4-Aminoquinolone piperidine amides: Noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity

Journal of Medicinal Chemistry

Volumn 57, Issue 12, 2014, Pages 5419-5434

  Naik, Maruti ^a   Humnabadkar, Vaishali ^a   Tantry, Subramanyam J ^a   Panda, Manoranjan ^a   Narayan, Ashwini ^a   Guptha, Supreeth ^a   Panduga, Vijender ^a   Manjrekar, Praveena ^a   Jena, Lalit Kumar ^a   Koushik, Krishna ^a   Shanbhag, Gajanan ^a   Jatheendranath, Sandesh ^a,d   Manjunatha, M R ^a   Gorai, Gopinath ^a   Bathula, Chandramohan ^a   Rudrapatna, Suresh ^a   Achar, Vijayashree ^a   Sharma, Sreevalli ^a   Ambady, Anisha ^a   Hegde, Naina ^a   Mahadevaswamy, Jyothi ^a   Kaur, Parvinder ^a   Sambandamurthy, Vasan K ^a   Awasthy, Disha ^a   Narayan, Chandan ^a,e   Ravishankar, Sudha ^a   Madhavapeddi, Prashanti ^a   Reddy, Jitendar ^a   Prabhakar, K R ^a   Saralaya, Ramanatha ^a   Chatterji, Monalisa ^a   Whiteaker, James ^a   McLaughlin, Bob ^a   Chiarelli, Laurent R ^b   Riccardi, Giovanna ^b   Pasca, Maria Rosalia ^b   Binda, Claudia ^b   Neres, João ^c   Dhar, Neeraj ^c   Signorino Gelo, François ^c   McKinney, John D ^c   Ramachandran, Vasanthi ^a   Shandil, Radha ^a   Tommasi, Ruben ^a   Iyer, Pravin S ^a   Narayanan, Shridhar ^a   Hosagrahara, Vinayak ^a   Kavanagh, Stefan ^a   Dinesh, Neela ^a   Ghorpade, Sandeep R ^a   more..

^a ASTRAZENECA   (United Kingdom)

^b UNIVERSITY OF PAVIA   (Italy)

^c EPFL   (Switzerland)

^d Pohang University of Science and Technology (POSTECH)   (South Korea)

^e JEALOTT S HILL RESEARCH STATION   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOQUINOLONE PIPERIDINE AMIDE DERIVATIVE; BEDAQUILINE; DECAPRENYLPHOSPHORYL BETA DEXTRO RIBOSE 2' EPIMERASE; EPIMERASE; ISONIAZID; MOXIFLOXACIN; PIPERIDINE DERIVATIVE; RIFAMPICIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; ENZYME KINETICS; IC 50; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CELL LINE, TUMOR; DRUG RESISTANCE, BACTERIAL; GENOME, BACTERIAL; HUMANS; KINETICS; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; MUTATION; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES; PIPERIDINES; PROTEIN BINDING; QUINOLONES; RATS, WISTAR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84903527119     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5005978     Document Type: Article

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