Regional brain-derived neurotrophic factor mRNA and protein levels following transient forebrain ischemia in the rat

Molecular Brain Research

Volumn 38, Issue 1, 1996, Pages 139-144

  Kokaia, Z ^a   Nawa, H ^b   Uchino, H ^a   Elmer E ^a   Kokaia, M ^a   Carnahan, J ^c   Smith, M L ^a   Siesjo B K ^a   Lindvall, O ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b NIIGATA UNIVERSITY   (Japan)

^c AMGEN INC   (United States)

Author keywords

Brain damage; Forebrain ischemia; Hippocampus; Neurotrophins; Rat

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA; NEUROTROPHIC FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENTATE GYRUS; ENZYME IMMUNOASSAY; FOREBRAIN; IN SITU HYBRIDIZATION; MALE; NEUROPROTECTION; NONHUMAN; PARIETAL LOBE; PRIORITY JOURNAL; RAT; TRANSIENT ISCHEMIC ATTACK;

ANIMALIA;

EID: 0029896172     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0169-328X(96)00002-2     Document Type: Article

References (36)

1. Beck, T., Lindholm, D., Castrén, E. and Wree, A., Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus, J. Cereb. Blood Flow Metab., 14 (1994) 689-692.
2. Bengzon, J., Söderström, S., Kokaia, Z., Kokaia, M., Ernfors, P., Persson, H., Ebendal, T. and Lindvall, O., Widespread increase of nerve growth factor protein in the rat forebrain after kindling-induced seizures, Brain Res., 587 (1992) 338-342.
3. Bergstedt, K., Hu, B.R. and Wieloch, T., Postischemic changes in protein synthesis in the rat brain. Effects by hypothermia, Exp. Brain Res., 95 (1993) 91-97.
4. Blöchl, A. and Thoenen, H., Characterization of nerve growth factor (NGF) release from hippocampal neurons: evidence for a constitutive and an unconventional sodium-dependent regulated pathway, Eur. J. Neurosci., 7 (1995) 1220-1228.
5. Castrén, E., Zafra, F., Thoenen, H. and Lindholm, D., Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex, Proc. Natl. Acad. Sci. USA, 89 (1992) 9444-9448.
6. Cheng, B. and Mattson, M.P., NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults, Brain Res., 640 (1994) 56-67.
7. Comelli, M.C., Guidolin, D., Seren, M.S., Zanoni, R., Canella, R., Rubini, R. and Manev, H., Time course, localization and pharmacological modulation of immediate early inducible genes, brain-derived neurotrophic factor and trkB messenger RNAs in the rat brain following photochemical stroke, Neuroscience, 55 (1993) 473-490.
8. DiStefano, P.S., Friedman, B., Radziejewski, C., Alexander, C., Boland, P., Schick, C.M., Lindsay, R.M. and Wiegand, S.J., The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons, Neuron, 8 (1992) 983-893.
9. Dugich-Djordjevich, M.M., Tocco, G., Lapchak, P.A., Pasinetti, G.M., Najm, I., Baudry, M. and Hefti, F., Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid., Neuroscience, 47 (1992) 303-315.
10. Ernfors, P., Wetmore, C., Olson, L. and Persson, H., Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family, Neuron, 5 (1990) 511-526.
11. Ghosh, A., Carnahan, J. and Greenberg, M.E., Requirement for BDNF in activity-dependent survival of cortical neurons, Science, 263 (1994) 1618-1623.
12. Hofer, M., Paglusi, S.R., Hohn, A., Leibrock, J. and Barde, Y.-A., Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain, EMBO J., 9 (1990) 2459-2464.
13. Hossmann, K.A., Disturbances of cerebral protein synthesis and ischemic cell death, Prog. Brain Res., 96 (1993) 161-177.
14. Isackson, P.J., Huntsman, M.M., Murray, K.D. and Gall, C.M., BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF, Neuron, 6 (1991) 937-948.
15. Kirino, T., Delayed neuronal death in the gerbil hippocampus following transient ischemia, Brain Res., 239 (1982) 57-69.
16. Koh, J.-Y., Gwag, B.J., Lobner, D. and Choi, D.W., Potentiated necrosis of cultured cortical neurons by neurotrophins, Science, 268 (1995) 573-575.
17. Kokaia, Z., Bengzon, J., Metsis, M., Kokaia, M., Persson, H. and Lindvall, O., Coexpression of neurotrophins and their receptors in neurons of the central nervous system, Proc. Natl. Acad. Sci. USA, 90 (1993) 6711-6715.
18. Kokaia, Z., Othberg, A., Kokaia, M. and Lindvall, O., BDNF makes cultured dentate granule cells more resistant to hypoglycemic damage, NeuroReport, 5 (1994) 1241-1244.
19. Kokaia, Z., Zhao, Q., Kokaia, M., Elmér, E., Metsis, M., Smith, M.-L., Siesjö, B.K. and Lindvall, O., Regulation of brain-derived neurotrophic factor gene expression after transient middle cerebral artery occlusion with and without brain damage, Exp. Neurol., 133 (1995) 215-224.
20. Korsching, S., Auburger, G., Heumann, R., Scott, J. and Thoenen, H., Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation, EMBO J., 4 (1985) 1389-1393.
21. Li, P.-A., Shalmoo, M., Smith, M.-L., Katsura, K. and Siesjö, B.K., The influence of plasma glucose concentrations on ischemic brain damage is a threshold function, Neurosci. Lett., 177 (1994) 63-65.
22. Lindvall, O., Ernfors, P., Bengzon, J., Kokaia, Z., Smith, M.-L., Siesjö, B.K. and Persson, H., Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 in the adult rat brain following cerebral ischemia and hypoglycemic coma, Proc. Natl. Acad. Sci. USA, 89 (1992) 648-652.
23. Lindvall, O., Kokaia, Z., Bengzon, J., Elmér, E. and Kokaia, M., Neurotrophins and brain insults, Trends Neurosci., 17 (1994) 490-496.
24. Minamisawa, H., Smith, M.-L. and Siesjö, B.K., The effect of mild hyperthermia and hypothermia on brain damage following 5, 10, and 15 minutes of forebrain ischemia, Ann. Neurol., 28 (1990) 26-33.
25. Miranda, R.C., Sohrabji, F. and Toran-Allerand, C.D., Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions, Proc. Natl. Acad. Sci. USA, 90 (1993) 6439-6443.
26. Nakao, N., Kokaia, Z., Odin, P. and Lindvall, O., Protective effects of BDNF and NT-3 but not PDGF against hypoglycemic injury to cultured striatal neurons, Exp. Neurol., 131 (1995) 1-10.
27. Nawa, H., Carnahan, J. and Gall, C., BDNF protein measured by a novel enzyme immunoassay in normal brain and after seizure: partial dissaccordance with mRNA levels, Eur. J. Neurosci., 7 (1995) 1527-1535.
28. Phillips, H.S., Hains, J.M., Laramee, G.R., Rosenthal, A. and Winslow, J.W., Widespread expression of BDNF but not NT-3 by target areas of basal forebrain cholinergic neurons, Science, 250 (1990) 290-294.
29. Pulsinelli, W.A., Brierley, J.B. and Plum, F., Temporal profile of neuronal damage in a model of transient forebrain ischemia, Ann. Neurol., 11 (1982) 491-498.
30. Shozuhara, H., Onodera, H., Katoh, S.R., Kato, K., Yamasaki, Y. and Kogure, K., Temporal profiles of nerve growth factor beta-subunit level in rat brain regions after transient ischemia, J. Neurochem., 59 (1992) 175-180.
31. Smith, M.-L., Auer, R.N. and Siesjö, B.K., The density and distribution of ischemic brain injury in the rat following 2-10 min of forebrain ischemia., Acta Neuropathol. (Berl.), 64 (1984) 319-332.
32. Smith, M.-L., Kalimo, H., Warner, D.S. and Siesjö, B.K., Morphological lesions in the brain preceding the development of postischemic seizures, Acta Neuropathol., 76 (1988) 253-264.
33. Takeda, A., Onodera, H., Sugimoto, A., Kogure, K., Obinata, M. and Shibahara, S., Coordinated expression of messenger RNAs for nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 in the rat hippocampus following transient forebrain ischemia, Neuroscience, 55 (1993) 23-31.
34. Timmusk, T., Palm, K., Metsis, M., Reintam, T., Paalme, V., Saarma, M. and Persson, H., Multiple promoters direct tissue-specific expression of the rat BDNF gene, Neuron, 10 (1993) 475-489.
35. Wetmore, C., Ernfors, P., Persson, H. and Olson, L., Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization, Exp. Neurol., 109 (1990) 141-152.
36. Wetmore, C., Olson, L. and Bean, A.J., Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors, J. Neurosci., 14 (1994) 1688-1700.