Progenitor cell therapy for the treatment of central nervous system injury: A review of the state of current clinical trials

Stem Cells International

Volumn , Issue , 2010, Pages

  Walker, Peter A ^a   Harting, Matthew T ^b   Shah, Shinil K ^a,c   Day, Mary Clare ^a   El Khoury, Ramy ^a   Savitz, Sean I ^a   Baumgartner, James ^a   Cox Jr , Charles S ^a,c  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; TISSUE PLASMINOGEN ACTIVATOR;

ALLOGENEIC STEM CELL TRANSPLANTATION; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BRAIN ISCHEMIA; CELL DIFFERENTIATION; CELL POPULATION; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL EFFECTIVENESS; CORD BLOOD STEM CELL TRANSPLANTATION; ENGRAFTMENT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; LUMBAR PUNCTURE; MESENCHYMAL STEM CELL TRANSPLANTATION; NERVOUS SYSTEM INFLAMMATION; NERVOUS SYSTEM INJURY; NEUROPROTECTION; NONHUMAN; PATIENT SAFETY; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REVIEW; SPINAL CORD INJURY; STEM CELL MOBILIZATION; STROMA CELL; TRAUMATIC BRAIN INJURY;

EID: 79959398498     PISSN: None     EISSN: 16879678     Source Type: Journal    
DOI: 10.4061/2010/369578     Document Type: Review

References (46)

1. Thompson H. J., A critical analysis of measures of caregiver and family functioning following traumatic brain injury The Journal of Neuroscience Nursing 2009 41 3 148 158
2. Lee H.-Y., Hwang J.-S., Jeng J.-S., Wang J.-D., Quality-adjusted life expectancy (QALE) and loss of QALE for patients with ischemic stroke and intracerebral hemorrhage: a 13-year follow-up Stroke 2010 41 4 739 744
3. Faul M., Wald M. M., Rutland-Brown W., Sullivent E. E., Sattin R. W., Using a cost-benefit analysis to estimate outcomes of a clinical treatment guideline: testing the Brain Trauma Foundation guidelines for the treatment of severe traumatic brain injury The Journal of Trauma 2007 63 6 1271 1278
4. Taylor T. N., Davis P. H., Torner J. C., Holmes J., Meyer J. W., Jacobson M. F., Lifetime cost of stroke in the United States Stroke 1996 27 9 1459 1466 (Pubitemid 26295889)
5. Scadden D. T., The stem-cell niche as an entity of action Nature 2006 441 7097 1075 1079 (Pubitemid 43990719)
6. Weiner L. P., Definitions and criteria for stem cells Methods in Molecular Biology 2008 438 3 8
7. Qu C., Mahmood A., Lu D., Goussev A., Xiong Y., Chopp M., Treatment of traumatic brain injury in mice with marrow stromal cells Brain Research 2008 1208 234 239
8. de Vasconcelos dos Santos A., da Costa Reis J., Diaz Paredes B., Therapeutic window for treatment of cortical ischemia with bone marrow-derived cells in rats Brain Research 2010 1306 149 158
9. Jung D.-I., Ha J., Kang B.-T., Kim J.-W., Quan F.-S., Lee J.-H., Woo E.-J., Park H.-M., A comparison of autologous and allogenic bone marrow-derived mesenchymal stem cell transplantation in canine spinal cord injury Journal of the Neurological Sciences 2009 285 1-2 67 77
10. Zhao L.-R., Duan W.-M., Reyes M., Keene C. D., Verfaillie C. M., Low W. C., Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats Experimental Neurology 2002 174 1 11 20 (Pubitemid 34218904)
11. Lu D., Mahmood A., Wang L., Li Y., Lu M., Chopp M., Adult bone marrow stromal cells administered intravenously to rats after traumatic brain injury migrate into brain and improve neurological outcome NeuroReport 2001 12 3 559 563 (Pubitemid 32173965)
12. Hayase M., Kitada M., Wakao S., Itokazu Y., Nozaki K., Hashimoto N., Takagi Y., Dezawa M., Committed neural progenitor cells derived from genetically modified bone marrow stromal cells ameliorate deficits in a rat model of stroke Journal of Cerebral Blood Flow and Metabolism 2009 29 8 1409 1420
13. Kuh S.-U., Cho Y.-E., Yoon D.-H., Kim K.-N., Ha Y., Functional recovery after human umbilical cord blood cells transplantation with brain-derived neutrophic factor into the spinal cord injured rat Acta Neurochirurgica 2005 147 9 985 992 (Pubitemid 41160071)
14. Castro R. F., Jackson K. A., Goodell M. A., Robertson C. S., Liu H., Shine H. D., Failure of bone marrow cells to transdifferentiate into neural cells in vivo Science 2002 297 5585 1299 (Pubitemid 34913161)
15. Wagers A. J., Sherwood R. I., Christensen J. L., Weissman I. L., Little evidence for developmental plasticity of adult hematopoietic stem cells Science 2002 297 5590 2256 2259
16. Roybon L., Ma Z., Asztely F., Fosum A., Jacobsen S. E. W., Brundin P., Li J.-Y., Failure of transdifferentiation of adult hematopoietic stem cells into neurons Stem Cells 2006 24 6 1594 1604 (Pubitemid 44464677)
17. Kim K. N., Oh S. H., Lee K. H., Yoon D. H., Effect of human mesenchymal stem cell transplantation combined with growth factor infusion in the repair of injured spinal cord Acta Neurochirurgica. Supplement 2006 99 133 136
18. Hunt D. P. J., Irvine K. A., Webber D. J., Compston D. A. S., Blakemore W. F., Chandran S., Effects of direct transplantation of multipotent mesenchymal stromal/stem cells into the demyelinated spinal cord Cell Transplantation 2008 17 7 865 873
19. Harting M. T., Jimenez F., Adams S. D., Mercer D. W., Cox C. S. Jr., Acute, regional inflammatory response after traumatic brain injury: implications for cellular therapy Surgery 2008 144 5 803 813
20. Aggarwal S., Pittenger M. F., Human mesenchymal stem cells modulate allogeneic immune cell responses Blood 2005 105 4 1815 1822 (Pubitemid 40223708)
21. Walker P. A., Harting M. T., Jimenez F., Direct intrathecal implantation of mesenchymal stromal cells leads to enhanced neuroprotection via an NFkappaB mediated increase in Interleukin 6 (IL-6) production Stem Cells and Development 2010 19 6 867 876
22. Liu N., Chen R., Du H., Wang J., Zhang Y., Wen J., Expression of IL-10 and TNF- in rats with cerebral infarction after transplantation with mesenchymal stem cells Cellular and Molecular Immunology 2009 6 3 207 213
23. Ajmo C. T. Jr., Collier L. A., Leonardo C. C., Hall A. A., Green S. M., Womble T. A., Cuevas J., Willing A. E., Pennypacker K. R., Blockade of adrenoreceptors inhibits the splenic response to stroke Experimental Neurology 2009 218 1 47 55
24. Vendrame M., Gemma C., Pennypacker K. R., Bickford P. C., Davis Sanberg C., Sanberg P. R., Willing A. E., Cord blood rescues stroke-induced changes in splenocyte phenotype and function Experimental Neurology 2006 199 1 191 200 (Pubitemid 43949266)
25. Németh K., Leelahavanichkul A., Yuen P. S. T., Mayer B., Parmelee A., Doi K., Robey P. G., Leelahavanichkul K., Koller B. H., Brown J. M., Hu X., Jelinek I., Star R. A., Mezey., Bone marrow stromal cells attenuate sepsis via prostaglandin E 2-dependent reprogramming of host macrophages to increase their interleukin-10 production Nature Medicine 2009 15 1 42 49
26. Yoon J.-K., Park B.-N., Shim W.-Y., In vivo tracking of 111In-labeled bone marrow mesenchymal stem cells in acute brain trauma model Nuclear Medicine and Biology 2010 37 3 381 388
27. Detante O., Moisan A., Dimastromatteo J., Intravenous administration of 99mTc-HMPAO-labeled human mesenchymal stem cells after stroke: in vivo imaging and biodistribution Cell Transplantation 2009 18 12 1369 1379
28. Vilalta M., Dégano I. R., Bag J., Gould D., Santos M., Garca-Arranz M., Ayats R., Fuster C., Chernajovsky Y., Garca-Olmo D., Rubio N., Blanco J., Biodistribution, long-term survival, and safety of human adipose tissue-derived mesenchymal stem cells transplanted in nude mice by high sensitivity non-invasive bioluminescence imaging Stem Cells and Development 2008 17 5 993 1003
29. Kang S.-K., Shin M.-J., Jung J. S., Kim Y. G., Kim C.-H., Autologous adipose tissue-derived stromal cells for treatment of spinal cord injury Stem Cells and Development 2006 15 4 583 594 (Pubitemid 44701177)
30. Fischer U. M., Harting M. T., Jimenez F., Monzon-Posadas W. O., Xue H., Savitz S. I., Laine G. A., Cox C. S., Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect Stem Cells and Development 2009 18 5 683 691
31. Prevention CfDCa, From the Centers for Disease Control and Prevention. Prevalence of disabilities and associated health conditions among adultsUnited States, 1999 Journal of the American Medical Association 2001 285 12 1571 1572
32. Stroke TNIoNDa, Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group The New England Journal of Medicine 1995 333 24 1581 1587
33. Shichinohe H., Kuroda S., Yano S., Hida K., Iwasaki Y., Role of SDF-1/CXCR4 system in survival and migration of bone marrow stromal cells after transplantation into mice cerebral infarct Brain Research 2007 1183 1 138 147 (Pubitemid 350088692)
34. Abe K., Therapeutic potential of neurotrophic factors and neural stem cells against ischemic brain injury Journal of Cerebral Blood Flow and Metabolism 2000 20 10 1393 1408
35. Amabile G., Meissner A., Induced pluripotent stem cells: current progress and potential for regenerative medicine Trends in Molecular Medicine 2009 15 2 59 68
36. Chopp M., Li Y., Treatment of stroke and intracerebral hemorrhage with cellular and pharmacological restorative therapies Acta Neurochirurgica. Supplement 2008 105 79 83
37. Brenneman M., Sharma S., Harting M., Strong R., Cox C. S. Jr., Aronowski J., Grotta J. C., Savitz S. I., Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle-aged rats Journal of Cerebral Blood Flow and Metabolism 2009 30 1 140 149
38. Saver J. L., Albers G. W., Dunn B., Johnston K. C., Fisher M., Stroke therapy academic industry roundtable (STAIR) recommendations for extended window acute stroke therapy trials Stroke 2009 40 7 2594 2600
39. Cox C. S. J., Baumgartner J. E., Harting M. T., Autologous bone marrow mononculear cell therapy for severe traumatic brain injury in children. Neurosurgery. In press
40. Sykov E., Jendelov P., Urdzkov L., Lesn P., Hejl A., Bone marrow stem cells and polymer hydrogelstwo strategies for spinal cord injury repair Cellular and Molecular Neurobiology 2006 26 7-8 1113 1129
41. Cristante A. F., Barros-Filho T. E. P., Tatsui N., Mendrone A., Caldas J. G., Camargo A., Alexandre A., J Teixeira W. G., Oliveira R. P., Marcon R. M., Stem cells in the treatment of chronic spinal cord injury: evaluation of somatosensitive evoked potentials in 39 patients Spinal Cord 2009 47 10 733 738
42. Callera F., do Nascimento R. X., Delivery of autologous bone marrow precursor cells into the spinal cord via lumbar puncture technique in patients with spinal cord injury: a preliminary safety study Experimental Hematology 2006 34 2 130 131 (Pubitemid 43184317)
43. Callera F., de Melo C. M. T. P., Magnetic resonance tracking of magnetically labeled autologous bone marrow CD34+ cells transplanted into the spinal cord via lumbar puncture technique in patients with chronic spinal cord injury: CD34+ cells' migration into the injured site Stem Cells and Development 2007 16 3 461 466 (Pubitemid 47016231)
44. Deda H., Inci M. C., Kureki A. E., Kayihan K., zgn E., Ustunsoy G., Kocabay S., Treatment of chronic spinal cord injured patients with autologous bone marrow-derived hematopoietic stem cell transplantation: 1-year follow-up Cytotherapy 2008 10 6 565 574
45. Yoon S. H., Shim Y. S., Park Y. H., Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony stimulating factor: phase I/II clinical trial Stem Cells 2007 25 8 2066 2073
46. Amariglio N., Hirshberg A., Scheithauer B. W., Cohen Y., Loewenthal R., Trakhtenbrot L., Paz N., Koren-Michowitz M., Waldman D., Leider-Trejo L., Toren A., Constantini S., Rechavi G., Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient PLoS Medicine 2009 6 2