BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Tα1-tubulin mRNA expression, and promote axonal regeneration

Journal of Neuroscience

Volumn 17, Issue 24, 1997, Pages 9583-9595

  Kobayashi, Nao R ^a,b   Fan, Da Peng ^b   Giehl, Klaus M ^a,d   Bedard, Annie M ^a   Wiegand, Stanley J ^c   Tetzlaff, Wolfram ^a,b  

^a UNIVERSITY OF OTTAWA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c REGENERON PHARMACEUTICALS INC   (United States)

^d SAARLAND UNIVERSITY   (Germany)

Author keywords

Axotomy; Cell body response; Gene expression; Neuronal atrophy; Neurotrophin; Peripheral nerve transplant; Regeneration, red nucleus; Spinal cord injury

Indexed keywords

ALPHA TUBULIN; BRAIN DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA; NEUROMODULIN; NEUROTROPHIN; NEUROTROPHIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL SIZE; CELL SUBPOPULATION; CONTROLLED STUDY; GENE EXPRESSION; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFUSION; MALE; NERVE CELL; NERVE FIBER TRANSECTION; NERVE GRAFT; NERVE REGENERATION; NONHUMAN; PERIPHERAL NERVE; PRIORITY JOURNAL; RAT; RED NUCLEUS; REGENERATION; RUBROSPINAL TRACT; SPINAL CORD INJURY;

EID: 0031467240     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-24-09583.1997     Document Type: Article

References (27)

1. Aguayo AJ, Rasminsky M, Bray GM, Carbonetto S, McKerracher L, Villegas-Perez MP, Vidal-Sanz M, Carter DA (1991) Degenerative and regenerative responses of injured neurons in the central nervous system for adult mammals. Philos Trans R Soc Lond [Biol] 331:337-343.
2. Aigner L, Caroni P (1995) Absence of persistent spreading, branching and adhesion in GAP-43 induces nerve sprouting in the adult nervous system of transgenic mice. Cell 83:269-278.
3. Alderson RF, Wiegand SJ, Anderson KD, Cai N, Cho NJ, Lindsay RM, Altar CA (1996) Neurotrophin-4/5 maintains the cholinergic phenotype of axotomized septal neurons. Eur J Neurosci 8:282-290.
4. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215:403-410.
5. Anderson KD, Alderson RF, Altar CA, Distefano PS, Corcoran TL, Lindsay RM, Wiegand SJ (1995) Differential distribution of exogenous BDNF, NGF and NT-3 in the brain corresponds to the relative abundance and distribution of high-affinity and low-affinity neurotrophin receptors. J Comp Neurol 357:296-317.
6. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith K A, Struhl K (1987) Current protocols in molecular biology. New York: Wiley-Interscience.
7. Barbacid M (1995) Structural and functional properties of TRK family of neurotrophin receptors. Ann NY Acad Sci 766:442-458.
8. Barron KD, Banerjee M, Dentinger MP, Scheibly ME, Mankes R (1989) Cytological and cytochemical (RNA) studies on rubral neurons after unilateral rubrospinal tractotomy: the impact of GM1 ganglioside administration. J Neurosci Res 22:331-337.
9. Basi GS, Jacobson RD, Virag I, Schilling J, Skene JHP (1987) Primary structure and transcriptional regulation of GAP-43, a protein associated with nerve growth. Cell 236:597-600.
10. Belliveau DJ, Krivko I, Kohn J, Lachance C, Pozniak C, Rusakov D, Kaplan D, Miller FD (1997) NGF and neurotrophin-3 both activate trkA on sympathetic neurons but differentially regulate survival and neuritogenesis. J Cell Biol 136:375-388.
11. Benowitz LI, Routtenberg A (1997) GAP-43: an intrinsic determinant of neuronal development and plasticity. Trends Neurosci 20:84-91.
12. Bisby MA, Tetzlaff W (1992) Changes in cytoskeletal protein synthesis following axon injury and during axon regeneration. Mol Neurobiol 6:107-123.
13. Bonhoeffer T (1996) Neurotrophins and activity-dependent development of the neocortex. Curr Opin Neurobiol 6:119-126.
14. Bothwell M (1995) Functional interactions of neurotrophins and neurotrophin receptors. Annu Rev Neurosci 18:223-253.
15. Bovolenta P, Wandosell F, Nieto-Sampedro M (1993) Characterization of a neurite outgrowth inhibitor expressed after CNS injury. J Neurosci 5:454-465.
16. Campbell G, Lieberman AR, Anderson PN, Turmaine M (1992) Regeneration of adult rat CNS axons into peripheral nerve autografts: ultrastructural studies of the early stages of axonal sprouting and regenerative axonal growth. J Neurocytol 21:755-787.
17. Caroni P, Schwab ME (1988) Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter. Neuron 1:85-96.
18. Caroni P, Aigner L, Arber S, Botteri F, Kapfhammer J, Brenner H-R (1995) GAP-43 and CAP-23 induce nerve sprouting in the adult nervous system of transgenic mice. Soc Neurosci Abstr 21:14.
19. Chen DF, Jhaveri S, Schneider GE (1995) Intrinsic changes in developing retinal neurons result in regenerative failure of their axons. Proc Natl Acad Sci USA 92:7287-7291.
20. Davies AM (1994) The role of neurotrophins in the developing nervous system. J Neurobiol 25:1334-1348.
21. Davies AM, Minichiello L, Klein R (1995) Developmental changes in NT-3 signaling via TrkA and TrkB in embryonic neurons. EMBO J 14:4482-4489.
22. Diener PS, Bregman BS (1994) Neurotrophic factors prevent the death of CNS neurons after spinal cord lesions in newborn rats. NeuroReport 5:1913-1917.
23. Doster SK, Lozano AM, Aguayo AJ, Willard MB (1991) Expression of the growth associated protein GAP-43 in adult rat retinal ganglion cells following axon injury. Neuron 6:635-647.
24. Egan DA, Flumerfelt BA, Gwyn DG (1977) Perikaryal volume changes and the time course of chromatolysis following cervical and thoracic lesions. Acta Neuropathol 37:13-19.
25. Fawcett JW, Mathews G, Housden E, Goedert M, Matus A (1994) Regenerating sciatic nerve axons contain the adult rather than embryonic pattern of microtubule associated protein. Neuroscience 61:789-804.
26. Lamballe F, Klein R, Barbacid M (1991) TrkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66:967-979.
27. Lewin GR, Barde Y-A (1996) Physiology of the neurotrophins. Annu Rev Neurosci 19:289-317.