Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response

Neuroscience and Biobehavioral Reviews

Volumn 51, Issue , 2015, Pages 164-188

  Andrews, Paul W ^a   Bharwani, Aadil ^a   Lee, Kyuwon R ^a   Fox, Molly ^b   Thomson, J Anderson ^c  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Analysis; Depression; Distraction; Energy regulation; Hippocampus; Hypothalamus; Learning; Plasticity; Prefrontal cortex; Serotonin; Working memory

Indexed keywords

CARBOHYDRATE; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; TIANEPTINE; TRYPTOPHAN; ANTIDEPRESSANT AGENT;

AMYGDALOID NUCLEUS; ANHEDONIA; ANXIETY; BRAIN DAMAGE; CALIBRATION; CHRONIC STRESS; CLEARANCE; DEPRESSION; DNA POLYMORPHISM; DORSAL RAPHE NUCLEUS; ENERGY HOMEOSTASIS; EVOLUTION; GENETIC MODEL; GLUTAMATE CLEARANCE; GLYCOLYSIS; HOMEOSTASIS; HUMAN; IMMOBILIZATION STRESS; INESCAPABLE SHOCK; INFECTION; JUGULAR VEIN; LEARNED HELPLESSNESS; MELANCHOLIA; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; NUCLEUS ACCUMBENS; OLFACTORY BULBECTOMY; ORIENTING RESPONSE; PREFRONTAL CORTEX; PROTEIN DEPLETION; REVIEW; RUMINATION; SEROTONIN CLEARANCE; SEROTONINERGIC SYSTEM; SEROTONINERGIC TRANSMISSION; SERT GENE; SOCIAL INTERACTION; STARVATION; SYMPTOM; TREATMENT RESPONSE; WORKING MEMORY; ANIMAL; BRAIN; DEPRESSIVE DISORDER; DRUG EFFECTS; METABOLISM;

ANIMALS; ANTIDEPRESSIVE AGENTS; BRAIN; DEPRESSIVE DISORDER; HUMANS; SEROTONIN; SEROTONIN UPTAKE INHIBITORS;

EID: 84923053470     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2015.01.018     Document Type: Review

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