Discovery of pyrazolopyridones as a novel class of noncovalent DprE1 inhibitor with potent anti-mycobacterial activity

Journal of Medicinal Chemistry

Volumn 57, Issue 11, 2014, Pages 4761-4771

  Panda, Manoranjan ^a   Ramachandran, Sreekanth ^a   Ramachandran, Vasanthi ^a   Shirude, Pravin S ^a   Humnabadkar, Vaishali ^a   Nagalapur, Kavitha ^a   Sharma, Sreevalli ^a   Kaur, Parvinder ^a   Guptha, Supreeth ^a   Narayan, Ashwini ^a   Mahadevaswamy, Jyothi ^a   Ambady, Anisha ^a   Hegde, Naina ^a   Rudrapatna, Suresh S ^a   Hosagrahara, Vinayak P ^a   Sambandamurthy, Vasan K ^a   Raichurkar, Anandkumar ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMYCOBACTERIAL AGENT; PYRAZOLE DERIVATIVE; PYRIDONE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GENE; DRUG STRUCTURE; ENZYME INHIBITION; GENE MAPPING; GENE MUTATION; IN VITRO STUDY; MEDICINAL CHEMISTRY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHYSICAL CHEMISTRY;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; CATALYTIC DOMAIN; DRUG RESISTANCE, BACTERIAL; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; MUTATION; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES; PYRAZOLES; PYRIDONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84902531985     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5002937     Document Type: Article

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