-
1
-
-
34547216747
-
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
-
DOI 10.1038/nature06014, PII NATURE06014
-
Moffatt MF, et al. (2007) Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 448:470-473. (Pubitemid 47123521)
-
(2007)
Nature
, vol.448
, Issue.7152
, pp. 470-473
-
-
Moffatt, M.F.1
Kabesch, M.2
Liang, L.3
Dixon, A.L.4
Strachan, D.5
Heath, S.6
Depner, M.7
Von Berg, A.8
Bufe, A.9
Rietschel, E.10
Heinzmann, A.11
Simma, B.12
Frischer, T.13
Willis-Owen, S.A.G.14
Wong, K.C.C.15
Illig, T.16
Vogelberg, C.17
Weiland, S.K.18
Von Mutius, E.19
Abecasis, G.R.20
Farrall, M.21
Gut, I.G.22
Lathrop, G.M.23
Cookson, W.O.C.24
more..
-
2
-
-
57349101088
-
Effect of 17q21 variants and smoking exposure in early-onset asthma
-
Bouzigon E, et al. (2008) Effect of 17q21 variants and smoking exposure in early-onset asthma. N Engl J Med 359:1985-1994.
-
(2008)
N Engl J Med
, vol.359
, pp. 1985-1994
-
-
Bouzigon, E.1
-
3
-
-
77957113600
-
A large-scale, consortium-based genomewide association study of asthma
-
GABRIEL Consortium
-
Moffatt MF, et al.; GABRIEL Consortium (2010) A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 363:1211-1221.
-
(2010)
N Engl J Med
, vol.363
, pp. 1211-1221
-
-
Moffatt, M.F.1
-
4
-
-
44449150336
-
ORMDL3 gene is associated with asthma in three ethnically diverse populations
-
DOI 10.1164/rccm.200711-1644OC
-
Galanter J, et al. (2008) ORMDL3 gene is associated with asthma in three ethnically diverse populations. Am J Respir Crit Care Med 177:1194-1200. (Pubitemid 351860927)
-
(2008)
American Journal of Respiratory and Critical Care Medicine
, vol.177
, Issue.11
, pp. 1194-1200
-
-
Galanter, J.M.1
Choudhry, S.2
Eng, C.3
Nazario, S.4
Rodriguez-Santana, J.R.5
Casal, J.6
Torres-Palacios, A.7
Salas, J.8
Chapela, R.9
Watson, H.G.10
Meade, K.11
LeNoir, M.12
Rodriguez-Cintron, W.13
Avila, P.C.14
Burchard, E.G.15
-
5
-
-
0036046814
-
ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins
-
Hjelmqvist L, et al. (2002) ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. Genome Biol 3: RESEARCH0027.
-
(2002)
Genome Biol
, vol.3
-
-
Hjelmqvist, L.1
-
6
-
-
77649121162
-
Orm family proteins mediate sphingolipid homeostasis
-
Breslow DK, et al. (2010) Orm family proteins mediate sphingolipid homeostasis. Nature 463:1048-1053.
-
(2010)
Nature
, vol.463
, pp. 1048-1053
-
-
Breslow, D.K.1
-
7
-
-
0033833857
-
Increased matrix metalloproteinase-9 in the airway after allergen challenge
-
Kelly EA, Busse WW, Jarjour NN (2000) Increased matrix metalloproteinase-9 in the airway after allergen challenge. Am J Respir Crit Care Med 162:1157-1161.
-
(2000)
Am J Respir Crit Care Med
, vol.162
, pp. 1157-1161
-
-
Kelly, E.A.1
Busse, W.W.2
Jarjour, N.N.3
-
9
-
-
4444368197
-
Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma
-
DOI 10.1165/rcmb.2004-0026OC
-
King NE, et al. (2004) Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma. Am J Respir Cell Mol Biol 31:257-265. (Pubitemid 39180294)
-
(2004)
American Journal of Respiratory Cell and Molecular Biology
, vol.31
, Issue.3
, pp. 257-265
-
-
King, N.E.1
Zimmermann, N.2
Pope, S.M.3
Fulkerson, P.C.4
Nikolaidis, N.M.5
Mishra, A.6
Witte, D.P.7
Rothenberg, M.E.8
-
10
-
-
34047143642
-
Increased expression of ADAM33 and ADAM8 with disease progression in asthma
-
DOI 10.1016/j.jaci.2006.12.665, PII S0091674907002308
-
Foley SC, et al. (2007) Increased expression of ADAM33 and ADAM8 with disease progression in asthma. J Allergy Clin Immunol 119:863-871. (Pubitemid 46527832)
-
(2007)
Journal of Allergy and Clinical Immunology
, vol.119
, Issue.4
, pp. 863-871
-
-
Foley, S.C.1
Mogas, A.K.2
Olivenstein, R.3
Fiset, P.O.4
Chakir, J.5
Bourbeau, J.6
Ernst, P.7
Lemiere, C.8
Martin, J.G.9
Hamid, Q.10
-
11
-
-
77954496749
-
The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma
-
Naus S, et al. (2010) The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma. Am J Respir Crit Care Med 181:1318-1328.
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 1318-1328
-
-
Naus, S.1
-
12
-
-
43349105246
-
+ T lymphocytes in tissue compared with blood and induction of CCL20 during the asthmatic late response
-
DOI 10.1111/j.1365-2249.2008.03657.x
-
Francis JN, Sabroe I, Lloyd CM, Durham SR, Till SJ (2008) Elevated CCR6+ CD4+ T lymphocytes in tissue compared with blood and induction of CCL20 during the asthmatic late response. Clin Exp Immunol 152:440-447. (Pubitemid 351661508)
-
(2008)
Clinical and Experimental Immunology
, vol.152
, Issue.3
, pp. 440-447
-
-
Francis, J.N.1
Sabroe, I.2
Lloyd, C.M.3
Durham, S.R.4
Till, S.J.5
-
13
-
-
77951665424
-
Analyses of asthma severity phenotypes and in flammatory proteins in subjects stratified by sputum granulocytes
-
National Heart, Lung, and Blood Institute Severe Asthma Research Program
-
Hastie AT, et al.; National Heart, Lung, and Blood Institute Severe Asthma Research Program (2010) Analyses of asthma severity phenotypes and in flammatory proteins in subjects stratified by sputum granulocytes. J Allergy Clin Immunol 125:1028-1036, e13.
-
(2010)
J Allergy Clin Immunol
, vol.125
-
-
Hastie, A.T.1
-
14
-
-
79953166053
-
CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells
-
Kim S, Lewis C, Nadel JA (2011) CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells. J Immunol 186:3392-3400.
-
(2011)
J Immunol
, vol.186
, pp. 3392-3400
-
-
Kim, S.1
Lewis, C.2
Nadel, J.A.3
-
15
-
-
35948941870
-
H2 cells and the expression of allergic airway disease
-
DOI 10.1038/nm1660, PII NM1660
-
WeckmannM, et al. (2007) Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease. Nat Med 13:1308-1315. (Pubitemid 350073595)
-
(2007)
Nature Medicine
, vol.13
, Issue.11
, pp. 1308-1315
-
-
Weckmann, M.1
Collison, A.2
Simpson, J.L.3
Kopp, M.V.4
Wark, P.A.B.5
Smyth, M.J.6
Yagita, H.7
Matthaei, K.I.8
Hansbro, N.9
Whitehead, B.10
Gibson, P.G.11
Foster, P.S.12
Mattes, J.13
-
16
-
-
0032698182
-
Neutrophilic inflammation in severe persistent asthma
-
Jatakanon A, et al. (1999) Neutrophilic inflammation in severe persistent asthma. Am J Respir Crit Care Med 160:1532-1539.
-
(1999)
Am J Respir Crit Care Med
, vol.160
, pp. 1532-1539
-
-
Jatakanon, A.1
-
17
-
-
0034063744
-
Interleukin-8 secretion and neutrophil recruitment accompanies induced sputum eosinophil activation in children with acute asthma
-
Norzila MZ, Fakes K, Henry RL, Simpson J, Gibson PG (2000) Interleukin-8 secretion and neutrophil recruitment accompanies induced sputum eosinophil activation in children with acute asthma. Am J Respir Crit Care Med 161:769-774. (Pubitemid 30171729)
-
(2000)
American Journal of Respiratory and Critical Care Medicine
, vol.161
, Issue.3 I
, pp. 769-774
-
-
Norzila, M.Z.1
Fakes, K.2
Henry, R.L.3
Simpson, J.4
Gibson, P.G.5
-
18
-
-
53149097377
-
Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease
-
Ying S, et al. (2008) Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease. J Immunol 181:2790-2798.
-
(2008)
J Immunol
, vol.181
, pp. 2790-2798
-
-
Ying, S.1
-
19
-
-
0242550716
-
Release of both CCR4-active and CXCR3-active chemokines during human allergic pulmonary late-phase reactions
-
DOI 10.1016/j.jaci.2003.08.012
-
Bochner BS, Hudson SA, Xiao HQ, Liu MC (2003) Release of both CCR4-active and CXCR3-active chemokines during human allergic pulmonary late-phase reactions. J Allergy Clin Immunol 112:930-934. (Pubitemid 37412061)
-
(2003)
Journal of Allergy and Clinical Immunology
, vol.112
, Issue.5
, pp. 930-934
-
-
Bochner, B.S.1
Hudson, S.A.2
Xiao, H.Q.3
Liu, M.C.4
-
20
-
-
0037093999
-
IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma
-
Medoff BD, et al. (2002) IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. J Immunol 168:5278-5286. (Pubitemid 34495996)
-
(2002)
Journal of Immunology
, vol.168
, Issue.10
, pp. 5278-5286
-
-
Medoff, B.D.1
Sauty, A.2
Tager, A.M.3
Maclean, J.A.4
Smith, R.N.5
Mathew, A.6
Dufour, J.H.7
Luster, A.D.8
-
21
-
-
80053171978
-
Attenuation of antigen-induced airway hyperresponsiveness and inflammation in CXCR3 knockout mice
-
Lin Y, et al. (2011) Attenuation of antigen-induced airway hyperresponsiveness and inflammation in CXCR3 knockout mice. Respir Res 12:123.
-
(2011)
Respir Res
, vol.12
, pp. 123
-
-
Lin, Y.1
-
22
-
-
82255173966
-
The unfolded protein response: From stress pathway to homeostatic regulation
-
Walter P, Ron D (2011) The unfolded protein response: From stress pathway to homeostatic regulation. Science 334:1081-1086.
-
(2011)
Science
, vol.334
, pp. 1081-1086
-
-
Walter, P.1
Ron, D.2
-
23
-
-
44449101173
-
ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum
-
DOI 10.1247/csf.07044
-
Adachi Y, et al. (2008) ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum. Cell Struct Funct 33:75-89. (Pubitemid 351860903)
-
(2008)
Cell Structure and Function
, vol.33
, Issue.1
, pp. 75-89
-
-
Adachi, Y.1
Yamamoto, K.2
Okada, T.3
Yoshida, H.4
Harada, A.5
Mori, K.6
-
24
-
-
67649771753
-
Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma
-
Mahn K, et al. (2009) Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma. Proc Natl Acad Sci USA 106:10775-10780.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 10775-10780
-
-
Mahn, K.1
-
25
-
-
84863418925
-
Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness
-
Doherty TA, et al. (2012) Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness. J Immunol 188:2622-2629.
-
(2012)
J Immunol
, vol.188
, pp. 2622-2629
-
-
Doherty, T.A.1
-
26
-
-
29144479205
-
Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium
-
DOI 10.1073/pnas.0509235102
-
Broide DH, et al. (2005) Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. Proc Natl Acad Sci USA 102:17723-17728. (Pubitemid 41803564)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.49
, pp. 17723-17728
-
-
Broide, D.H.1
Lawrence, T.2
Doherty, T.3
Cho, J.Y.4
Miller, M.5
McElwain, K.6
McElwain, S.7
Karin, M.8
-
27
-
-
84861226876
-
Mechanisms elevating ORMDL3 expression in recurrent wheeze patients: Role of Ets-1, p300 and CREB
-
Jin R, et al. (2012) Mechanisms elevating ORMDL3 expression in recurrent wheeze patients: Role of Ets-1, p300 and CREB. Int J Biochem Cell Biol 44:1174-1183.
-
(2012)
Int J Biochem Cell Biol
, vol.44
, pp. 1174-1183
-
-
Jin, R.1
-
28
-
-
77953881949
-
Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming
-
Elo LL, et al. (2010) Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming. Immunity 32:852-862.
-
(2010)
Immunity
, vol.32
, pp. 852-862
-
-
Elo, L.L.1
-
29
-
-
0026514960
-
Cytokines in symptomatic asthma airways
-
Broide DH, et al. (1992) Cytokines in symptomatic asthma airways. J Allergy Clin Immunol 89:958-967.
-
(1992)
J Allergy Clin Immunol
, vol.89
, pp. 958-967
-
-
Broide, D.H.1
-
30
-
-
0034038544
-
Airway hyperresponsiveness and airway obstruction in transgenic mice. Morphologic correlates in mice overexpressing interleukin (IL)-11 and IL-6 in the lung
-
Kuhn C, 3rd, et al. (2000) Airway hyperresponsiveness and airway obstruction in transgenic mice. Morphologic correlates in mice overexpressing interleukin (IL)-11 and IL-6 in the lung. Am J Respir Cell Mol Biol 22:289-295.
-
(2000)
Am J Respir Cell Mol Biol
, vol.22
, pp. 289-295
-
-
Kuhn III, C.1
-
31
-
-
78651468793
-
The oligoadenylate synthetase family: An ancient protein family with multiple antiviral activities
-
Kristiansen H, Gad HH, Eskildsen-Larsen S, Despres P, Hartmann R (2011) The oligoadenylate synthetase family: An ancient protein family with multiple antiviral activities. J Interferon Cytokine Res 31:41-47.
-
(2011)
J Interferon Cytokine Res
, vol.31
, pp. 41-47
-
-
Kristiansen, H.1
Gad, H.H.2
Eskildsen-Larsen, S.3
Despres, P.4
Hartmann, R.5
-
32
-
-
0037067319
-
2′-5′ oligoadenylate synthetase plays a critical role in interferon-gamma inhibition of respiratory syncytial virus infection of human epithelial cells
-
DOI 10.1074/jbc.M200211200
-
Behera AK, Kumar M, Lockey RF, Mohapatra SS (2002) 2′-5′ Oligoadenylate synthetase plays a critical role in interferon-gamma inhibition of respiratory syncytial virus infection of human epithelial cells. J Biol Chem 277:25601-25608. (Pubitemid 34951877)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.28
, pp. 25601-25608
-
-
Behera, A.K.1
Kumar, M.2
Lockey, R.F.3
Mohapatra, S.S.4
-
33
-
-
77649150074
-
The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress
-
Cantero-Recasens G, Fandos C, Rubio-Moscardo F, Valverde MA, Vicente R (2010) The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress. Hum Mol Genet 19:111-121.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 111-121
-
-
Cantero-Recasens, G.1
Fandos, C.2
Rubio-Moscardo, F.3
Valverde, M.A.4
Vicente, R.5
|