-
1
-
-
84856111924
-
The unfolded protein response: Controlling cell fate decisions under er stress and beyond
-
Hetz C. The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol. 2012; 13: 89-102.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 89-102
-
-
Hetz, C.1
-
2
-
-
84865245211
-
Unfolded protein response
-
Cao SS, Kaufman RJ. Unfolded protein response. Curr Biol. 2012; 22: R622-R626.
-
(2012)
Curr Biol
, vol.22
, pp. R622-R626
-
-
Cao, S.S.1
Kaufman, R.J.2
-
3
-
-
84903749341
-
Cell death opposing unfoldedprotein-response signals converge on death receptor 5 to control apoptosis
-
Lu M, Lawrence DA, Marsters S, et al. Cell death. Opposing unfoldedprotein-response signals converge on death receptor 5 to control apoptosis. Science. 2014; 345: 98-101.
-
(2014)
Science
, vol.345
, pp. 98-101
-
-
Lu, M.1
Lawrence, D.A.2
Marsters, S.3
-
4
-
-
82255173966
-
The unfolded protein response: From stress pathway to homeostatic regulation
-
Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science. 2011; 334: 1081-1086.
-
(2011)
Science
, vol.334
, pp. 1081-1086
-
-
Walter, P.1
Ron, D.2
-
5
-
-
79952264011
-
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
-
Tabas I, Ron D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol. 2011; 13: 184-190.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 184-190
-
-
Tabas, I.1
Ron, D.2
-
6
-
-
84864682160
-
IRE1alpha induces thioredoxininteracting protein to activate the nlrp3 inflammasome and promote programmed cell death under irremediable er stress
-
Lerner AG, Upton JP, Praveen PV, et al. IRE1alpha induces thioredoxininteracting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab. 2012; 16: 250-264.
-
(2012)
Cell Metab
, vol.16
, pp. 250-264
-
-
Lerner, A.G.1
Upton, J.P.2
Praveen, P.V.3
-
7
-
-
84868525253
-
IRE1alpha cleaves select micrornas during er stress to derepress translation of proapoptotic caspase-2
-
Upton JP, Wang L, Han D, et al. IRE1alpha cleaves select microRNAs during ER stress to derepress translation of proapoptotic caspase-2. Science. 2012; 338: 818-822.
-
(2012)
Science
, vol.338
, pp. 818-822
-
-
Upton, J.P.1
Wang, L.2
Han, D.3
-
8
-
-
84905492694
-
Allosteric inhibition of the ire1alpha rnase preserves cell viability and function during endoplasmic reticulum stress
-
Ghosh R, Wang L, Wang ES, et al. Allosteric inhibition of the IRE1alpha RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 2014; 158: 534-548.
-
(2014)
Cell
, vol.158
, pp. 534-548
-
-
Ghosh, R.1
Wang, L.2
Wang, E.S.3
-
9
-
-
33751069967
-
Adaptation to er stress is mediated by differential stabilities of pro-survival and pro-Apoptotic mrnas and proteins
-
Rutkowski DT, Arnold SM, Miller CN, et al. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-Apoptotic mRNAs and proteins. PLoS Biol. 2006; 4: e374.
-
(2006)
PLoS Biol
, vol.4
, pp. e374
-
-
Rutkowski, D.T.1
Arnold, S.M.2
Miller, C.N.3
-
10
-
-
84877578475
-
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
-
Han J, Back SH, Hur J, et al. ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat Cell Biol. 2013; 15: 481-490.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 481-490
-
-
Han, J.1
Back, S.H.2
Hur, J.3
-
12
-
-
84873422293
-
The cell biology of the intestinal epithelium and its relation to inflammatory bowel disease
-
Deuring JJ, de Haar C, Kuipers EJ, et al. The cell biology of the intestinal epithelium and its relation to inflammatory bowel disease. Int J Biochem Cell Biol. 2013; 45: 798-806.
-
(2013)
J Biochem Cell Biol
, vol.45
, pp. 798-806
-
-
Deuring, J.J.1
De Haar, C.2
Kuipers, E.J.3
-
13
-
-
77954399232
-
Drug targeting strategies for the treatment of inflammatory bowel disease: A mechanistic update
-
Dahan A, Amidon GL, Zimmermann EM. Drug targeting strategies for the treatment of inflammatory bowel disease: a mechanistic update. Expert Rev Clin Immunol. 2010; 6: 543-550.
-
(2010)
Expert Rev Clin Immunol
, vol.6
, pp. 543-550
-
-
Dahan, A.1
Amidon, G.L.2
Zimmermann, E.M.3
-
14
-
-
35548974423
-
Identification of stem cells in small intestine and colon by marker gene lgr5
-
Barker N, van Es JH, Kuipers J, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007; 449: 1003-1007.
-
(2007)
Nature
, vol.449
, pp. 1003-1007
-
-
Barker, N.1
Van Es, J.H.2
Kuipers, J.3
-
15
-
-
67349123408
-
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
-
Sato T, Vries RG, Snippert HJ, et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature. 2009; 459: 262-265.
-
(2009)
Nature
, vol.459
, pp. 262-265
-
-
Sato, T.1
Vries, R.G.2
Snippert, H.J.3
-
16
-
-
84904051527
-
Ex vivo culture of the intestinal epithelium: Strategies and applications
-
Leushacke M, Barker N. Ex vivo culture of the intestinal epithelium: strategies and applications. Gut. 2014; 63: 1345-1354.
-
(2014)
Gut
, vol.63
, pp. 1345-1354
-
-
Leushacke, M.1
Barker, N.2
-
18
-
-
58549111588
-
Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
-
Vaishnava S, Behrendt CL, Ismail AS, et al. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc Natl Acad Sci U S A. 2008; 105: 20858-20863.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 20858-20863
-
-
Vaishnava, S.1
Behrendt, C.L.2
Ismail, A.S.3
-
19
-
-
77950353786
-
Homeostasis and inflammation in the intestine
-
Garrett WS, Gordon JI, Glimcher LH. Homeostasis and inflammation in the intestine. Cell. 2010; 140: 859-870.
-
(2010)
Cell
, vol.140
, pp. 859-870
-
-
Garrett, W.S.1
Gordon, J.I.2
Glimcher, L.H.3
-
21
-
-
0036500996
-
Colorectal cancer in mice genetically deficient in the mucin muc2
-
Velcich A, Yang W, Heyer J, et al. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science. 2002; 295: 1726-1729.
-
(2002)
Science
, vol.295
, pp. 1726-1729
-
-
Velcich, A.1
Yang, W.2
Heyer, J.3
-
22
-
-
79960875661
-
Intestinal secretory cell er stress and inflammation
-
McGuckin MA, Eri RD, Das I, et al. Intestinal secretory cell ER stress and inflammation. Biochem Soc Trans. 2011; 39: 1081-1085.
-
(2011)
Biochem Soc Trans
, vol.39
, pp. 1081-1085
-
-
McGuckin, M.A.1
Eri, R.D.2
Das, I.3
-
23
-
-
65749101996
-
Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease
-
Kaser A, Blumberg RS. Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease. Semin Immunol. 2009; 21: 156-163.
-
(2009)
Semin Immunol
, vol.21
, pp. 156-163
-
-
Kaser, A.1
Blumberg, R.S.2
-
24
-
-
79959271087
-
Intestinal homeostasis and its breakdown in inflammatory bowel disease
-
Maloy KJ, Powrie F. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature. 2011; 474: 298-306.
-
(2011)
Nature
, vol.474
, pp. 298-306
-
-
Maloy, K.J.1
Powrie, F.2
-
25
-
-
50249086073
-
XBP1 links er stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
-
Kaser A, Lee AH, Franke A, et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 2008; 134: 743-756.
-
(2008)
Cell
, vol.134
, pp. 743-756
-
-
Kaser, A.1
Lee, A.H.2
Franke, A.3
-
26
-
-
84887621906
-
Paneth cells as a site of origin for intestinal inflammation
-
Adolph TE, Tomczak MF, Niederreiter L, et al. Paneth cells as a site of origin for intestinal inflammation. Nature. 2013; 503: 272-276.
-
(2013)
Nature
, vol.503
, pp. 272-276
-
-
Adolph, T.E.1
Tomczak, M.F.2
Niederreiter, L.3
-
27
-
-
74749103667
-
Disruption of paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in agr22/2 mice
-
Zhao F, Edwards R, Dizon D, et al. Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr22/2 mice. Dev Biol. 2010; 338: 270-279.
-
(2010)
Dev Biol
, vol.338
, pp. 270-279
-
-
Zhao, F.1
Edwards, R.2
Dizon, D.3
-
28
-
-
66349091311
-
The protein disulfide isomerase agr2 is essential for production of intestinal mucus
-
Park SW, Zhen G, Verhaeghe C, et al. The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. Proc Natl Acad Sci U S A. 2009; 106: 6950-6955.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 6950-6955
-
-
Park, S.W.1
Zhen, G.2
Verhaeghe, C.3
-
29
-
-
84867375353
-
ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, oas, and atf6
-
Miller M, Tam AB, Cho JY, et al. ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6. Proc Natl Acad Sci U S A. 2012; 109: 16648-16653.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 16648-16653
-
-
Miller, M.1
Tam, A.B.2
Cho, J.Y.3
-
31
-
-
84876356353
-
The er stress transducer ire1beta is required for airway epithelial mucin production
-
Martino MB, Jones L, Brighton B, et al. The ER stress transducer IRE1beta is required for airway epithelial mucin production. Mucosal Immunol. 2013; 6: 639-654.
-
(2013)
Mucosal Immunol
, vol.6
, pp. 639-654
-
-
Martino, M.B.1
Jones, L.2
Brighton, B.3
-
32
-
-
0035094262
-
Increased sensitivity to dextran sodium sulfate colitis in ire1beta-deficient mice
-
Bertolotti A, Wang X, Novoa I, et al. Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. J Clin Invest. 2001; 107: 585-593.
-
(2001)
J Clin Invest
, vol.107
, pp. 585-593
-
-
Bertolotti, A.1
Wang, X.2
Novoa, I.3
-
33
-
-
84874251933
-
Negative feedback by ire1beta optimizes mucin production in goblet cells
-
Tsuru A, Fujimoto N, Takahashi S, et al. Negative feedback by IRE1beta optimizes mucin production in goblet cells. Proc Natl Acad Sci U S A. 2013; 110: 2864-2869.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 2864-2869
-
-
Tsuru, A.1
Fujimoto, N.2
Takahashi, S.3
-
34
-
-
65649084877
-
Positive role of ccaat/enhancerbinding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis
-
Namba T, Tanaka K, Ito Y, et al. Positive role of CCAAT/enhancerbinding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis. Am J Pathol. 2009; 174: 1786-1798.
-
(2009)
Am J Pathol
, vol.174
, pp. 1786-1798
-
-
Namba, T.1
Tanaka, K.2
Ito, Y.3
-
35
-
-
62549129560
-
Enhanced sensitivity to dss colitis caused by a hypomorphic mbtps1 mutation disrupting the atf6-driven unfolded protein response
-
Brandl K, Rutschmann S, Li X, et al. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A. 2009; 106: 3300-3305.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 3300-3305
-
-
Brandl, K.1
Rutschmann, S.2
Li, X.3
-
36
-
-
84858020459
-
The endoplasmic reticulum stress transducer oasis is involved in the terminal differentiation of goblet cells in the large intestine
-
Asada R, Saito A, Kawasaki N, et al. The endoplasmic reticulum stress transducer OASIS is involved in the terminal differentiation of goblet cells in the large intestine. J Biol Chem. 2012; 287: 8144-8153.
-
(2012)
J Biol Chem
, vol.287
, pp. 8144-8153
-
-
Asada, R.1
Saito, A.2
Kawasaki, N.3
-
37
-
-
84894628100
-
Increased susceptibility to dextran sulfate sodium-induced colitis in the endoplasmic reticulum stress transducer oasis deficient mice
-
Hino K, Saito A, Asada R, et al. Increased susceptibility to dextran sulfate sodium-induced colitis in the endoplasmic reticulum stress transducer OASIS deficient mice. PLoS One. 2014; 9: e88048.
-
(2014)
PLoS One
, vol.9
, pp. e88048
-
-
Hino, K.1
Saito, A.2
Asada, R.3
-
38
-
-
84876486995
-
The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice
-
Cao SS, Zimmermann EM, Chuang BM, et al. The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice. Gastroenterology. 2013; 144: 989-1000.e6.
-
(2013)
Gastroenterology
, vol.144
, pp. 989-1000e6
-
-
Cao, S.S.1
Zimmermann, E.M.2
Chuang, B.M.3
-
39
-
-
77957195829
-
Abnormally expressed er stress response chaperone gp96 in cd favours adherent-invasive escherichia coli invasion
-
Rolhion N, Barnich N, Bringer MA, et al. Abnormally expressed ER stress response chaperone Gp96 in CD favours adherent-invasive Escherichia coli invasion. Gut. 2010; 59: 1355-1362.
-
(2010)
Gut
, vol.59
, pp. 1355-1362
-
-
Rolhion, N.1
Barnich, N.2
Bringer, M.A.3
-
41
-
-
84902211251
-
Genomic atg16l1 risk allele-restricted paneth cell er stress in quiescent crohn's disease
-
Deuring JJ, Fuhler GM, Konstantinov SR, et al. Genomic ATG16L1 risk allele-restricted Paneth cell ER stress in quiescent Crohn's disease. Gut. 2014; 63: 1081-1091.
-
(2014)
Gut
, vol.63
, pp. 1081-1091
-
-
Deuring, J.J.1
Fuhler, G.M.2
Konstantinov, S.R.3
-
42
-
-
84896468061
-
Embracing the void-how much do we really know about targeting and translocation to the endoplasmic reticulum
-
Aviram N, Schuldiner M. Embracing the void-how much do we really know about targeting and translocation to the endoplasmic reticulum. Curr Opin Cell Biol. 2014; 29C: 8-17.
-
(2014)
Curr Opin Cell Biol
, vol.29
, pp. 8-17
-
-
Aviram, N.1
Schuldiner, M.2
-
43
-
-
84898720437
-
Phosphorylation of eif2alpha is dispensable for differentiation but required at a posttranscriptional level for paneth cell function and intestinal homeostasis in mice
-
Cao SS, Wang M, Harrington JC, et al. Phosphorylation of eIF2alpha is dispensable for differentiation but required at a posttranscriptional level for paneth cell function and intestinal homeostasis in mice. Inflamm Bowel Dis. 2014; 20: 712-722.
-
(2014)
Inflamm Bowel Dis
, vol.20
, pp. 712-722
-
-
Cao, S.S.1
Wang, M.2
Harrington, J.C.3
-
44
-
-
84865000368
-
PKR protects colonic epithelium against colitis through the unfolded protein response and prosurvival signaling
-
Cao SS, Song B, Kaufman RJ. PKR protects colonic epithelium against colitis through the unfolded protein response and prosurvival signaling. Inflamm Bowel Dis. 2012; 18: 1735-1742.
-
(2012)
Inflamm Bowel Dis
, vol.18
, pp. 1735-1742
-
-
Cao, S.S.1
Song, B.2
Kaufman, R.J.3
-
45
-
-
84876419410
-
PKR in dss-induced colitis: A matter of genetic background and maternal microflora
-
Cao SS, Kaufman RJ. PKR in DSS-induced colitis: a matter of genetic background and maternal microflora. Inflamm Bowel Dis. 2013; 19: E49-E50.
-
(2013)
Inflamm Bowel Dis
, vol.19
, pp. E49-E50
-
-
Cao, S.S.1
Kaufman, R.J.2
-
46
-
-
33846234333
-
Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: Impact on chronic inflammation
-
Shkoda A, Ruiz PA, Daniel H, et al. Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation. Gastroenterology. 2007; 132: 190-207.
-
(2007)
Gastroenterology
, vol.132
, pp. 190-207
-
-
Shkoda, A.1
Ruiz, P.A.2
Daniel, H.3
-
47
-
-
41549092745
-
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
-
Heazlewood CK, Cook MC, Eri R, et al. Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med. 2008; 5: e54.
-
(2008)
PLoS Med
, vol.5
, pp. e54
-
-
Heazlewood, C.K.1
Cook, M.C.2
Eri, R.3
-
48
-
-
36549058329
-
Translational inhibition of colonic epithelial heat shock proteins by ifn-gamma and tnf-Alpha in intestinal inflammation
-
Hu S, Ciancio MJ, Lahav M, et al. Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-Alpha in intestinal inflammation. Gastroenterology. 2007; 133: 1893-1904.
-
(2007)
Gastroenterology
, vol.133
, pp. 1893-1904
-
-
Hu, S.1
Ciancio, M.J.2
Lahav, M.3
-
49
-
-
80052110662
-
Altered endoplasmic reticulum stress affects translation in inactive colon tissue from patients with ulcerative colitis
-
Treton X, Pedruzzi E, Cazals-Hatem D, et al. Altered endoplasmic reticulum stress affects translation in inactive colon tissue from patients with ulcerative colitis. Gastroenterology. 2011; 141: 1024-1035.
-
(2011)
Gastroenterology
, vol.141
, pp. 1024-1035
-
-
Treton, X.1
Pedruzzi, E.2
Cazals-Hatem, D.3
-
50
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol. 2007; 8: 519-529.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
51
-
-
79955106916
-
An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity
-
Eri RD, Adams RJ, Tran TV, et al. An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity. Mucosal Immunol. 2011; 4: 354-364.
-
(2011)
Mucosal Immunol
, vol.4
, pp. 354-364
-
-
Eri, R.D.1
Adams, R.J.2
Tran, T.V.3
-
52
-
-
84880653498
-
IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells
-
Hasnain SZ, Tauro S, Das I, et al. IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells. Gastroenterology. 2013; 144: 357-368.
-
(2013)
Gastroenterology
, vol.144
, pp. 357-368
-
-
Hasnain, S.Z.1
Tauro, S.2
Das, I.3
-
53
-
-
84880650333
-
Glucocorticoids alleviate intestinal er stress by enhancing protein folding and degradation of misfolded proteins
-
Das I, Png CW, Oancea I, et al. Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins. J Exp Med. 2013; 210: 1201-1216.
-
(2013)
J Exp Med
, vol.210
, pp. 1201-1216
-
-
Das, I.1
Png, C.W.2
Oancea, I.3
-
54
-
-
0344665555
-
ABC of oral bioavailability: Transporters as gatekeepers in the gut
-
Dietrich CG, Geier A, Oude Elferink RP. ABC of oral bioavailability: transporters as gatekeepers in the gut. Gut. 2003; 52: 1788-1795.
-
(2003)
Gut
, vol.52
, pp. 1788-1795
-
-
Dietrich, C.G.1
Geier, A.2
Oude Elferink, R.P.3
-
55
-
-
84055223938
-
Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding
-
Deuring JJ, de Haar C, Koelewijn CL, et al. Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding. Biochem J. 2012; 441: 87-93.
-
(2012)
Biochem J
, vol.441
, pp. 87-93
-
-
Deuring, J.J.1
De Haar, C.2
Koelewijn, C.L.3
-
56
-
-
84884983191
-
Exposure of colonic epithelial cells to oxidative and endoplasmic reticulum stress causes rapid potassium efflux and calcium influx
-
Shabala L, Walker EJ, Eklund A, et al. Exposure of colonic epithelial cells to oxidative and endoplasmic reticulum stress causes rapid potassium efflux and calcium influx. Cell Biochem Funct. 2013; 31: 603-611.
-
(2013)
Cell Biochem Funct
, vol.31
, pp. 603-611
-
-
Shabala, L.1
Walker, E.J.2
Eklund, A.3
-
57
-
-
84876998128
-
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response
-
Heijmans J, van Lidth de Jeude JF, Koo BK, et al. ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell Rep. 2013; 3: 1128-1139.
-
(2013)
Cell Rep
, vol.3
, pp. 1128-1139
-
-
Heijmans, J.1
Van De Lidth, J.J.F.2
Koo, B.K.3
-
58
-
-
84885437087
-
ER stress transcription factor xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells
-
Niederreiter L, Fritz TM, Adolph TE, et al. ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells. J Exp Med. 2013; 210: 2041-2056.
-
(2013)
J Exp Med
, vol.210
, pp. 2041-2056
-
-
Niederreiter, L.1
Fritz, T.M.2
Adolph, T.E.3
-
59
-
-
84868261605
-
Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 upregulated modulator of apoptosis
-
Neal MD, Sodhi CP, Jia H, et al. Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 upregulated modulator of apoptosis. J Biol Chem. 2012; 287: 37296-37308.
-
(2012)
J Biol Chem
, vol.287
, pp. 37296-37308
-
-
Neal, M.D.1
Sodhi, C.P.2
Jia, H.3
-
60
-
-
84898071827
-
Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis
-
Afrazi A, Branca MF, Sodhi CP, et al. Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis. J Biol Chem. 2014; 289: 9584-9599.
-
(2014)
J Biol Chem
, vol.289
, pp. 9584-9599
-
-
Afrazi, A.1
Branca, M.F.2
Sodhi, C.P.3
-
62
-
-
69449086287
-
HLA-b27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with th17 activation in transgenic rats
-
DeLay ML, Turner MJ, Klenk EI, et al. HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats. Arthritis Rheum. 2009; 60: 2633-2643.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 2633-2643
-
-
Delay, M.L.1
Turner, M.J.2
Klenk, E.I.3
-
63
-
-
84864148120
-
Endoplasmic reticulum stress response promotes cytotoxic phenotype of cd8alphabeta+ intraepithelial lymphocytes in a mouse model for crohn's disease-like ileitis
-
Chang JS, Ocvirk S, Berger E, et al. Endoplasmic reticulum stress response promotes cytotoxic phenotype of CD8alphabeta+ intraepithelial lymphocytes in a mouse model for Crohn's disease-like ileitis. J Immunol. 2012; 189: 1510-1520.
-
(2012)
J Immunol
, vol.189
, pp. 1510-1520
-
-
Chang, J.S.1
Ocvirk, S.2
Berger, E.3
-
64
-
-
84884834982
-
The role and potential therapeutic application of myeloid-derived suppressor cells in tnbs-induced colitis
-
Guan Q, Moreno S, Qing G, et al. The role and potential therapeutic application of myeloid-derived suppressor cells in TNBS-induced colitis. J Leukoc Biol. 2013; 94: 803-811.
-
(2013)
J Leukoc Biol
, vol.94
, pp. 803-811
-
-
Guan, Q.1
Moreno, S.2
Qing, G.3
-
65
-
-
84902162433
-
ER stress regulates myeloid-derived suppressor cell fate through trail-r-mediated apoptosis
-
Condamine T, Kumar V, Ramachandran IR, et al. ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis. J Clin Invest. 2014; 124: 2626-2639.
-
(2014)
J Clin Invest
, vol.124
, pp. 2626-2639
-
-
Condamine, T.1
Kumar, V.2
Ramachandran, I.R.3
-
66
-
-
0035913294
-
Plasma cell differentiation requires the transcription factor xbp-1
-
Reimold AM, Iwakoshi NN, Manis J, et al. Plasma cell differentiation requires the transcription factor XBP-1. Nature. 2001; 412: 300-307.
-
(2001)
Nature
, vol.412
, pp. 300-307
-
-
Reimold, A.M.1
Iwakoshi, N.N.2
Manis, J.3
-
67
-
-
54049110990
-
Endoplasmic reticulum stress regulator xbp-1 contributes to effector cd8+ t cell differentiation during acute infection
-
Kamimura D, Bevan MJ. Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection. J Immunol. 2008; 181: 5433-5441.
-
(2008)
J Immunol
, vol.181
, pp. 5433-5441
-
-
Kamimura, D.1
Bevan, M.J.2
-
68
-
-
77956917631
-
XBP-1 couples endoplasmic reticulum stress to augmented ifn-beta induction via a cis-Acting enhancer in macrophages
-
Zeng L, Liu YP, Sha H, et al. XBP-1 couples endoplasmic reticulum stress to augmented IFN-beta induction via a cis-Acting enhancer in macrophages. J Immunol. 2010; 185: 2324-2330.
-
(2010)
J Immunol
, vol.185
, pp. 2324-2330
-
-
Zeng, L.1
Liu, Y.P.2
Sha, H.3
-
69
-
-
17144418984
-
Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors blimp-1 and xbp-1
-
Gatto D, Pfister T, Jegerlehner A, et al. Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1. J Exp Med. 2005; 201: 993-1005.
-
(2005)
J Exp Med
, vol.201
, pp. 993-1005
-
-
Gatto, D.1
Pfister, T.2
Jegerlehner, A.3
-
70
-
-
23244447258
-
Targeting positive regulatory domain i-binding factor 1 and x box-binding protein 1 transcription factors by multiple myeloma-reactive ctl
-
Lotz C, Mutallib SA, Oehlrich N, et al. Targeting positive regulatory domain I-binding factor 1 and X box-binding protein 1 transcription factors by multiple myeloma-reactive CTL. J Immunol. 2005; 175: 1301-1309.
-
(2005)
J Immunol
, vol.175
, pp. 1301-1309
-
-
Lotz, C.1
Mutallib, S.A.2
Oehlrich, N.3
-
71
-
-
34948897411
-
The transcription factor xbp-1 is essential for the development and survival of dendritic cells
-
Iwakoshi NN, Pypaert M, Glimcher LH. The transcription factor XBP-1 is essential for the development and survival of dendritic cells. J Exp Med. 2007; 204: 2267-2275.
-
(2007)
J Exp Med
, vol.204
, pp. 2267-2275
-
-
Iwakoshi, N.N.1
Pypaert, M.2
Glimcher, L.H.3
-
72
-
-
47049098902
-
Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic ifn-beta induction via x-box binding protein
-
Smith JA, Turner MJ, DeLay ML, et al. Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein Eur J Immunol. 2008; 38: 1194-1203.
-
(2008)
Eur J Immunol
, vol.38
, pp. 1194-1203
-
-
Smith, J.A.1
Turner, M.J.2
Delay, M.L.3
-
73
-
-
77952060407
-
Survive an innate immune response through xbp1
-
Kaser A, Blumberg RS. Survive an innate immune response through XBP1. Cell Res. 2010; 20: 506-507.
-
(2010)
Cell Res
, vol.20
, pp. 506-507
-
-
Kaser, A.1
Blumberg, R.S.2
-
74
-
-
77649135472
-
An essential role for xbp-1 in host protection against immune activation in c
-
Richardson CE, Kooistra T, Kim DH. An essential role for XBP-1 in host protection against immune activation in C. elegans. Nature. 2010; 463: 1092-1095.
-
(2010)
Elegans. Nature
, vol.463
, pp. 1092-1095
-
-
Richardson, C.E.1
Kooistra, T.2
Kim, D.H.3
-
75
-
-
79953034321
-
ER stress and its regulator x-box-binding protein-1 enhance polyic-induced innate immune response in dendritic cells
-
Hu F, Yu X, Wang H, et al. ER stress and its regulator X-box-binding protein-1 enhance polyIC-induced innate immune response in dendritic cells. Eur J Immunol. 2011; 41: 1086-1097.
-
(2011)
Eur J Immunol
, vol.41
, pp. 1086-1097
-
-
Hu, F.1
Yu, X.2
Wang, H.3
-
76
-
-
81755177847
-
Physiological ire-1-xbp-1 and pek-1 signaling in caenorhabditis elegans larval development and immunity
-
Richardson CE, Kinkel S, Kim DH. Physiological IRE-1-XBP-1 and PEK-1 signaling in Caenorhabditis elegans larval development and immunity. PLoS Genet. 2011; 7: e1002391.
-
(2011)
PLoS Genet
, vol.7
, pp. e1002391
-
-
Richardson, C.E.1
Kinkel, S.2
Kim, D.H.3
-
77
-
-
79955820105
-
Exogenous norepinephrine correlates with macrophage endoplasmic reticulum stress response in association with xbp-1
-
Yang C, Zhou JY, Zhong HJ, et al. Exogenous norepinephrine correlates with macrophage endoplasmic reticulum stress response in association with XBP-1. J Surg Res. 2011; 168: 262-271.
-
(2011)
J Surg Res
, vol.168
, pp. 262-271
-
-
Yang, C.1
Zhou, J.Y.2
Zhong, H.J.3
-
78
-
-
84865725097
-
Organismal regulation of xbp-1-mediated unfolded protein response during development and immune activation
-
Sun J, Liu Y, Aballay A. Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation. EMBO Rep. 2012; 13: 855-860.
-
(2012)
EMBO Rep
, vol.13
, pp. 855-860
-
-
Sun, J.1
Liu, Y.2
Aballay, A.3
-
79
-
-
77954593364
-
Inositol-requiring 1/x-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism
-
Kaufman RJ, Cao S. Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism. EMBO Mol Med. 2010; 2: 189-192.
-
(2010)
EMBO Mol Med
, vol.2
, pp. 189-192
-
-
Kaufman, R.J.1
Cao, S.2
-
80
-
-
0037385313
-
Plasma cell diffeerentiation and the unfolded protein response intersect at the transcription factor xbp-1
-
Iwakoshi NN, Lee AH, Vallabhajosyula P, et al. Plasma cell diffeerentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol. 2003; 4: 321-329.
-
(2003)
Nat Immunol
, vol.4
, pp. 321-329
-
-
Iwakoshi, N.N.1
Lee, A.H.2
Vallabhajosyula, P.3
-
81
-
-
38449092991
-
Identification of erdj3 and obf-1/bob-1/ oca-b as direct targets of xbp-1 during plasma cell differentiation
-
Shen Y, Hendershot LM. Identification of ERdj3 and OBF-1/BOB-1/ OCA-B as direct targets of XBP-1 during plasma cell differentiation. J Immunol. 2007; 179: 2969-2978.
-
(2007)
J Immunol
, vol.179
, pp. 2969-2978
-
-
Shen, Y.1
Hendershot, L.M.2
-
82
-
-
77955711608
-
IRE1alpha controls cyclin a1 expression and promotes cell proliferation through xbp-1
-
Thorpe JA, Schwarze SR. IRE1alpha controls cyclin A1 expression and promotes cell proliferation through XBP-1. Cell Stress Chaperones. 2010; 15: 497-508.
-
(2010)
Cell Stress Chaperones
, vol.15
, pp. 497-508
-
-
Thorpe, J.A.1
Schwarze, S.R.2
-
83
-
-
14944371187
-
The unfolded protein response sensor ire1alpha is required at 2 distinct steps in b cell lymphopoiesis
-
Zhang K, Wong HN, Song B, et al. The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. J Clin Invest. 2005; 115: 268-281.
-
(2005)
J Clin Invest
, vol.115
, pp. 268-281
-
-
Zhang, K.1
Wong, H.N.2
Song, B.3
-
84
-
-
84894424803
-
The unfolded-protein-response sensor ire-1alpha regulates the function of cd8alpha+ dendritic cells
-
Osorio F, Tavernier SJ, Hoffmann E, et al. The unfolded-protein-response sensor IRE-1alpha regulates the function of CD8alpha+ dendritic cells. Nat Immunol. 2014; 15: 248-257.
-
(2014)
Nat Immunol
, vol.15
, pp. 248-257
-
-
Osorio, F.1
Tavernier, S.J.2
Hoffmann, E.3
-
85
-
-
33646491144
-
C/ebp homologous protein (chop) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation
-
Endo M, Mori M, Akira S, et al. C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation. J Immunol. 2006; 176: 6245-6253.
-
(2006)
J Immunol
, vol.176
, pp. 6245-6253
-
-
Endo, M.1
Mori, M.2
Akira, S.3
-
86
-
-
78049271424
-
Endoplasmic reticulum stress-induced transcription factor, chop, is crucial for dendritic cell il-23 expression
-
Goodall JC, Wu C, Zhang Y, et al. Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression. Proc Natl Acad Sci U S A. 2010; 107: 17698-17703.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 17698-17703
-
-
Goodall, J.C.1
Wu, C.2
Zhang, Y.3
-
87
-
-
21044456603
-
Glycoprotein (gp) 96 expression: Induced during differentiation of intestinal macrophages but impaired in crohn's disease
-
Schreiter K, Hausmann M, Spoettl T, et al. Glycoprotein (gp) 96 expression: induced during differentiation of intestinal macrophages but impaired in Crohn's disease. Gut. 2005; 54: 935-943.
-
(2005)
Gut
, vol.54
, pp. 935-943
-
-
Schreiter, K.1
Hausmann, M.2
Spoettl, T.3
-
88
-
-
84901767455
-
MZB1 is a grp94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon er stress
-
Rosenbaum M, Andreani V, Kapoor T, et al. MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress. Genes Dev. 2014; 28: 1165-1178.
-
(2014)
Genes Dev
, vol.28
, pp. 1165-1178
-
-
Rosenbaum, M.1
Andreani, V.2
Kapoor, T.3
-
89
-
-
84900428774
-
The modulation of endoplasmic reticulum stress by chemical chaperone upregulates immune negative cytokine il-35 in apolipoprotein e-deficient mice
-
Wang B, Dai S, Dong Z, et al. The modulation of endoplasmic reticulum stress by chemical chaperone upregulates immune negative cytokine IL-35 in apolipoprotein E-deficient mice. PLoS One. 2014; 9: e87787.
-
(2014)
PLoS One
, vol.9
, pp. e87787
-
-
Wang, B.1
Dai, S.2
Dong, Z.3
-
90
-
-
80054856034
-
Interleukin-35 mediates mucosal immune responses that protect against t-cell-dependent colitis
-
Wirtz S, Billmeier U, McHedlidze T, et al. Interleukin-35 mediates mucosal immune responses that protect against T-cell-dependent colitis. Gastroenterology. 2011; 141: 1875-1886.
-
(2011)
Gastroenterology
, vol.141
, pp. 1875-1886
-
-
Wirtz, S.1
Billmeier, U.2
McHedlidze, T.3
-
91
-
-
84888386346
-
Keeping the bowel regular: The emerging role of treg as a therapeutic target in inflammatory bowel disease
-
Gibson DJ, Ryan EJ, Doherty GA. Keeping the bowel regular: the emerging role of Treg as a therapeutic target in inflammatory bowel disease. Inflamm Bowel Dis. 2013; 19: 2716-2724.
-
(2013)
Inflamm Bowel Dis
, vol.19
, pp. 2716-2724
-
-
Gibson, D.J.1
Ryan, E.J.2
Doherty, G.A.3
-
92
-
-
13644256191
-
A selective inhibitor of eif2alpha dephosphorylation protects cells from er stress
-
Boyce M, Bryant KF, Jousse C, et al. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science. 2005; 307: 935-939.
-
(2005)
Science
, vol.307
, pp. 935-939
-
-
Boyce, M.1
Bryant, K.F.2
Jousse, C.3
-
93
-
-
84920484402
-
Combined nadph oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerative colitis-like disease in mice
-
Treton X, Pedruzzi E, Guichard C, et al. Combined NADPH oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerative colitis-like disease in mice. PLoS One. 2014; 9: e101669.
-
(2014)
PLoS One
, vol.9
, pp. e101669
-
-
Treton, X.1
Pedruzzi, E.2
Guichard, C.3
-
94
-
-
84870335319
-
Glutamine treatment attenuates endoplasmic reticulum stress and apoptosis in tnbs-induced colitis
-
Crespo I, San-Miguel B, Prause C, et al. Glutamine treatment attenuates endoplasmic reticulum stress and apoptosis in TNBS-induced colitis. PLoS One. 2012; 7: e50407.
-
(2012)
PLoS One
, vol.7
, pp. e50407
-
-
Crespo, I.1
San-Miguel, B.2
Prause, C.3
-
95
-
-
84903795970
-
Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease
-
Cao SS, Kaufman RJ. Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxid Redox Signal. 2014; 21: 396-413.
-
(2014)
Antioxid Redox Signal
, vol.21
, pp. 396-413
-
-
Cao, S.S.1
Kaufman, R.J.2
-
96
-
-
47949099916
-
From endoplasmic-reticulum stress to the inflammatory response
-
Zhang K, Kaufman RJ. From endoplasmic-reticulum stress to the inflammatory response. Nature. 2008; 454: 455-462.
-
(2008)
Nature
, vol.454
, pp. 455-462
-
-
Zhang, K.1
Kaufman, R.J.2
-
99
-
-
84862862332
-
Epithelial antimicrobial defence of the skin and intestine
-
Gallo RL, Hooper LV. Epithelial antimicrobial defence of the skin and intestine. Nat Rev Immunol. 2012; 12: 503-516.
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 503-516
-
-
Gallo, R.L.1
Hooper, L.V.2
|