Identification of less lipophilic riminophenazine derivatives for the treatment of drug-resistant tuberculosis

Journal of Medicinal Chemistry

Volumn 55, Issue 19, 2012, Pages 8409-8417

  Zhang, Dongfeng ^a   Lu, Yu ^b   Liu, Kai ^a   Liu, Binna ^a   Wang, Jingbin ^a   Zhang, Gang ^a   Zhang, Hao ^a   Liu, Yang ^a   Wang, Bin ^b   Zheng, Meiqin ^b   Fu, Lei ^b   Hou, Yanyan ^a   Gong, Ningbo ^a   Lv, Yang ^a   Li, Chun ^a   Cooper, Christopher B ^c   Upton, Anna M ^c   Yin, Dali ^a   Ma, Zhenkun ^c   Huang, Haihong ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOFAZIMINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; DRUG SAFETY; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; LIPOPHILICITY; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; MULTIDRUG RESISTANT TUBERCULOSIS; NONHUMAN; TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; CLOFAZIMINE; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MULTIPLE, BACTERIAL; MALE; MICE; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP; TOXICITY TESTS, ACUTE; TUBERCULOSIS, MULTIDRUG-RESISTANT;

EID: 84867345635     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300828h     Document Type: Article

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