Brain-derived neurotrophic factor but not forced arm use improves long-term outcome after photothrombotic stroke and transiently upregulates binding densities of excitatory glutamate receptors in the rat brain

Stroke

Volumn 39, Issue 3, 2008, Pages 1012-1021

  Müller, Harald D ^a   Hanumanthiah, Kiran M ^b   Diederich, Kai ^c   Schwab, Stefan ^b,d   Schäbitz, Wolf Rüdiger ^b,c   Sommer, Clemens ^a,e  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^e UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Forced arm use; Receptors; Stroke; Trophic factors

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; DIZOCILPINE; GLUTAMATE RECEPTOR; MUSCIMOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTRANSMITTER RECEPTOR; SODIUM CHLORIDE; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; AMINO ACID RECEPTOR BLOCKING AGENT; DIZOCILPINE MALEATE; LIGAND;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN ISCHEMIA; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FROZEN SECTION; IN VITRO STUDY; LIGAND BINDING; MALE; NEUROPSYCHOLOGICAL TEST; NEUROTRANSMISSION; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RECEPTOR DENSITY; RECEPTOR UPREGULATION; STROKE; TREATMENT OUTCOME; ANIMAL; BRAIN; BRAIN INFARCTION; DRUG EFFECT; EXERCISE; FORELIMB; METABOLISM; MOTOR ACTIVITY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOTHERAPY; UPREGULATION; WISTAR RAT;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; AUTORADIOGRAPHY; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CEREBRAL INFARCTION; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; FORELIMB; GABA AGONISTS; INTRACRANIAL THROMBOSIS; LIGANDS; MALE; MOTOR ACTIVITY; MUSCIMOL; PHYSICAL THERAPY MODALITIES; RATS; RATS, WISTAR; RECEPTORS, GLUTAMATE; RESTRAINT, PHYSICAL; STROKE; UP-REGULATION;

EID: 41249102074     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.107.495069     Document Type: Article

References (26)

1. Chen R, Cohen LG, Hallett M. Nervous system reorganization following injury. Neuroscience. 2002;4:761-773.
2. Schäbitz W-R, Berger C, Kollmar R, Seitz M, Tanay E, Kiessling M, Schwab S, Sommer C. Effect of BDNF treatment and forced arm use on functional motor recovery after small cortical ischemia. Stroke. 2004;35:992-997.
3. Taub E, Uswatte G, Elbert T. New treatments in neurorehabilitation founded on basic research. Nat Rev Neurosci. 2002;3:228-236.
4. Jolkkonen J, Gallagher NP, Zilles K, Sivenius J. Behavioral deficits and recovery following transient focal cerebral ischemia in rats: glutamatergic and GABAergic receptor densities. Behav Brain Res. 2003;138:187-200.
5. Watson BD, Dietrich WD, Busto R, Wachtel MS, Ginsberg MD. Induction of reproducible brain infarction by photochemically initiated thrombosis. Ann Neurol. 1985;17:497-504.
6. Schallert T, Hernandez TD, Barth TM. Recovery of function after brain damage: severe and chronic disruption by diazepam. Brain Res. 1986;379:104-111.
7. Chen J, Li Y, Wang L, Lu M, Zhang X, Chopp M. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke. 2001;32:1005-1011.
8. Hamm RJ, Pike BR, O'Dell DM, Lyeth BG, Jenkins LW. The Rotorod test: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury. J Neurotrauma. 1994;11:187-196.
9. Schneider A, Wysocki R, Pitzer C, Krüger C, Laage R, Schwab S, Bach A, Schäbitz WR. An extended window of opportunity for G-CSF treatment in cerebral ischemia. BMC Biol. 2006;4:36.
10. Schallert T, Kozlowski DA, Humm JL, Cocke RR. Use-dependent structural events in recovery of function. Adv Neurol. 1997;73:229-238.
11. Shanina EV, Redecker C, Reinecke S, Schallert T, Witte OW. Long-term effects of sequential cortical infarcts on scar size, brain volume and cognitive functional. Behav Brain Res. 2005;158:69-77.
12. Zilles K, Wu J, Crusio WE, Schwegler H. Water maze and radial maze learning and the density of binding sites of glutamate, GABA, and serotonin receptors in the hippocampus of inbred mouse strains. Hippocampus. 2000;10:213-225.
13. 3H]Muscimol binding to GABAA receptors is upregulated in CA1 neurons of the gerbil hippocampus in the ischemia tolerant state. Stroke. 2002;33:1698-1705.
14. A receptors in the cortical penumbra. Mol Brain Res. 2003;111:24-30.
15. Zilles K, Wree A. Cortex: a real and laminar structure. In: Paxinos G, ed. The Rat Nervous System, 2nd ed. New York: Academic Press; 1995: 649-685.
16. Könönen M, Kuikka JT, Husso-Saastamoinen M, Vanninen E, Vanninen R, Soimakallio S, Mervaala E, Sivenius J, Pitkanen K, Tarkka IM. Increased perfusion in motor areas after constraint-induced movement therapy in chronic stroke: a single-photon emission computerized tomography study. J Cereb Blood Flow Metab. 2005;25:1668-1674.
17. Jones TA, Schallert T. Use-dependent growth of pyramidal neurons after neocortical damage. J Neurosci. 1994;14:2140-2152.
18. Bidmon HJ, Jancsik V, Schleicher A, Hagemann G, Witte OW, Woodhams P, Zilles K. Structural alterations and changes in cytoskeletal proteins and proteoglycans after focal cortical ischemia. Neuroscience. 1998;82:397-420.
19. Kawamata T, Dietrich WD, Schallert T, Gotts JE, Cocke RR, Benowitz LI, Finkelstein SP. Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction. Proc Natl Acad Sci U S A. 1997;94:8179-8184.
20. Stroemer RP, Kent TA, Hulsebosch CE. Enhanced neocortical neural sprouting, synaptogenesis, and behavioral recovery with D-amphetamine therapy after neocortical infarction in rats. Stroke. 1998;29:2381-2395.
21. Voroin LL, Cherubini E. 'Deaf, mute and whispering' silent synapses: their role in synaptic plasticity. J Physiol. 2004;557:3-12.
22. Voss OP, Milne S, Sharkey J, O'Neill MJ, McCulloch J. Molecular mechanisms of neurite growth with AMPA receptor potentiation. Neuropharmacology. 2007;52:590-597.
23. Buchkremer-Ratzmann I, August M, Hagemann G, Witte OW. Electrophysiological transcortical diaschisis after cortical photothrombosis in rat brain. Stroke. 1996;27:1105-1111.
24. Lee J-M, Zipfel GJ, Choi DW. The changing landscape of ischaemic brain injury mechanisms. Nature. 1999;399(suppl):A7-A14.
25. Barth TM, Grant ML, Schallert T. Effects of MK-801 on recovery from sensorimotor cortex lesions. Stroke. 1990;21:III153-157.
26. Biegon A, Fry PA, Paden CM, Alexandrovich A, Tsenter J, Shohami E. Dynamic changes in N-methyl-D-aspartate receptors after closed head injury in mice: implications for treatment of neurological and cognitive deficits. Proc Natl Acad Sci U S A. 2004;101:5117-5122.