Target Prediction for an Open Access Set of Compounds Active against Mycobacterium tuberculosis

PLoS Computational Biology

Volumn 9, Issue 10, 2013, Pages

  Martínez Jiménez, Francisco ^a,b   Papadatos, George ^c   Yang, Lun ^d   Wallace, Iain M ^c   Kumar, Vinod ^d   Pieper, Ursula ^e   Sali, Andrej ^e   Brown, James R ^d   Overington, John P ^c   Marti Renom, Marc A ^a,b  

^a Centre Nacional d'Analisi Genomica CNAG   (Spain)

^b CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Italy)

^d GLAXOSMITHKLINE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; DRUG THERAPY; TUBES (COMPONENTS);

CAUSATIVE AGENTS; CO-INFECTIONS; GLAXO SMITHKLINE; INFECTIOUS DISEASE; M. TUBERCULOSIS; MULTIDRUG RESISTANCE; MYCOBACTERIUM TUBERCULOSIS; OPENACCESS; PHARMACEUTICAL COMPANY; TARGET PREDICTION;

STRAIN;

GSK 1402290A; GSK 1829727A; GSK 1829729A; GSK 1829816A; GSK 270671A; GSK 479031A; GSK 547481A; GSK 547490A; GSK 547491A; GSK 547499A; GSK 547500A; GSK 547511A; GSK 547512A; GSK 547527A; GSK 547528A; GSK 547543A; GSK 975784A; GSK 975810A; GSK 975839A; GSK 975840A; GSK 975842A; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; BIOASSAY; DATA ANALYSIS; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; MATHEMATICAL COMPUTING; MYCOBACTERIUM TUBERCULOSIS; PREDICTION; STRUCTURAL HOMOLOGY;

MYCOBACTERIUM TUBERCULOSIS;

AMINO ACID SEQUENCE; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; COMPUTATIONAL BIOLOGY; DATABASES, CHEMICAL; DRUG DISCOVERY; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT;

EID: 84887302442     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003253     Document Type: Article

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