Azaindoles: Noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are efficacious in vivo

Journal of Medicinal Chemistry

Volumn 56, Issue 23, 2013, Pages 9701-9708

  Shirude, Pravin S ^a   Shandil, Radha ^a   Sadler, Claire ^a   Naik, Maruti ^a   Hosagrahara, Vinayak ^a   Hameed, Shahul ^a   Shinde, Vikas ^a   Bathula, Chandramohan ^a   Humnabadkar, Vaishali ^a   Kumar, Naveen ^a   Reddy, Jitendar ^a   Panduga, Vijender ^a   Sharma, Sreevalli ^a   Ambady, Anisha ^a   Hegde, Naina ^a   Whiteaker, James ^a   McLaughlin, Robert E ^a   Gardner, Humphrey ^a   Madhavapeddi, Prashanti ^a   Ramachandran, Vasanthi ^a   Kaur, Parvinder ^a   Narayan, Ashwini ^a   Guptha, Supreeth ^a   Awasthy, Disha ^a   Narayan, Chandan ^a   Mahadevaswamy, Jyothi ^a   Vishwas, K G ^a   Ahuja, Vijaykamal ^a   Srivastava, Abhishek ^a   Prabhakar, Kr ^a   Bharath, Sowmya ^a   Kale, Ramesh ^a   Ramaiah, Manjunatha ^a   Choudhury, Nilanjana Roy ^a   Sambandamurthy, Vasan K ^a   Solapure, Suresh ^a   Iyer, Pravin S ^a   Narayanan, Shridhar ^a   Chatterji, Monalisa ^a   more..

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; AZAINDOLE DERIVATIVE; DECAPRENYLPHOSPHORYL BETA D RIBOSE2' EPIMERASE; EPIMERASE; INDOLE DERIVATIVE; ISONIAZID; N (2 FLUOROETHYL) 1 [(6 METHOXY 5 METHYLPYRIMIDIN 4 YL)METHYL] 1H PYRROLO[3,2 B]PYRIDINE 3 CARBOXAMIDE; N (2 FLUOROETHYL) 1 [(6 METHOXY 5 METHYLPYRIMIDIN 4 YL)METHYL] 6 METHYL 1H PYRROLO[3,2 B]PYRIDINE 3 CARBOXAMIDE; N (2 HYDROXYETHYL) 1 [(6 METHOXY 5 METHYLPYRIMIDIN 4 YL)METHYL] 6 METHYL 1H PYRROLO[3,2 B]PYRIDINE 3 CARBOXAMIDE; N (CYCLOPROPYLMETHYL) 1 (2 METHYLBENZYL) 1H PYRROLO[3,2 B]PYRIDINE 3 CARBOXAMIDE; N (CYCLOPROPYLMETHYL) 1 [(6 METHOXY 5 METHYLPYRIMIDIN 4 YL)METHYL] 1H PYRROLO[3,2 B]PYRIDINE 3 CARBOXAMIDE; RIFAMPICIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG ACTIVITY; DRUG EFFICACY; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS;

EID: 84890543354     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401382v     Document Type: Article

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