PKR in DSS-induced Colitis: A matter of genetic background and maternal microflora?

Inflammatory Bowel Diseases

Volumn 19, Issue 3, 2013, Pages

  Cao, Stewart Siyan ^a   Kaufman, Randal J ^a  

^a Neuroscience Aging and Stem Cell Research Center ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; INITIATION FACTOR 2ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE R;

CARBOXY TERMINAL SEQUENCE; COLITIS; ENZYME PHOSPHORYLATION; GENE DELETION; GENETIC ASSOCIATION; INTESTINE FLORA; LETTER; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CELL PROLIFERATION; COLITIS; COLON; EIF-2 KINASE; EPITHELIUM; FEMALE; MALE; UNFOLDED PROTEIN RESPONSE;

EID: 84876419410     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.22978     Document Type: Letter

References (12)

1. Abraham N, Stojdl DF, Duncan PI, et al. Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR. J Biol Chem. 1999;274: 5953-5962.
2. Rath E, Berger E, Messlik A, et al. Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis of intestinal inflammation. Gut. 2012;61: 1269-1278.
3. Yang YL, Reis LF, Pavlovic J, et al. Deficient signaling in mice devoid of double-stranded RNAdependent protein kinase. EMBO J. 199515;14: 6095-6106.
4. Cao SS, Song B, Kaufman RJ. PKR protects colonic epithelium against colitis through the unfolded protein response and prosurvival signaling. Inflamm Bowel Dis. 2012;18:1735-1742.
5. Baltzis D, Li S, Koromilas AE. Functional characterization of pkr gene products expressed in cells from mice with a targeted deletion of the N terminus or C terminus domain of PKR. J Biol Chem. 2002;277: 38364-38372.
6. Mähler M, Bristol IJ, Leiter EH, et al. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am J Physiol. 1998;274(3 Pt 1):G544-551.
7. Melgar S, Karlsson A, Michaëlsson E. Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation. Am J Physiol Gastrointest Liver Physiol. 2005;288: G1328-1338.
8. Mähler M, Bristol IJ, Sundberg JP, et al. Genetic analysis of susceptibility to dextran sulfate sodiuminduced colitis in mice. Genomics. 1999;55:147- 156.
9. Garrett WS, Gallini CA, Yatsunenko T, et al. Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe. 2010;8: 292-300.
10. Elinav E, Strowig T, Kau AL, et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell. 2011;145: 745-757.
11. Kazemi S, Mounir Z, Baltzis D, et al. A novel function of eIF2alpha kinases as inducers of the phosphoinositide-3 kinase signaling pathway. Mol Biol Cell. 2007;18:3635-3644.
12. Vanhaesebroeck B, Guillermet-Guibert J, Graupera M, et al. The emerging mechanisms of isoform-specific PI3K signalling. Nat Rev Mol Cell Biol. 2010;11: 329-341.