinatorial therapies for CNS regeneration Exp Neurol 209 2008 313 320
    • (2008) Exp Neurol , vol.209 , pp. 313-320
    • Lu, P.1    Tuszynski, M.H.2
  • 100
    • 3242711266 scopus 로고    scopus 로고
    • Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury
    • P. Lu, H. Yang, L.L. Jones, M.T. Filbin, and M.H. Tuszynski Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury J Neurosci 24 2004 6402 6409
    • (2004) J Neurosci , vol.24 , pp. 6402-6409
    • Lu, P.1    Yang, H.2    Jones, L.L.3    Filbin, M.T.4    Tuszynski, M.H.5
  • 101
    • 0033614665 scopus 로고    scopus 로고
    • FGF-8 protects cultured rat hippocampal neurons from oxidative insult
    • R.J. Mark, K.S. Fuson, K. Keane-Lazar, and P.C. May FGF-8 protects cultured rat hippocampal neurons from oxidative insult Brain Res 830 1999 88 93
    • (1999) Brain Res , vol.830 , pp. 88-93
    • Mark, R.J.1    Fuson, K.S.2    Keane-Lazar, K.3    May, P.C.4
  • 103
    • 41949110690 scopus 로고    scopus 로고
    • Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: An open-label, phase i trial
    • W.J. Marks Jr., J.L. Ostrem, L. Verhagen, P.A. Starr, P.S. Larson, R.A. Bakay, R. Taylor, D.A. Cahn-Weiner, A.J. Stoessl, C.W. Olanow, and R.T. Bartus Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial Lancet Neurol 7 2008 400 408
    • (2008) Lancet Neurol , vol.7 , pp. 400-408
    • Marks, Jr.W.J.1    Ostrem, J.L.2    Verhagen, L.3    Starr, P.A.4    Larson, P.S.5    Bakay, R.A.6    Taylor, R.7    Cahn-Weiner, D.A.8    Stoessl, A.J.9    Olanow, C.W.10    Bartus, R.T.11
  • 104
    • 84862773330 scopus 로고    scopus 로고
    • Neurotrophic factors in combinatorial approaches for spinal cord regeneration
    • J. McCall, N. Weidner, and A. Blesch Neurotrophic factors in combinatorial approaches for spinal cord regeneration Cell Tissue Res 349 2012 27 37
    • (2012) Cell Tissue Res , vol.349 , pp. 27-37
    • McCall, J.1    Weidner, N.2    Blesch, A.3
  • 106
    • 34548684100 scopus 로고    scopus 로고
    • GDNF selectively promotes regeneration of injury-primed sensory neurons in the lesioned spinal cord
    • C.D. Mills, A.J. Allchorne, R.S. Griffin, C.J. Woolf, and M. Costigan GDNF selectively promotes regeneration of injury-primed sensory neurons in the lesioned spinal cord Mol Cell Neurosci 36 2007 185 194
    • (2007) Mol Cell Neurosci , vol.36 , pp. 185-194
    • Mills, C.D.1    Allchorne, A.J.2    Griffin, R.S.3    Woolf, C.J.4    Costigan, M.5
  • 107
    • 18044391661 scopus 로고    scopus 로고
    • Spinal cord injury is accompanied by chronic progressive demyelination
    • T. Mo, and H.S. Keirstead Spinal cord injury is accompanied by chronic progressive demyelination J Comp Neurol 486 2005 373 383
    • (2005) J Comp Neurol , vol.486 , pp. 373-383
    • Mo, T.1    Keirstead, H.S.2
  • 108
    • 41249102074 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor but not forced arm use improves long-term outcome after photothrombotic stroke and transiently upregulates binding densities of excitatory glutamate receptors in the rat brain
    • H.D. Müller, K.M. Hanumanthiah, K. Diederich, S. Schwab, W.R. Schäbitz, and C. Sommer Brain-derived neurotrophic factor but not forced arm use improves long-term outcome after photothrombotic stroke and transiently upregulates binding densities of excitatory glutamate receptors in the rat brain Stroke 39 2008 1012 1021
    • (2008) Stroke , vol.39 , pp. 1012-1021
    • Müller, H.D.1    Hanumanthiah, K.M.2    Diederich, K.3    Schwab, S.4    Schäbitz, W.R.5    Sommer, C.6
  • 109
    • 2442475352 scopus 로고    scopus 로고
    • Stem cell transplantation and other novel techniques for promoting recovery from spinal cord injury
    • T.M. Myckatyn, S.E. Mackinnon, and J.W. McDonald Stem cell transplantation and other novel techniques for promoting recovery from spinal cord injury Tanspl Immunol 12 2004 343 358
    • (2004) Tanspl Immunol , vol.12 , pp. 343-358
    • Myckatyn, T.M.1    Mackinnon, S.E.2    McDonald, J.W.3
  • 110
    • 79952182383 scopus 로고    scopus 로고
    • Potential therapeutic uses of BDNF in neurological and psychiatric disorders
    • A.H. Nagahara, and M.H. Tuszynski Potential therapeutic uses of BDNF in neurological and psychiatric disorders Nat Rev Drug Discov 10 2011 209 219
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 209-219
    • Nagahara, A.H.1    Tuszynski, M.H.2
  • 111
    • 0037071890 scopus 로고    scopus 로고
    • Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation
    • S. Neumann, F. Bradke, M. Tessier-Lavigne, and A.I. Basbaum Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation Neuron 34 2002 885 893
    • (2002) Neuron , vol.34 , pp. 885-893
    • Neumann, S.1    Bradke, F.2    Tessier-Lavigne, M.3    Basbaum, A.I.4
  • 112
    • 0033137077 scopus 로고    scopus 로고
    • Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury
    • S. Neumann, and C.J. Woolf Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury Neuron 23 1999 83 91
    • (1999) Neuron , vol.23 , pp. 83-91
    • Neumann, S.1    Woolf, C.J.2
  • 113
    • 2942558484 scopus 로고    scopus 로고
    • The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery
    • E. Nikulina, J.L. Tidwell, H.N. Dai, B.S. Bregman, and M.T. Filbin The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery Proc Natl Acad Sci USA 101 2004 8786 8790
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8786-8790
    • Nikulina, E.1    Tidwell, J.L.2    Dai, H.N.3    Bregman, B.S.4    Filbin, M.T.5
  • 114
    • 1842453983 scopus 로고    scopus 로고
    • Biopolymers and biodegradable smart implants for tissue regeneration after spinal cord injury
    • L.N. Novikova, L.N. Novikov, and J.O. Kellerth Biopolymers and biodegradable smart implants for tissue regeneration after spinal cord injury Curr Opin Neurol 16 2003 711 715
    • (2003) Curr Opin Neurol , vol.16 , pp. 711-715
    • Novikova, L.N.1    Novikov, L.N.2    Kellerth, J.O.3
  • 115
    • 55749098498 scopus 로고    scopus 로고
    • Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses
    • H. Ohtaki, J.H. Ylostalo, J.E. Foraker, A.P. Robinson, R.L. Reger, S. Shioda, and D.J. Prockop Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses Proc Natl Acad Sci USA 105 2008 14638 14643
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 14638-14643
    • Ohtaki, H.1    Ylostalo, J.H.2    Foraker, J.E.3    Robinson, A.P.4    Reger, R.L.5    Shioda, S.6    Prockop, D.J.7
  • 116
    • 0037106090 scopus 로고    scopus 로고
    • Stem cell biology of the central nervous system
    • H. Okano Stem cell biology of the central nervous system J Neurosci Res 69 2002 698 707
    • (2002) J Neurosci Res , vol.69 , pp. 698-707
    • Okano, H.1
  • 117
    • 38549154182 scopus 로고    scopus 로고
    • Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia
    • T. Onda, O. Honmou, K. Harada, K. Houkin, H. Hamada, and J.D. Kocsis Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia J Cereb Blood Flow Metab 28 2008 329 340
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 329-340
    • Onda, T.1    Honmou, O.2    Harada, K.3    Houkin, K.4    Hamada, H.5    Kocsis, J.D.6
  • 119
    • 70450158749 scopus 로고    scopus 로고
    • Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury/paraplegia: A pilot clinical study
    • R. Pal, N.K. Venkataramana, A. Bansal, S. Balaraju, M. Jan, R. Chandra, A. Dixit, A. Rauthan, U. Murgod, and S. Totey Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury/paraplegia: a pilot clinical study Cytotherapy 11 2009 897 911
    • (2009) Cytotherapy , vol.11 , pp. 897-911
    • Pal, R.1    Venkataramana, N.K.2    Bansal, A.3    Balaraju, S.4    Jan, M.5    Chandra, R.6    Dixit, A.7    Rauthan, A.8    Murgod, U.9    Totey, S.10
  • 120
    • 0038488948 scopus 로고    scopus 로고
    • The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands
    • G. Paratcha, F. Ledda, and C.F. Ibanez The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands Cell 113 2003 867 879
    • (2003) Cell , vol.113 , pp. 867-879
    • Paratcha, G.1    Ledda, F.2    Ibanez, C.F.3
  • 121
    • 21844442589 scopus 로고    scopus 로고
    • Treatment of complete spinal cord injury patients by autologous bone marrow cell transplantation an administration of granulocyte-macrophage colony stimulating factor
    • H.C. Park, Y.S. Shim, Y. Ha, S.H. Yoon, S.R. Park, B.H. Choi, and H.S. Park Treatment of complete spinal cord injury patients by autologous bone marrow cell transplantation an administration of granulocyte-macrophage colony stimulating factor Tissue Eng 11 2005 913 922
    • (2005) Tissue Eng , vol.11 , pp. 913-922
    • Park, H.C.1    Shim, Y.S.2    Ha, Y.3    Yoon, S.H.4    Park, S.R.5    Choi, B.H.6    Park, H.S.7
  • 122
    • 34648860537 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury
    • A.M. Parr, C.H. Tator, and A. Keating Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury Bone Marrow Transplant 40 2007 609 619
    • (2007) Bone Marrow Transplant , vol.40 , pp. 609-619
    • Parr, A.M.1    Tator, C.H.2    Keating, A.3
  • 123
    • 64749093912 scopus 로고    scopus 로고
    • Grafting of human bone marrow stromal cells into spinal cord injury: A comparison of delivery methods
    • C. Paul, A.F. Samdani, R.R. Betz, I. Fischer, and B. Neuhuber Grafting of human bone marrow stromal cells into spinal cord injury: a comparison of delivery methods Spine 34 2009 328 334
    • (2009) Spine , vol.34 , pp. 328-334
    • Paul, C.1    Samdani, A.F.2    Betz, R.R.3    Fischer, I.4    Neuhuber, B.5
  • 125
    • 37549070995 scopus 로고    scopus 로고
    • Neuroprotection by imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway
    • C.H. Peng, S.H. Chiou, S.J. Chen, Y.C. Chou, H.H. Ku, C.K. Cheng, C.J. Yen, T.H. Tsai, Y.L. Chang, and C.L. Kao Neuroprotection by imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway Eur Neuropsychopharmacol 18 2008 128 140
    • (2008) Eur Neuropsychopharmacol , vol.18 , pp. 128-140
    • Peng, C.H.1    Chiou, S.H.2    Chen, S.J.3    Chou, Y.C.4    Ku, H.H.5    Cheng, C.K.6    Yen, C.J.7    Tsai, T.H.8    Chang, Y.L.9    Kao, C.L.10
  • 126
    • 0036169480 scopus 로고    scopus 로고
    • IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo
    • D. Perrelet, A. Ferri, P. Liston, P. Muzzin, R.G. Korneluk, and A.C. Kato IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo Nat Cell Biol 4 2002 175 179
    • (2002) Nat Cell Biol , vol.4 , pp. 175-179
    • Perrelet, D.1    Ferri, A.2    Liston, P.3    Muzzin, P.4    Korneluk, R.G.5    Kato, A.C.6
  • 127
    • 39349104562 scopus 로고    scopus 로고
    • Brain-derived neurotropic factor/TrkB signaling in the pathogenesis and novel pharmacotherapy of schizophrenia
    • A. Pillai Brain-derived neurotropic factor/TrkB signaling in the pathogenesis and novel pharmacotherapy of schizophrenia Neurosignals 16 2008 183 193
    • (2008) Neurosignals , vol.16 , pp. 183-193
    • Pillai, A.1
  • 129
    • 79960570561 scopus 로고    scopus 로고
    • Pharmacological interventions for spinal cord injury: Where do we stand? How might we step forward?
    • A.G. Rabchevsky, S.P. Patel, and J.E. Springer Pharmacological interventions for spinal cord injury: where do we stand? How might we step forward? Pharmacol Ther 132 2011 15 29
    • (2011) Pharmacol Ther , vol.132 , pp. 15-29
    • Rabchevsky, A.G.1    Patel, S.P.2    Springer, J.E.3
  • 131
    • 38149140867 scopus 로고    scopus 로고
    • Spinal cord injury treatment with intrathecal autologous bone marrow stromal cell transplantation: The first clinical trial case report
    • F. Saito, T. Nakatani, M. Iwase, Y. Maeda, A. Hirakawa, Y. Murao, Y. Suzuki, R. Onodera, M. Fukushima, and C. Ide Spinal cord injury treatment with intrathecal autologous bone marrow stromal cell transplantation: the first clinical trial case report J Trauma 64 2008 53 59
    • (2008) J Trauma , vol.64 , pp. 53-59
    • Saito, F.1    Nakatani, T.2    Iwase, M.3    Maeda, Y.4    Hirakawa, A.5    Murao, Y.6    Suzuki, Y.7    Onodera, R.8    Fukushima, M.9    Ide, C.10
  • 132
    • 84859326618 scopus 로고    scopus 로고
    • Administration of cultured autologous bone marrow stromal cells into cerebrospinal fluid in spinal injury patients: A pilot study
    • F. Saito, T. Nakatani, M. Iwase, Y. Maeda, Y. Murao, Y. Suzuki, M. Fukushima, and C. Ide Administration of cultured autologous bone marrow stromal cells into cerebrospinal fluid in spinal injury patients: a pilot study Restor Neurol Neurosci 30 2012 127 136
    • (2012) Restor Neurol Neurosci , vol.30 , pp. 127-136
    • Saito, F.1    Nakatani, T.2    Iwase, M.3    Maeda, Y.4    Murao, Y.5    Suzuki, Y.6    Fukushima, M.7    Ide, C.8
  • 133
    • 0344737616 scopus 로고    scopus 로고
    • FGF-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury
    • P.S. Sapieha, M. Peltier, K.G. Rendahl, W.C. Manning, and A. Di Polo FGF-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury Mol Cell Neurosci 24 2003 656 672
    • (2003) Mol Cell Neurosci , vol.24 , pp. 656-672
    • Sapieha, P.S.1    Peltier, M.2    Rendahl, K.G.3    Manning, W.C.4    Di Polo, A.5
  • 134
    • 72449122797 scopus 로고    scopus 로고
    • BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury
    • M. Sasaki, C. Radtke, A.M. Tan, P. Zhao, H. Hamada, K. Houkin, O. Honmou, and J.D. Kocsis BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury J Neurosci 29 2009 14932 14941
    • (2009) J Neurosci , vol.29 , pp. 14932-14941
    • Sasaki, M.1    Radtke, C.2    Tan, A.M.3    Zhao, P.4    Hamada, H.5    Houkin, K.6    Honmou, O.7    Kocsis, J.D.8
  • 135
    • 13444293278 scopus 로고    scopus 로고
    • Migration of mesenchymal stem cells through cerebrospinal fluid into injured spinal cord tissue
    • K. Satake, J. Lou, and L.G. Lenke Migration of mesenchymal stem cells through cerebrospinal fluid into injured spinal cord tissue Spine 29 2004 1971 1979
    • (2004) Spine , vol.29 , pp. 1971-1979
    • Satake, K.1    Lou, J.2    Lenke, L.G.3
  • 136
    • 0033004063 scopus 로고    scopus 로고
    • Neurotrophin regulation of synaptic transmission
    • E.M. Schuman Neurotrophin regulation of synaptic transmission Curr Opin Neurobiol 9 1999 105 109
    • (1999) Curr Opin Neurobiol , vol.9 , pp. 105-109
    • Schuman, E.M.1
  • 137
    • 29744441582 scopus 로고    scopus 로고
    • Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodeling after stroke
    • L.H. Shen, Y. Li, J. Chen, J. Zhang, P. Vanguri, J. Borneman, and M. Chopp Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodeling after stroke Neuroscience 137 2006 393 399
    • (2006) Neuroscience , vol.137 , pp. 393-399
    • Shen, L.H.1    Li, Y.2    Chen, J.3    Zhang, J.4    Vanguri, P.5    Borneman, J.6    Chopp, M.7
  • 139
    • 0742288565 scopus 로고    scopus 로고
    • Regeneration beyond the glial scar
    • J. Silver, and J.H. Miller Regeneration beyond the glial scar Nat Rev Neurosci 5 2004 146 156
    • (2004) Nat Rev Neurosci , vol.5 , pp. 146-156
    • Silver, J.1    Miller, J.H.2
  • 140
    • 0028238769 scopus 로고
    • Functions of the neurotrophins during nervous system development: What the knockouts are teaching us
    • W.D. Snider Functions of the neurotrophins during nervous system development: what the knockouts are teaching us Cell 77 1994 627 638
    • (1994) Cell , vol.77 , pp. 627-638
    • Snider, W.D.1
  • 141
    • 58849135840 scopus 로고    scopus 로고
    • Reduction of cystic cavity, promotion of axonal regeneration and sparing, and functional recovery with transplanted bone marrow stromal cell-derived Schwann cells after contusion injury to the adult rat spinal cord
    • Y. Someya, M. Koda, M. Dezawa, T. Kadota, M. Hashimoto, T. Kamada, Y. Nishio, R. Kadota, C. Mannoji, T. Miyashita, A. Okawa, K. Yoshinaga, and M. Yamazaki Reduction of cystic cavity, promotion of axonal regeneration and sparing, and functional recovery with transplanted bone marrow stromal cell-derived Schwann cells after contusion injury to the adult rat spinal cord J Neurosurg Spine 9 2008 600 610
    • (2008) J Neurosurg Spine , vol.9 , pp. 600-610
    • Someya, Y.1    Koda, M.2    Dezawa, M.3    Kadota, T.4    Hashimoto, M.5    Kamada, T.6    Nishio, Y.7    Kadota, R.8    Mannoji, C.9    Miyashita, T.10    Okawa, A.11    Yoshinaga, K.12    Yamazaki, M.13
  • 142
    • 43049139914 scopus 로고    scopus 로고
    • Inflammation and tumour microenvironments: Defining the migratory itinerary of mesenchymal stem cells
    • E. Spaeth, A. Klopp, J. Dembinski, M. Andreeff, and F. Marini Inflammation and tumour microenvironments: Defining the migratory itinerary of mesenchymal stem cells Gene Ther 15 2008 730 738
    • (2008) Gene Ther , vol.15 , pp. 730-738
    • Spaeth, E.1    Klopp, A.2    Dembinski, J.3    Andreeff, M.4    Marini, F.5
  • 144
    • 0036703612 scopus 로고    scopus 로고
    • Schwann cell but not olfactory ensheathing glia transplants improve hindlimb locomotor performance in the moderately contused adult rat thoracic spinal cord
    • T. Takami, M. Oudega, M.L. Bates, P.M. Wood, N. Kleitman, and M.B. Bunge Schwann cell but not olfactory ensheathing glia transplants improve hindlimb locomotor performance in the moderately contused adult rat thoracic spinal cord J Neurosci 22 2002 6670 6681
    • (2002) J Neurosci , vol.22 , pp. 6670-6681
    • Takami, T.1    Oudega, M.2    Bates, M.L.3    Wood, P.M.4    Kleitman, N.5    Bunge, M.B.6
  • 145
    • 0142151019 scopus 로고    scopus 로고
    • Fibroblast growth factor- inducible-14 is induced in axotomized neurons and promotes neurite outgrowth
    • K. Tanabe, I. Bonilla, J.A. Winkles, and S.M. Strittmatter Fibroblast growth factor- inducible-14 is induced in axotomized neurons and promotes neurite outgrowth J Neurosci 23 2003 9675 9686
    • (2003) J Neurosci , vol.23 , pp. 9675-9686
    • Tanabe, K.1    Bonilla, I.2    Winkles, J.A.3    Strittmatter, S.M.4
  • 146
    • 33845875170 scopus 로고    scopus 로고
    • PARsing the events of myelination
    • C. Taveggia, and J.L. Salzer PARsing the events of myelination Nat Neurosci 10 2007 17 18
    • (2007) Nat Neurosci , vol.10 , pp. 17-18
    • Taveggia, C.1    Salzer, J.L.2
  • 147
  • 148
    • 0027973375 scopus 로고
    • Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons
    • L. Tessarollo, K.S. Vogel, M.E. Palko, S.W. Reid, and L.F. Parada Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons Proc Natl Acad Sci USA 91 1994 11844 11848
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11844-11848
    • Tessarollo, L.1    Vogel, K.S.2    Palko, M.E.3    Reid, S.W.4    Parada, L.F.5
  • 149
    • 0345227300 scopus 로고    scopus 로고
    • Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy, and provides limited regeneration
    • C.A. Tobias, J.S. Shumsky, M. Shibata, M.H. Tuszynski, I. Fischer, A. Tessler, and M. Murray Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy, and provides limited regeneration Exp Neurol 184 2003 97 113
    • (2003) Exp Neurol , vol.184 , pp. 97-113
    • Tobias, C.A.1    Shumsky, J.S.2    Shibata, M.3    Tuszynski, M.H.4    Fischer, I.5    Tessler, A.6    Murray, M.7
  • 151
    • 0037654372 scopus 로고    scopus 로고
    • Growth-factor gene therapy for neurodegenerative disorders
    • M.H. Tuszynski Growth-factor gene therapy for neurodegenerative disorders Lancet Neurol 1 2002 51 57
    • (2002) Lancet Neurol , vol.1 , pp. 51-57
    • Tuszynski, M.H.1
  • 152
    • 33746238490 scopus 로고    scopus 로고
    • BDNF increases release probability and the size of a rapidly recycling vesicle pool within rat hippocampal excitatory synapses
    • W.J. Tyler, X.L. Zhang, K. Hartman, J. Winterer, W. Muller, P.K. Stanton, and L. Pozzo-Miller BDNF increases release probability and the size of a rapidly recycling vesicle pool within rat hippocampal excitatory synapses J Physiol 574 2006 787 803
    • (2006) J Physiol , vol.574 , pp. 787-803
    • Tyler, W.J.1    Zhang, X.L.2    Hartman, K.3    Winterer, J.4    Muller, W.5    Stanton, P.K.6    Pozzo-Miller, L.7
  • 153
    • 33745112188 scopus 로고    scopus 로고
    • BDNF promotes connections of corticospinal neurons onto spared descending interneurons in spinal cord injured rats
    • R. Vavrek, J. Girgis, W. Tetzlaff, G.W. Hiebert, and K. Fouad BDNF promotes connections of corticospinal neurons onto spared descending interneurons in spinal cord injured rats Brain 129 2006 1534 1545
    • (2006) Brain , vol.129 , pp. 1534-1545
    • Vavrek, R.1    Girgis, J.2    Tetzlaff, W.3    Hiebert, G.W.4    Fouad, K.5
  • 154
    • 79959398498 scopus 로고    scopus 로고
    • Progenitor cell therapy for the treatment of central nervous system injury: A review of the state of current clinical trials
    • P.A. Walker, M.T. Harting, S.K. Shah, M.C. Day, R. El Khoury, S.I. Savitz, J. Baumgartner, and C.S. Cox Progenitor cell therapy for the treatment of central nervous system injury: a review of the state of current clinical trials Stem Cells Int 2010 2010 369578
    • (2010) Stem Cells Int , vol.2010 , pp. 369578
    • Walker, P.A.1    Harting, M.T.2    Shah, S.K.3    Day, M.C.4    El Khoury, R.5    Savitz, S.I.6    Baumgartner, J.7    Cox, C.S.8
  • 155
    • 0017121995 scopus 로고
    • Studies on the control of myelinogenesis. II. Evidence for neuronal regulation of myelin production
    • H.J. Weinberg, and P.S. Spencer Studies on the control of myelinogenesis. II. Evidence for neuronal regulation of myelin production Brain Res 113 1976 363 378
    • (1976) Brain Res , vol.113 , pp. 363-378
    • Weinberg, H.J.1    Spencer, P.S.2
  • 156
    • 84866936382 scopus 로고    scopus 로고
    • BDNF: The career of a multifaceted neurotrophin in spinal cord injury
    • N. Weishaupt, A. Blesch, and K. Fouad BDNF: the career of a multifaceted neurotrophin in spinal cord injury Exp Neurol 238 2012 254 264
    • (2012) Exp Neurol , vol.238 , pp. 254-264
    • Weishaupt, N.1    Blesch, A.2    Fouad, K.3
  • 157
    • 0035873540 scopus 로고    scopus 로고
    • Neurotrophic factors and receptors in the immature and adult spinal cord after mechanical injury or kainic acid
    • J. Widenfalk, K. Lundstromer, M. Jubran, S. Brene, and L. Olson Neurotrophic factors and receptors in the immature and adult spinal cord after mechanical injury or kainic acid J Neurosci 21 2001 3457 3475
    • (2001) J Neurosci , vol.21 , pp. 3457-3475
    • Widenfalk, J.1    Lundstromer, K.2    Jubran, M.3    Brene, S.4    Olson, L.5
  • 158
    • 0025816941 scopus 로고
    • Hypophagia is induced by intracerebroventricular administration of nerve growth factor
    • L.R. Williams Hypophagia is induced by intracerebroventricular administration of nerve growth factor Exp Neurol 113 1991 31 37
    • (1991) Exp Neurol , vol.113 , pp. 31-37
    • Williams, L.R.1
  • 159
    • 0031037424 scopus 로고    scopus 로고
    • Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor
    • J. Winkler, G.A. Ramirez, H.G. Kuhn, D.A. Peterson, P.A. Day-Lollini, G.R. Stewart, M.H. Tuszynski, F.H. Gage, and L.J. Thal Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor Ann Neurol 41 1997 82 93
    • (1997) Ann Neurol , vol.41 , pp. 82-93
    • Winkler, J.1    Ramirez, G.A.2    Kuhn, H.G.3    Peterson, D.A.4    Day-Lollini, P.A.5    Stewart, G.R.6    Tuszynski, M.H.7    Gage, F.H.8    Thal, L.J.9
  • 161
    • 79952155004 scopus 로고    scopus 로고
    • Concise review: Bone marrow for the treatment of spinal cord injury: Mechanisms and clinical applications
    • K.T. Wright, W. El Masri, A. Osman, J. Chowdhury, and W.E. Johnson Concise review: bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications Stem Cells 29 2011 169 178
    • (2011) Stem Cells , vol.29 , pp. 169-178
    • Wright, K.T.1    El Masri, W.2    Osman, A.3    Chowdhury, J.4    Johnson, W.E.5
  • 163
    • 40949161757 scopus 로고    scopus 로고
    • Nerve repair using acidic fibroblast growth factor in human cervical spinal cord injury: A preliminary Phase i clinical study
    • J.C. Wu, W.C. Huang, Y.A. Tsai, Y.C. Chen, and H. Cheng Nerve repair using acidic fibroblast growth factor in human cervical spinal cord injury: a preliminary Phase I clinical study J Neurosurg Spine 8 2008 208 214
    • (2008) J Neurosurg Spine , vol.8 , pp. 208-214
    • Wu, J.C.1    Huang, W.C.2    Tsai, Y.A.3    Chen, Y.C.4    Cheng, H.5
  • 164
    • 0028854836 scopus 로고
    • In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons
    • Q. Yan, C. Matheson, and O.T. Lopez In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons Nature 373 1995 341 344
    • (1995) Nature , vol.373 , pp. 341-344
    • Yan, Q.1    Matheson, C.2    Lopez, O.T.3
  • 165
    • 27844468688 scopus 로고    scopus 로고
    • Identification of an ectodomain within the LAR protein tyrosine phosphatase receptor that binds homophilically and activates signaling pathways promoting neurite outgrowth
    • T. Yang, W. Yin, V.D. Derevyanny, L.A. Moore, and F.M. Longo Identification of an ectodomain within the LAR protein tyrosine phosphatase receptor that binds homophilically and activates signaling pathways promoting neurite outgrowth Eur J Neurosci 22 2005 2159 2170
    • (2005) Eur J Neurosci , vol.22 , pp. 2159-2170
    • Yang, T.1    Yin, W.2    Derevyanny, V.D.3    Moore, L.A.4    Longo, F.M.5
  • 166
    • 34547915244 scopus 로고    scopus 로고
    • Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony stimulating factor: Phase I/II clinical train
    • S.H. Yoon, Y.S. Shim, Y.H. Park, J.K. Chung, J.H. Nam, M.O. Kim, H.C. Park, S.R. Park, B.H. Min, E.Y. Kim, B.H. Choi, H. Park, and Y. Ha Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony stimulating factor: phase I/II clinical train Stem Cells 25 2007 2066 2073
    • (2007) Stem Cells , vol.25 , pp. 2066-2073
    • Yoon, S.H.1    Shim, Y.S.2    Park, Y.H.3    Chung, J.K.4    Nam, J.H.5    Kim, M.O.6    Park, H.C.7    Park, S.R.8    Min, B.H.9    Kim, E.Y.10    Choi, B.H.11    Park, H.12    Ha, Y.13
  • 167
    • 77949754231 scopus 로고    scopus 로고
    • Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease
    • A. Yoshii, and M. Constantine-Paton Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease Dev Neurobiol 70 2010 304 322
    • (2010) Dev Neurobiol , vol.70 , pp. 304-322
    • Yoshii, A.1    Constantine-Paton, M.2
  • 168
    • 69649084348 scopus 로고    scopus 로고
    • GDNF-enhanced axonal regeneration and myelination following spinal cord injury is mediated by primary effects on neurons
    • L. Zhang, Z. Ma, G.M. Smith, X. Wen, Y. Pressman, P.M. Wood, and X.M. Xu GDNF-enhanced axonal regeneration and myelination following spinal cord injury is mediated by primary effects on neurons Glia 57 2009 1178 1191
    • (2009) Glia , vol.57 , pp. 1178-1191
    • Zhang, L.1    Ma, Z.2    Smith, G.M.3    Wen, X.4    Pressman, Y.5    Wood, P.M.6    Xu, X.M.7
  • 169
    • 0037442795 scopus 로고    scopus 로고
    • Neurotrophin-3 expressed in situ induces axonal plasticity in the adult injured spinal cord
    • L. Zhou, B.J. Baumgartner, S.J. Hill-Felberg, L.R. McGowen, and H.D. Shine Neurotrophin-3 expressed in situ induces axonal plasticity in the adult injured spinal cord J Neurosci 23 2003 1424 1431
    • (2003) J Neurosci , vol.23 , pp. 1424-1431
    • Zhou, L.1    Baumgartner, B.J.2    Hill-Felberg, S.J.3    McGowen, L.R.4    Shine, H.D.5
  • 170
    • 56049103562 scopus 로고    scopus 로고
    • Functional recovery of chronic paraplegic pigs after autologous transplantation of bone marrow stromal cells
    • M. Zurita, J. Vaquero, C. Bonilla, M. Santos, J. De Haro, S. Oya, and C. Aguayo Functional recovery of chronic paraplegic pigs after autologous transplantation of bone marrow stromal cells Transplantation 86 2008 845 853
    • (2008) Transplantation , vol.86 , pp. 845-853
    • Zurita, M.1    Vaquero, J.2    Bonilla, C.3    Santos, M.4    De Haro, J.5    Oya, S.6    Aguayo, C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.