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Volumn 57, Issue 1, 2014, Pages 44-51

HLA-B27 misfolding and ankylosing spondylitis

Author keywords

Ankylosing spondylitis; Autophagy; Endoplasmic reticulum stress; MHC class I; Protein misfolding; Spondyloarthritis; Unfolded protein response

Indexed keywords

BETA INTERFERON; HLA B27 ANTIGEN; INTERLEUKIN 17; INTERLEUKIN 23; UBIQUITIN PROTEIN LIGASE E3;

EID: 84884414051     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2013.07.013     Document Type: Review
Times cited : (174)

References (78)
  • 1
    • 0033136630 scopus 로고    scopus 로고
    • Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure
    • Allen R.L., O'Callaghan C.A., McMichael A.J., Bowness P. Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure. Journal of Immunology 1999, 162:5045-5048.
    • (1999) Journal of Immunology , vol.162 , pp. 5045-5048
    • Allen, R.L.1    O'Callaghan, C.A.2    McMichael, A.J.3    Bowness, P.4
  • 4
    • 0025234494 scopus 로고
    • Guilt by association: HLA-B27 and ankylosing spondylitis
    • Benjamin R.J., Parham P. Guilt by association: HLA-B27 and ankylosing spondylitis. Immunology Today 1990, 11:137-142.
    • (1990) Immunology Today , vol.11 , pp. 137-142
    • Benjamin, R.J.1    Parham, P.2
  • 5
    • 0037352755 scopus 로고    scopus 로고
    • Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling
    • Bird L.A., Peh C.A., Kollnberger S., Elliott T., McMichael A.J., Bowness P. Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling. European Journal of Immunology 2003, 33:748-759.
    • (2003) European Journal of Immunology , vol.33 , pp. 748-759
    • Bird, L.A.1    Peh, C.A.2    Kollnberger, S.3    Elliott, T.4    McMichael, A.J.5    Bowness, P.6
  • 9
    • 79957819259 scopus 로고    scopus 로고
    • Expression of MHC class I dimers and ERAP1 in an ankylosing spondylitis patient cohort
    • Campbell E.C., Fettke F., Bhat S., Morley K.D., Powis S.J. Expression of MHC class I dimers and ERAP1 in an ankylosing spondylitis patient cohort. Immunology 2011, 133:379-385.
    • (2011) Immunology , vol.133 , pp. 379-385
    • Campbell, E.C.1    Fettke, F.2    Bhat, S.3    Morley, K.D.4    Powis, S.J.5
  • 10
    • 0036903889 scopus 로고    scopus 로고
    • Increased level of HLA-B27 expression in ankylosing spondylitis patients compared with healthy HLA-B27-positive subjects: a possible further susceptibility factor for the development of disease
    • Cauli A., Dessole G., Fiorillo M.T., Vacca A., Mameli A., Bitti P., Passiu G., Sorrentino R., Mathieu A. Increased level of HLA-B27 expression in ankylosing spondylitis patients compared with healthy HLA-B27-positive subjects: a possible further susceptibility factor for the development of disease. Rheumatology (Oxford) 2002, 41:1375-1379.
    • (2002) Rheumatology (Oxford) , vol.41 , pp. 1375-1379
    • Cauli, A.1    Dessole, G.2    Fiorillo, M.T.3    Vacca, A.4    Mameli, A.5    Bitti, P.6    Passiu, G.7    Sorrentino, R.8    Mathieu, A.9
  • 13
    • 84903907928 scopus 로고    scopus 로고
    • Evidence that autophagy,but not the unfolded protein response, regulates the expression of IL-23 in thegut of patients with ankylosing spondylitis and subclinical gut inflammation
    • Published Online First: [5 Jun, 2013]
    • Ciccia F., Accardo-Palumbo A., Rizzo A., Guggino G., Raimondo S., Giardina A., Can-nizzaro A., Colbert R.A., Alessandro R., Triolo G. Evidence that autophagy,but not the unfolded protein response, regulates the expression of IL-23 in thegut of patients with ankylosing spondylitis and subclinical gut inflammation. Annals of the Rheumatic Diseases 2013, Published Online First: [5 Jun, 2013]. 10.1136/annrheumdis-2012-202925.
    • (2013) Annals of the Rheumatic Diseases
    • Ciccia, F.1    Accardo-Palumbo, A.2    Rizzo, A.3    Guggino, G.4    Raimondo, S.5    Giardina, A.6    Can-nizzaro, A.7    Colbert, R.A.8    Alessandro, R.9    Triolo, G.10
  • 15
    • 0034214169 scopus 로고    scopus 로고
    • HLA-B27 misfolding: a solution to the spondyloarthropathy conundrum?
    • Colbert R.A. HLA-B27 misfolding: a solution to the spondyloarthropathy conundrum?. Molecular Medicine Today 2000, 6:224-230.
    • (2000) Molecular Medicine Today , vol.6 , pp. 224-230
    • Colbert, R.A.1
  • 17
    • 84879691837 scopus 로고    scopus 로고
    • Identification of multiple risk variantsfor ankylosing spondylitis through high-density genotyping of immune-relatedloci
    • International Genetics of Ankylosing Spondylitis Consortium (IGAS)
    • Cortes A., Hadler J., Pointon J.P., Robinson P.C., Karaderi T., Leo P., Cremin K., Pryce K., Harris J., Lee S., et al. Identification of multiple risk variantsfor ankylosing spondylitis through high-density genotyping of immune-relatedloci. Nature Genetics 2013, 45:730-738. International Genetics of Ankylosing Spondylitis Consortium (IGAS).
    • (2013) Nature Genetics , vol.45 , pp. 730-738
    • Cortes, A.1    Hadler, J.2    Pointon, J.P.3    Robinson, P.C.4    Karaderi, T.5    Leo, P.6    Cremin, K.7    Pryce, K.8    Harris, J.9    Lee, S.10
  • 19
    • 69449086287 scopus 로고    scopus 로고
    • HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats
    • DeLay M.L., Turner M.J., Klenk E.I., Smith J.A., Sowders D.P., Colbert R.A. HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats. Arthritis & Rheumatism 2009, 60:2633-2643.
    • (2009) Arthritis & Rheumatism , vol.60 , pp. 2633-2643
    • DeLay, M.L.1    Turner, M.J.2    Klenk, E.I.3    Smith, J.A.4    Sowders, D.P.5    Colbert, R.A.6
  • 21
    • 56249104422 scopus 로고    scopus 로고
    • Upregulation of 78-kDa glucose-regulated protein in macrophages in peripheral joints of active ankylosing spondylitis
    • Dong W., Zhang Y., Yan M., Liu H., Chen Z., Zhu P. Upregulation of 78-kDa glucose-regulated protein in macrophages in peripheral joints of active ankylosing spondylitis. Scandinavian Journal of Rheumatology 2008, 37:1-8.
    • (2008) Scandinavian Journal of Rheumatology , vol.37 , pp. 1-8
    • Dong, W.1    Zhang, Y.2    Yan, M.3    Liu, H.4    Chen, Z.5    Zhu, P.6
  • 22
    • 79959359494 scopus 로고    scopus 로고
    • Spondyloarthritis
    • Dougados M., Baeten D. Spondyloarthritis. Lancet 2011, 377:2127-2137.
    • (2011) Lancet , vol.377 , pp. 2127-2137
    • Dougados, M.1    Baeten, D.2
  • 25
    • 79960899377 scopus 로고    scopus 로고
    • Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
    • Evans D.M., Spencer C.C., Pointon J.J., Su Z., Harvey D., Kochan G., Oppermann U., Dilthey A., Pirinen M., Stone M.A., et al. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nature Genetics 2011, 43:761-767.
    • (2011) Nature Genetics , vol.43 , pp. 761-767
    • Evans, D.M.1    Spencer, C.C.2    Pointon, J.J.3    Su, Z.4    Harvey, D.5    Kochan, G.6    Oppermann, U.7    Dilthey, A.8    Pirinen, M.9    Stone, M.A.10
  • 26
    • 84857873959 scopus 로고    scopus 로고
    • Interferon-gamma contributes to HLA-B27-associated unfolded protein response in spondyloarthropathies
    • Feng Y., Ding J., Fan C.M., Zhu P. Interferon-gamma contributes to HLA-B27-associated unfolded protein response in spondyloarthropathies. Journal of Rheumatology 2012, 39:574-582.
    • (2012) Journal of Rheumatology , vol.39 , pp. 574-582
    • Feng, Y.1    Ding, J.2    Fan, C.M.3    Zhu, P.4
  • 29
    • 79952036205 scopus 로고    scopus 로고
    • Protein misfolding and cellular stress: an overview
    • Gregersen N., Bross P. Protein misfolding and cellular stress: an overview. Methods in Molecular Biology 2010, 648:3-23.
    • (2010) Methods in Molecular Biology , vol.648 , pp. 3-23
    • Gregersen, N.1    Bross, P.2
  • 36
    • 34948897411 scopus 로고    scopus 로고
    • The transcription factor XBP-1 is essential for the development and survival of dendritic cells
    • Iwakoshi N.N., Pypaert M., Glimcher L.H. The transcription factor XBP-1 is essential for the development and survival of dendritic cells. Journal of Experimental Medicine 2007, 204:2267-2275.
    • (2007) Journal of Experimental Medicine , vol.204 , pp. 2267-2275
    • Iwakoshi, N.N.1    Pypaert, M.2    Glimcher, L.H.3
  • 42
    • 78649338141 scopus 로고    scopus 로고
    • Autophagy and the integrated stress response
    • Kroemer G., Marino G., Levine B. Autophagy and the integrated stress response. Molecular Cell 2010, 40:280-293.
    • (2010) Molecular Cell , vol.40 , pp. 280-293
    • Kroemer, G.1    Marino, G.2    Levine, B.3
  • 43
    • 41749114288 scopus 로고    scopus 로고
    • Autophagy: basic principles and relevance to disease
    • Kundu M., Thompson C.B. Autophagy: basic principles and relevance to disease. Annual Review of Pathology 2008, 3:427-455.
    • (2008) Annual Review of Pathology , vol.3 , pp. 427-455
    • Kundu, M.1    Thompson, C.B.2
  • 44
    • 47049123836 scopus 로고    scopus 로고
    • The interleukin-23/interleukin-17 axis in spondyloarthritis
    • Layh-Schmitt G., Colbert R.A. The interleukin-23/interleukin-17 axis in spondyloarthritis. Current Opinion in Rheumatology 2008, 20:392-397.
    • (2008) Current Opinion in Rheumatology , vol.20 , pp. 392-397
    • Layh-Schmitt, G.1    Colbert, R.A.2
  • 45
    • 84881362894 scopus 로고    scopus 로고
    • HLA-B27 alters the response to TNFalpha and promotes osteoclastogenesis in bone marrow monocytes from HLA-B27 transgenic rats
    • Layh-Schmitt G., Yang E.Y., Kwon G., Colbert R.A. HLA-B27 alters the response to TNFalpha and promotes osteoclastogenesis in bone marrow monocytes from HLA-B27 transgenic rats. Arthritis & Rheumatism 2013, 65:2123-2131.
    • (2013) Arthritis & Rheumatism , vol.65 , pp. 2123-2131
    • Layh-Schmitt, G.1    Yang, E.Y.2    Kwon, G.3    Colbert, R.A.4
  • 47
    • 0027525106 scopus 로고
    • The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2
    • Madden D.R., Garboczi D.N., Wiley D.C. The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2. Cell 1993, 75:693-708.
    • (1993) Cell , vol.75 , pp. 693-708
    • Madden, D.R.1    Garboczi, D.N.2    Wiley, D.C.3
  • 48
    • 77951290227 scopus 로고    scopus 로고
    • TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
    • Martinon F., Chen X., Lee A.H., Glimcher L.H. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nature Immunology 2010, 11:411-418.
    • (2010) Nature Immunology , vol.11 , pp. 411-418
    • Martinon, F.1    Chen, X.2    Lee, A.H.3    Glimcher, L.H.4
  • 50
    • 0029738444 scopus 로고    scopus 로고
    • The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway, implications for the pathogenesis of dialysis-related amyloidosis
    • Miyata T., Hori O., Zhang J., Yan S.D., Ferran L., Iida Y., Schmidt A.M. The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway, implications for the pathogenesis of dialysis-related amyloidosis. Journal of Clinical Investigation 1996, 98:1088-1094.
    • (1996) Journal of Clinical Investigation , vol.98 , pp. 1088-1094
    • Miyata, T.1    Hori, O.2    Zhang, J.3    Yan, S.D.4    Ferran, L.5    Iida, Y.6    Schmidt, A.M.7
  • 51
    • 0037157856 scopus 로고    scopus 로고
    • Sequential assistance of molecular chaperones and transient formation of covalent complexes during protein degradation from the ER
    • Molinari M., Galli C., Piccaluga V., Pieren M., Paganetti P. Sequential assistance of molecular chaperones and transient formation of covalent complexes during protein degradation from the ER. Journal of Cell Biology 2002, 158:247-257.
    • (2002) Journal of Cell Biology , vol.158 , pp. 247-257
    • Molinari, M.1    Galli, C.2    Piccaluga, V.3    Pieren, M.4    Paganetti, P.5
  • 52
    • 27944464985 scopus 로고    scopus 로고
    • Persistent glycoprotein misfolding activates the glucosidase II/UGT1-driven calnexin cycle to delay aggregation and loss of folding competence
    • Molinari M., Galli C., Vanoni O., Arnold S.M., Kaufman R.J. Persistent glycoprotein misfolding activates the glucosidase II/UGT1-driven calnexin cycle to delay aggregation and loss of folding competence. Molecular Cell 2005, 20:503-512.
    • (2005) Molecular Cell , vol.20 , pp. 503-512
    • Molinari, M.1    Galli, C.2    Vanoni, O.3    Arnold, S.M.4    Kaufman, R.J.5
  • 53
    • 0028917887 scopus 로고
    • Species-specific differences in chaperone interaction of human and mouse major histocompatibility complex class I molecules
    • Noessner E., Parham P. Species-specific differences in chaperone interaction of human and mouse major histocompatibility complex class I molecules. Journal of Experimental Medicine 1995, 181:327-337.
    • (1995) Journal of Experimental Medicine , vol.181 , pp. 327-337
    • Noessner, E.1    Parham, P.2
  • 56
    • 84860585350 scopus 로고    scopus 로고
    • Genetics of spondyloarthritis - beyond the MHC
    • Reveille J.D. Genetics of spondyloarthritis - beyond the MHC. Nature Reviews Rheumatology 2012, 8:296-304.
    • (2012) Nature Reviews Rheumatology , vol.8 , pp. 296-304
    • Reveille, J.D.1
  • 59
    • 0034795140 scopus 로고    scopus 로고
    • The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
    • Schmidt A.M., Yan S.D., Yan S.F., Stern D.M. The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. Journal of Clinical Investigation 2001, 108:949-955.
    • (2001) Journal of Clinical Investigation , vol.108 , pp. 949-955
    • Schmidt, A.M.1    Yan, S.D.2    Yan, S.F.3    Stern, D.M.4
  • 60
    • 66449133523 scopus 로고    scopus 로고
    • Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis
    • Shen H., Goodall J.C., Hill Gaston J.S. Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis. Arthritis & Rheumatism 2009, 60:1647-1656.
    • (2009) Arthritis & Rheumatism , vol.60 , pp. 1647-1656
    • Shen, H.1    Goodall, J.C.2    Hill Gaston, J.S.3
  • 62
    • 45349092221 scopus 로고    scopus 로고
    • Gene expression analysis of macrophages derived from ankylosing spondylitis patients reveals interferon-gamma dysregulation
    • Smith J.A., Barnes M.D., Hong D., DeLay M.L., Inman R.D., Colbert R.A. Gene expression analysis of macrophages derived from ankylosing spondylitis patients reveals interferon-gamma dysregulation. Arthritis & Rheumatism 2008, 58:1640-1649.
    • (2008) Arthritis & Rheumatism , vol.58 , pp. 1640-1649
    • Smith, J.A.1    Barnes, M.D.2    Hong, D.3    DeLay, M.L.4    Inman, R.D.5    Colbert, R.A.6
  • 63
    • 47049098902 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1
    • Smith J.A., Turner M.J., DeLay M.L., Klenk E.I., Sowders D.P., Colbert R.A. Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1. European Journal of Immunology 2008, 38:1194-1203.
    • (2008) European Journal of Immunology , vol.38 , pp. 1194-1203
    • Smith, J.A.1    Turner, M.J.2    DeLay, M.L.3    Klenk, E.I.4    Sowders, D.P.5    Colbert, R.A.6
  • 64
    • 84867803600 scopus 로고    scopus 로고
    • Therapeutic controversies: tumor necrosis factor alpha inhibitors in ankylosing spondylitis
    • Song I.H., Maksymowych W.P. Therapeutic controversies: tumor necrosis factor alpha inhibitors in ankylosing spondylitis. Rheumatic Disease Clinics of North America 2012, 38:613-633.
    • (2012) Rheumatic Disease Clinics of North America , vol.38 , pp. 613-633
    • Song, I.H.1    Maksymowych, W.P.2
  • 65
    • 0022533999 scopus 로고
    • Monoclonal antibodies raised against denatured HLA-B locus H-chains permit biochemical characterization of certain HLA-C locus products
    • Stam N.J., Spits H., Ploegh H.L. Monoclonal antibodies raised against denatured HLA-B locus H-chains permit biochemical characterization of certain HLA-C locus products. Journal of Immunology 1986, 137:2299-2306.
    • (1986) Journal of Immunology , vol.137 , pp. 2299-2306
    • Stam, N.J.1    Spits, H.2    Ploegh, H.L.3
  • 68
    • 0027300353 scopus 로고
    • Susceptibility to inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of B27 expression
    • Taurog J.D., Maika S.D., Simmons W.A., Breban M., Hammer R.E. Susceptibility to inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of B27 expression. Journal of Immunology 1993, 150:4168-4178.
    • (1993) Journal of Immunology , vol.150 , pp. 4168-4178
    • Taurog, J.D.1    Maika, S.D.2    Simmons, W.A.3    Breban, M.4    Hammer, R.E.5
  • 69
    • 33645852216 scopus 로고    scopus 로고
    • Additional human beta(2)-microglobulin curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27-transgenic rats
    • Tran T.M., Dorris M.L., Satumtira N., Richardson J.A., Hammer R.E., Shang J., Taurog J.D. Additional human beta(2)-microglobulin curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27-transgenic rats. Arthritis & Rheumatism 2006, 54:1317-1327.
    • (2006) Arthritis & Rheumatism , vol.54 , pp. 1317-1327
    • Tran, T.M.1    Dorris, M.L.2    Satumtira, N.3    Richardson, J.A.4    Hammer, R.E.5    Shang, J.6    Taurog, J.D.7
  • 70
    • 1842476244 scopus 로고    scopus 로고
    • HLA-B27 in transgenic rats forms disulfide-linked heavy chain oligomers and multimers that bind to the chaperone BiP
    • Tran T.M., Satumtira N., Dorris M.L., May E., Wang A., Furuta E., Taurog J.D. HLA-B27 in transgenic rats forms disulfide-linked heavy chain oligomers and multimers that bind to the chaperone BiP. Journal of Immunology 2004, 172:5110-5119.
    • (2004) Journal of Immunology , vol.172 , pp. 5110-5119
    • Tran, T.M.1    Satumtira, N.2    Dorris, M.L.3    May, E.4    Wang, A.5    Furuta, E.6    Taurog, J.D.7
  • 71
    • 33846194065 scopus 로고    scopus 로고
    • HLA-B27 up-regulation causes accumulation of misfolded heavy chains and correlates with the magnitude of the unfolded protein response in transgenic rats: Implications for the pathogenesis of spondylarthritis-like disease
    • Turner M.J., Delay M.L., Bai S., Klenk E., Colbert R.A. HLA-B27 up-regulation causes accumulation of misfolded heavy chains and correlates with the magnitude of the unfolded protein response in transgenic rats: Implications for the pathogenesis of spondylarthritis-like disease. Arthritis & Rheumatism 2007, 56:215-223.
    • (2007) Arthritis & Rheumatism , vol.56 , pp. 215-223
    • Turner, M.J.1    Delay, M.L.2    Bai, S.3    Klenk, E.4    Colbert, R.A.5
  • 73
    • 84876410429 scopus 로고    scopus 로고
    • Unspliced XBP1 controls autophagy through FoxO1
    • Vidal R.L., Hetz C. Unspliced XBP1 controls autophagy through FoxO1. Cell Research 2013, 23:463-464.
    • (2013) Cell Research , vol.23 , pp. 463-464
    • Vidal, R.L.1    Hetz, C.2
  • 74
    • 34248178540 scopus 로고    scopus 로고
    • Serum IL-17, BMP-7, and bone turnover markers in patients with ankylosing spondylitis
    • Wendling D., Cedoz J.P., Racadot E., Dumoulin G. Serum IL-17, BMP-7, and bone turnover markers in patients with ankylosing spondylitis. Joint Bone Spine 2007, 74:304-305.
    • (2007) Joint Bone Spine , vol.74 , pp. 304-305
    • Wendling, D.1    Cedoz, J.P.2    Racadot, E.3    Dumoulin, G.4
  • 75
    • 40949123747 scopus 로고    scopus 로고
    • TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes
    • Yarilina A., Park-Min K.H., Antoniv T., Hu X., Ivashkiv L.B. TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes. Nature Immunology 2008, 9:378-387.
    • (2008) Nature Immunology , vol.9 , pp. 378-387
    • Yarilina, A.1    Park-Min, K.H.2    Antoniv, T.3    Hu, X.4    Ivashkiv, L.B.5
  • 76
    • 82455210509 scopus 로고    scopus 로고
    • Ankylosing spondylitis macrophage production of higher levels of interleukin-23 in response to lipopolysaccharide without induction of a significant unfolded protein response
    • Zeng L., Lindstrom M.J., Smith J.A. Ankylosing spondylitis macrophage production of higher levels of interleukin-23 in response to lipopolysaccharide without induction of a significant unfolded protein response. Arthritis & Rheumatism 2011, 63:3807-3817.
    • (2011) Arthritis & Rheumatism , vol.63 , pp. 3807-3817
    • Zeng, L.1    Lindstrom, M.J.2    Smith, J.A.3
  • 77
    • 77956917631 scopus 로고    scopus 로고
    • XBP-1 couples endoplasmic reticulum stress to augmented IFN-beta induction via a cis-acting enhancer in macrophages
    • Zeng L., Liu Y.P., Sha H., Chen H., Qi L., Smith J.A. XBP-1 couples endoplasmic reticulum stress to augmented IFN-beta induction via a cis-acting enhancer in macrophages. Journal of Immunology 2010, 185:2324-2330.
    • (2010) Journal of Immunology , vol.185 , pp. 2324-2330
    • Zeng, L.1    Liu, Y.P.2    Sha, H.3    Chen, H.4    Qi, L.5    Smith, J.A.6


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