Integration of chemical and RNAi multiparametric profiles identifies triggers of intracellular mycobacterial killing

Cell Host and Microbe

Volumn 13, Issue 2, 2013, Pages 129-142

  Sundaramurthy, Varadharajan ^a   Barsacchi, Rico ^a   Samusik, Nikolay ^a   Marsico, Giovanni ^a   Gilleron, Jerome ^a   Kalaidzidis, Inna ^a   Meyenhofer, Felix ^a   Bickle, Marc ^a   Kalaidzidis, Yannis ^a,b   Zerial, Marino ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

HALOPERIDOL; NORTRIPTYLINE; PROCHLORPERAZINE EDISYLATE; SMALL INTERFERING RNA;

ARTICLE; AUTOPHAGY; BACTERIAL SURVIVAL; CELL MIGRATION; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; GENETIC ASSOCIATION; GENETIC SCREENING; HUMAN; HUMAN CELL; IMAGE ANALYSIS; INTRACELLULAR KILLING; MACROPHAGE; MOLECULAR LIBRARY; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RNA INTERFERENCE;

EID: 84873918966     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2013.01.008     Document Type: Article

References (46)

1. E. Alix, S. Mukherjee, and C.R. Roy Subversion of membrane transport pathways by vacuolar pathogens J. Cell Biol. 195 2011 943 952
2. J.A. Armstrong, and P.D. Hart Response of cultured macrophages to Mycobacterium tuberculosis, with observations on fusion of lysosomes with phagosomes J. Exp. Med. 134 1971 713 740
3. S.M. Behar, M. Divangahi, and H.G. Remold Evasion of innate immunity by Mycobacterium tuberculosis: is death an exit strategy? Nat. Rev. Microbiol. 8 2010 668 674
4. C. Bucci, R.G. Parton, I.H. Mather, H. Stunnenberg, K. Simons, B. Hoflack, and M. Zerial The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway Cell 70 1992 715 728
5. A. Caspi, R. Granek, and M. Elbaum Diffusion and directed motion in cellular transport Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 66 2002 011916 10.1103/PhysRevE.66.011916 (Pubitemid 40599009)
6. M. Chen, H. Gan, and H.G. Remold A mechanism of virulence: virulent Mycobacterium tuberculosis strain H37Rv, but not attenuated H37Ra, causes significant mitochondrial inner membrane disruption in macrophages leading to necrosis J. Immunol. 176 2006 3707 3716 (Pubitemid 43364017)
7. S. Christoforidis, H.M. McBride, R.D. Burgoyne, and M. Zerial The Rab5 effector EEA1 is a core component of endosome docking Nature 397 1999 621 625 (Pubitemid 29091948)
8. C. Collinet, M. Stöter, C.R. Bradshaw, N. Samusik, J.C. Rink, D. Kenski, B. Habermann, F. Buchholz, R. Henschel, and M.S. Mueller Systems survey of endocytosis by multiparametric image analysis Nature 464 2010 243 249
9. P. Del Conte-Zerial, L. Brusch, J.C. Rink, C. Collinet, Y. Kalaidzidis, M. Zerial, and A. Deutsch Membrane identity and GTPase cascades regulated by toggle and cut-out switches Mol. Syst. Biol. 4 2008 206 10.1038/msb.2008.45 (Pubitemid 352001264)
10. M. Desjardins, L.A. Huber, R.G. Parton, and G. Griffiths Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus J. Cell Biol. 124 1994 677 688 (Pubitemid 24085778)
11. S. Dhandayuthapani, L.E. Via, C.A. Thomas, P.M. Horowitz, D. Deretic, and V. Deretic Green fluorescent protein as a marker for gene expression and cell biology of mycobacterial interactions with macrophages Mol. Microbiol. 17 1995 901 912
12. M.D. Dyer, T.M. Murali, and B.W. Sobral The landscape of human proteins interacting with viruses and other pathogens PLoS Pathog. 4 2008 e32 10.1371/journal.ppat.0040032 (Pubitemid 351340702)
13. U.S. Eggert, A.A. Kiger, C. Richter, Z.E. Perlman, N. Perrimon, T.J. Mitchison, and C.M. Field Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets PLoS Biol. 2 2004 e379 10.1371/journal.pbio.0020379 (Pubitemid 40280520)
14. G.D. Fairn, and S. Grinstein How nascent phagosomes mature to become phagolysosomes Trends Immunol. 33 2012 397 405
15. L. Foret, J.E. Dawson, R. Villaseñor, C. Collinet, A. Deutsch, L. Brusch, M. Zerial, Y. Kalaidzidis, and F. Jülicher A general theoretical framework to infer endosomal network dynamics from quantitative image analysis Curr. Biol. 22 2012 1381 1390
16. R.A. Fratti, J.M. Backer, J. Gruenberg, S. Corvera, and V. Deretic Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest J. Cell Biol. 154 2001 631 644 (Pubitemid 34286167)
17. M.G. Gutierrez, S.S. Master, S.B. Singh, G.A. Taylor, M.I. Colombo, and V. Deretic Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages Cell 119 2004 753 766 (Pubitemid 40017683)
18. R. Huang, N. Southall, Y. Wang, A. Yasgar, P. Shinn, A. Jadhav, D.T. Nguyen, and C.P. Austin The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics Sci. Transl. Med. 3 2011 10.1126/scitranslmed.3001862 80ps16
19. P. Imming, C. Sinning, and A. Meyer Drugs, their targets and the nature and number of drug targets Nat. Rev. Drug Discov. 5 2006 821 834 (Pubitemid 44480536)
20. R. Jayachandran, V. Sundaramurthy, B. Combaluzier, P. Mueller, H. Korf, K. Huygen, T. Miyazaki, I. Albrecht, J. Massner, and J. Pieters Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin Cell 130 2007 37 50 (Pubitemid 47031320)
21. S. Jayaswal, M.A. Kamal, R. Dua, S. Gupta, T. Majumdar, G. Das, D. Kumar, and K.V. Rao Identification of host-dependent survival factors for intracellular Mycobacterium tuberculosis through an siRNA screen PLoS Pathog. 6 2010 e1000839 10.1371/journal.ppat.1000839
22. Karnovsky, M. (1971). Use of ferrocyanide-reduced osmium tetroxide in electron microscopy. In Proceedings of the Eleventh Annual Meeting of the American Society for Cell Biology.
23. J. Keane, H.G. Remold, and H. Kornfeld Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages J. Immunol. 164 2000 2016 2020 (Pubitemid 30108758)
24. S. Kimura, T. Noda, and T. Yoshimori Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3 Autophagy 3 2007 452 460 (Pubitemid 47293726)
25. D.J. Klionsky, H. Abeliovich, P. Agostinis, D.K. Agrawal, G. Aliev, D.S. Askew, M. Baba, E.H. Baehrecke, B.A. Bahr, and A. Ballabio Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes Autophagy 4 2008 151 175 (Pubitemid 351231180)
26. T. Kobayashi, E. Stang, K.S. Fang, P. de Moerloose, R.G. Parton, and J. Gruenberg A lipid associated with the antiphospholipid syndrome regulates endosome structure and function Nature 392 1998 193 197 (Pubitemid 28162794)
27. A. Koul, T. Herget, B. Klebl, and A. Ullrich Interplay between mycobacteria and host signalling pathways Nat. Rev. Microbiol. 2 2004 189 202 (Pubitemid 39490082)
28. C. Kuijl, N.D. Savage, M. Marsman, A.W. Tuin, L. Janssen, D.A. Egan, M. Ketema, R. van den Nieuwendijk, S.J. van den Eeden, and A. Geluk Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1 Nature 450 2007 725 730 (Pubitemid 350207691)
29. D. Kumar, L. Nath, M.A. Kamal, A. Varshney, A. Jain, S. Singh, and K.V. Rao Genome-wide analysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis Cell 140 2010 731 743
30. M. Laplante, and D.M. Sabatini mTOR signaling in growth control and disease Cell 149 2012 274 293
31. T. Matsuzawa, B.H. Kim, A.R. Shenoy, S. Kamitani, M. Miyake, and J.D. Macmicking IFN-γ elicits macrophage autophagy via the p38 MAPK signaling pathway J. Immunol. 189 2012 813 818
32. J. Pieters Mycobacterium tuberculosis and the macrophage: maintaining a balance Cell Host Microbe 3 2008 399 407 (Pubitemid 351773101)
33. M. Ponpuak, A.S. Davis, E.A. Roberts, M.A. Delgado, C. Dinkins, Z. Zhao, H.W. Virgin 4th, G.B. Kyei, T. Johansen, I. Vergne, and V. Deretic Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties Immunity 32 2010 329 341
34. I. Poser, M. Sarov, J.R. Hutchins, J.K. Hériché, Y. Toyoda, A. Pozniakovsky, D. Weigl, A. Nitzsche, B. Hegemann, and A.W. Bird BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals Nat. Methods 5 2008 409 415 (Pubitemid 351619099)
35. R. Regenthal, M. Krueger, C. Koeppel, and R. Preiss Drug levels: therapeutic and toxic serum/plasma concentrations of common drugs J. Clin. Monit. Comput. 15 1999 529 544 (Pubitemid 30311655)
36. J. Rink, E. Ghigo, Y. Kalaidzidis, and M. Zerial Rab conversion as a mechanism of progression from early to late endosomes Cell 122 2005 735 749 (Pubitemid 41242638)
37. M. Rossi, E.R. Munarriz, S. Bartesaghi, M. Milanese, D. Dinsdale, M.A. Guerra-Martin, E.T. Bampton, P. Glynn, G. Bonanno, and R.A. Knight Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux J. Cell Sci. 122 2009 3330 3339
38. D.G. Russell Mycobacterium tuberculosis: here today, and here tomorrow Nat. Rev. Mol. Cell Biol. 2 2001 569 577 (Pubitemid 33674008)
39. S.L. Schmid, and P.R. Cullis Membrane sorting. Endosome marker is fat not fiction Nature 392 1998 135 136 (Pubitemid 28162769)
40. A. Schwegmann, and F. Brombacher Host-directed drug targeting of factors hijacked by pathogens Sci. Signal. 1 2008 re8
41. P.O. Seglen, and P.B. Gordon 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes Proc. Natl. Acad. Sci. USA 79 1982 1889 1892 (Pubitemid 12088533)
42. C. Settembre, C. Di Malta, V.A. Polito, M. Garcia Arencibia, F. Vetrini, S. Erdin, S.U. Erdin, T. Huynh, D. Medina, and P. Colella TFEB links autophagy to lysosomal biogenesis Science 332 2011 1429 1433
43. H. Shubin, J. Sherson, E. Pennes, A. Glaskin, and A. Sokmensuer Prochlorperazine (compazine) as an aid in the treatment of pulmonary tuberculosis Antibiotic Med. Clin. Ther. 5 1958 305 309
44. D.C. Swinney, and J. Anthony How were new medicines discovered? Nat. Rev. Drug Discov. 10 2011 507 519
45. I. Vergne, J. Chua, H.H. Lee, M. Lucas, J. Belisle, and V. Deretic Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis Proc. Natl. Acad. Sci. USA 102 2005 4033 4038 (Pubitemid 40388550)
46. J. Zschocke, N. Zimmermann, B. Berning, V. Ganal, F. Holsboer, and T. Rein Antidepressant drugs diversely affect autophagy pathways in astrocytes and neurons - dissociation from cholesterol homeostasis Neuropsychopharmacology 36 2011 1754 1768