SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 13, 2013, Pages 3848-3851

The synergic modeling for the binding of fluoroquinolone antibiotics to the hERG potassium channel

(3) Ryu, Sunghi a Imai, Yumi N a Oiki, Shigetoshi b

a TAKEDA PHARMACEUTICAL COMPANY LIMITED (Japan)

b UNIVERSITY OF FUKUI (Japan)

Author keywords

Binding mode prediction; Carboxyl group; Electrophysiology; hERG liability; Tandem dimer mutant

Indexed keywords

LEVOFLOXACIN; POTASSIUM CHANNEL HERG; SPARFLOXACIN;

ARTICLE; BINDING SITE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG PROTEIN BINDING; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING;

ANTI-BACTERIAL AGENTS; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHER-A-GO-GO POTASSIUM CHANNELS; FLUOROQUINOLONES; HUMANS; MODELS, MOLECULAR; POTASSIUM CHANNEL BLOCKERS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84878887598 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.04.074 Document Type: Article

Times cited : (5)

References (22)

1
- 0029002969
- M.C. Sanguinetti, C. Jiang, M.E. Curran, and M.T. Keating Cell 81 1995 299
- (1995) Cell , vol.81 , pp. 299
- Sanguinetti, M.C.¹ Jiang, C.² Curran, M.E.³ Keating, M.T.⁴

2
- 50249099700
- J.C. Hancox, M.J. McPate, A.E. Harchi, and Y.H. Zhang Pharmacol. Ther. 119 2008 118
- (2008) Pharmacol. Ther. , vol.119 , pp. 118
- Hancox, J.C.¹ McPate, M.J.² Harchi, A.E.³ Zhang, Y.H.⁴

3
- 0037122751
- S.R. Fletcher, F. Burkamp, P. Blurton, S.K. Cheng, R. Clarkson, D. O'Connor, D. Spinks, M. Tudge, M.B. van Niel, S. Patel, K. Chapman, R. Marwood, S. Shepheard, G. Bentley, G.P. Cook, L.J. Bristow, J.L. Castro, P.H. Hutson, and A.M. MacLeod J. Med. Chem. 45 2002 492
- (2002) J. Med. Chem. , vol.45 , pp. 492
- Fletcher, S.R.¹ Burkamp, F.² Blurton, P.³ Cheng, S.K.⁴ Clarkson, R.⁵ O'Connor, D.⁶ Spinks, D.⁷ Tudge, M.⁸ Van Niel, M.B.⁹ Patel, S.¹⁰ Chapman, K.¹¹ Marwood, R.¹² Shepheard, S.¹³ Bentley, G.¹⁴ Cook, G.P.¹⁵ Bristow, L.J.¹⁶ Castro, J.L.¹⁷ Hutson, P.H.¹⁸ Macleod, A.M.¹⁹

4
- 0035974740
- I.M. Bell, S.N. Gallicchio, M. Abrams, D.C. Beshore, C.A. Buser, J.C. Culberson, J. Davide, M. Ellis-Hutchings, C. Fernandes, J.B. Gibbs, S.L. Graham, G.D. Hartman, D.C. Heimbrook, C.F. Homnick, J.R. Huff, K. Kassahun, K.S. Koblan, N.E. Kohl, R.B. Lobell, J.J. Lynch Jr., P.A. Miller, C.A. Omer, A.D. Rodrigues, E.S. Walsh, and T.M. Williams J. Med. Chem. 44 2001 2933
- (2001) J. Med. Chem. , vol.44 , pp. 2933
- Bell, I.M.¹ Gallicchio, S.N.² Abrams, M.³ Beshore, D.C.⁴ Buser, C.A.⁵ Culberson, J.C.⁶ Davide, J.⁷ Ellis-Hutchings, M.⁸ Fernandes, C.⁹ Gibbs, J.B.¹⁰ Graham, S.L.¹¹ Hartman, G.D.¹² Heimbrook, D.C.¹³ Homnick, C.F.¹⁴ Huff, J.R.¹⁵ Kassahun, K.¹⁶ Koblan, K.S.¹⁷ Kohl, N.E.¹⁸ Lobell, R.B.¹⁹ Lynch, Jr.J.J.²⁰ more..

5
- 84893008503
- Jaeschke, G.; Alanine, A.; Bourson, A.; Buettelmann, B.; Fischer, H.; Gill, R.; Heitz, M.-P.; Huwyler, J.; Kemp, J. A.; Kansy, M.; Mutel, V.; Pinard, E.; Trube, G.; Wyler, R. Oral presentation at the XVII International Symposium on Medicinal Chemistry in Barcelona, 2002.
- (2002) Oral Presentation at the XVII International Symposium on Medicinal Chemistry in Barcelona
- Jaeschke, G.¹ Alanine, A.² Bourson, A.³ Buettelmann, B.⁴ Fischer, H.⁵ Gill, R.⁶ Heitz, M.-P.⁷ Huwyler, J.⁸ Kemp, J.A.⁹ Kansy, M.¹⁰ Mutel, V.¹¹ Pinard, E.¹² Trube, G.¹³ Wyler, R.¹⁴

6
- 0036856403
- C.R. Scherer, C. Lerche, N. Decher, A.T. Dennis, P. Maier, E. Ficker, A.E. Busch, B. Wollnik, and K. Steinmeyer Br. J. Pharmacol. 137 2002 892
- (2002) Br. J. Pharmacol. , vol.137 , pp. 892
- Scherer, C.R.¹ Lerche, C.² Decher, N.³ Dennis, A.T.⁴ Maier, P.⁵ Ficker, E.⁶ Busch, A.E.⁷ Wollnik, B.⁸ Steinmeyer, K.⁹

7
- 30344450817
- C.G. Thomson, E. Carlson, G.G. Chicchi, J.J. Kulagowski, M.M. Kurtz, C.J. Swain, K.-L.C. Tsao, and A. Wheeldon Bioorg. Med. Chem. Lett. 16 2006 811
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 811
- Thomson, C.G.¹ Carlson, E.² Chicchi, G.G.³ Kulagowski, J.J.⁴ Kurtz, M.M.⁵ Swain, C.J.⁶ Tsao, K.-L.C.⁷ Wheeldon, A.⁸

8
- 33748770143
- B.Y. Zhu, Z.J. Jia, P. Zhang, T. Su, W. Huang, E. Goldman, D. Tumas, V. Kadambi, P. Eddy, U. Sinha, R.M. Scarborough, and Y. Song Bioorg. Med. Chem. Lett. 16 2006 5507
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 5507
- Zhu, B.Y.¹ Jia, Z.J.² Zhang, P.³ Su, T.⁴ Huang, W.⁵ Goldman, E.⁶ Tumas, D.⁷ Kadambi, V.⁸ Eddy, P.⁹ Sinha, U.¹⁰ Scarborough, R.M.¹¹ Song, Y.¹²

9
- 0035170062
- J. Kang, L. Wang, X.L. Chen, D.J. Triggle, and D. Rampe Mol. Pharmacol. 59 2001 122
- (2001) Mol. Pharmacol. , vol.59 , pp. 122
- Kang, J.¹ Wang, L.² Chen, X.L.³ Triggle, D.J.⁴ Rampe, D.⁵

10
- 33947731626
- S.T. Murphy, H.L. Case, E. Ellsworth, S. Hagen, M. Huband, T. Joannides, C. Limberakis, K.R. Marotti, A.M. Ottolini, M. Rauckhorst, J. Starr, M. Stier, C. Taylor, T. Zhu, A. Blaser, W.A. Denny, G.-L. Lu, J.B. Smaill, and F. Rivault Bioorg. Med. Chem. Lett. 17 2007 2150
- (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 2150
- Murphy, S.T.¹ Case, H.L.² Ellsworth, E.³ Hagen, S.⁴ Huband, M.⁵ Joannides, T.⁶ Limberakis, C.⁷ Marotti, K.R.⁸ Ottolini, A.M.⁹ Rauckhorst, M.¹⁰ Starr, J.¹¹ Stier, M.¹² Taylor, C.¹³ Zhu, T.¹⁴ Blaser, A.¹⁵ Denny, W.A.¹⁶ Lu, G.-L.¹⁷ Smaill, J.B.¹⁸ Rivault, F.¹⁹

11
- 33646581672
- A.J. Alexandrou, R.S. Duncan, A. Sullivan, J.C. Hancox, D.J. Leishman, H.J. Witchel, and J.L. Leaney Br. J. Pharmacol. 147 2006 905
- (2006) Br. J. Pharmacol. , vol.147 , pp. 905
- Alexandrou, A.J.¹ Duncan, R.S.² Sullivan, A.³ Hancox, J.C.⁴ Leishman, D.J.⁵ Witchel, H.J.⁶ Leaney, J.L.⁷

12
- 64349094193
- Y.N. Imai, S.H. Ryu, and S. Oiki J. Med. Chem. 52 2009 1630
- (2009) J. Med. Chem. , vol.52 , pp. 1630
- Imai, Y.N.¹ Ryu, S.H.² Oiki, S.³

13
- 44249086160
- T. Myokai, S. Ryu, H. Shimizu, and S. Oiki Mol. Pharmacol. 73 2008 1643
- (2008) Mol. Pharmacol. , vol.73 , pp. 1643
- Myokai, T.¹ Ryu, S.² Shimizu, H.³ Oiki, S.⁴

14
- 0034710933
- A structural basis for drug-induced long QT syndrome
- J.S. Mitcheson, J. Chen, M. Lin, C. Culberson, and M.C. Sanguinetti A structural basis for drug-induced long QT syndrome Proc. Natl. Acad. Sci. USA 97 2000 12329
- (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 12329
- Mitcheson, J.S.¹ Chen, J.² Lin, M.³ Culberson, C.⁴ Sanguinetti, M.C.⁵

15
- 0031576989
- M.J. Bower, F.E. Cohen, and R.L. Dunbrack Jr. J. Mol. Biol. 267 1997 1268
- (1997) J. Mol. Biol. , vol.267 , pp. 1268
- Bower, M.J.¹ Cohen, F.E.² Dunbrack, Jr.R.L.³

16
- 0033954256
- H.M. Berman, J. Westbrook, Z. Feng, G. Gilliland, T.N. Bhat, H. Weissig, I.N. Shindyalov, and P.E. Bourne Nucleic Acids Res. 28 2000 235
- (2000) Nucleic Acids Res. , vol.28 , pp. 235
- Berman, H.M.¹ Westbrook, J.² Feng, Z.³ Gilliland, G.⁴ Bhat, T.N.⁵ Weissig, H.⁶ Shindyalov, I.N.⁷ Bourne, P.E.⁸

17
- 0027968068
- J.D. Thompson, D.G. Higgins, and T.J. Gibson Nucleic Acids Res. 22 1994 4673
- (1994) Nucleic Acids Res. , vol.22 , pp. 4673
- Thompson, J.D.¹ Higgins, D.G.² Gibson, T.J.³

18
- 0028854034
- G. Jones, P. Willet, and R.C. Glen J. Mol. Biol. 245 1995 43
- (1995) J. Mol. Biol. , vol.245 , pp. 43
- Jones, G.¹ Willet, P.² Glen, R.C.³

19
- 0004313703
- Chemical Computing Group: Montreal, Quebec, Canada
- MOE (Molecular Operating Environment), version 2005; Chemical Computing Group: Montreal, Quebec, Canada, 2005.
- (2005) MOE (Molecular Operating Environment), Version 2005

20
- 33750524034
- T. Hirano, S. Yasuda, Y. Osaka, M. Kobayashi, S. Itagaki, and K. Iseki Biochim. Biophys. Acta 1758 2006 1743
- (2006) Biochim. Biophys. Acta , vol.1758 , pp. 1743
- Hirano, T.¹ Yasuda, S.² Osaka, Y.³ Kobayashi, M.⁴ Itagaki, S.⁵ Iseki, K.⁶

21
- 84878820203
- (in Japanese)
- VEGAMOX™ Drug Medicine Interview Form, 2006, (in Japanese).
- (2006) VEGAMOX™ Drug Medicine Interview Form

22
- 13544254609
- F.M.E. Wagenlehner, and K.G. Naber Curr. Infect. Dis. Reports 7 2005 9
- (2005) Curr. Infect. Dis. Reports , vol.7 , pp. 9
- Wagenlehner, F.M.E.¹ Naber, K.G.²

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.