A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Kumar, Anuradha ^a   Casey, Allen ^b   Odingo, Joshua ^b   Kesicki, Edward A ^b   Abrahams, Garth ^c   Vieth, Michal ^d   Masquelin, Thierry ^d   Mizrahi, Valerie ^c   Hipskind, Philip A ^d   Sherman, David R ^a   Parish, Tanya ^b  

^a SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^b INFECTIOUS DISEASE RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 BIPHENYL 4 CYANOPYRROLE 2 CARBOXYLIC ACID DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; PANTOTHENATE SYNTHETASE; RECOMBINANT PROTEIN; SYNTHETASE; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CLASSIFICATION; DRUG CYTOTOXICITY; DRUG TARGETING; ENZYME ASSAY; ENZYME INHIBITION; GROWTH INHIBITION; HIGH THROUGHPUT SEQUENCING; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; VERO CELL;

ANIMALS; BACTERIAL PROTEINS; CERCOPITHECUS AETHIOPS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; MICE; MICROBIAL VIABILITY; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE SYNTHASES; RECOMBINANT PROTEINS; TUBERCULOSIS; VERO CELLS;

EID: 84892415655     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072786     Document Type: Article

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