-
1
-
-
80455140368
-
Ulcerative colitis
-
Danese S, Fiocchi C. Ulcerative colitis. N Engl J Med. 2011;365:1713-1725.
-
(2011)
N Engl J Med
, vol.365
, pp. 1713-1725
-
-
Danese, S.1
Fiocchi, C.2
-
2
-
-
79959271087
-
Intestinal homeostasis and its breakdown in inflammatory bowel disease
-
Maloy KJ, Powrie F. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature. 2011;474:298-306.
-
(2011)
Nature
, vol.474
, pp. 298-306
-
-
Maloy, K.J.1
Powrie, F.2
-
3
-
-
39449126502
-
The Foxp3+ regulatory T cell: A jack of all trades, master of regulation
-
Tang Q, Bluestone JA. The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol. 2008;9:239-244.
-
(2008)
Nat Immunol
, vol.9
, pp. 239-244
-
-
Tang, Q.1
Bluestone, J.A.2
-
4
-
-
27144495833
-
How do CD4+CD25+ regulatory T cells control autoimmunity?
-
Bluestone JA, Tang Q. How do CD4+CD25+ regulatory T cells control autoimmunity? Curr Opin Immunol. 2005;17:638-642.
-
(2005)
Curr Opin Immunol
, vol.17
, pp. 638-642
-
-
Bluestone, J.A.1
Tang, Q.2
-
5
-
-
79951772860
-
Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria
-
Hadis U, Wahl B, Sculz O, et al. Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity. 2011;34:237-246.
-
(2011)
Immunity
, vol.34
, pp. 237-246
-
-
Hadis, U.1
Wahl, B.2
Sculz, O.3
-
6
-
-
41549169557
-
Contextual regulation of inflammation: A duet by transforming growth factor-beta and interleukin-10
-
Li MO, Flavell RA. Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10. Immunity. 2008;28: 468-476.
-
(2008)
Immunity
, vol.28
, pp. 468-476
-
-
Li, M.O.1
Flavell, R.A.2
-
7
-
-
62949223226
-
Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression
-
e1301-1303
-
Fantini MC, Rizzo A, Fina D, et al. Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression. Gastroenterology. 2009;136:1308-1316; e1301-1303.
-
(2009)
Gastroenterology
, vol.136
, pp. 1308-1316
-
-
Fantini, M.C.1
Rizzo, A.2
Fina, D.3
-
8
-
-
34250351459
-
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
-
Deaglio S, Dwyer KM, Gao W, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med. 2007;204:1257-1265.
-
(2007)
J Exp Med
, vol.204
, pp. 1257-1265
-
-
Deaglio, S.1
Dwyer, K.M.2
Gao, W.3
-
9
-
-
0037446531
-
Cutting edge: Cure of colitis by CD4+CD25+ regulatory T cells
-
Mottet C, Uhlig HH, Powrie H. Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol. 2003;170:3939-3943.
-
(2003)
J Immunol
, vol.170
, pp. 3939-3943
-
-
Mottet, C.1
Uhlig, H.H.2
Powrie, H.3
-
10
-
-
33745255734
-
CD4+CD25+ cell depletion from the normal CD4+ T cell pool prevents tolerance toward the intestinal flora and leads to chronic colitis in immunodeficient mice
-
Veltkamp C, Ruhwald R, Giesem T, et al. CD4+CD25+ cell depletion from the normal CD4+ T cell pool prevents tolerance toward the intestinal flora and leads to chronic colitis in immunodeficient mice. Inflamm Bowel Dis. 2006;12:437-446.
-
(2006)
Inflamm Bowel Dis
, vol.12
, pp. 437-446
-
-
Veltkamp, C.1
Ruhwald, R.2
Giesem, T.3
-
11
-
-
44549084734
-
Interleukin-21: A critical regulator of the balance between effector and regulatory T-cell responses
-
Monteleone G, Pallone F, MacDonald TT. Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses. Trends Immunol. 2008;29:290-294.
-
(2008)
Trends Immunol
, vol.29
, pp. 290-294
-
-
Monteleone, G.1
Pallone, F.2
MacDonald, T.T.3
-
12
-
-
0036241690
-
Critical role of caspases in the regulation of apoptosis and proliferation of mucosal T cells
-
Sturm A, Mohr S, Fiocchi C. Critical role of caspases in the regulation of apoptosis and proliferation of mucosal T cells. Gastroenterology. 2002; 122:1334-1345.
-
(2002)
Gastroenterology
, vol.122
, pp. 1334-1345
-
-
Sturm, A.1
Mohr, S.2
Fiocchi, C.3
-
13
-
-
65549123867
-
Natural and adaptive foxp3+ regulatory T cells: More of the same or a division of labor?
-
Curotto de Lafaille MA, Lafaille JJ. Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? Immunity. 2009;30:626-635.
-
(2009)
Immunity
, vol.30
, pp. 626-635
-
-
Curotto De Lafaille, M.A.1
Lafaille, J.J.2
-
14
-
-
33746338535
-
Interleukin-10-secreting type 1 regulatory T cells in rodents and humans
-
Roncarolo MG, Gregori S, Battaglia, et al. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol Rev. 2006;212:28-50.
-
(2006)
Immunol Rev
, vol.212
, pp. 28-50
-
-
Roncarolo, M.G.1
Gregori, S.2
Battaglia3
-
15
-
-
0029150110
-
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
-
Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 1995;155:1151-1164.
-
(1995)
J Immunol
, vol.155
, pp. 1151-1164
-
-
Sakaguchi, S.1
Sakaguchi, N.2
Asano, M.3
-
16
-
-
34047174849
-
Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production
-
Allan SE, Crome SQ, Crellin N, et al. Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol. 2007;19:345-354.
-
(2007)
Int Immunol
, vol.19
, pp. 345-354
-
-
Allan, S.E.1
Crome, S.Q.2
Crellin, N.3
-
17
-
-
34247277666
-
Foxp3 in control of the regulatory T cell lineage
-
Zheng Y, Rudensky AY. Foxp3 in control of the regulatory T cell lineage. Nat Immunol. 2007;8:457-462.
-
(2007)
Nat Immunol
, vol.8
, pp. 457-462
-
-
Zheng, Y.1
Rudensky, A.Y.2
-
18
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori S, Nomura T, Sakaguchi S, et al. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299:1057-1061.
-
(2003)
Science
, vol.299
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
19
-
-
2142643604
-
Control of immune pathology by regulatory T cells
-
discussion 98-105, 106-114
-
Powrie F, Read S, Mottet C, et al. Control of immune pathology by regulatory T cells. Novartis Found Symp. 2003;252 92-98; discussion 98-105, 106-114.
-
(2003)
Novartis Found Symp
, vol.252
, pp. 92-98
-
-
Powrie, F.1
Read, S.2
Mottet, C.3
-
20
-
-
0037385330
-
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
-
Fontenot JD, Gavin MA, Rudensky, et al. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. 2003; 4:330-336.
-
(2003)
Nat Immunol
, vol.4
, pp. 330-336
-
-
Fontenot, J.D.1
Ma Rudensky, G.2
-
22
-
-
0035167967
-
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
-
Bennett CL, Christie J, Ramsdell F, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet. 2001;27:20-21.
-
(2001)
Nat Genet
, vol.27
, pp. 20-21
-
-
Bennett, C.L.1
Christie, J.2
Ramsdell, F.3
-
23
-
-
0036345337
-
Origin of regulatory T cells with known specificity for antigen
-
Apostolou I, Sarukhan A, Klein L, et al. Origin of regulatory T cells with known specificity for antigen. Nat Immunol. 2002;3:756-763.
-
(2002)
Nat Immunol
, vol.3
, pp. 756-763
-
-
Apostolou, I.1
Sarukhan, A.2
Klein, L.3
-
24
-
-
65549145814
-
Control of regulatory T cell lineage commitment and maintenance
-
Josefowicz SZ, Rudensky A. Control of regulatory T cell lineage commitment and maintenance. Immunity. 2009;30:616-625.
-
(2009)
Immunity
, vol.30
, pp. 616-625
-
-
Josefowicz, S.Z.1
Rudensky, A.2
-
25
-
-
34250216635
-
A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-beta
-
Selvaraj RK, Geiger TL. A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-beta. J Immunol. 2007;178:7667-7677.
-
(2007)
J Immunol
, vol.178
, pp. 7667-7677
-
-
Selvaraj, R.K.1
Geiger, T.L.2
-
26
-
-
0348223787
-
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
-
Chen W, Jin W, Hardegen N, et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med. 2003;198:1875-1886.
-
(2003)
J Exp Med
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
Jin, W.2
Hardegen, N.3
-
27
-
-
34547757390
-
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
-
Sun CM, Hall JA, Blank RB, et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med. 2007;204:1775-1785.
-
(2007)
J Exp Med
, vol.204
, pp. 1775-1785
-
-
Sun, C.M.1
Hall, J.A.2
Blank, R.B.3
-
28
-
-
85027947787
-
Induction of colonic regulatory T cells by indigenous Clostridium species
-
Atarashi K, Tanoue T, Shima T, et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science. 2011;331:337-341.
-
(2011)
Science
, vol.331
, pp. 337-341
-
-
Atarashi, K.1
Tanoue, T.2
Shima, T.3
-
29
-
-
77249150015
-
The role of TLRs NLRs and RLRs in mucosal innate immunity and homeostasis
-
Lavelle EC, Murphy C, O'Neill LA, et al. The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis. Mucosal Immunol. 2010;3:17-28.
-
(2010)
Mucosal Immunol
, vol.3
, pp. 17-28
-
-
Lavelle, E.C.1
Murphy, C.2
O'Neill, L.A.3
-
30
-
-
53349164200
-
Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses
-
Hall JA, Bouladoux N, Sun CM, et al. Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity. 2008;29:637-649.
-
(2008)
Immunity
, vol.29
, pp. 637-649
-
-
Hall, J.A.1
Bouladoux, N.2
Sun, C.M.3
-
31
-
-
32444432610
-
Toll-like receptor 2 controls expansion and function of regulatory T cells
-
Sutmuller RP, den Brok MH, Kramer M, et al. Toll-like receptor 2 controls expansion and function of regulatory T cells. J Clin Invest. 2006;116: 485-494.
-
(2006)
J Clin Invest
, vol.116
, pp. 485-494
-
-
Sutmuller, R.P.1
Den Brok, M.H.2
Kramer, M.3
-
32
-
-
33750375612
-
Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis
-
Uhlig HH, Coombes J, Mottet C, et al. Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis. J Immunol. 2006;177:5852-5860.
-
(2006)
J Immunol
, vol.177
, pp. 5852-5860
-
-
Uhlig, H.H.1
Coombes, J.2
Mottet, C.3
-
33
-
-
70949087383
-
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
-
Glocker EO, Kotlarz D, Boztug H, et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med. 2009;361: 2033-2045.
-
(2009)
N Engl J Med
, vol.361
, pp. 2033-2045
-
-
Glocker, E.O.1
Kotlarz, D.2
Boztug, H.3
-
34
-
-
84864206050
-
Loss of interleukin-10 signaling and infantile inflammatory bowel disease: Implications for diagnosis and therapy
-
Kotlarz D, Beier R, Murugan D, et al. Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy. Gastroenterology. 2012; 143:347-355.
-
(2012)
Gastroenterology
, vol.143
, pp. 347-355
-
-
Kotlarz, D.1
Beier, R.2
Murugan, D.3
-
35
-
-
84875221954
-
Clinical outcome in IL-10- and IL-10 receptor-deficient patients with or without hematopoietic stem cell transplantation
-
Engelhardt KR, Shah N, Faizura-Yeop I, et al. Clinical outcome in IL-10- and IL-10 receptor-deficient patients with or without hematopoietic stem cell transplantation. J Allergy Clin Immunol. 2013;131:825-830.
-
(2013)
J Allergy Clin Immunol
, vol.131
, pp. 825-830
-
-
Engelhardt, K.R.1
Shah, N.2
Faizura-Yeop, I.3
-
37
-
-
32244442562
-
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
-
Veldhoen M, Hocking RJ, Atkins CJ, et al. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006;24:179-189.
-
(2006)
Immunity
, vol.24
, pp. 179-189
-
-
Veldhoen, M.1
Hocking, R.J.2
Atkins, C.J.3
-
38
-
-
77249137663
-
Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease
-
Eastaff-Leung N, Mabarrack N, Barbour A, et al. Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease. J Clin Immunol. 2010;30:80-89.
-
(2010)
J Clin Immunol
, vol.30
, pp. 80-89
-
-
Eastaff-Leung, N.1
Mabarrack, N.2
Barbour, A.3
-
39
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441:235-238.
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
-
40
-
-
84875681575
-
The role of inflammasome-derived IL-1 in driving IL-17 responses
-
Mills KH, Dungan LS, Jones SA, et al. The role of inflammasome-derived IL-1 in driving IL-17 responses. J Leukoc Biol. 2013;93:489-497.
-
(2013)
J Leukoc Biol
, vol.93
, pp. 489-497
-
-
Mills, K.H.1
Dungan, L.S.2
Jones, S.A.3
-
41
-
-
34848876937
-
Cutting edge: Trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells
-
Dominitzki S, Fantini MC, Neufert C, et al. Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells. J Immunol. 2007;179:2041-2045.
-
(2007)
J Immunol
, vol.179
, pp. 2041-2045
-
-
Dominitzki, S.1
Fantini, M.C.2
Neufert, C.3
-
42
-
-
0035162560
-
Disruption of a new forkhead/ winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
-
Brunkow ME, Jeffery EW, Hjerrild KA, et al. Disruption of a new forkhead/ winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet. 2001;27:68-73.
-
(2001)
Nat Genet
, vol.27
, pp. 68-73
-
-
Brunkow, M.E.1
Jeffery, E.W.2
Hjerrild, K.A.3
-
43
-
-
34247160955
-
Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation
-
Makita S, Kanai T, Nemoto Y, et al. Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation. J Immunol. 2007;178:4937-4946.
-
(2007)
J Immunol
, vol.178
, pp. 4937-4946
-
-
Makita, S.1
Kanai, T.2
Nemoto, Y.3
-
44
-
-
36248976097
-
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
-
Pandiyan P, Zheng L, Ishihara S, et al. CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol. 2007;8:1353-1362.
-
(2007)
Nat Immunol
, vol.8
, pp. 1353-1362
-
-
Pandiyan, P.1
Zheng, L.2
Ishihara, S.3
-
45
-
-
79952439279
-
CD4+CD25+ regulatory T cells suppress Th17-responses in an experimental colitis model
-
Ogino H, Nakamura K, Ihara E, et al. CD4+CD25+ regulatory T cells suppress Th17-responses in an experimental colitis model. Dig Dis Sci. 2011;56:376-386.
-
(2011)
Dig Dis Sci
, vol.56
, pp. 376-386
-
-
Ogino, H.1
Nakamura, K.2
Ihara, E.3
-
46
-
-
33847161301
-
The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25 (+)Foxp3(+) regulatory T cells
-
Maillard MH, Cotta-de-Almeida V, Takeshima F, et al. The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25 (+)Foxp3(+) regulatory T cells. J Exp Med. 2007;204:381-391.
-
(2007)
J Exp Med
, vol.204
, pp. 381-391
-
-
Maillard, M.H.1
Cotta-De-Almeida, V.2
Takeshima, F.3
-
47
-
-
45549098368
-
Development of inflammatory bowel disease in Long-Evans Cinnamon rats based on CD4+CD25+Foxp3+ regulatory T cell dysfunction
-
Ishimaru N, Yamada A, Kohashi M, et al. Development of inflammatory bowel disease in Long-Evans Cinnamon rats based on CD4+CD25+Foxp3+ regulatory T cell dysfunction. J Immunol. 2008;180:6997-7008.
-
(2008)
J Immunol
, vol.180
, pp. 6997-7008
-
-
Ishimaru, N.1
Yamada, A.2
Kohashi, M.3
-
48
-
-
80052573212
-
Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNF alpha treatment
-
Veltkamp C, Anstaett M, Wahl K, et al. Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNF alpha treatment. Gut. 2011;60:1345-1353.
-
(2011)
Gut
, vol.60
, pp. 1345-1353
-
-
Veltkamp, C.1
Anstaett, M.2
Wahl, K.3
-
49
-
-
78650080500
-
Therapy with anti-TNF alpha antibody enhances number and function of Foxp3(+) regulatory T cells in inflammatory bowel diseases
-
Boschetti G, Nancey S, Sardi F, et al. Therapy with anti-TNF alpha antibody enhances number and function of Foxp3(+) regulatory T cells in inflammatory bowel diseases. Inflamm Bowel Dis. 2011; 17:160-170.
-
(2011)
Inflamm Bowel Dis
, vol.17
, pp. 160-170
-
-
Boschetti, G.1
Nancey, S.2
Sardi, F.3
-
50
-
-
51249084103
-
Anti tumour necrosis-alpha therapy increases the number of FOXP3 regulatory T cells in children affected by Crohn's disease
-
Ricciardelli I, Lindley KJ, Londei M, et al. Anti tumour necrosis-alpha therapy increases the number of FOXP3 regulatory T cells in children affected by Crohn's disease. Immunology. 2008;125:178-183.
-
(2008)
Immunology
, vol.125
, pp. 178-183
-
-
Ricciardelli, I.1
Lindley, K.J.2
Londei, M.3
-
51
-
-
80052906811
-
Adalimumab treatment in Crohn's disease does not induce early changes in regulatory T cells
-
Dige A, Hvas CL, Deleuran B, et al. Adalimumab treatment in Crohn's disease does not induce early changes in regulatory T cells. Scand J Gastroenterol. 2011;46:1206-1214.
-
(2011)
Scand J Gastroenterol
, vol.46
, pp. 1206-1214
-
-
Dige, A.1
Hvas, C.L.2
Deleuran, B.3
-
52
-
-
20444434616
-
Peripheral and intestinal regulatory CD4+ CD25 (high) T cells in inflammatory bowel disease
-
Maul J, Loddenkemper C, Mundt P, et al. Peripheral and intestinal regulatory CD4+ CD25 (high) T cells in inflammatory bowel disease. Gastroenterology. 2005;128:1868-1878.
-
(2005)
Gastroenterology
, vol.128
, pp. 1868-1878
-
-
Maul, J.1
Loddenkemper, C.2
Mundt, P.3
-
53
-
-
36249014365
-
Characterization of FOXP3+CD4+ regulatory T cells in Crohn's disease
-
Saruta M, Yu QT, Fleshner PR, et al. Characterization of FOXP3+CD4+ regulatory T cells in Crohn's disease. Clin Immunol. 2007;125:281-290.
-
(2007)
Clin Immunol
, vol.125
, pp. 281-290
-
-
Saruta, M.1
Yu, Q.T.2
Fleshner, P.R.3
-
54
-
-
34249309861
-
Expression and functional characterization of FOXP3+ CD4+ regulatory T cells in ulcerative colitis
-
Yu QT, Saruta M, Avanesyan A, et al. Expression and functional characterization of FOXP3+ CD4+ regulatory T cells in ulcerative colitis. Inflamm Bowel Dis. 2007;13:191-199.
-
(2007)
Inflamm Bowel Dis
, vol.13
, pp. 191-199
-
-
Yu, Q.T.1
Saruta, M.2
Avanesyan, A.3
-
55
-
-
79954527727
-
Increase of regulatory T cells in ileal mucosa of untreated pediatric Crohn's disease patients
-
Reikvam DH, Perminow G, Lyckander LG, et al. Increase of regulatory T cells in ileal mucosa of untreated pediatric Crohn's disease patients. Scand J Gastroenterol. 2011;46:550-560.
-
(2011)
Scand J Gastroenterol
, vol.46
, pp. 550-560
-
-
Reikvam, D.H.1
Perminow, G.2
Lyckander, L.G.3
-
56
-
-
71149084582
-
Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function
-
Kmieciak M, Gowda M, Graham L, et al. Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. J Transl Med. 2009;7:89.
-
(2009)
J Transl Med
, vol.7
, pp. 89
-
-
Kmieciak, M.1
Gowda, M.2
Graham, L.3
-
57
-
-
79952300978
-
Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases
-
Hovhannisyan Z, Treatman J, Littman DR, et al. Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. Gastroenterology. 2011;140: 957-965.
-
(2011)
Gastroenterology
, vol.140
, pp. 957-965
-
-
Hovhannisyan, Z.1
Treatman, J.2
Littman, D.R.3
-
58
-
-
33745275219
-
Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity
-
Holmen N, Lundgren A, Lundin S, et al. Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity. Inflamm Bowel Dis. 2006;12:447-456.
-
(2006)
Inflamm Bowel Dis
, vol.12
, pp. 447-456
-
-
Holmen, N.1
Lundgren, A.2
Lundin, S.3
-
59
-
-
3543140687
-
Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy
-
Ehrenstein MR, Evans JG, Singh A, et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med. 2004;200:277-285.
-
(2004)
J Exp Med
, vol.200
, pp. 277-285
-
-
Ehrenstein, M.R.1
Evans, J.G.2
Singh, A.3
-
60
-
-
33846900430
-
Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus
-
Valencia X, Yarboro C, Illei G, et al. Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol. 2007;178:2579-2588.
-
(2007)
J Immunol
, vol.178
, pp. 2579-2588
-
-
Valencia, X.1
Yarboro, C.2
Illei, G.3
-
61
-
-
84859439270
-
Phase I clinical trial of Smad7 knockdown using antisense oligonucleotide in patients with active Crohn's disease
-
Monteleone G, Fantini MC, Onali S, et al. Phase I clinical trial of Smad7 knockdown using antisense oligonucleotide in patients with active Crohn's disease. Mol Ther. 2012;20:870-876.
-
(2012)
Mol Ther
, vol.20
, pp. 870-876
-
-
Monteleone, G.1
Fantini, M.C.2
Onali, S.3
-
62
-
-
0034679703
-
Blockade of transforming growth factor beta/Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity
-
Nakao A, Miike S, Hatano M, et al. Blockade of transforming growth factor beta/Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity. J Exp Med. 2000;192:151-158.
-
(2000)
J Exp Med
, vol.192
, pp. 151-158
-
-
Nakao, A.1
Miike, S.2
Hatano, M.3
-
64
-
-
0031573593
-
A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease
-
Plevy SE, Landers CJ, Prehn J, et al. A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease. J Immunol. 1997;159:6276-6282.
-
(1997)
J Immunol
, vol.159
, pp. 6276-6282
-
-
Plevy, S.E.1
Landers, C.J.2
Prehn, J.3
-
65
-
-
0027486125
-
Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease
-
Murch SH, Braegger CP, Walker-Smith JA, et al. Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease. Gut. 1993;34:1705-1709.
-
(1993)
Gut
, vol.34
, pp. 1705-1709
-
-
Murch, S.H.1
Braegger, C.P.2
Walker-Smith, J.A.3
-
66
-
-
34548531881
-
Blockage of tumor necrosis factor prevents intestinal mucosal inflammation through down-regulation of interleukin-23 secretion
-
Liu Z, Jiu J, Liu S, et al. Blockage of tumor necrosis factor prevents intestinal mucosal inflammation through down-regulation of interleukin-23 secretion. J Autoimmun. 2007;29:187-194.
-
(2007)
J Autoimmun
, vol.29
, pp. 187-194
-
-
Liu, Z.1
Jiu, J.2
Liu, S.3
-
67
-
-
76949094665
-
Future biologic targets for IBD: Potentials and pitfalls
-
Melmed GY, Targan SR. Future biologic targets for IBD: potentials and pitfalls. Nat Rev Gastroenterol Hepatol. 2010;7:110-117.
-
(2010)
Nat Rev Gastroenterol Hepatol
, vol.7
, pp. 110-117
-
-
Melmed, G.Y.1
Targan, S.R.2
-
68
-
-
79959958989
-
Development of inflammatory bowel disease in patients with juvenile idiopathic arthritis treated with etanercept
-
van Dijken TD, Vastert SJ, Gerloni VM, et al. Development of inflammatory bowel disease in patients with juvenile idiopathic arthritis treated with etanercept. J Rheumatol. 2011;38:1441-1446.
-
(2011)
J Rheumatol
, vol.38
, pp. 1441-1446
-
-
Van Dijken, T.D.1
Vastert, S.J.2
Gerloni, V.M.3
-
69
-
-
84867980671
-
Development of inflammatory bowel disease during anti-TNF-alpha therapy for inflammatory rheumatic disease. A nationwide series
-
Toussirot É, Houvenagel É, Goëb V, et al. Development of inflammatory bowel disease during anti-TNF-alpha therapy for inflammatory rheumatic disease. A nationwide series. Joint Bone Spine. 2012;79:457-463.
-
(2012)
Joint Bone Spine
, vol.79
, pp. 457-463
-
-
Toussirot, É.1
Houvenagel, É.2
Goëb, V.3
-
70
-
-
0034754477
-
Etanercept for active Crohn's disease: A randomized, double-blind, placebo-controlled trial
-
Sandborn WJ, Hanauer SB, Katz S, et al. Etanercept for active Crohn's disease: a randomized, double-blind, placebo-controlled trial. Gastroenterology. 2001;121:1088-1094.
-
(2001)
Gastroenterology
, vol.121
, pp. 1088-1094
-
-
Sandborn, W.J.1
Hanauer, S.B.2
Katz, S.3
-
71
-
-
33646397611
-
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
-
Yen D, Cheung J, Scheerens H, et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest. 2006; 116:1310-1316.
-
(2006)
J Clin Invest
, vol.116
, pp. 1310-1316
-
-
Yen, D.1
Cheung, J.2
Scheerens, H.3
-
72
-
-
41349121555
-
Regulation of gut inflammation and th17 cell response by interleukin-21
-
Fina D, Sarra M, Fantini MC, et al. Regulation of gut inflammation and th17 cell response by interleukin-21. Gastroenterology. 2008;134: 1038-1048.
-
(2008)
Gastroenterology
, vol.134
, pp. 1038-1048
-
-
Fina, D.1
Sarra, M.2
Fantini, M.C.3
-
73
-
-
0037216498
-
Increased expression of interleukin 17 in inflammatory bowel disease
-
Fujino S, Andoh A, Bamba S, et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut. 2003;52:65-70.
-
(2003)
Gut
, vol.52
, pp. 65-70
-
-
Fujino, S.1
Andoh, A.2
Bamba, S.3
-
74
-
-
33846446041
-
Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta
-
Nadkarni S, Mauri C, Ehrenstein MR. Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta. J Exp Med. 2007;204:33-39.
-
(2007)
J Exp Med
, vol.204
, pp. 33-39
-
-
Nadkarni, S.1
Mauri, C.2
Ehrenstein, M.R.3
-
75
-
-
3543140687
-
Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy
-
Ehrenstein MR, Evans JG, Singh A, et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med. 2004;200:277-285.
-
(2004)
J Exp Med
, vol.200
, pp. 277-285
-
-
Ehrenstein, M.R.1
Evans, J.G.2
Singh, A.3
-
76
-
-
81855209849
-
Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14(+) macrophages
-
Atreya R, Zimmer M, Bartsch B, et al. Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14(+) macrophages. Gastroenterology. 2011;141:2026-2038.
-
(2011)
Gastroenterology
, vol.141
, pp. 2026-2038
-
-
Atreya, R.1
Zimmer, M.2
Bartsch, B.3
-
77
-
-
14944382276
-
Infliximab induces potent antiinflammatory responses by outside-to-inside signals through transmembrane TNF-alpha
-
Mitoma H, Horiuchi T, Hatta N, et al. Infliximab induces potent antiinflammatory responses by outside-to-inside signals through transmembrane TNF-alpha. Gastroenterology. 2005;128:376-392.
-
(2005)
Gastroenterology
, vol.128
, pp. 376-392
-
-
Mitoma, H.1
Horiuchi, T.2
Hatta, N.3
-
78
-
-
77955747724
-
Reciprocal changes of Foxp3 expression in blood and intestinal mucosa in IBD patients responding to infliximab
-
Li Z, Arijs I, De Hertogh G, et al. Reciprocal changes of Foxp3 expression in blood and intestinal mucosa in IBD patients responding to infliximab. Inflamm Bowel Dis. 2010;16:1299-1310.
-
(2010)
Inflamm Bowel Dis
, vol.16
, pp. 1299-1310
-
-
Li, Z.1
Arijs, I.2
De Hertogh, G.3
-
79
-
-
78249240373
-
Peripheral regulatory T cells and serum transforming growth factor-beta: Relationship with clinical response to infliximab in Crohn's disease
-
Di Sabatino A, Biancheri P, Piconese S, et al. Peripheral regulatory T cells and serum transforming growth factor-beta: relationship with clinical response to infliximab in Crohn's disease. Inflamm Bowel Dis. 2010;16:1891-1897.
-
(2010)
Inflamm Bowel Dis
, vol.16
, pp. 1891-1897
-
-
Di Sabatino, A.1
Biancheri, P.2
Piconese, S.3
-
80
-
-
77952500102
-
Discrete changes in circulating regulatory T cells during infliximab treatment of Crohn's disease
-
Hvas CL, Kelsen J, Agnholt J, et al. Discrete changes in circulating regulatory T cells during infliximab treatment of Crohn's disease. Autoimmunity. 2010;43:325-333.
-
(2010)
Autoimmunity
, vol.43
, pp. 325-333
-
-
Hvas, C.L.1
Kelsen, J.2
Agnholt, J.3
-
81
-
-
84863581114
-
Altered immunoregulatory profile during anti-tumour necrosis factor treatment of patients with inflammatory bowel disease
-
Grundstrom J, Linton L, Thunberg S, et al. Altered immunoregulatory profile during anti-tumour necrosis factor treatment of patients with inflammatory bowel disease. Clin Exp Immunol. 2012;169:137-147.
-
(2012)
Clin Exp Immunol
, vol.169
, pp. 137-147
-
-
Grundstrom, J.1
Linton, L.2
Thunberg, S.3
-
82
-
-
84859606047
-
Mucosal cytokine gene expression profiles as biomarkers of response to infliximab in ulcerative colitis
-
Rismo R, Olsen T, Cui G, et al. Mucosal cytokine gene expression profiles as biomarkers of response to infliximab in ulcerative colitis. Scand J Gastroenterol. 2012;47:538-547.
-
(2012)
Scand J Gastroenterol
, vol.47
, pp. 538-547
-
-
Rismo, R.1
Olsen, T.2
Cui, G.3
-
83
-
-
23044440808
-
FoxP3(+)CD4(+)CD25(+) T cells with regulatory properties can be cultured from colonic mucosa of patients with Crohn's disease
-
Kelsen J, Agnholt J, Hoffmann HJ, et al. FoxP3(+)CD4(+)CD25(+) T cells with regulatory properties can be cultured from colonic mucosa of patients with Crohn's disease. Clin Exp Immunol. 2005;141:549-557.
-
(2005)
Clin Exp Immunol
, vol.141
, pp. 549-557
-
-
Kelsen, J.1
Agnholt, J.2
Hoffmann, H.J.3
-
84
-
-
53749094183
-
CTLA-4 control over Foxp3+ regulatory T cell function
-
Wing K, Onishi Y, Prieto-Martin P, et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science. 2008;322:271-275.
-
(2008)
Science
, vol.322
, pp. 271-275
-
-
Wing, K.1
Onishi, Y.2
Prieto-Martin, P.3
-
85
-
-
77952754636
-
Different proliferative potential and migratory characteristics of human CD4+ regulatory T cells that express either CD45RA or CD45RO
-
Booth NJ, McQuaid AJ, Sobande T, et al. Different proliferative potential and migratory characteristics of human CD4+ regulatory T cells that express either CD45RA or CD45RO. J Immunol. 2010; 184:4317-4326.
-
(2010)
J Immunol
, vol.184
, pp. 4317-4326
-
-
Booth, N.J.1
McQuaid, A.J.2
Sobande, T.3
-
86
-
-
84872185913
-
CD4(+)CD25 (+)CD127 (low/-) T cells: A more specific Treg population in human peripheral blood
-
Yu N, Li X, Song W, et al. CD4(+)CD25 (+)CD127 (low/-) T cells: a more specific Treg population in human peripheral blood. Inflammation. 2012; 35:1773-1780.
-
(2012)
Inflammation
, vol.35
, pp. 1773-1780
-
-
Yu, N.1
Li, X.2
Song, W.3
-
87
-
-
78349232055
-
Expression of CD39 by human peripheral blood CD4+ CD25+ T cells denotes a regulatory memory phenotype
-
Dwyer KM, Hanidziar D, Putheti, et al. Expression of CD39 by human peripheral blood CD4+ CD25+ T cells denotes a regulatory memory phenotype. Am J Transplant. 2010;10:2410-2420.
-
(2010)
Am J Transplant
, vol.10
, pp. 2410-2420
-
-
Dwyer, K.M.1
Hanidziar, D.2
Putheti3
-
88
-
-
84868095501
-
CD73 is a phenotypic marker of effector memory Th17 cells in inflammatory bowel disease
-
Doherty GA, Bai A, Hanidziar D, et al. CD73 is a phenotypic marker of effector memory Th17 cells in inflammatory bowel disease. Eur J Immunol. 2012;42:3062-3072.
-
(2012)
Eur J Immunol
, vol.42
, pp. 3062-3072
-
-
Doherty, G.A.1
Bai, A.2
Hanidziar, D.3
-
90
-
-
79951917669
-
Mouse and human intestinal immunity: Same ballpark, different players; Different rules, same score
-
Gibbons DL, Spencer J. Mouse and human intestinal immunity: same ballpark, different players; different rules, same score. Mucosal Immunol. 2011;4:148-157.
-
(2011)
Mucosal Immunol
, vol.4
, pp. 148-157
-
-
Gibbons, D.L.1
Spencer, J.2
-
91
-
-
70449532980
-
Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection
-
Oldenhove G, Bouladoux N, Wohlfert EA, et al. Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity. 2009;31:772-786.
-
(2009)
Immunity
, vol.31
, pp. 772-786
-
-
Oldenhove, G.1
Bouladoux, N.2
Wohlfert, E.A.3
-
92
-
-
77951483356
-
Plasticity of T reg at infected sites
-
Wohlfert E, Belkaid Y. Plasticity of T reg at infected sites. Mucosal Immunol. 2010;3:213-215.
-
(2010)
Mucosal Immunol
, vol.3
, pp. 213-215
-
-
Wohlfert, E.1
Belkaid, Y.2
-
93
-
-
33745817085
-
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
-
Liu W, Putnam AL, Xu-Yu Z, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med. 2006;203:1701-1711.
-
(2006)
J Exp Med
, vol.203
, pp. 1701-1711
-
-
Liu, W.1
Putnam, A.L.2
Xu-Yu, Z.3
-
94
-
-
84880968811
-
Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+ CD25+FOXP3+ Treg subpopulations
-
Scotta C, Esposito M, Fazekasova H, et al. Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+ CD25+FOXP3+ Treg subpopulations. Haematologica. 2013;98:1291-1299.
-
(2013)
Haematologica
, vol.98
, pp. 1291-1299
-
-
Scotta, C.1
Esposito, M.2
Fazekasova, H.3
-
95
-
-
53049091561
-
A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease
-
Sandborn WJ, Feagan BG, Fedorak RN, et al. A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease. Gastroenterology. 2008;135: 1130-1141.
-
(2008)
Gastroenterology
, vol.135
, pp. 1130-1141
-
-
Sandborn, W.J.1
Feagan, B.G.2
Fedorak, R.N.3
-
96
-
-
84871701834
-
Ustekinumab induction and maintenance therapy in refractory Crohn's disease
-
Sandborn WJ, Gasink C, Gao LL, et al. Ustekinumab induction and maintenance therapy in refractory Crohn's disease. New Engl J Med. 2012;367:1519-1528.
-
(2012)
New Engl J Med
, vol.367
, pp. 1519-1528
-
-
Sandborn, W.J.1
Gasink, C.2
Gao, L.L.3
-
97
-
-
79956315886
-
Intestinal bacterial colonization induces mutualistic regulatory T cell responses
-
Geuking MB, Cahenzli J, Lawson MA, et al. Intestinal bacterial colonization induces mutualistic regulatory T cell responses. Immunity. 2011;34: 794-806.
-
(2011)
Immunity
, vol.34
, pp. 794-806
-
-
Geuking, M.B.1
Cahenzli, J.2
Lawson, M.A.3
-
98
-
-
79956311926
-
The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
-
Round JL, Lee SM, Li J, et al. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science. 2011;332:974-977.
-
(2011)
Science
, vol.332
, pp. 974-977
-
-
Round, J.L.1
Lee, S.M.2
Li, J.3
-
99
-
-
84868109200
-
Safety and efficacy of antigenspecific regulatory T-cell therapy for patients with refractory Crohn's disease
-
e1202
-
Desreumaux P, Foussat A, Allez M, et al. Safety and efficacy of antigenspecific regulatory T-cell therapy for patients with refractory Crohn's disease. Gastroenterology. 2012;143:1207-1217, e1202.
-
(2012)
Gastroenterology
, vol.143
, pp. 1207-1217
-
-
Desreumaux, P.1
Foussat, A.2
Allez, M.3
|