메뉴 건너뛰기




Volumn 10, Issue 2, 2015, Pages 217-229

The future for early-stage tuberculosis drug discovery

Author keywords

drug target; essential genes; high throughput screening; Mycobacterium tuberculosis; tuberculosis drug discovery

Indexed keywords

TUBERCULOSTATIC AGENT;

EID: 84923180646     PISSN: 17460913     EISSN: 17460921     Source Type: Journal    
DOI: 10.2217/fmb.14.125     Document Type: Review
Times cited : (65)

References (100)
  • 1
    • 84859421891 scopus 로고    scopus 로고
    • Contribution of effux activity to isoniazid resistance in the Mycobacterium tuberculosis complex
    • Rodrigues L, Machado D, Couto I, Amaral L, Viveiros M. Contribution of effux activity to isoniazid resistance in the Mycobacterium tuberculosis complex. Infect. Genet. Evol. 12(4), 695-700 (2012).
    • (2012) Infect. Genet. Evol. , vol.12 , Issue.4 , pp. 695-700
    • Rodrigues, L.1    Machado, D.2    Couto, I.3    Amaral, L.4    Viveiros, M.5
  • 2
    • 0013853271 scopus 로고
    • Effect of rifamycin on protein synthesis
    • Calvori C, Frontali L, Leoni L, Tecce G. Effect of rifamycin on protein synthesis. Nature 207(995), 417-418 (1965).
    • (1965) Nature , vol.207 , Issue.995 , pp. 417-418
    • Calvori, C.1    Frontali, L.2    Leoni, L.3    Tecce, G.4
  • 3
    • 0015373050 scopus 로고
    • Effect of isoniazid on the in vivo mycolic acid synthesis, cell growth, and viability of Mycobacterium tuberculosis
    • Takayama K, Wang L, David HL. Effect of isoniazid on the in vivo mycolic acid synthesis, cell growth, and viability of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 2(1), 29-35 (1972).
    • (1972) Antimicrob. Agents Chemother. , vol.2 , Issue.1 , pp. 29-35
    • Takayama, K.1    Wang, L.2    David, H.L.3
  • 4
    • 3342880792 scopus 로고    scopus 로고
    • Nitric oxide generated from isoniazid activation by KatG: Source of nitric oxide and activity against Mycobacterium tuberculosis
    • Timmins GS, Master S, Rusnak F, Deretic V. Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 48(8), 3006-3009 (2004).
    • (2004) Antimicrob. Agents Chemother. , vol.48 , Issue.8 , pp. 3006-3009
    • Timmins, G.S.1    Master, S.2    Rusnak, F.3    Deretic, V.4
  • 5
    • 0024431530 scopus 로고
    • Inhibition of synthesis of arabinogalactan by ethambutol in Mycobacterium smegmatis
    • Takayama K, Kilburn JO. Inhibition of synthesis of arabinogalactan by ethambutol in Mycobacterium smegmatis. Antimicrob. Agents Chemother. 33(9), 1493-1499 (1989).
    • (1989) Antimicrob. Agents Chemother. , vol.33 , Issue.9 , pp. 1493-1499
    • Takayama, K.1    Kilburn, J.O.2
  • 6
    • 0032508046 scopus 로고    scopus 로고
    • Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
    • Cole ST, Brosch R, Parkhill J et al. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393(6685), 537-544 (1998).
    • (1998) Nature , vol.393 , Issue.6685 , pp. 537-544
    • Cole, S.T.1    Brosch, R.2    Parkhill, J.3
  • 7
    • 0036777599 scopus 로고    scopus 로고
    • Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains
    • Fleischmann RD, Alland D, Eisen JA et al. Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains. J. Bacteriol. 184(19), 5479-5490 (2002).
    • (2002) J. Bacteriol. , vol.184 , Issue.19 , pp. 5479-5490
    • Fleischmann, R.D.1    Alland, D.2    Eisen, J.A.3
  • 9
    • 33845903833 scopus 로고    scopus 로고
    • Drugs for bad bugs: Confronting the challenges of antibacterial discovery
    • Payne DJ, Gwynn MN, Holmes DJ, Pompliano DL. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. 6(1), 29-40 (2007).
    • (2007) Nat. Rev. Drug Discov. , vol.6 , Issue.1 , pp. 29-40
    • Payne, D.J.1    Gwynn, M.N.2    Holmes, D.J.3    Pompliano, D.L.4
  • 10
    • 84923195505 scopus 로고    scopus 로고
    • Working Group on New TB Drugs. Discovery portfolio
    • Working Group on New TB Drugs. Discovery portfolio. www.newtbdrugs.org/pipeline-discovery.php
  • 11
    • 84878211646 scopus 로고    scopus 로고
    • Assay development for identifying inhibitors of the mycobacterial FadD32 activity
    • Galandrin S, Guillet V, Rane RS et al. Assay development for identifying inhibitors of the mycobacterial FadD32 activity. J. Biomol. Screen. 18(5), 576-587 (2013).
    • (2013) J. Biomol. Screen. , vol.18 , Issue.5 , pp. 576-587
    • Galandrin, S.1    Guillet, V.2    Rane, R.S.3
  • 12
    • 84892415655 scopus 로고    scopus 로고
    • A high-throughput screen against pantothenate synthetase (PanC) identifes 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis
    • Kumar A, Casey A, Odingo J et al. A high-throughput screen against pantothenate synthetase (PanC) identifes 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis. PLoS ONE 8(11), e72786 (2013).
    • (2013) PLoS ONE , vol.8 , Issue.11 , pp. e72786
    • Kumar, A.1    Casey, A.2    Odingo, J.3
  • 13
    • 84921743804 scopus 로고    scopus 로고
    • Identifcation of anti-tuberculosis agents that target the cell-division protein FtsZ
    • Lin Y, Zhu N, Han Y, Jiang J, Si S. Identifcation of anti-tuberculosis agents that target the cell-division protein FtsZ. J. Antibiot. (Tokyo) 67 (9), 671-676 (2014).
    • (2014) J. Antibiot. (Tokyo) , vol.67 , Issue.9 , pp. 671-676
    • Lin, Y.1    Zhu, N.2    Han, Y.3    Jiang, J.4    Si, S.5
  • 15
    • 84884567429 scopus 로고    scopus 로고
    • Rostirolla DC et al Discovery of new inhibitors of Mycobacterium tuberculosis InhA enzyme using virtual screening and a 3D-pharmacophore-based approach
    • Pauli I, Dos Santos RN, Rostirolla DC et al Discovery of new inhibitors of Mycobacterium tuberculosis InhA enzyme using virtual screening and a 3D-pharmacophore-based approach. J. Chem. Inf. Model. 53(9), 2390-2401 (2013).
    • (2013) J. Chem. Inf. Model. , vol.53 , Issue.9 , pp. 2390-2401
    • Pauli, I.1    Dos Santos, R.N.2
  • 16
    • 84864401215 scopus 로고    scopus 로고
    • Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening
    • Abrahams GL, Kumar A, Savvi S et al. Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening. Chem. Biol. 19(7), 844-854 (2012).
    • (2012) Chem. Biol. , vol.19 , Issue.7 , pp. 844-854
    • Abrahams, G.L.1    Kumar, A.2    Savvi, S.3
  • 17
    • 84864261321 scopus 로고    scopus 로고
    • Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis
    • Flipo M, Willand N, Lecat-Guillet N et al. Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis. J. Med. Chem. 55(14), 6391-6402 (2012).
    • (2012) J. Med. Chem. , vol.55 , Issue.14 , pp. 6391-6402
    • Flipo, M.1    Willand, N.2    Lecat-Guillet, N.3
  • 18
    • 33846874537 scopus 로고    scopus 로고
    • A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase
    • White EL, Southwork K, Ross L et al. A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase. J. Biomol. Screen. 12(1), 100-105 (2007).
    • (2007) J. Biomol. Screen. , vol.12 , Issue.1 , pp. 100-105
    • White, E.L.1    Southwork, K.2    Ross, L.3
  • 19
    • 84908126777 scopus 로고    scopus 로고
    • TuberQ: A Mycobacterium tuberculosis protein druggability database
    • Radusky L, Defelipe LA, Lanzarotti E et al. TuberQ: a Mycobacterium tuberculosis protein druggability database. Database (Oxford) 2014, 1-10 (2014).
    • (2014) Database (Oxford) , vol.2014 , pp. 1-10
    • Radusky, L.1    Defelipe, L.A.2    Lanzarotti, E.3
  • 21
    • 0036774642 scopus 로고    scopus 로고
    • Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv
    • Camus JC, Pryor MJ, Médigue C, Cole ST. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Microbiology 148(Pt 10), 2967-2973 (2002).
    • (2002) Microbiology , vol.148 , pp. 2967-2973
    • Camus, J.C.1    Pryor, M.J.2    Médigue, C.3    Cole, S.T.4
  • 22
    • 84893784333 scopus 로고    scopus 로고
    • Tuberculosis drug discovery in the post-post-genomic era
    • Lechartier B, Rybniker J, Zumla A, Cole ST. Tuberculosis drug discovery in the post-post-genomic era. EMBO Mol. Med. 6(2), 158-168 (2014).
    • (2014) EMBO Mol. Med. , vol.6 , Issue.2 , pp. 158-168
    • Lechartier, B.1    Rybniker, J.2    Zumla, A.3    Cole, S.T.4
  • 23
    • 79952760675 scopus 로고    scopus 로고
    • Depletion of antibiotic targets has widely varying effects on growth
    • Wei JR, Krishnamoorthy V, Murphy K et al. Depletion of antibiotic targets has widely varying effects on growth. Proc. Natl Acad. Sci. USA 108(10), 4176-4181 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , Issue.10 , pp. 4176-4181
    • Wei, J.R.1    Krishnamoorthy, V.2    Murphy, K.3
  • 24
    • 84900394823 scopus 로고    scopus 로고
    • Filtration improves the performance of a high-throughput screen for anti-mycobacterial compounds
    • Cheng N, Porter MA, Frick LW et al. Filtration improves the performance of a high-throughput screen for anti-mycobacterial compounds. PLoS ONE 9(5), e96348 (2014).
    • (2014) PLoS ONE , vol.9 , Issue.5 , pp. e96348
    • Cheng, N.1    Porter, M.A.2    Frick, L.W.3
  • 25
    • 84867334162 scopus 로고    scopus 로고
    • Comprehensive ana-lysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis
    • Franzblau SG, Degroote MA, Cho SH et al. Comprehensive ana-lysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis. Tuberculosis (Edinb.) 92(6), 453-458 (2012).
    • (2012) Tuberculosis (Edinb.) , vol.92 , Issue.6 , pp. 453-458
    • Franzblau, S.G.1    Degroote, M.A.2    Cho, S.H.3
  • 26
    • 84865253965 scopus 로고    scopus 로고
    • Identifcation of novel inhibitors of M. Tuberculosis growth using whole cell based high-throughput screening
    • Stanley SA, Grant SS, Kawate T et al. Identifcation of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem. Biol. 7(8), 1377-1384 (2012).
    • (2012) ACS Chem. Biol. , vol.7 , Issue.8 , pp. 1377-1384
    • Stanley, S.A.1    Grant, S.S.2    Kawate, T.3
  • 27
    • 79251537963 scopus 로고    scopus 로고
    • A chemical genetic screen in Mycobacterium tuberculosis identifes carbon-source-dependent growth inhibitors devoid of in vivo effcacy
    • Pethe K, Sequeira PC, Agarwalla S et al. A chemical genetic screen in Mycobacterium tuberculosis identifes carbon-source-dependent growth inhibitors devoid of in vivo effcacy. Nat. Commun. 1, 57 (2010).
    • (2010) Nat. Commun. , vol.1 , pp. 57
    • Pethe, K.1    Sequeira, P.C.2    Agarwalla, S.3
  • 28
    • 78049460213 scopus 로고    scopus 로고
    • Evaluation of the Mycobacterium smegmatis and BCG models for the discovery of Mycobacterium tuberculosis inhibitors
    • Altaf M, Miller CH, Bellows DS, O'toole R. Evaluation of the Mycobacterium smegmatis and BCG models for the discovery of Mycobacterium tuberculosis inhibitors. Tuberculosis (Edinb.) 90(6), 333-337 (2010).
    • (2010) Tuberculosis (Edinb.) , vol.90 , Issue.6 , pp. 333-337
    • Altaf, M.1    Miller, C.H.2    Bellows, D.S.3    O'Toole, R.4
  • 29
    • 84879707160 scopus 로고    scopus 로고
    • Identifcation of a small molecule with activity against drug-resistant and persistent tuberculosis
    • Wang F, Sambandan D, Halder R et al. Identifcation of a small molecule with activity against drug-resistant and persistent tuberculosis. Proc. Natl Acad. Sci. USA 110(27), E2510-E2517 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , Issue.27 , pp. E2510-E2517
    • Wang, F.1    Sambandan, D.2    Halder, R.3
  • 30
    • 84867061487 scopus 로고    scopus 로고
    • Nonsteroidal anti-infammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials
    • Gold B, Pingle M, Brickner SJ et al. Nonsteroidal anti-infammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proc. Natl Acad. Sci. USA 109(40), 16004-16011 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , Issue.40 , pp. 16004-16011
    • Gold, B.1    Pingle, M.2    Brickner, S.J.3
  • 31
    • 73649143180 scopus 로고    scopus 로고
    • High content screening identifes decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors
    • Christophe T, Jackson M, Jeon HK et al. High content screening identifes decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors. PLoS Pathog. 5(10), e1000645 (2009).
    • (2009) PLoS Pathog. , vol.5 , Issue.10 , pp. e1000645
    • Christophe, T.1    Jackson, M.2    Jeon, H.K.3
  • 32
    • 79960302847 scopus 로고    scopus 로고
    • Synergistic drug combinations for tuberculosis therapy identifed by a novel high-throughput screen
    • Ramón-García S, Ng C, Anderson H et al. Synergistic drug combinations for tuberculosis therapy identifed by a novel high-throughput screen. Antimicrob. Agents Chemother. 55(8), 3861-3869 (2011).
    • (2011) Antimicrob. Agents Chemother. , vol.55 , Issue.8 , pp. 3861-3869
    • Ramón-García, S.1    Ng, C.2    Anderson, H.3
  • 33
    • 84895732971 scopus 로고    scopus 로고
    • Identifcation of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth
    • Stanley SA, Barczak AK, Silvis MR. Identifcation of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. PLoS Pathog. 10(2), e1003946 (2014).
    • (2014) PLoS Pathog. , vol.10 , Issue.2 , pp. e1003946
    • Stanley, S.A.1    Barczak, A.K.2    Silvis, M.R.3
  • 34
    • 84873918966 scopus 로고    scopus 로고
    • Integration of chemical and RNAi multiparametric profles identifes triggers of intracellular mycobacterial killing
    • Sundaramurthy V, Barsacchi R, Samusik N et al. Integration of chemical and RNAi multiparametric profles identifes triggers of intracellular mycobacterial killing. Cell Host Microbe 13(2), 129-142 (2013).
    • (2013) Cell Host Microbe , vol.13 , Issue.2 , pp. 129-142
    • Sundaramurthy, V.1    Barsacchi, R.2    Samusik, N.3
  • 35
    • 70350765485 scopus 로고    scopus 로고
    • High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv
    • Ananthan S, Faaleolea ER, Goldman RC et al. High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv. Tuberculosis (Edinb.) 89(5), 334-353 (2009).
    • (2009) Tuberculosis (Edinb.) , vol.89 , Issue.5 , pp. 334-353
    • Ananthan, S.1    Faaleolea, E.R.2    Goldman, R.C.3
  • 36
    • 70449108128 scopus 로고    scopus 로고
    • Antituberculosis activity of the molecular libraries screening center network library
    • Maddry JA, Ananthan S, Goldman RC et al. Antituberculosis activity of the molecular libraries screening center network library. Tuberculosis (Edinb.) 89(5), 354-363 (2009).
    • (2009) Tuberculosis (Edinb.) , vol.89 , Issue.5 , pp. 354-363
    • Maddry, J.A.1    Ananthan, S.2    Goldman, R.C.3
  • 37
    • 84868100639 scopus 로고    scopus 로고
    • Targeting drug tolerance in mycobacteria: A perspective from mycobacterial bioflms
    • Islam MS, Richards JP, Ojha AK. Targeting drug tolerance in mycobacteria: a perspective from mycobacterial bioflms. Expert Rev. Anti. Infect. Ther. 10(9), 1055-1066 (2012).
    • (2012) Expert Rev. Anti. Infect. Ther. , vol.10 , Issue.9 , pp. 1055-1066
    • Islam, M.S.1    Richards, J.P.2    Ojha, A.K.3
  • 38
    • 84886571125 scopus 로고    scopus 로고
    • Identifcation of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model
    • Grant SS, Kawate T, Nag PP et al. Identifcation of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model. ACS Chem. Biol. 8(10), 2224-2234 (2013).
    • (2013) ACS Chem. Biol. , vol.8 , Issue.10 , pp. 2224-2234
    • Grant, S.S.1    Kawate, T.2    Nag, P.P.3
  • 39
    • 19944429772 scopus 로고    scopus 로고
    • A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
    • Andries K, Verhasselt P, Guillemont J et al. A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science 307, 5707 (2005).
    • (2005) Science , vol.307 , pp. 5707
    • Andries, K.1    Verhasselt, P.2    Guillemont, J.3
  • 40
    • 84864332596 scopus 로고    scopus 로고
    • Discovery and development of SQ109: A new antitubercular drug with a novel mechanism of action
    • Sacksteder KA, Protopopova M, Barry CE, Iii, Andries K, Nacy CA. Discovery and development of SQ109: a new antitubercular drug with a novel mechanism of action. Future Microbiol. 7(7), 823-837 (2012).
    • (2012) Future Microbiol. , vol.7 , Issue.7 , pp. 823-837
    • Sacksteder, K.A.1    Protopopova, M.2    Barry, C.E.3    Andries, K.4    Nacy, C.A.5
  • 41
    • 77951298792 scopus 로고    scopus 로고
    • The mechanism of action of PA-824: Novel insights from transcriptional profling
    • Manjunatha U, Boshoff HI, Barry CE. The mechanism of action of PA-824: novel insights from transcriptional profling. Commun. Integr. Biol. 2(3), 215-218 (2009).
    • (2009) Commun. Integr. Biol. , vol.2 , Issue.3 , pp. 215-218
    • Manjunatha, U.1    Boshoff, H.I.2    Barry, C.E.3
  • 42
    • 65649096556 scopus 로고    scopus 로고
    • Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis
    • Makarov V, Manina G, Mikusova K et al. Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. Science 324(5928), 801-804 (2009).
    • (2009) Science , vol.324 , Issue.5928 , pp. 801-804
    • Makarov, V.1    Manina, G.2    Mikusova, K.3
  • 43
    • 84896716778 scopus 로고    scopus 로고
    • Towards a new combination therapy for tuberculosis with next generation benzothiazinones
    • Makarov V, Lechartier B, Zhang M et al. Towards a new combination therapy for tuberculosis with next generation benzothiazinones. EMBO Mol. Med. 6(3), 372-383 (2014).
    • (2014) EMBO Mol. Med. , vol.6 , Issue.3 , pp. 372-383
    • Makarov, V.1    Lechartier, B.2    Zhang, M.3
  • 44
    • 84455173193 scopus 로고    scopus 로고
    • MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212
    • La Rosa V, Poce G, Canseco JO et al. MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212. Antimicrob. Agents Chemother. 56(1), 324-331 (2012).
    • (2012) Antimicrob. Agents Chemother. , vol.56 , Issue.1 , pp. 324-331
    • La Rosa, V.1    Poce, G.2    Canseco, J.O.3
  • 45
    • 84858677107 scopus 로고    scopus 로고
    • Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane
    • Grzegorzewicz AE, Pham H, Gundi VA et al. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat. Chem. Biol. 8(4), 334-341 (2012).
    • (2012) Nat. Chem. Biol. , vol.8 , Issue.4 , pp. 334-341
    • Grzegorzewicz, A.E.1    Pham, H.2    Gundi, V.A.3
  • 46
    • 84876272210 scopus 로고    scopus 로고
    • Tetrahydropyrazolo[1, 5-A]pyrimidine-3-carboxamide and N-benzyl-6', 7'-dihydrospiro[piperidine-4, 4'-thieno[3, 2-c] pyran] analogues with bactericidal effcacy against Mycobacterium tuberculosis targeting MmpL3
    • Remuiñán MJ, Pérez-Herrán E, Rullás J et al. Tetrahydropyrazolo[1, 5-a]pyrimidine-3-carboxamide and N-benzyl-6', 7'-dihydrospiro[piperidine-4, 4'-thieno[3, 2-c] pyran] analogues with bactericidal effcacy against Mycobacterium tuberculosis targeting MmpL3. PLoS ONE 8(4), e60933 (2013).
    • (2013) PLoS ONE , vol.8 , Issue.4 , pp. e60933
    • Remuiñán, M.J.1    Pérez-Herrán, E.2    Rullás, J.3
  • 47
    • 84863404695 scopus 로고    scopus 로고
    • SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis
    • Tahlan K, Wilson R, Kastrinsky DB et al. SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 56(4), 1797-1809 (2012).
    • (2012) Antimicrob. Agents Chemother. , vol.56 , Issue.4 , pp. 1797-1809
    • Tahlan, K.1    Wilson, R.2    Kastrinsky, D.B.3
  • 48
    • 84891722137 scopus 로고    scopus 로고
    • Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis
    • Rao SP, Lakshminarayana SB, Kondreddi RR et al. Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis. Sci. Transl. Med. 5(214), 214ra168 (2013).
    • (2013) Sci. Transl. Med. , vol.5 , Issue.214 , pp. 214ra168
    • Rao, S.P.1    Lakshminarayana, S.B.2    Kondreddi, R.R.3
  • 49
    • 84890543354 scopus 로고    scopus 로고
    • Azaindoles: Noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are effcacious in vivo
    • Shirude PS, Shandil R, Sadler C et al. Azaindoles: noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are effcacious in vivo. J. Med. Chem. 56(23), 9701-9708 (2013).
    • (2013) J. Med. Chem. , vol.56 , Issue.23 , pp. 9701-9708
    • Shirude, P.S.1    Shandil, R.2    Sadler, C.3
  • 50
    • 84903527119 scopus 로고    scopus 로고
    • 4-aminoquinolone piperidine amides: Noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity J
    • Naik M, Humnabadkar V, Tantry SJ et al. 4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity J. Med. Chem. 57(12), 5419-5434 (2014).
    • (2014) Med. Chem. , vol.57 , Issue.12 , pp. 5419-5434
    • Naik, M.1    Humnabadkar, V.2    Tantry, S.J.3
  • 51
    • 84902531985 scopus 로고    scopus 로고
    • Discovery of pyrazolopyridones as a novel class of noncovalent DprE1 inhibitor with potent anti-mycobacterial activity
    • Panda M, Ramachandran S, Ramachandran V et al. Discovery of pyrazolopyridones as a novel class of noncovalent DprE1 inhibitor with potent anti-mycobacterial activity. J. Med. Chem. 57(11), 4761-4771 (2014).
    • (2014) J. Med. Chem. , vol.57 , Issue.11 , pp. 4761-4771
    • Panda, M.1    Ramachandran, S.2    Ramachandran, V.3
  • 52
    • 84900449838 scopus 로고    scopus 로고
    • Design and syntheses of anti-tuberculosis agents inspired by BTZ043 using a scaffold simplifcation strategy
    • Tiwari R, Möllmann U, Cho S, Franzblau SG, Miller PA, Miller MJ. Design and syntheses of anti-tuberculosis agents inspired by BTZ043 using a scaffold simplifcation strategy. ACS Med. Chem. Lett. 5(5), 587-591 (2014).
    • (2014) ACS Med. Chem. Lett. , vol.5 , Issue.5 , pp. 587-591
    • Tiwari, R.1    Möllmann, U.2    Cho, S.3    Franzblau, S.G.4    Miller, P.A.5    Miller, M.J.6
  • 53
    • 84864128973 scopus 로고    scopus 로고
    • A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis
    • Mak PA, Rao SP, Ping Tan M et al. A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis. ACS Chem. Biol. 7 (7), 1190-1197 (2012).
    • (2012) ACS Chem. Biol. , vol.7 , Issue.7 , pp. 1190-1197
    • Mak, P.A.1    Rao, S.P.2    Ping Tan, M.3
  • 54
    • 84879939125 scopus 로고    scopus 로고
    • Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32
    • Stanley SA, Kawate T, Iwase N et al. Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32. Proc. Natl Acad. Sci. USA 110 (28), 11565-11570 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , Issue.28 , pp. 11565-11570
    • Stanley, S.A.1    Kawate, T.2    Iwase, N.3
  • 55
    • 84886920443 scopus 로고    scopus 로고
    • Inhibition of the frst step in synthesis of the mycobacterial cell wall core, catalyzed by the GlcNAc-1-phosphate transferase WecA, by the novel caprazamycin derivative CPZEN-45
    • Ishizaki Y, Hayashi C, Inoue K et al. Inhibition of the frst step in synthesis of the mycobacterial cell wall core, catalyzed by the GlcNAc-1-phosphate transferase WecA, by the novel caprazamycin derivative CPZEN-45. J. Biol. Chem. 288(42), 30309-30319 (2013).
    • (2013) J. Biol. Chem. , vol.288 , Issue.42 , pp. 30309-30319
    • Ishizaki, Y.1    Hayashi, C.2    Inoue, K.3
  • 56
    • 84887406804 scopus 로고    scopus 로고
    • Why are membrane targets discovered by phenotypic screens and genome sequencing in Mycobacterium tuberculosis?
    • Goldman RC. Why are membrane targets discovered by phenotypic screens and genome sequencing in Mycobacterium tuberculosis? Tuberculosis (Edinb.) 93(6), 569-588 (2013).
    • (2013) Tuberculosis (Edinb.) , vol.93 , Issue.6 , pp. 569-588
    • Goldman, R.C.1
  • 57
    • 55249104697 scopus 로고    scopus 로고
    • Low hanging fruit in infectious disease drug development
    • Kraus CN. Low hanging fruit in infectious disease drug development. Curr. Opin. Microbiol. 11(5), 434-438 (2008).
    • (2008) Curr. Opin. Microbiol. , vol.11 , Issue.5 , pp. 434-438
    • Kraus, C.N.1
  • 58
    • 84923195503 scopus 로고    scopus 로고
    • A randomised controlled trial of a 4-month gatifoxacin-containing regimen vs. Standard 6-month regimen for treating drug-susceptible pulmonary tuberculosis: Main effcacy and safety results of the OFLOTUB trial
    • Paris, France, 30 October-3 November
    • Merle C, Fielding K, Lapujade O et al. A randomised controlled trial of a 4-month gatifoxacin-containing regimen vs. standard 6-month regimen for treating drug-susceptible pulmonary tuberculosis: main effcacy and safety results of the OFLOTUB trial. Presented at: 44th Union World Conference on Lung Health. Paris, France, 30 October-3 November 2013.
    • (2013) Presented At: 44th Union World Conference on Lung Health
    • Merle, C.1    Fielding, K.2    Lapujade, O.3
  • 59
    • 84255201091 scopus 로고    scopus 로고
    • The oxazolidinones: Past, present, and future
    • Shaw KJ, Barbachyn MR. The oxazolidinones: past, present, and future. Ann. NY Acad. Sci. 1241, 48-70 (2011).
    • (2011) Ann. NY Acad. Sci. , vol.1241 , pp. 48-70
    • Shaw, K.J.1    Barbachyn, M.R.2
  • 60
    • 79952346767 scopus 로고    scopus 로고
    • Susceptibility of clinical Mycobacterium tuberculosis isolates to a potentially less toxic derivate of linezolid, PNU-100480
    • Alffenaar JW, Van Der Laan T, Simons S et al. Susceptibility of clinical Mycobacterium tuberculosis isolates to a potentially less toxic derivate of linezolid, PNU-100480. Antimicrob. Agents Chemother. 55 (3), 1287-1289 (2011).
    • (2011) Antimicrob. Agents Chemother. , vol.55 , Issue.3 , pp. 1287-1289
    • Alffenaar, J.W.1    Van Der Laan, T.2    Simons, S.3
  • 61
    • 84891550770 scopus 로고    scopus 로고
    • Bactericidal activity and mechanism of action of AZD5847: A novel oxazolidinone for treatment of tuberculosis
    • Balasubramanian V, Solapure S, Iyer H et al. Bactericidal activity and mechanism of action of AZD5847: a novel oxazolidinone for treatment of tuberculosis. Antimicrob. Agents Chemother. 58(1), 495-502 (2014).
    • (2014) Antimicrob. Agents Chemother. , vol.58 , Issue.1 , pp. 495-502
    • Balasubramanian, V.1    Solapure, S.2    Iyer, H.3
  • 62
    • 84867614599 scopus 로고    scopus 로고
    • Linezolid for treatment of chronic extensively drug-resistant tuberculosis
    • Lee M, Lee J, Carroll MW et al. Linezolid for treatment of chronic extensively drug-resistant tuberculosis. N. Engl. J. Med. 367(17), 1508-1518 (2012).
    • (2012) N. Engl. J. Med. , vol.367 , Issue.17 , pp. 1508-1518
    • Lee, M.1    Lee, J.2    Carroll, M.W.3
  • 63
    • 84880167301 scopus 로고    scopus 로고
    • Linezolid to treat extensively drug-resistant TB: Retrospective data are confrmed by experimental evidence
    • Sotgiu G, Centis R, D'ambrosio L, Spanevello A, Migliori GB; International Group for the study of Linezolid. Linezolid to treat extensively drug-resistant TB: retrospective data are confrmed by experimental evidence. Eur. Respir. J. 42(1), 288-290 (2013).
    • (2013) Eur. Respir. J. , vol.42 , Issue.1 , pp. 288-290
    • Sotgiu, G.1    Centis, R.2    D'Ambrosio, L.3    Spanevello, A.4    Migliori, G.B.5
  • 64
    • 84867345635 scopus 로고    scopus 로고
    • Identifcation of less lipophilic riminophenazine derivatives for the treatment of drug-resistant tuberculosis
    • Zhang D, Lu Y, Liu K et al. Identifcation of less lipophilic riminophenazine derivatives for the treatment of drug-resistant tuberculosis. J. Med. Chem. 55(19), 8409-8417 (2012).
    • (2012) J. Med. Chem. , vol.55 , Issue.19 , pp. 8409-8417
    • Zhang, D.1    Lu, Y.2    Liu, K.3
  • 65
    • 38049038389 scopus 로고    scopus 로고
    • Daily dosing of rifapentine cures tuberculosis in three months or less in the murine model
    • Rosenthal IM, Zhang M, Williams KN et al. Daily dosing of rifapentine cures tuberculosis in three months or less in the murine model. PLoS Med. 4(12), e344 (2007).
    • (2007) PLoS Med. , vol.4 , Issue.12 , pp. e344
    • Rosenthal, I.M.1    Zhang, M.2    Williams, K.N.3
  • 66
    • 0029861539 scopus 로고    scopus 로고
    • Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations
    • Moghazeh SL, Pan X, Arain T, Stover CK, Musser JM, Kreiswirth BN. Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations. Antimicrob. Agents Chemother. 40(11), 2655-2657 (1996).
    • (1996) Antimicrob. Agents Chemother. , vol.40 , Issue.11 , pp. 2655-2657
    • Moghazeh, S.L.1    Pan, X.2    Arain, T.3    Stover, C.K.4    Musser, J.M.5    Kreiswirth, B.N.6
  • 67
    • 0031795962 scopus 로고    scopus 로고
    • Relationship between antimycobacterial activities of rifampicin, rifabutin and KRM-1648 and rpoB mutations of Mycobacterium tuberculosis
    • Yang B, Koga H, Ohno H et al. Relationship between antimycobacterial activities of rifampicin, rifabutin and KRM-1648 and rpoB mutations of Mycobacterium tuberculosis. J. Antimicrob. Chemother. 42(5), 621-628 (1998).
    • (1998) J. Antimicrob. Chemother. , vol.42 , Issue.5 , pp. 621-628
    • Yang, B.1    Koga, H.2    Ohno, H.3
  • 68
    • 0034955967 scopus 로고    scopus 로고
    • Safety and bactericidal activity of rifalazil in patients with pulmonary tuberculosis
    • Dietze R, Teixeira L, Rocha LM et al. Safety and bactericidal activity of rifalazil in patients with pulmonary tuberculosis. Antimicrob. Agents Chemother. 45 (7), 1972-1976 (2001).
    • (2001) Antimicrob. Agents Chemother. , vol.45 , Issue.7 , pp. 1972-1976
    • Dietze, R.1    Teixeira, L.2    Rocha, L.M.3
  • 69
    • 84860277072 scopus 로고    scopus 로고
    • Structure-based design of novel benzoxazinorifamycins with potent binding affnity to wild-type and rifampin-resistant mutant Mycobacterium tuberculosis RNA polymerases
    • Gill SK, Xu H, Kirchhoff PD et al. Structure-based design of novel benzoxazinorifamycins with potent binding affnity to wild-type and rifampin-resistant mutant Mycobacterium tuberculosis RNA polymerases. J. Med. Chem. 55(8), 3814-3826 (2012).
    • (2012) J. Med. Chem. , vol.55 , Issue.8 , pp. 3814-3826
    • Gill, S.K.1    Xu, H.2    Kirchhoff, P.D.3
  • 70
  • 71
    • 79956366828 scopus 로고    scopus 로고
    • Nanomedicine and experimental tuberculosis: Facts, faws, and future
    • Pandey R, Ahmad Z. Nanomedicine and experimental tuberculosis: facts, faws, and future. Nanomedicine 7(3), 259-272 (2011).
    • (2011) Nanomedicine , vol.7 , Issue.3 , pp. 259-272
    • Pandey, R.1    Ahmad, Z.2
  • 72
    • 76849101592 scopus 로고    scopus 로고
    • Nanotechnology diagnostics for infectious diseases prevalent in developing countries
    • Hauck TS, Giri S, Gao Y, Chan WC. Nanotechnology diagnostics for infectious diseases prevalent in developing countries. Adv. Drug Deliv. Rev. 62(4-5), 438-448 (2010).
    • (2010) Adv. Drug Deliv. Rev. , vol.62 , Issue.4-5 , pp. 438-448
    • Hauck, T.S.1    Giri, S.2    Gao, Y.3    Chan, W.C.4
  • 73
    • 0344010111 scopus 로고    scopus 로고
    • Nanoparticle encapsulated antitubercular drugs as a potential oral drug delivery system against murine tuberculosis
    • Pandey R, Zahoor A, Sharma S, Khuller GK. Nanoparticle encapsulated antitubercular drugs as a potential oral drug delivery system against murine tuberculosis. Tuberculosis (Edinb.) 83(6), 373-378 (2003).
    • (2003) Tuberculosis (Edinb.) , vol.83 , Issue.6 , pp. 373-378
    • Pandey, R.1    Zahoor, A.2    Sharma, S.3    Khuller, G.K.4
  • 74
    • 20444385102 scopus 로고    scopus 로고
    • Solid lipid particle based inhalable sustained drug delivery system against experimental tuberculosis
    • Pandey R, Khuller GK. Solid lipid particle based inhalable sustained drug delivery system against experimental tuberculosis. Tuberculosis (Edinb.) 85(4), 227-234 (2005).
    • (2005) Tuberculosis (Edinb.) , vol.85 , Issue.4 , pp. 227-234
    • Pandey, R.1    Khuller, G.K.2
  • 75
    • 35348885989 scopus 로고    scopus 로고
    • Torsade de pointes associated with moxifoxacin: A rare but potentially fatal adverse event
    • Altin T, Ozcan O, Turhan S et al. Torsade de pointes associated with moxifoxacin: a rare but potentially fatal adverse event. Can. J. Cardiol. 23(11), 907-908 (2007).
    • (2007) Can. J. Cardiol. , vol.23 , Issue.11 , pp. 907-908
    • Altin, T.1    Ozcan, O.2    Turhan, S.3
  • 77
    • 84923212724 scopus 로고    scopus 로고
    • Severe QT interval prolongation associated with moxifoxacin: A case report
    • Koide T, Shiba M, Tanaka K et al. Severe QT interval prolongation associated with moxifoxacin: a case report. Cases J. 409, 1 (2008).
    • (2008) Cases J. , vol.409 , pp. 1
    • Koide, T.1    Shiba, M.2    Tanaka, K.3
  • 78
    • 0035170062 scopus 로고    scopus 로고
    • Interactions of a series of fuoroquinolone antibacterial drugs with the human cardiac K+ channel HERG
    • Kang J, Wang L, Chen XL, Triggle DJ, Rampe D. Interactions of a series of fuoroquinolone antibacterial drugs with the human cardiac K+ channel HERG. Mol. Pharmacol. 59(1), 122-126 (2001).
    • (2001) Mol. Pharmacol. , vol.59 , Issue.1 , pp. 122-126
    • Kang, J.1    Wang, L.2    Chen, X.L.3    Triggle, D.J.4    Rampe, D.5
  • 80
    • 84878887598 scopus 로고    scopus 로고
    • The synergic modeling for the binding of fuoroquinolone antibiotics to the hERG potassium channel
    • Ryu S, Imai YN, Oiki S. The synergic modeling for the binding of fuoroquinolone antibiotics to the hERG potassium channel. Bioorg. Med. Chem. Lett. 23(13), 3848-3851 (2013).
    • (2013) Bioorg. Med. Chem. Lett. , vol.23 , Issue.13 , pp. 3848-3851
    • Ryu, S.1    Imai, Y.N.2    Oiki, S.3
  • 82
    • 84876256428 scopus 로고    scopus 로고
    • + channel blockade: Exploring heteroaromaticity and rigidity in novel pyridine analogues of dofetilide
    • + channel blockade: exploring heteroaromaticity and rigidity in novel pyridine analogues of dofetilide. J. Med. Chem. 56(7), 2828-2840 (2013).
    • (2013) J. Med. Chem. , vol.56 , Issue.7 , pp. 2828-2840
    • Carvalho, J.F.1    Louvel, J.2    Doornbos, M.L.3
  • 83
    • 81555223850 scopus 로고    scopus 로고
    • Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II: Broad-spectrum antibacterial agents with reduced hERG activity
    • Reck F, Alm R, Brassil P et al. Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II: broad-spectrum antibacterial agents with reduced hERG activity. J. Med. Chem. 54(22), 7834-7847 (2011).
    • (2011) J. Med. Chem. , vol.54 , Issue.22 , pp. 7834-7847
    • Reck, F.1    Alm, R.2    Brassil, P.3
  • 84
    • 84864941895 scopus 로고    scopus 로고
    • Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pK(a): Antibacterial agents with an improved safety profle
    • Reck F, Alm RA, Brassil P et al. Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pK(a): antibacterial agents with an improved safety profle. J. Med. Chem. 55 (15), 6916-6933 (2012).
    • (2012) J. Med. Chem. , vol.55 , Issue.15 , pp. 6916-6933
    • Reck, F.1    Alm, R.A.2    Brassil, P.3
  • 85
    • 84902499633 scopus 로고    scopus 로고
    • Novel N-linked aminopiperidine-based gyrase inhibitors with improved hERG and in vivo effcacy against Mycobacterium tuberculosis
    • Hameed PS, Patil V, Solapure S et al. Novel N-linked aminopiperidine-based gyrase inhibitors with improved hERG and in vivo effcacy against Mycobacterium tuberculosis. J. Med. Chem. 57(11), 4889-4905 (2014).
    • (2014) J. Med. Chem. , vol.57 , Issue.11 , pp. 4889-4905
    • Hameed, P.S.1    Patil, V.2    Solapure, S.3
  • 86
    • 84884505005 scopus 로고    scopus 로고
    • Identifcation of new drug targets and resistance mechanisms in Mycobacterium tuberculosis
    • Ioerger TR, O'malley T, Liao R et al. Identifcation of new drug targets and resistance mechanisms in Mycobacterium tuberculosis. PLoS ONEe 8(9), e75245 (2013).
    • (2013) PLoS ONEe , vol.8 , Issue.9 , pp. e75245
    • Ioerger, T.R.1    O'Malley, T.2    Liao, R.3
  • 87
    • 84899576523 scopus 로고    scopus 로고
    • Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2
    • Gavrish E, Sit CS, Cao S et al. Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2. Chem. Biol. 21(4), 509-528 (2014).
    • (2014) Chem. Biol. , vol.21 , Issue.4 , pp. 509-528
    • Gavrish, E.1    Sit, C.S.2    Cao, S.3
  • 88
    • 13444292249 scopus 로고    scopus 로고
    • Using genome-wide transcriptional profling to elucidate small-molecule mechanism
    • Butcher RA, Schreiber SL. Using genome-wide transcriptional profling to elucidate small-molecule mechanism. Curr. Opin. Chem. Biol. 9(1), 25-30 (2005).
    • (2005) Curr. Opin. Chem. Biol. , vol.9 , Issue.1 , pp. 25-30
    • Butcher, R.A.1    Schreiber, S.L.2
  • 89
    • 4544312369 scopus 로고    scopus 로고
    • The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: Novel insights into drug mechanisms of action
    • Boshoff HI, Myers TG, Copp BR, Mcneil MR, Wilson MA, Barry CE 3rd. The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action. J. Biol. Chem. 279, 40174-40184 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 40174-40184
    • Boshoff, H.I.1    Myers, T.G.2    Copp, B.R.3    McNeil, M.R.4    Wilson, M.A.5    Barry, C.E.6
  • 91
    • 84890499902 scopus 로고    scopus 로고
    • Metabolomics deveal D-Alanine:D-Alanine ligase as the target of D-cycloserine in Mycobacterium tuberculosis
    • Prosser GA, De Varvalho LP. Metabolomics deveal D-Alanine:D-Alanine ligase as the target of D-cycloserine in Mycobacterium tuberculosis. ACS Med. Chem. Lett. 4, 1233-1237 (2013).
    • (2013) ACS Med. Chem. Lett. , vol.4 , pp. 1233-1237
    • Prosser, G.A.1    De Varvalho, L.P.2
  • 92
    • 76049084586 scopus 로고    scopus 로고
    • Ta rg e t identifcation using drug affnity responsive target stability (DARTS)
    • Lomenick B, Hao R, Jonai N et al. Ta rg e t identifcation using drug affnity responsive target stability (DARTS). Proc. Natl Acad. Sci. USA 106(51), 21984-21989 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , Issue.51 , pp. 21984-21989
    • Lomenick, B.1    Hao, R.2    Jonai, N.3
  • 93
    • 84887302442 scopus 로고    scopus 로고
    • Target prediction for an open access set of compounds active against Mycobacterium tuberculosis
    • Martínez-Jiménez F, Papadatos G, Yang L et al. Target prediction for an open access set of compounds active against Mycobacterium tuberculosis. PLoS Comput. Biol. 9 (10), e1003253 (2013).
    • (2013) PLoS Comput. Biol. , vol.9 , Issue.10 , pp. e1003253
    • Martínez-Jiménez, F.1    Papadatos, G.2    Yang, L.3
  • 94
    • 67049158003 scopus 로고    scopus 로고
    • Fishing the target of antitubercular compounds: In silico target deconvolution model development and validation
    • Prathipati P, Ma NL, Manjunatha UH, Bender A. Fishing the target of antitubercular compounds: in silico target deconvolution model development and validation. J. Proteome Res. 8(6), 2788-2798 (2009).
    • (2009) J. Proteome Res. , vol.8 , Issue.6 , pp. 2788-2798
    • Prathipati, P.1    Ma, N.L.2    Manjunatha, U.H.3    Bender, A.4
  • 95
    • 78649661569 scopus 로고    scopus 로고
    • The Mycobacterium tuberculosis drugome and its polypharmacological implications PLoS Comput
    • Kinnings SL, Xie L, Fung KH, Jackson RM, Xie L, Bourne PE. The Mycobacterium tuberculosis drugome and its polypharmacological implications PLoS Comput. Biol. 6 (11), e1000976 (2010).
    • (2010) Biol. , vol.6 , Issue.11 , pp. e1000976
    • Kinnings, S.L.1    Xie, L.2    Fung, K.H.3    Jackson, R.M.4    Xie, L.5    Bourne, P.E.6
  • 96
    • 84923195502 scopus 로고    scopus 로고
    • Seven pharmaceutical companies join academic researchers to speed TB drug discovery
    • Seven pharmaceutical companies join academic researchers to speed TB drug discovery. www.idri.org/press-6-25-12.php
  • 97
    • 84923195501 scopus 로고    scopus 로고
    • The Lilly TB drug discovery initiative
    • The Lilly TB drug discovery initiative. www.tbdrugdiscovery.org
  • 98
    • 84923195500 scopus 로고    scopus 로고
    • MM4TB more medicines for tuberculosis
    • MM4TB more medicines for tuberculosis. www.mm4tb.org
  • 99
    • 84923195499 scopus 로고    scopus 로고
    • We bT B
    • We bT B. www.webtb.org
  • 100
    • 84923195498 scopus 로고    scopus 로고
    • Tuberculosis trials consortium (TBTC)
    • Tuberculosis trials consortium (TBTC). www.cdc.gov


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.