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Volumn 21, Issue 3, 2015, Pages 636-644

Endoplasmic reticulum stress and unfolded protein response in inflammatory bowel disease

Author keywords

apoptosis; intestinal epithelial cells; mucosal immunity; new therapies; protein folding and secretion

Indexed keywords

APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL DIFFERENTIATION; CELL FUNCTION; CELL MIGRATION; CELL POPULATION; CELL SURVIVAL; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; EPITHELIUM CELL; GOBLET CELL; HOMEOSTASIS; HUMAN; IMMUNOCOMPETENT CELL; INFLAMMATORY BOWEL DISEASE; INTESTINE CELL; NONHUMAN; PANETH CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN SECRETION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; ANIMAL; PATHOPHYSIOLOGY;

EID: 84923398377     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/MIB.0000000000000238     Document Type: Article
Times cited : (67)

References (99)
  • 1
    • 84856111924 scopus 로고    scopus 로고
    • The unfolded protein response: Controlling cell fate decisions under er stress and beyond
    • Hetz C. The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol. 2012; 13: 89-102.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 89-102
    • Hetz, C.1
  • 2
    • 84865245211 scopus 로고    scopus 로고
    • Unfolded protein response
    • Cao SS, Kaufman RJ. Unfolded protein response. Curr Biol. 2012; 22: R622-R626.
    • (2012) Curr Biol , vol.22 , pp. R622-R626
    • Cao, S.S.1    Kaufman, R.J.2
  • 3
    • 84903749341 scopus 로고    scopus 로고
    • Cell death opposing unfoldedprotein-response signals converge on death receptor 5 to control apoptosis
    • Lu M, Lawrence DA, Marsters S, et al. Cell death. Opposing unfoldedprotein-response signals converge on death receptor 5 to control apoptosis. Science. 2014; 345: 98-101.
    • (2014) Science , vol.345 , pp. 98-101
    • Lu, M.1    Lawrence, D.A.2    Marsters, S.3
  • 4
    • 82255173966 scopus 로고    scopus 로고
    • The unfolded protein response: From stress pathway to homeostatic regulation
    • Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science. 2011; 334: 1081-1086.
    • (2011) Science , vol.334 , pp. 1081-1086
    • Walter, P.1    Ron, D.2
  • 5
    • 79952264011 scopus 로고    scopus 로고
    • Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
    • Tabas I, Ron D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol. 2011; 13: 184-190.
    • (2011) Nat Cell Biol , vol.13 , pp. 184-190
    • Tabas, I.1    Ron, D.2
  • 6
    • 84864682160 scopus 로고    scopus 로고
    • IRE1alpha induces thioredoxininteracting protein to activate the nlrp3 inflammasome and promote programmed cell death under irremediable er stress
    • Lerner AG, Upton JP, Praveen PV, et al. IRE1alpha induces thioredoxininteracting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab. 2012; 16: 250-264.
    • (2012) Cell Metab , vol.16 , pp. 250-264
    • Lerner, A.G.1    Upton, J.P.2    Praveen, P.V.3
  • 7
    • 84868525253 scopus 로고    scopus 로고
    • IRE1alpha cleaves select micrornas during er stress to derepress translation of proapoptotic caspase-2
    • Upton JP, Wang L, Han D, et al. IRE1alpha cleaves select microRNAs during ER stress to derepress translation of proapoptotic caspase-2. Science. 2012; 338: 818-822.
    • (2012) Science , vol.338 , pp. 818-822
    • Upton, J.P.1    Wang, L.2    Han, D.3
  • 8
    • 84905492694 scopus 로고    scopus 로고
    • Allosteric inhibition of the ire1alpha rnase preserves cell viability and function during endoplasmic reticulum stress
    • Ghosh R, Wang L, Wang ES, et al. Allosteric inhibition of the IRE1alpha RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 2014; 158: 534-548.
    • (2014) Cell , vol.158 , pp. 534-548
    • Ghosh, R.1    Wang, L.2    Wang, E.S.3
  • 9
    • 33751069967 scopus 로고    scopus 로고
    • Adaptation to er stress is mediated by differential stabilities of pro-survival and pro-Apoptotic mrnas and proteins
    • Rutkowski DT, Arnold SM, Miller CN, et al. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-Apoptotic mRNAs and proteins. PLoS Biol. 2006; 4: e374.
    • (2006) PLoS Biol , vol.4 , pp. e374
    • Rutkowski, D.T.1    Arnold, S.M.2    Miller, C.N.3
  • 10
    • 84877578475 scopus 로고    scopus 로고
    • ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
    • Han J, Back SH, Hur J, et al. ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat Cell Biol. 2013; 15: 481-490.
    • (2013) Nat Cell Biol , vol.15 , pp. 481-490
    • Han, J.1    Back, S.H.2    Hur, J.3
  • 12
    • 84873422293 scopus 로고    scopus 로고
    • The cell biology of the intestinal epithelium and its relation to inflammatory bowel disease
    • Deuring JJ, de Haar C, Kuipers EJ, et al. The cell biology of the intestinal epithelium and its relation to inflammatory bowel disease. Int J Biochem Cell Biol. 2013; 45: 798-806.
    • (2013) J Biochem Cell Biol , vol.45 , pp. 798-806
    • Deuring, J.J.1    De Haar, C.2    Kuipers, E.J.3
  • 13
    • 77954399232 scopus 로고    scopus 로고
    • Drug targeting strategies for the treatment of inflammatory bowel disease: A mechanistic update
    • Dahan A, Amidon GL, Zimmermann EM. Drug targeting strategies for the treatment of inflammatory bowel disease: a mechanistic update. Expert Rev Clin Immunol. 2010; 6: 543-550.
    • (2010) Expert Rev Clin Immunol , vol.6 , pp. 543-550
    • Dahan, A.1    Amidon, G.L.2    Zimmermann, E.M.3
  • 14
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene lgr5
    • Barker N, van Es JH, Kuipers J, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007; 449: 1003-1007.
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Barker, N.1    Van Es, J.H.2    Kuipers, J.3
  • 15
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • Sato T, Vries RG, Snippert HJ, et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature. 2009; 459: 262-265.
    • (2009) Nature , vol.459 , pp. 262-265
    • Sato, T.1    Vries, R.G.2    Snippert, H.J.3
  • 16
    • 84904051527 scopus 로고    scopus 로고
    • Ex vivo culture of the intestinal epithelium: Strategies and applications
    • Leushacke M, Barker N. Ex vivo culture of the intestinal epithelium: strategies and applications. Gut. 2014; 63: 1345-1354.
    • (2014) Gut , vol.63 , pp. 1345-1354
    • Leushacke, M.1    Barker, N.2
  • 18
    • 58549111588 scopus 로고    scopus 로고
    • Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
    • Vaishnava S, Behrendt CL, Ismail AS, et al. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc Natl Acad Sci U S A. 2008; 105: 20858-20863.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 20858-20863
    • Vaishnava, S.1    Behrendt, C.L.2    Ismail, A.S.3
  • 19
    • 77950353786 scopus 로고    scopus 로고
    • Homeostasis and inflammation in the intestine
    • Garrett WS, Gordon JI, Glimcher LH. Homeostasis and inflammation in the intestine. Cell. 2010; 140: 859-870.
    • (2010) Cell , vol.140 , pp. 859-870
    • Garrett, W.S.1    Gordon, J.I.2    Glimcher, L.H.3
  • 21
    • 0036500996 scopus 로고    scopus 로고
    • Colorectal cancer in mice genetically deficient in the mucin muc2
    • Velcich A, Yang W, Heyer J, et al. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science. 2002; 295: 1726-1729.
    • (2002) Science , vol.295 , pp. 1726-1729
    • Velcich, A.1    Yang, W.2    Heyer, J.3
  • 22
    • 79960875661 scopus 로고    scopus 로고
    • Intestinal secretory cell er stress and inflammation
    • McGuckin MA, Eri RD, Das I, et al. Intestinal secretory cell ER stress and inflammation. Biochem Soc Trans. 2011; 39: 1081-1085.
    • (2011) Biochem Soc Trans , vol.39 , pp. 1081-1085
    • McGuckin, M.A.1    Eri, R.D.2    Das, I.3
  • 23
    • 65749101996 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease
    • Kaser A, Blumberg RS. Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease. Semin Immunol. 2009; 21: 156-163.
    • (2009) Semin Immunol , vol.21 , pp. 156-163
    • Kaser, A.1    Blumberg, R.S.2
  • 24
    • 79959271087 scopus 로고    scopus 로고
    • Intestinal homeostasis and its breakdown in inflammatory bowel disease
    • Maloy KJ, Powrie F. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature. 2011; 474: 298-306.
    • (2011) Nature , vol.474 , pp. 298-306
    • Maloy, K.J.1    Powrie, F.2
  • 25
    • 50249086073 scopus 로고    scopus 로고
    • XBP1 links er stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
    • Kaser A, Lee AH, Franke A, et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 2008; 134: 743-756.
    • (2008) Cell , vol.134 , pp. 743-756
    • Kaser, A.1    Lee, A.H.2    Franke, A.3
  • 26
    • 84887621906 scopus 로고    scopus 로고
    • Paneth cells as a site of origin for intestinal inflammation
    • Adolph TE, Tomczak MF, Niederreiter L, et al. Paneth cells as a site of origin for intestinal inflammation. Nature. 2013; 503: 272-276.
    • (2013) Nature , vol.503 , pp. 272-276
    • Adolph, T.E.1    Tomczak, M.F.2    Niederreiter, L.3
  • 27
    • 74749103667 scopus 로고    scopus 로고
    • Disruption of paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in agr22/2 mice
    • Zhao F, Edwards R, Dizon D, et al. Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr22/2 mice. Dev Biol. 2010; 338: 270-279.
    • (2010) Dev Biol , vol.338 , pp. 270-279
    • Zhao, F.1    Edwards, R.2    Dizon, D.3
  • 28
    • 66349091311 scopus 로고    scopus 로고
    • The protein disulfide isomerase agr2 is essential for production of intestinal mucus
    • Park SW, Zhen G, Verhaeghe C, et al. The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. Proc Natl Acad Sci U S A. 2009; 106: 6950-6955.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 6950-6955
    • Park, S.W.1    Zhen, G.2    Verhaeghe, C.3
  • 29
    • 84867375353 scopus 로고    scopus 로고
    • ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, oas, and atf6
    • Miller M, Tam AB, Cho JY, et al. ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6. Proc Natl Acad Sci U S A. 2012; 109: 16648-16653.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 16648-16653
    • Miller, M.1    Tam, A.B.2    Cho, J.Y.3
  • 30
    • 84872370695 scopus 로고    scopus 로고
    • ORMDL3 modulates store-operated calcium entry and lymphocyte activation
    • Carreras-Sureda A, Cantero-Recasens G, Rubio-Moscardo F, et al. ORMDL3 modulates store-operated calcium entry and lymphocyte activation. Hum Mol Genet. 2013; 22: 519-530.
    • (2013) Hum Mol Genet , vol.22 , pp. 519-530
    • Carreras-Sureda, A.1    Cantero-Recasens, G.2    Rubio-Moscardo, F.3
  • 31
    • 84876356353 scopus 로고    scopus 로고
    • The er stress transducer ire1beta is required for airway epithelial mucin production
    • Martino MB, Jones L, Brighton B, et al. The ER stress transducer IRE1beta is required for airway epithelial mucin production. Mucosal Immunol. 2013; 6: 639-654.
    • (2013) Mucosal Immunol , vol.6 , pp. 639-654
    • Martino, M.B.1    Jones, L.2    Brighton, B.3
  • 32
    • 0035094262 scopus 로고    scopus 로고
    • Increased sensitivity to dextran sodium sulfate colitis in ire1beta-deficient mice
    • Bertolotti A, Wang X, Novoa I, et al. Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. J Clin Invest. 2001; 107: 585-593.
    • (2001) J Clin Invest , vol.107 , pp. 585-593
    • Bertolotti, A.1    Wang, X.2    Novoa, I.3
  • 33
    • 84874251933 scopus 로고    scopus 로고
    • Negative feedback by ire1beta optimizes mucin production in goblet cells
    • Tsuru A, Fujimoto N, Takahashi S, et al. Negative feedback by IRE1beta optimizes mucin production in goblet cells. Proc Natl Acad Sci U S A. 2013; 110: 2864-2869.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 2864-2869
    • Tsuru, A.1    Fujimoto, N.2    Takahashi, S.3
  • 34
    • 65649084877 scopus 로고    scopus 로고
    • Positive role of ccaat/enhancerbinding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis
    • Namba T, Tanaka K, Ito Y, et al. Positive role of CCAAT/enhancerbinding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis. Am J Pathol. 2009; 174: 1786-1798.
    • (2009) Am J Pathol , vol.174 , pp. 1786-1798
    • Namba, T.1    Tanaka, K.2    Ito, Y.3
  • 35
    • 62549129560 scopus 로고    scopus 로고
    • Enhanced sensitivity to dss colitis caused by a hypomorphic mbtps1 mutation disrupting the atf6-driven unfolded protein response
    • Brandl K, Rutschmann S, Li X, et al. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A. 2009; 106: 3300-3305.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 3300-3305
    • Brandl, K.1    Rutschmann, S.2    Li, X.3
  • 36
    • 84858020459 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress transducer oasis is involved in the terminal differentiation of goblet cells in the large intestine
    • Asada R, Saito A, Kawasaki N, et al. The endoplasmic reticulum stress transducer OASIS is involved in the terminal differentiation of goblet cells in the large intestine. J Biol Chem. 2012; 287: 8144-8153.
    • (2012) J Biol Chem , vol.287 , pp. 8144-8153
    • Asada, R.1    Saito, A.2    Kawasaki, N.3
  • 37
    • 84894628100 scopus 로고    scopus 로고
    • Increased susceptibility to dextran sulfate sodium-induced colitis in the endoplasmic reticulum stress transducer oasis deficient mice
    • Hino K, Saito A, Asada R, et al. Increased susceptibility to dextran sulfate sodium-induced colitis in the endoplasmic reticulum stress transducer OASIS deficient mice. PLoS One. 2014; 9: e88048.
    • (2014) PLoS One , vol.9 , pp. e88048
    • Hino, K.1    Saito, A.2    Asada, R.3
  • 38
    • 84876486995 scopus 로고    scopus 로고
    • The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice
    • Cao SS, Zimmermann EM, Chuang BM, et al. The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice. Gastroenterology. 2013; 144: 989-1000.e6.
    • (2013) Gastroenterology , vol.144 , pp. 989-1000e6
    • Cao, S.S.1    Zimmermann, E.M.2    Chuang, B.M.3
  • 39
    • 77957195829 scopus 로고    scopus 로고
    • Abnormally expressed er stress response chaperone gp96 in cd favours adherent-invasive escherichia coli invasion
    • Rolhion N, Barnich N, Bringer MA, et al. Abnormally expressed ER stress response chaperone Gp96 in CD favours adherent-invasive Escherichia coli invasion. Gut. 2010; 59: 1355-1362.
    • (2010) Gut , vol.59 , pp. 1355-1362
    • Rolhion, N.1    Barnich, N.2    Bringer, M.A.3
  • 41
    • 84902211251 scopus 로고    scopus 로고
    • Genomic atg16l1 risk allele-restricted paneth cell er stress in quiescent crohn's disease
    • Deuring JJ, Fuhler GM, Konstantinov SR, et al. Genomic ATG16L1 risk allele-restricted Paneth cell ER stress in quiescent Crohn's disease. Gut. 2014; 63: 1081-1091.
    • (2014) Gut , vol.63 , pp. 1081-1091
    • Deuring, J.J.1    Fuhler, G.M.2    Konstantinov, S.R.3
  • 42
    • 84896468061 scopus 로고    scopus 로고
    • Embracing the void-how much do we really know about targeting and translocation to the endoplasmic reticulum
    • Aviram N, Schuldiner M. Embracing the void-how much do we really know about targeting and translocation to the endoplasmic reticulum. Curr Opin Cell Biol. 2014; 29C: 8-17.
    • (2014) Curr Opin Cell Biol , vol.29 , pp. 8-17
    • Aviram, N.1    Schuldiner, M.2
  • 43
    • 84898720437 scopus 로고    scopus 로고
    • Phosphorylation of eif2alpha is dispensable for differentiation but required at a posttranscriptional level for paneth cell function and intestinal homeostasis in mice
    • Cao SS, Wang M, Harrington JC, et al. Phosphorylation of eIF2alpha is dispensable for differentiation but required at a posttranscriptional level for paneth cell function and intestinal homeostasis in mice. Inflamm Bowel Dis. 2014; 20: 712-722.
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 712-722
    • Cao, S.S.1    Wang, M.2    Harrington, J.C.3
  • 44
    • 84865000368 scopus 로고    scopus 로고
    • PKR protects colonic epithelium against colitis through the unfolded protein response and prosurvival signaling
    • Cao SS, Song B, Kaufman RJ. PKR protects colonic epithelium against colitis through the unfolded protein response and prosurvival signaling. Inflamm Bowel Dis. 2012; 18: 1735-1742.
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 1735-1742
    • Cao, S.S.1    Song, B.2    Kaufman, R.J.3
  • 45
    • 84876419410 scopus 로고    scopus 로고
    • PKR in dss-induced colitis: A matter of genetic background and maternal microflora
    • Cao SS, Kaufman RJ. PKR in DSS-induced colitis: a matter of genetic background and maternal microflora. Inflamm Bowel Dis. 2013; 19: E49-E50.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. E49-E50
    • Cao, S.S.1    Kaufman, R.J.2
  • 46
    • 33846234333 scopus 로고    scopus 로고
    • Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: Impact on chronic inflammation
    • Shkoda A, Ruiz PA, Daniel H, et al. Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation. Gastroenterology. 2007; 132: 190-207.
    • (2007) Gastroenterology , vol.132 , pp. 190-207
    • Shkoda, A.1    Ruiz, P.A.2    Daniel, H.3
  • 47
    • 41549092745 scopus 로고    scopus 로고
    • Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
    • Heazlewood CK, Cook MC, Eri R, et al. Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med. 2008; 5: e54.
    • (2008) PLoS Med , vol.5 , pp. e54
    • Heazlewood, C.K.1    Cook, M.C.2    Eri, R.3
  • 48
    • 36549058329 scopus 로고    scopus 로고
    • Translational inhibition of colonic epithelial heat shock proteins by ifn-gamma and tnf-Alpha in intestinal inflammation
    • Hu S, Ciancio MJ, Lahav M, et al. Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-Alpha in intestinal inflammation. Gastroenterology. 2007; 133: 1893-1904.
    • (2007) Gastroenterology , vol.133 , pp. 1893-1904
    • Hu, S.1    Ciancio, M.J.2    Lahav, M.3
  • 49
    • 80052110662 scopus 로고    scopus 로고
    • Altered endoplasmic reticulum stress affects translation in inactive colon tissue from patients with ulcerative colitis
    • Treton X, Pedruzzi E, Cazals-Hatem D, et al. Altered endoplasmic reticulum stress affects translation in inactive colon tissue from patients with ulcerative colitis. Gastroenterology. 2011; 141: 1024-1035.
    • (2011) Gastroenterology , vol.141 , pp. 1024-1035
    • Treton, X.1    Pedruzzi, E.2    Cazals-Hatem, D.3
  • 50
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol. 2007; 8: 519-529.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 51
    • 79955106916 scopus 로고    scopus 로고
    • An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity
    • Eri RD, Adams RJ, Tran TV, et al. An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity. Mucosal Immunol. 2011; 4: 354-364.
    • (2011) Mucosal Immunol , vol.4 , pp. 354-364
    • Eri, R.D.1    Adams, R.J.2    Tran, T.V.3
  • 52
    • 84880653498 scopus 로고    scopus 로고
    • IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells
    • Hasnain SZ, Tauro S, Das I, et al. IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells. Gastroenterology. 2013; 144: 357-368.
    • (2013) Gastroenterology , vol.144 , pp. 357-368
    • Hasnain, S.Z.1    Tauro, S.2    Das, I.3
  • 53
    • 84880650333 scopus 로고    scopus 로고
    • Glucocorticoids alleviate intestinal er stress by enhancing protein folding and degradation of misfolded proteins
    • Das I, Png CW, Oancea I, et al. Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins. J Exp Med. 2013; 210: 1201-1216.
    • (2013) J Exp Med , vol.210 , pp. 1201-1216
    • Das, I.1    Png, C.W.2    Oancea, I.3
  • 54
    • 0344665555 scopus 로고    scopus 로고
    • ABC of oral bioavailability: Transporters as gatekeepers in the gut
    • Dietrich CG, Geier A, Oude Elferink RP. ABC of oral bioavailability: transporters as gatekeepers in the gut. Gut. 2003; 52: 1788-1795.
    • (2003) Gut , vol.52 , pp. 1788-1795
    • Dietrich, C.G.1    Geier, A.2    Oude Elferink, R.P.3
  • 55
    • 84055223938 scopus 로고    scopus 로고
    • Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding
    • Deuring JJ, de Haar C, Koelewijn CL, et al. Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding. Biochem J. 2012; 441: 87-93.
    • (2012) Biochem J , vol.441 , pp. 87-93
    • Deuring, J.J.1    De Haar, C.2    Koelewijn, C.L.3
  • 56
    • 84884983191 scopus 로고    scopus 로고
    • Exposure of colonic epithelial cells to oxidative and endoplasmic reticulum stress causes rapid potassium efflux and calcium influx
    • Shabala L, Walker EJ, Eklund A, et al. Exposure of colonic epithelial cells to oxidative and endoplasmic reticulum stress causes rapid potassium efflux and calcium influx. Cell Biochem Funct. 2013; 31: 603-611.
    • (2013) Cell Biochem Funct , vol.31 , pp. 603-611
    • Shabala, L.1    Walker, E.J.2    Eklund, A.3
  • 57
    • 84876998128 scopus 로고    scopus 로고
    • ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response
    • Heijmans J, van Lidth de Jeude JF, Koo BK, et al. ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell Rep. 2013; 3: 1128-1139.
    • (2013) Cell Rep , vol.3 , pp. 1128-1139
    • Heijmans, J.1    Van De Lidth, J.J.F.2    Koo, B.K.3
  • 58
    • 84885437087 scopus 로고    scopus 로고
    • ER stress transcription factor xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells
    • Niederreiter L, Fritz TM, Adolph TE, et al. ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells. J Exp Med. 2013; 210: 2041-2056.
    • (2013) J Exp Med , vol.210 , pp. 2041-2056
    • Niederreiter, L.1    Fritz, T.M.2    Adolph, T.E.3
  • 59
    • 84868261605 scopus 로고    scopus 로고
    • Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 upregulated modulator of apoptosis
    • Neal MD, Sodhi CP, Jia H, et al. Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 upregulated modulator of apoptosis. J Biol Chem. 2012; 287: 37296-37308.
    • (2012) J Biol Chem , vol.287 , pp. 37296-37308
    • Neal, M.D.1    Sodhi, C.P.2    Jia, H.3
  • 60
    • 84898071827 scopus 로고    scopus 로고
    • Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis
    • Afrazi A, Branca MF, Sodhi CP, et al. Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis. J Biol Chem. 2014; 289: 9584-9599.
    • (2014) J Biol Chem , vol.289 , pp. 9584-9599
    • Afrazi, A.1    Branca, M.F.2    Sodhi, C.P.3
  • 61
  • 62
    • 69449086287 scopus 로고    scopus 로고
    • HLA-b27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with th17 activation in transgenic rats
    • DeLay ML, Turner MJ, Klenk EI, et al. HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats. Arthritis Rheum. 2009; 60: 2633-2643.
    • (2009) Arthritis Rheum , vol.60 , pp. 2633-2643
    • Delay, M.L.1    Turner, M.J.2    Klenk, E.I.3
  • 63
    • 84864148120 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress response promotes cytotoxic phenotype of cd8alphabeta+ intraepithelial lymphocytes in a mouse model for crohn's disease-like ileitis
    • Chang JS, Ocvirk S, Berger E, et al. Endoplasmic reticulum stress response promotes cytotoxic phenotype of CD8alphabeta+ intraepithelial lymphocytes in a mouse model for Crohn's disease-like ileitis. J Immunol. 2012; 189: 1510-1520.
    • (2012) J Immunol , vol.189 , pp. 1510-1520
    • Chang, J.S.1    Ocvirk, S.2    Berger, E.3
  • 64
    • 84884834982 scopus 로고    scopus 로고
    • The role and potential therapeutic application of myeloid-derived suppressor cells in tnbs-induced colitis
    • Guan Q, Moreno S, Qing G, et al. The role and potential therapeutic application of myeloid-derived suppressor cells in TNBS-induced colitis. J Leukoc Biol. 2013; 94: 803-811.
    • (2013) J Leukoc Biol , vol.94 , pp. 803-811
    • Guan, Q.1    Moreno, S.2    Qing, G.3
  • 65
    • 84902162433 scopus 로고    scopus 로고
    • ER stress regulates myeloid-derived suppressor cell fate through trail-r-mediated apoptosis
    • Condamine T, Kumar V, Ramachandran IR, et al. ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis. J Clin Invest. 2014; 124: 2626-2639.
    • (2014) J Clin Invest , vol.124 , pp. 2626-2639
    • Condamine, T.1    Kumar, V.2    Ramachandran, I.R.3
  • 66
    • 0035913294 scopus 로고    scopus 로고
    • Plasma cell differentiation requires the transcription factor xbp-1
    • Reimold AM, Iwakoshi NN, Manis J, et al. Plasma cell differentiation requires the transcription factor XBP-1. Nature. 2001; 412: 300-307.
    • (2001) Nature , vol.412 , pp. 300-307
    • Reimold, A.M.1    Iwakoshi, N.N.2    Manis, J.3
  • 67
    • 54049110990 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress regulator xbp-1 contributes to effector cd8+ t cell differentiation during acute infection
    • Kamimura D, Bevan MJ. Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection. J Immunol. 2008; 181: 5433-5441.
    • (2008) J Immunol , vol.181 , pp. 5433-5441
    • Kamimura, D.1    Bevan, M.J.2
  • 68
    • 77956917631 scopus 로고    scopus 로고
    • XBP-1 couples endoplasmic reticulum stress to augmented ifn-beta induction via a cis-Acting enhancer in macrophages
    • Zeng L, Liu YP, Sha H, et al. XBP-1 couples endoplasmic reticulum stress to augmented IFN-beta induction via a cis-Acting enhancer in macrophages. J Immunol. 2010; 185: 2324-2330.
    • (2010) J Immunol , vol.185 , pp. 2324-2330
    • Zeng, L.1    Liu, Y.P.2    Sha, H.3
  • 69
    • 17144418984 scopus 로고    scopus 로고
    • Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors blimp-1 and xbp-1
    • Gatto D, Pfister T, Jegerlehner A, et al. Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1. J Exp Med. 2005; 201: 993-1005.
    • (2005) J Exp Med , vol.201 , pp. 993-1005
    • Gatto, D.1    Pfister, T.2    Jegerlehner, A.3
  • 70
    • 23244447258 scopus 로고    scopus 로고
    • Targeting positive regulatory domain i-binding factor 1 and x box-binding protein 1 transcription factors by multiple myeloma-reactive ctl
    • Lotz C, Mutallib SA, Oehlrich N, et al. Targeting positive regulatory domain I-binding factor 1 and X box-binding protein 1 transcription factors by multiple myeloma-reactive CTL. J Immunol. 2005; 175: 1301-1309.
    • (2005) J Immunol , vol.175 , pp. 1301-1309
    • Lotz, C.1    Mutallib, S.A.2    Oehlrich, N.3
  • 71
    • 34948897411 scopus 로고    scopus 로고
    • The transcription factor xbp-1 is essential for the development and survival of dendritic cells
    • Iwakoshi NN, Pypaert M, Glimcher LH. The transcription factor XBP-1 is essential for the development and survival of dendritic cells. J Exp Med. 2007; 204: 2267-2275.
    • (2007) J Exp Med , vol.204 , pp. 2267-2275
    • Iwakoshi, N.N.1    Pypaert, M.2    Glimcher, L.H.3
  • 72
    • 47049098902 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic ifn-beta induction via x-box binding protein
    • Smith JA, Turner MJ, DeLay ML, et al. Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein Eur J Immunol. 2008; 38: 1194-1203.
    • (2008) Eur J Immunol , vol.38 , pp. 1194-1203
    • Smith, J.A.1    Turner, M.J.2    Delay, M.L.3
  • 73
    • 77952060407 scopus 로고    scopus 로고
    • Survive an innate immune response through xbp1
    • Kaser A, Blumberg RS. Survive an innate immune response through XBP1. Cell Res. 2010; 20: 506-507.
    • (2010) Cell Res , vol.20 , pp. 506-507
    • Kaser, A.1    Blumberg, R.S.2
  • 74
    • 77649135472 scopus 로고    scopus 로고
    • An essential role for xbp-1 in host protection against immune activation in c
    • Richardson CE, Kooistra T, Kim DH. An essential role for XBP-1 in host protection against immune activation in C. elegans. Nature. 2010; 463: 1092-1095.
    • (2010) Elegans. Nature , vol.463 , pp. 1092-1095
    • Richardson, C.E.1    Kooistra, T.2    Kim, D.H.3
  • 75
    • 79953034321 scopus 로고    scopus 로고
    • ER stress and its regulator x-box-binding protein-1 enhance polyic-induced innate immune response in dendritic cells
    • Hu F, Yu X, Wang H, et al. ER stress and its regulator X-box-binding protein-1 enhance polyIC-induced innate immune response in dendritic cells. Eur J Immunol. 2011; 41: 1086-1097.
    • (2011) Eur J Immunol , vol.41 , pp. 1086-1097
    • Hu, F.1    Yu, X.2    Wang, H.3
  • 76
    • 81755177847 scopus 로고    scopus 로고
    • Physiological ire-1-xbp-1 and pek-1 signaling in caenorhabditis elegans larval development and immunity
    • Richardson CE, Kinkel S, Kim DH. Physiological IRE-1-XBP-1 and PEK-1 signaling in Caenorhabditis elegans larval development and immunity. PLoS Genet. 2011; 7: e1002391.
    • (2011) PLoS Genet , vol.7 , pp. e1002391
    • Richardson, C.E.1    Kinkel, S.2    Kim, D.H.3
  • 77
    • 79955820105 scopus 로고    scopus 로고
    • Exogenous norepinephrine correlates with macrophage endoplasmic reticulum stress response in association with xbp-1
    • Yang C, Zhou JY, Zhong HJ, et al. Exogenous norepinephrine correlates with macrophage endoplasmic reticulum stress response in association with XBP-1. J Surg Res. 2011; 168: 262-271.
    • (2011) J Surg Res , vol.168 , pp. 262-271
    • Yang, C.1    Zhou, J.Y.2    Zhong, H.J.3
  • 78
    • 84865725097 scopus 로고    scopus 로고
    • Organismal regulation of xbp-1-mediated unfolded protein response during development and immune activation
    • Sun J, Liu Y, Aballay A. Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation. EMBO Rep. 2012; 13: 855-860.
    • (2012) EMBO Rep , vol.13 , pp. 855-860
    • Sun, J.1    Liu, Y.2    Aballay, A.3
  • 79
    • 77954593364 scopus 로고    scopus 로고
    • Inositol-requiring 1/x-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism
    • Kaufman RJ, Cao S. Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism. EMBO Mol Med. 2010; 2: 189-192.
    • (2010) EMBO Mol Med , vol.2 , pp. 189-192
    • Kaufman, R.J.1    Cao, S.2
  • 80
    • 0037385313 scopus 로고    scopus 로고
    • Plasma cell diffeerentiation and the unfolded protein response intersect at the transcription factor xbp-1
    • Iwakoshi NN, Lee AH, Vallabhajosyula P, et al. Plasma cell diffeerentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol. 2003; 4: 321-329.
    • (2003) Nat Immunol , vol.4 , pp. 321-329
    • Iwakoshi, N.N.1    Lee, A.H.2    Vallabhajosyula, P.3
  • 81
    • 38449092991 scopus 로고    scopus 로고
    • Identification of erdj3 and obf-1/bob-1/ oca-b as direct targets of xbp-1 during plasma cell differentiation
    • Shen Y, Hendershot LM. Identification of ERdj3 and OBF-1/BOB-1/ OCA-B as direct targets of XBP-1 during plasma cell differentiation. J Immunol. 2007; 179: 2969-2978.
    • (2007) J Immunol , vol.179 , pp. 2969-2978
    • Shen, Y.1    Hendershot, L.M.2
  • 82
    • 77955711608 scopus 로고    scopus 로고
    • IRE1alpha controls cyclin a1 expression and promotes cell proliferation through xbp-1
    • Thorpe JA, Schwarze SR. IRE1alpha controls cyclin A1 expression and promotes cell proliferation through XBP-1. Cell Stress Chaperones. 2010; 15: 497-508.
    • (2010) Cell Stress Chaperones , vol.15 , pp. 497-508
    • Thorpe, J.A.1    Schwarze, S.R.2
  • 83
    • 14944371187 scopus 로고    scopus 로고
    • The unfolded protein response sensor ire1alpha is required at 2 distinct steps in b cell lymphopoiesis
    • Zhang K, Wong HN, Song B, et al. The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. J Clin Invest. 2005; 115: 268-281.
    • (2005) J Clin Invest , vol.115 , pp. 268-281
    • Zhang, K.1    Wong, H.N.2    Song, B.3
  • 84
    • 84894424803 scopus 로고    scopus 로고
    • The unfolded-protein-response sensor ire-1alpha regulates the function of cd8alpha+ dendritic cells
    • Osorio F, Tavernier SJ, Hoffmann E, et al. The unfolded-protein-response sensor IRE-1alpha regulates the function of CD8alpha+ dendritic cells. Nat Immunol. 2014; 15: 248-257.
    • (2014) Nat Immunol , vol.15 , pp. 248-257
    • Osorio, F.1    Tavernier, S.J.2    Hoffmann, E.3
  • 85
    • 33646491144 scopus 로고    scopus 로고
    • C/ebp homologous protein (chop) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation
    • Endo M, Mori M, Akira S, et al. C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation. J Immunol. 2006; 176: 6245-6253.
    • (2006) J Immunol , vol.176 , pp. 6245-6253
    • Endo, M.1    Mori, M.2    Akira, S.3
  • 86
    • 78049271424 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-induced transcription factor, chop, is crucial for dendritic cell il-23 expression
    • Goodall JC, Wu C, Zhang Y, et al. Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression. Proc Natl Acad Sci U S A. 2010; 107: 17698-17703.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 17698-17703
    • Goodall, J.C.1    Wu, C.2    Zhang, Y.3
  • 87
    • 21044456603 scopus 로고    scopus 로고
    • Glycoprotein (gp) 96 expression: Induced during differentiation of intestinal macrophages but impaired in crohn's disease
    • Schreiter K, Hausmann M, Spoettl T, et al. Glycoprotein (gp) 96 expression: induced during differentiation of intestinal macrophages but impaired in Crohn's disease. Gut. 2005; 54: 935-943.
    • (2005) Gut , vol.54 , pp. 935-943
    • Schreiter, K.1    Hausmann, M.2    Spoettl, T.3
  • 88
    • 84901767455 scopus 로고    scopus 로고
    • MZB1 is a grp94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon er stress
    • Rosenbaum M, Andreani V, Kapoor T, et al. MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress. Genes Dev. 2014; 28: 1165-1178.
    • (2014) Genes Dev , vol.28 , pp. 1165-1178
    • Rosenbaum, M.1    Andreani, V.2    Kapoor, T.3
  • 89
    • 84900428774 scopus 로고    scopus 로고
    • The modulation of endoplasmic reticulum stress by chemical chaperone upregulates immune negative cytokine il-35 in apolipoprotein e-deficient mice
    • Wang B, Dai S, Dong Z, et al. The modulation of endoplasmic reticulum stress by chemical chaperone upregulates immune negative cytokine IL-35 in apolipoprotein E-deficient mice. PLoS One. 2014; 9: e87787.
    • (2014) PLoS One , vol.9 , pp. e87787
    • Wang, B.1    Dai, S.2    Dong, Z.3
  • 90
    • 80054856034 scopus 로고    scopus 로고
    • Interleukin-35 mediates mucosal immune responses that protect against t-cell-dependent colitis
    • Wirtz S, Billmeier U, McHedlidze T, et al. Interleukin-35 mediates mucosal immune responses that protect against T-cell-dependent colitis. Gastroenterology. 2011; 141: 1875-1886.
    • (2011) Gastroenterology , vol.141 , pp. 1875-1886
    • Wirtz, S.1    Billmeier, U.2    McHedlidze, T.3
  • 91
    • 84888386346 scopus 로고    scopus 로고
    • Keeping the bowel regular: The emerging role of treg as a therapeutic target in inflammatory bowel disease
    • Gibson DJ, Ryan EJ, Doherty GA. Keeping the bowel regular: the emerging role of Treg as a therapeutic target in inflammatory bowel disease. Inflamm Bowel Dis. 2013; 19: 2716-2724.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 2716-2724
    • Gibson, D.J.1    Ryan, E.J.2    Doherty, G.A.3
  • 92
    • 13644256191 scopus 로고    scopus 로고
    • A selective inhibitor of eif2alpha dephosphorylation protects cells from er stress
    • Boyce M, Bryant KF, Jousse C, et al. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science. 2005; 307: 935-939.
    • (2005) Science , vol.307 , pp. 935-939
    • Boyce, M.1    Bryant, K.F.2    Jousse, C.3
  • 93
    • 84920484402 scopus 로고    scopus 로고
    • Combined nadph oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerative colitis-like disease in mice
    • Treton X, Pedruzzi E, Guichard C, et al. Combined NADPH oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerative colitis-like disease in mice. PLoS One. 2014; 9: e101669.
    • (2014) PLoS One , vol.9 , pp. e101669
    • Treton, X.1    Pedruzzi, E.2    Guichard, C.3
  • 94
    • 84870335319 scopus 로고    scopus 로고
    • Glutamine treatment attenuates endoplasmic reticulum stress and apoptosis in tnbs-induced colitis
    • Crespo I, San-Miguel B, Prause C, et al. Glutamine treatment attenuates endoplasmic reticulum stress and apoptosis in TNBS-induced colitis. PLoS One. 2012; 7: e50407.
    • (2012) PLoS One , vol.7 , pp. e50407
    • Crespo, I.1    San-Miguel, B.2    Prause, C.3
  • 95
    • 84903795970 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease
    • Cao SS, Kaufman RJ. Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxid Redox Signal. 2014; 21: 396-413.
    • (2014) Antioxid Redox Signal , vol.21 , pp. 396-413
    • Cao, S.S.1    Kaufman, R.J.2
  • 96
    • 47949099916 scopus 로고    scopus 로고
    • From endoplasmic-reticulum stress to the inflammatory response
    • Zhang K, Kaufman RJ. From endoplasmic-reticulum stress to the inflammatory response. Nature. 2008; 454: 455-462.
    • (2008) Nature , vol.454 , pp. 455-462
    • Zhang, K.1    Kaufman, R.J.2
  • 98
    • 84155184582 scopus 로고    scopus 로고
    • Mucins in inflammatory bowel diseases and colorectal cancer
    • Sheng YH, Hasnain SZ, Florin TH, et al. Mucins in inflammatory bowel diseases and colorectal cancer. J Gastroenterol Hepatol. 2012; 27: 28-38.
    • (2012) J Gastroenterol Hepatol , vol.27 , pp. 28-38
    • Sheng, Y.H.1    Hasnain, S.Z.2    Florin, T.H.3
  • 99
    • 84862862332 scopus 로고    scopus 로고
    • Epithelial antimicrobial defence of the skin and intestine
    • Gallo RL, Hooper LV. Epithelial antimicrobial defence of the skin and intestine. Nat Rev Immunol. 2012; 12: 503-516.
    • (2012) Nat Rev Immunol , vol.12 , pp. 503-516
    • Gallo, R.L.1    Hooper, L.V.2


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