Phosphorylation of eif2α is dispensable for differentiation but required at a posttranscriptional level for paneth cell function and intestinal homeostasis in mice

Inflammatory Bowel Diseases

Volumn 20, Issue 4, 2014, Pages 712-722

  Cao, Stewart S ^a,b,d   Wang, Miao ^a   Harrington, Jane C ^c,e   Chuang, Brandy Mengchieh ^a   Eckmann, Lars ^c   Kaufman, Randal J ^a  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d Columbia University College of Phys and Surg ^*  (United States)

^e MEDICAL UNIVERSITY OF THE AMERICAS   (Saint Kitts and Nevis)

Author keywords

Endoplasmic reticulum stress; ER associated mRNA translation; Inflammatory bowel disease; Intestinal epithelial cells; Unfolded protein response

Indexed keywords

ALPHA INTERFERON; INITIATION FACTOR 2ALPHA; LYSOZYME; MESSENGER RNA; VILLIN; CHAPERONE; DEXTRAN SULFATE; GAMMA INTERFERON; INITIATION FACTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CELL FRACTIONATION; CELL FUNCTION; CELL PROLIFERATION; CELL RENEWAL; COLITIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; HOMEOSTASIS; MITOCHONDRION; MOUSE; MOUTH INFECTION; NONHUMAN; PANETH CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SALMONELLA TYPHIMURIUM; SALMONELLOSIS; SECRETORY GRANULE; ANIMAL; ANIMAL SALMONELLOSIS; APOPTOSIS; BIOSYNTHESIS; C3H MOUSE; CHEMICALLY INDUCED; DISEASE PREDISPOSITION; ENDOPLASMIC RETICULUM; GENETICS; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; PHYSIOLOGICAL STRESS; PHYSIOLOGY; PROTEIN SYNTHESIS; RIBOSOME; SECRETORY VESICLE; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; ULTRASTRUCTURE; UNFOLDED PROTEIN RESPONSE;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; COLITIS; DEXTRAN SULFATE; DISEASE SUSCEPTIBILITY; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR-2; HOMEOSTASIS; INTERFERON-GAMMA; MICE; MICE, INBRED C3H; MICE, TRANSGENIC; MOLECULAR CHAPERONES; MURAMIDASE; PANETH CELLS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; RIBOSOMES; RNA, MESSENGER; SALMONELLA INFECTIONS, ANIMAL; SECRETORY VESICLES; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; UNFOLDED PROTEIN RESPONSE;

EID: 84898720437     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/MIB.0000000000000010     Document Type: Article

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